(Q37213623)

19 August 2017

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title

Tumor-microenvironment interactions: dangerous liaisons (English)

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19 August 2017

Isaac P Witz

1

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19 August 2017

publication date

1 January 2008

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Advances in Cancer Research

19 August 2017

published in

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19 August 2017

volume

100

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19 August 2017

page(s)

203-229

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Genetic evidence for a tumor suppressor role of HIF-2alpha.

19 August 2017

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7 January 2021

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7 January 2021

Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions.

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7 January 2021

Modulation of tumor growth by inhibitory Fc(gamma) receptor expressed by human melanoma cells

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Expression of low-affinity Fc gamma receptor by a human metastatic melanoma line.

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A Chemical Proteomics Approach for the Identification of Accessible Antigens Expressed in Human Kidney Cancer

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Hypoxia, gene expression, and metastasis

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7 January 2021

Secretion of pleiotrophin stimulates breast cancer progression through remodeling of the tumor microenvironment.

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7 January 2021

Fibroblasts are critical determinants in prostatic cancer growth and dissemination

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7 January 2021

Increasing metastatic potential is associated with increasing genetic instability of clones isolated from murine neoplasms

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7 January 2021

Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

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7 January 2021

MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis

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7 January 2021

A visual-quantitative analysis of fibroblastic stromagenesis in breast cancer progression

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7 January 2021

Role of the stromal microenvironment in carcinogenesis of the prostate

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7 January 2021

Tumor acidity, chemoresistance and proton pump inhibitors.

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7 January 2021

Paradoxical roles of the immune system during cancer development

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7 January 2021

De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent

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7 January 2021

Role of tissue stroma in cancer cell invasion

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7 January 2021

Critical role of N-cadherin in myofibroblast invasion and migration in vitro stimulated by colon-cancer-cell-derived TGF-beta or wounding

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7 January 2021

Investigating hypoxic tumor physiology through gene expression patterns

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7 January 2021

Matrix metalloproteinases and tumor metastasis

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7 January 2021

In vivo and in vitro invasiveness of a rat colon-cancer cell line maintaining E-cadherin expression: an enhancing role of tumor-associated myofibroblasts

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7 January 2021

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7 January 2021

Tumor-Bound Immunoglobulins: An In Vivo Phenomenon of Masked Specificity 2

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7 January 2021

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7 January 2021

Endothelial adhesion molecules in breast cancer invasion into the vascular and lymphatic systems.

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7 January 2021

Antitumor activities of TEM8-Fc: an engineered antibody-like molecule targeting tumor endothelial marker 8.

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7 January 2021

The vesiculo-vacuolar organelle (VVO). A new endothelial cell permeability organelle

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7 January 2021

Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels

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7 January 2021

New functions for the matrix metalloproteinases in cancer progression

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7 January 2021

Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation

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7 January 2021

Receptors involved in microenvironment-driven molecular evolution of cancer cells

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7 January 2021

VEGF and the quest for tumour angiogenesis factors

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7 January 2021

Biological diversity in metastatic neoplasms: origins and implications.

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7 January 2021

Role of angiogenesis in tumor growth and metastasis

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7 January 2021

Angiogenesis: an organizing principle for drug discovery?

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7 January 2021

Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB

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7 January 2021

The myofibroblast in wound healing and fibrocontractive diseases

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7 January 2021

Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties

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7 January 2021

Why do cancers have high aerobic glycolysis?

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7 January 2021

Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft

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7 January 2021

Alternative activation of macrophages

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7 January 2021

The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis

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7 January 2021

Tumour metastasis to the liver, and the roles of proteinases and adhesion molecules: new concepts from in vivo videomicroscopy

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7 January 2021

Platelets and metastasis revisited: a novel fatty link

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7 January 2021

Hypoxia--a key regulatory factor in tumour growth

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7 January 2021

Angiostatic activity of DNA methyltransferase inhibitors

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7 January 2021

Identification of Epigenetically Silenced Genes in Tumor Endothelial Cells

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7 January 2021

Melanoma antigens: immunological and biological characterization and clinical significance

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7 January 2021

Visualization of tumor cell extravasation

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7 January 2021

Tumor-associated endothelial cells with cytogenetic abnormalities.

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7 January 2021

A new perspective on tumor endothelial cells: unexpected chromosome and centrosome abnormalities

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7 January 2021

Tumor progression: potential role of unstable genomic changes

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7 January 2021

Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis

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7 January 2021

Clinical application of antiangiogenic therapy: microvessel density, what it does and doesn't tell us.

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7 January 2021

Cancer: a Systems Biology disease

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7 January 2021

Dysregulation of the endothelial cellular response to oxidative stress in cancer

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7 January 2021

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

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7 January 2021

The contribution of endogenous sources of DNA damage to the multiple mutations in cancer

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7 January 2021

Tumor angiogenesis and accessibility: role of vascular endothelial growth factor

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7 January 2021

Angiogenesis in brain tumours

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7 January 2021

Therapeutic targeting of the tumor microenvironment

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7 January 2021

The role of the microenvironment and intercellular cross-talk in tumor angiogenesis

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7 January 2021

Fibroblasts in cancer

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7 January 2021

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7 January 2021

The specific blocking of humoral immune cytolysis mediated by anti-tumor antibodies degraded by lysosomal enzymes of tumor origin

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7 January 2021

Clinical translation of angiogenesis inhibitors

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7 January 2021

Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

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7 January 2021

Tumor-driven evolution of immunosuppressive networks during malignant progression

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7 January 2021

Serological detection of a polyoma-tumor-associated membrane antigen

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7 January 2021

Why do we not all die of cancer at an early age?

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7 January 2021

Macrophages and the hypoxic tumour microenvironment

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7 January 2021

Low dose geldanamycin inhibits hepatocyte growth factor and hypoxia-stimulated invasion of cancer cells

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7 January 2021

B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma

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7 January 2021

Dynamism of tumour vasculature in the early phase of cancer progression: outcomes from oesophageal cancer research

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7 January 2021

Reconstruction of functionally normal and malignant human breast tissues in mice

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7 January 2021

Regulation of the metastatic process by E-selectin and stress-activated protein kinase-2/p38.

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7 January 2021

Dual role of macrophages in tumor growth and angiogenesis

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7 January 2021

Tumor cell-organ microenvironment interactions in the pathogenesis of cancer metastasis

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7 January 2021

Microenvironmental influences in melanoma progression

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7 January 2021

Tie2-expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2.

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7 January 2021

Hypoxia: a key regulator of angiogenesis in cancer

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7 January 2021

Role of infiltrated leucocytes in tumour growth and spread

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7 January 2021

Soluble galectin-3 is a strong, colonic epithelial-cell-derived, lamina propria fibroblast-stimulating factor

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7 January 2021

Regulation of transcription and translation by hypoxia

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7 January 2021

Gene alterations identified by expression profiling in tumor-associated endothelial cells from invasive ovarian carcinoma

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7 January 2021

Genetic and epigenetic alterations as hallmarks of the intricate road to cancer.

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7 January 2021

Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors

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7 January 2021

The origin and function of tumor-associated macrophages

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7 January 2021

Role of tumor-associated macrophages in tumor progression and invasion

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7 January 2021

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

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7 January 2021

Tumour-associated host cells participating at invasion and metastasis : targets for therapy?

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7 January 2021

Hepatocyte growth factor and the Met system as a mediator of tumor-stromal interactions.

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7 January 2021

Endothelial cell responses to hypoxia: initiation of a cascade of cellular interactions

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7 January 2021

Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy?

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7 January 2021

Intratumor immunologic heterogeneity

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7 January 2021

Characterization of immunoglobulins eluted from murine tumor cells: binding patterns of cytotoxic anti-tumor IgG

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7 January 2021

Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R

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7 January 2021

Tumor endothelial markers: new targets for cancer therapy

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7 January 2021

Progression of mouse mammary tumors: MCP-1-TNFalpha cross-regulatory pathway and clonal expression of promalignancy and antimalignancy factors

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7 January 2021

Evolution of genome-phenome diversity under environmental stress

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7 January 2021

Enhancement of tumorigenicity of human breast adenocarcinoma cells in nude mice by matrigel and fibroblasts

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7 January 2021

Impaired tumor growth in colony-stimulating factor 1 (CSF-1)-deficient, macrophage-deficient op/op mouse: evidence for a role of CSF-1-dependent macrophages in formation of tumor stroma

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7 January 2021

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

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7 January 2021

Stromal fibroblasts in cancer: a novel tumor-promoting cell type

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7 January 2021

Uniform overexpression and rapid accessibility of alpha5beta1 integrin on blood vessels in tumors

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7 January 2021

Cytogenetic abnormalities in cancer: with special emphasis on tumor heterogeneity

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7 January 2021

Co-opting macrophage traits in cancer progression: a consequence of tumor cell fusion?

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7 January 2021

Comparative gene expression analysis of ovarian carcinoma and normal ovarian epithelium by serial analysis of gene expression

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7 January 2021

Tumour-educated macrophages promote tumour progression and metastasis

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7 January 2021

Hypoxia signalling in cancer and approaches to enforce tumour regression

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7 January 2021

Stromal induction of breast cancer: inflammation and invasion

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Tumor-bound immunoglobulins. Evidence for thein vivo coating of tumor cells by potentially cytotoxic anti-tumor antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Increased expression of Fc gamma receptor in cancer patients and tumor bearing mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Tumor-associated immunoglobulins. Enhancement of syngeneic tumors by IgG2-containing tumor eluates.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Lymphocytotoxic autoantibodies eluted from in vivo propagating sarcoma cells of mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Notch signaling in the regulation of tumor angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Microenvironment-induced cancer metastasis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Melanoma-stroma interactions: structural and functional aspects

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

The Extra-domain A of Fibronectin Is a Vascular Marker of Solid Tumors and Metastases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Expression genetics in cancer: shifting the focus from DNA to RNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Morphological analysis of neovascularization at early stages of rat splenic autografts in comparison with tumor angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Occurrence of a fetal fibroblast phenotype in familial breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Genes that distinguish physiological and pathological angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Hypoxia, clonal selection, and the role of HIF-1 in tumor progression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Targeting HIF-1 for cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Antiangiogenic strategies on defense: on the possibility of blocking rebounds by the tumor vasculature after chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Human breast carcinoma desmoplasia is PDGF initiated.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Tumor angiogenesis: cause or consequence of cancer?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

The fibroblast: sentinel cell and local immune modulator in tumor tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Differential regulation of chemokine production by Fcgamma receptor engagement in human monocytes: association of CCL1 with a distinct form of M2 monocyte activation (M2b, Type 2).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Selective evolutionary pressure from the tissue microenvironment drives tumor progression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Molecular chaperones in the etiology and therapy of cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Genes expressed in human tumor endothelium

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

The hypoxic tumour microenvironment and metastatic progression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Hypoxia-driven selection of the metastatic phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Inflammatory cell infiltration of tumors: Jekyll or Hyde

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

SA-Lea and tumor metastasis: the old prediction and recent findings

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Stromal cells can contribute oncogenic signals

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Know thy neighbor: stromal cells can contribute oncogenic signals

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Interaction of endosialin/TEM1 with extracellular matrix proteins mediates cell adhesion and migration

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Extracellular heat shock protein 90: a role for a molecular chaperone in cell motility and cancer metastasis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Profiling molecular targets of TGF-beta1 in prostate fibroblast-to-myofibroblast transdifferentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculature

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Cancer genes and the pathways they control

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Mammalian heparanase: involvement in cancer metastasis, angiogenesis and normal development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Stress response genes: the genes that make cancer metastasize

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

New paradigm for vessel intravasation by tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Macrophages and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

The selectin-selectin ligand axis in tumor progression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Yin-yang activities and vicious cycles in the tumor microenvironment

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Serologically detectable specific and cross-reactive antigens on the membrane of a polyoma virus-induced murine tumor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

The tumor microenvironment in the post-PAGET era.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

FcR may function as a progression factor of nonlymphoid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Lymphatic or hematogenous dissemination: how does a metastatic tumor cell decide?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Cellular heterogeneity in tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Regulation of cancer metastasis by stress pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

A systems biology approach to genetic studies of complex diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Overexpression of platelet-derived growth factor receptor alpha in endothelial cells of hepatocellular carcinoma associated with high metastatic potential

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

The murine Fc-gamma (Fc gamma) receptor type II B1 is a tumorigenicity-enhancing factor in polyoma-virus-transformed 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Contribution of the intracellular domain of murine Fc-gamma receptor type IIB1 to its tumor-enhancing potential

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Targeting selectins and selectin ligands in inflammation and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Increased spontaneous mutation rates and prevalence of karyotype abnormalities in highly metastatic human melanoma cell lines.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

1 reference

7 January 2021

Transcriptional Regulation of Expression of Carbohydrate Ligands for Cell Adhesion Molecules in the Selectin Family

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Possibilities of interference with the immune system of tumor bearers by non-lymphoid Fc gamma RII expressing tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

Stromal involvement in malignant growth

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2900007-9

7 January 2021

10.1016/S0065-230X(08)00007-9

Identifiers

DOI

1 reference

19 August 2017

1 reference