(Q37157838)

18 August 2017

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title

Alpha-synuclein and Parkinson's disease: a proteomic view (English)

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18 August 2017

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2

Leonardo Lopiano

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18 August 2017

Mauro Fasano

1

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18 August 2017

publication date

1 April 2008

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Expert Review of Proteomics

18 August 2017

published in

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18 August 2017

volume

5

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18 August 2017

issue

2

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18 August 2017

page(s)

239-248

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Parkinson's disease. First of two parts

18 August 2017

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Protein aggregation in the pathogenesis of familial and sporadic Parkinson's disease

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Alpha-synuclein in Lewy bodies

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Alpha-synuclein and neurodegenerative diseases

21 January 2018

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Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

21 January 2018

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Melanin, tyrosine hydroxylase, calbindin and substance P in the human midbrain and substantia nigra in relation to nigrostriatal projections and differential neuronal susceptibility in Parkinson's disease

21 January 2018

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Is the vulnerability of neurons in the substantia nigra of patients with Parkinson's disease related to their neuromelanin content?

21 January 2018

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Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics

21 January 2018

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Neuromelanin in human dopamine neurons: Comparison with peripheral melanins and relevance to Parkinson's disease

21 January 2018

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Structural changes in alpha-synuclein affect its chaperone-like activity in vitro

21 January 2018

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Etiology of Parkinson's disease: Genetics and environment revisited

21 January 2018

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A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins

21 January 2018

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A topological model of the interaction between alpha-synuclein and sodium dodecyl sulfate micelles.

21 January 2018

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Oxidative stress and genetics in the pathogenesis of Parkinson's disease

21 January 2018

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Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein

21 January 2018

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Unraveling the pathogenesis of Parkinson's disease--the contribution of monogenic forms

21 January 2018

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Genetics of Parkinson's disease and parkinsonism

21 January 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

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Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

21 January 2018

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Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications

21 January 2018

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alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity

21 January 2018

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Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult

21 January 2018

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Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

21 January 2018

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Human alpha-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine.

21 January 2018

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Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

21 January 2018

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Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease?

21 January 2018

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Cell systems and the toxic mechanism(s) of alpha-synuclein

21 January 2018

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Neurodegenerative diseases and oxidative stress

21 January 2018

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https://api.crossref.org/works/10.1586%2F14789450.5.2.239

21 January 2018

1 reference

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Alpha-synuclein and dopamine metabolism

21 January 2018

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Modifications of the iron-neuromelanin system in Parkinson's disease

21 January 2018

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Is neuromelanin changed in Parkinson's disease? Investigations by magnetic spectroscopies.

21 January 2018

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Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease

21 January 2018

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Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes

21 January 2018

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Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.

21 January 2018

1 reference

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Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

21 January 2018

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Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

21 January 2018

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Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease

21 January 2018

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Stable interaction between G-actin and neurofilament light subunit in dopaminergic neurons.

21 January 2018

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Residual substantia nigra neuromelanin in Parkinson's disease is cross-linked to alpha-synuclein.

21 January 2018

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Stages in the development of Parkinson's disease-related pathology

21 January 2018

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Biomarkers and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Biomarkers of neurodegenerative disorders: how good are they?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Biomarkers in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Proteomics in neurodegeneration--disease driven approaches.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

2D gel blood serum biomarkers reveal differential clinical proteomics of the neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

The proteomic approach in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Proteome analysis of mesencephalic tissues: evidence for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Proteome analysis of human substantia nigra in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

"Subcellular proteomics" of neuromelanin granules isolated from the human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Proteomics of the human brain: sub-proteomes might hold the key to handle brain complexity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Proteome analysis of human substantia nigra in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Clonal expansion and not cell interconversion is the basis for the neuroblast and nonneuronal types of the SK-N-SH neuroblastoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Dopamine induces autophagic cell death and alpha-synuclein increase in human neuroblastoma SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

alpha-Synuclein protects SH-SY5Y cells from dopamine toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Analysis of alpha-synuclein-associated proteins by quantitative proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Identification of novel proteins associated with both alpha-synuclein and DJ-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Identification of proteins involved in microglial endocytosis of alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

A Drosophila model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Proteomics of Caenorhabditis elegans over-expressing human alpha-synuclein analyzed by fluorogenic derivatization-liquid chromatography/tandem mass spectrometry: identification of actin and several ribosomal proteins as negative markers at early Par

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Protein expression in a Drosophila model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Lifetime proteomic profiling of an A30P alpha-synuclein Drosophila model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Parkinson's disease: mechanisms and models

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Proteomics-driven progress in neurodegeneration research

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.5.2.239

Transduced Tat-alpha-synuclein protects against oxidative stress in vitro and in vivo.

21 January 2018

1 reference

3 January 2024

https://opencitations.net/index/api/v1/citations/10.5483/BMBREP.2006.39.3.253

Identifiers

DOI

10.1586/14789450.5.2.239

1 reference

18 August 2017

1 reference