(Q37183495)

English

The antifolates

scientific article published on June 2012

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

18 August 2017

The antifolates (English)

1 reference

Europe PubMed Central

18 August 2017

author name string

Michele Visentin

1

1 reference

Europe PubMed Central

18 August 2017

Rongbao Zhao

2

1 reference

Europe PubMed Central

18 August 2017

I David Goldman

3

1 reference

Europe PubMed Central

18 August 2017

publication date

1 June 2012

1 reference

Europe PubMed Central

18 August 2017

Hematology / Oncology Clinics of North America

1 reference

Europe PubMed Central

18 August 2017

26

1 reference

Europe PubMed Central

18 August 2017

3

1 reference

Europe PubMed Central

18 August 2017

629-48, ix

1 reference

Europe PubMed Central

18 August 2017

Therapeutic targeting of a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter

1 reference

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1 reference

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1 reference

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Mechanisms of membrane transport of folates into cells and across epithelia

1 reference

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Escalating intravenous methotrexate improves event-free survival in children with standard-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group

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Effectiveness of high-dose methotrexate in T-cell lymphoblastic leukemia and advanced-stage lymphoblastic lymphoma: a randomized study by the Children's Oncology Group (POG 9404).

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Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas

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EC-145, a folate-targeted Vinca alkaloid conjugate for the potential treatment of folate receptor-expressing cancers.

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The antifolates: evolution, new agents in the clinic, and how targeting delivery via specific membrane transporters is driving the development of a next generation of folate analogs

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Folate-targeted therapies for cancer

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6 September 2017

Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors

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Methotrexate and psoriasis: 2009 National Psoriasis Foundation Consensus Conference

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Advances in the pathogenesis and treatment of IBD

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6 September 2017

Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues

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Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research

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Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid

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Exploitation of the folate receptor in the management of cancer and inflammatory disease

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Structure and function of the reduced folate carrier a paradigm of a major facilitator superfamily mammalian nutrient transporter

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The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier

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Exploratory study of 99mTc-EC20 imaging for identifying patients with folate receptor-positive solid tumors.

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Preclinical antitumor activity of a novel folate-targeted dual drug conjugate

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Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate

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The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption

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Molecular basis of antifolate resistance

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Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications

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Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption

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The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis.

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Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay

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Preclinical evaluation of (99m)Tc-EC20 for imaging folate receptor-positive tumors

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A review of folate receptor alpha cycling and 5-methyltetrahydrofolate accumulation with an emphasis on cell models in vitro

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A prominent low-pH methotrexate transport activity in human solid tumors: contribution to the preservation of methotrexate pharmacologic activity in HeLa cells lacking the reduced folate carrier

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Resistance to antifolates

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Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis.

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Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier

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Concepts in use of high-dose methotrexate therapy.

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26 June 2018

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26 June 2018

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26 June 2018

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26 June 2018

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3 September 2018

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3 September 2018

Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier: association with the presence of a secondary transport pathway

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3 September 2018

Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter

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3 September 2018

Activity of a novel anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against human lymphoma is superior to methotrexate and correlates with tumor RFC-1 gene expression.

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3 September 2018

Phase II Study of Pemetrexed With and Without Folic Acid and Vitamin B12 as Front-Line Therapy in Malignant Pleural Mesothelioma

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3 September 2018

Raltitrexed (Tomudex): an alternative choice in patients intolerant to 5-fluorouracil

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3 September 2018

Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.

1 reference

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3 September 2018

Mouse folylpoly-gamma-glutamate synthetase isoforms respond differently to feedback inhibition by folylpolyglutamate cofactors

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3 September 2018

Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells

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3 September 2018

Regulation of folate and one-carbon metabolism in mammalian cells. II. Effect of folylpoly-gamma-glutamate synthetase substrate specificity and level on folate metabolism and folylpoly-gamma-glutamate specificity of metabolic cycles of one-carbon me

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3 September 2018

Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin

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3 September 2018

The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis.

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3 September 2018

Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3777421

3 September 2018

Polyglutamylation, an important element in methotrexate cytotoxicity and selectivity in tumor versus murine granulocytic progenitor cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/22520983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22520983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results

1 reference

https://pubmed.ncbi.nlm.nih.gov/22520983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antifolate polyglutamylation and competitive drug displacement at dihydrofolate reductase as important elements in leucovorin rescue in L1210 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22520983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro chemosensitivity of freshly explanted tumor cells to pemetrexed is correlated with target gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/22520983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methotrexate infusions and intensive supportive care in the management of children with acute lymphocytic leukemia: follow-up report

1 reference

https://pubmed.ncbi.nlm.nih.gov/22520983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/22520983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HER2 status and efficacy of adjuvant anthracyclines in early breast cancer: a pooled analysis of randomized trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/22520983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical trials and pharmacokinetics of intermittent high-dose methotrexate-"leucovorin rescue" for children with malignant tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22520983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leptomeningeal metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22520983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic consequences of a reversed pH gradient in rat tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22520983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate specificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/22520983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of aminopterin and amethopterin toxicity by citrovorum factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22520983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22520983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasmalemmal pH-gradients in drug-sensitive and drug-resistant MCF-7 human breast carcinoma xenografts measured by 31P magnetic resonance spectroscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22520983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I and pharmacokinetic study of 10-propargyl-10-deazaaminopterin, a new antifolate

1 reference

https://pubmed.ncbi.nlm.nih.gov/22520983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the role of membrane transport and polyglutamation of methotrexate in gut and the Ehrlich tumor in vivo as factors in drug sensitivity and selectivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22520983

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.HOC.2012.02.002

1 reference

Europe PubMed Central

18 August 2017

1 reference

Europe PubMed Central

18 August 2017

1 reference

Europe PubMed Central

18 August 2017

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