(Q37216524)

19 August 2017

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title

Faulty spindle checkpoint and cohesion protein activities predispose oocytes to premature chromosome separation and aneuploidy (English)

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19 August 2017

John B Mailhes

1

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19 August 2017

1 October 2008

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Environmental and Molecular Mutagenesis

19 August 2017

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19 August 2017

49

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19 August 2017

8

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19 August 2017

642-658

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Detection and correction of merotelic kinetochore orientation by Aurora B and its partners

19 August 2017

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Regulation of centromeric cohesion by sororin independently of the APC/C

21 January 2018

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Mechanisms of spontaneous and chemically-induced aneuploidy in mammalian oogenesis: basis of sex-specific differences in response to aneugens and the necessity for further tests.

21 January 2018

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The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

21 January 2018

1 reference

Loss of Rec8 from chromosome arm and centromere region is required for homologous chromosome separation and sister chromatid separation, respectively, in mammalian meiosis.

21 January 2018

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Transient exposure to the Eg5 kinesin inhibitor monastrol leads to syntelic orientation of chromosomes and aneuploidy in mouse oocytes

21 January 2018

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Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast

21 January 2018

1 reference

7 January 2021

Predivision in human oocytes at meiosis I: a mechanism for trisomy formation in man.

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7 January 2021

First meiotic division abnormalities in human oocytes: mechanism of trisomy formation.

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7 January 2021

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7 January 2021

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

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7 January 2021

Fission yeast Bub1 is essential in setting up the meiotic pattern of chromosome segregation

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7 January 2021

Genome-wide survey of protein kinases required for cell cycle progression.

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7 January 2021

Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint

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7 January 2021

Functionality of the spindle checkpoint during the first meiotic division of mammalian oocytes.

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7 January 2021

Anaphase Spindle Mechanics Prevent Mis-Segregation of Merotelically Oriented Chromosomes

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7 January 2021

Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p

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7 January 2021

Okadaic acid: a new probe for the study of cellular regulation

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7 January 2021

Structure and functions of the 20S and 26S proteasomes

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7 January 2021

Kiss and break up--a safe passage to anaphase in mitosis and meiosis.

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7 January 2021

Meiosis-activating sterol protects oocytes from precocious chromosome segregation

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7 January 2021

Sequential FISH analysis of oocytes and polar bodies reveals aneuploidy mechanisms

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7 January 2021

Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency

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7 January 2021

Running on a treadmill: dynamic inhibition of APC/C by the spindle checkpoint.

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7 January 2021

Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2

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7 January 2021

Onset of chromosome segregation at the metaphase to anaphase transition of the cell cycle.

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7 January 2021

A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes

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7 January 2021

Gender differences in germ-cell mutagenesis and genetic risk

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7 January 2021

Increased susceptibility to maternal aneuploidy demonstrated by comparative genomic hybridization analysis of human MII oocytes and first polar bodies

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7 January 2021

Aurora B is required for mitotic chromatin-induced phosphorylation of Op18/Stathmin

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7 January 2021

Derivation of embryonic germ cells and male gametes from embryonic stem cells.

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7 January 2021

Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast.

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7 January 2021

Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore

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7 January 2021

Age-associated alteration of gene expression patterns in mouse oocytes.

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7 January 2021

Regulation of meiotic cell divisions and determination of gamete quality: impact of reproductive toxins

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7 January 2021

Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B.

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7 January 2021

To err (meiotically) is human: the genesis of human aneuploidy

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7 January 2021

The origin of aneuploidy in humans

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7 January 2021

Cohesin cleavage by separase required for anaphase and cytokinesis in human cells

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7 January 2021

Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2.

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7 January 2021

Homologue disjunction in mouse oocytes requires proteolysis of securin and cyclin B1.

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7 January 2021

SMC1beta-deficient female mice provide evidence that cohesins are a missing link in age-related nondisjunction.

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7 January 2021

Mad2 prevents aneuploidy and premature proteolysis of cyclin B and securin during meiosis I in mouse oocytes

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7 January 2021

RNA interference in meiosis I human oocytes: towards an understanding of human aneuploidy.

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7 January 2021

Maternal age, paternal age, and human chromosome abnormality: nature, magnitude, etiology, and mechanisms of effects

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7 January 2021

Human chromatid cohesin component hRad21 is phosphorylated in M phase and associated with metaphase centromeres

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7 January 2021

Cohesin defects lead to premature sister chromatid separation, kinetochore dysfunction, and spindle-assembly checkpoint activation

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7 January 2021

Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation

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7 January 2021

A model system for increased meiotic nondisjunction in older oocytes

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7 January 2021

Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis

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7 January 2021

Slk19p is necessary to prevent separation of sister chromatids in meiosis I

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7 January 2021

Maintenance of cohesin at centromeres after meiosis I in budding yeast requires a kinetochore-associated protein related to MEI-S332.

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7 January 2021

Chromosomal enrichment and activation of the aurora B pathway are coupled to spatially regulate spindle assembly

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7 January 2021

Partial downregulation of MAD1 causes spindle checkpoint inactivation and aneuploidy, but does not confer resistance towards taxol

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7 January 2021

Towards a unifying model for the metaphase/anaphase transition

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7 January 2021

The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis.

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7 January 2021

Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization

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7 January 2021

Shugoshin collaborates with protein phosphatase 2A to protect cohesin

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7 January 2021

Wapl controls the dynamic association of cohesin with chromatin

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7 January 2021

Role of Polo-like kinase CDC5 in programming meiosis I chromosome segregation

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7 January 2021

Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis

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7 January 2021

The molecular basis of sister-chromatid cohesion

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7 January 2021

Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells

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7 January 2021

Breast cancer risk associated with genotypic polymorphism of the mitotic checkpoint genes: a multigenic study on cancer susceptibility

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7 January 2021

Identification and characterization of SA/Scc3p subunits in the Xenopus and human cohesin complexes

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7 January 2021

Reduced expression of MAD2, BCL2, and MAP kinase activity in pig oocytes after in vitro aging are associated with defects in sister chromatid segregation during meiosis II and embryo fragmentation after activation

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7 January 2021

Preferential pericentric lesions and aneuploidy induced in mouse oocytes by the topoisomerase II inhibitor etoposide.

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7 January 2021

1,2-propanediol-induced premature centromere separation in mouse oocytes and aneuploidy in one-cell zygotes.

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7 January 2021

Postovulatory ageing of mouse oocytes in vivo and premature centromere separation and aneuploidy.

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7 January 2021

Okadaic acid, an inhibitor of protein phosphatase 1 and 2A, induces premature separation of sister chromatids during meiosis I and aneuploidy in mouse oocytes in vitro

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7 January 2021

Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome

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7 January 2021

Etoposide induces heritable chromosomal aberrations and aneuploidy during male meiosis in the mouse

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7 January 2021

Meiosis: cell-cycle controls shuffle and deal.

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7 January 2021

A genome-wide screen identifies genes required for centromeric cohesion

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7 January 2021

Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells

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7 January 2021

Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells.

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7 January 2021

MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

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7 January 2021

Susceptibility to chromosome malsegregation in lymphocytes of women who had a Down syndrome child in young age

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7 January 2021

The complete removal of cohesin from chromosome arms depends on separase

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7 January 2021

Disseminating the genome: joining, resolving, and separating sister chromatids during mitosis and meiosis

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7 January 2021

Segregating sister genomes: the molecular biology of chromosome separation

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7 January 2021

How do so few control so many?

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7 January 2021

From a single double helix to paired double helices and back

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7 January 2021

The structure and function of SMC and kleisin complexes

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7 January 2021

Splitting the chromosome: cutting the ties that bind sister chromatids

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7 January 2021

Accumulation of Mad2-Cdc20 complex during spindle checkpoint activation requires binding of open and closed conformers of Mad2 in Saccharomyces cerevisiae

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7 January 2021

Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I.

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7 January 2021

Origin and mechanisms of non-disjunction in human autosomal trisomies

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7 January 2021

Influence of postovulatory aging on chromosome segregation during the second meiotic division in mouse oocytes: a parthenogenetic analysis

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7 January 2021

Gender effects on the incidence of aneuploidy in mammalian germ cells

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7 January 2021

A Caenorhabditis elegans cohesion protein with functions in meiotic chromosome pairing and disjunction

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7 January 2021

Mechanisms of non-disjunction in human female meiosis: the co-existence of two modes of malsegregation evidenced by the karyotyping of 1397 in-vitro unfertilized oocytes.

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7 January 2021

The chromosomal analysis of human oocytes. An overview of established procedures

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7 January 2021

The APC is dispensable for first meiotic anaphase in Xenopus oocytes.

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7 January 2021

Genetic Analysis of the Oocyte?A Review

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7 January 2021

RNAi knock-down mice: an emerging technology for post-genomic functional genetics.

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7 January 2021

Cohesin component dynamics during meiotic prophase I in mammalian oocytes

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7 January 2021

Aneuploidy and cancer

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7 January 2021

Keeping sister chromatids together: cohesins in meiosis

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7 January 2021

Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression

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7 January 2021

Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.

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7 January 2021

The vertebrate cell kinetochore and its roles during mitosis

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7 January 2021

Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle

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7 January 2021

Chromatid disjunction in unfertilized ageing oocytes.

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7 January 2021

The incidence of aneuploidy in human oocytes assessed by conventional cytogenetic analysis

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7 January 2021

The contradictory information on the distribution of non-disjunction and pre-division in female gametes

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7 January 2021

Mining meiosis and gametogenesis with DNA microarrays

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7 January 2021

Separase is required for chromosome segregation during meiosis I in Caenorhabditis elegans

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7 January 2021

Scc1/Rad21/Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells

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7 January 2021

Transgenic RNAi in mouse oocytes: a simple and fast approach to study gene function.

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7 January 2021

Mitosis: aurora gives chromosomes a healthy stretch

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7 January 2021

Association between spindle assembly checkpoint expression and maternal age in human oocytes

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7 January 2021

Post-ovulatory aging of mouse oocytes leads to decreased MAD2 transcripts and increased frequencies of premature centromere separation and anaphase.

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7 January 2021

Trichlorfon induces spindle disturbances in V79 cells and aneuploidy in male mouse germ cells

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7 January 2021

Cohesin ensures bipolar attachment of microtubules to sister centromeres and resists their precocious separation.

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7 January 2021

Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections

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7 January 2021

PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation

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7 January 2021

The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation

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7 January 2021

The meiosis I-to-meiosis II transition in mouse oocytes requires separase activity

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7 January 2021

Characterization of fission yeast cohesin: essential anaphase proteolysis of Rad21 phosphorylated in the S phase

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7 January 2021

Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication

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7 January 2021

Embryonic stem cells can form germ cells in vitro

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7 January 2021

The spindle assembly checkpoint is not essential for CSF arrest of mouse oocytes

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7 January 2021

Chromosome cohesion and segregation in mitosis and meiosis

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7 January 2021

Chromosome cohesion and separation: from men and molecules

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7 January 2021

Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1

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7 January 2021

Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast

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7 January 2021

Sister chromatid cohesion and recombination in meiosis

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7 January 2021

Evidence of a high proportion of premature unbalanced separation of sister chromatids in the first polar bodies of women of advanced age.

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7 January 2021

Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase

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7 January 2021

Structural damage to meiotic chromosomes impairs DNA recombination and checkpoint control in mammalian oocytes

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7 January 2021

Cellular roles of dna topoisomerases: a molecular perspective

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7 January 2021

Shugoshin, a guardian for sister chromatid segregation

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7 January 2021

Biological aging and the etiology of aneuploidy

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7 January 2021

Metaphase I arrest upon activation of the Mad2-dependent spindle checkpoint in mouse oocytes

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7 January 2021

Shugoshin protects cohesin complexes at centromeres

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7 January 2021

Kinetochore dynein: its dynamics and role in the transport of the Rough deal checkpoint protein

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7 January 2021

Maternal age and trisomy--a unifying mechanism of formation.

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7 January 2021

Basic mechanism of eukaryotic chromosome segregation

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7 January 2021

Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer

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7 January 2021

Diazepam induces meiotic delay, aneuploidy and predivision of homologues and chromatids in mammalian oocytes.

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7 January 2021

Chromosome morphogenesis: condensin-dependent cohesin removal during meiosis.

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7 January 2021

Okadaic acid affects spindle organization in metaphase II-arrested rat oocytes.

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7 January 2021

'Anaphase' and cytokinesis in the absence of chromosomes.

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7 January 2021

Intra-oocyte localization of MAD2 and its relationship with kinetochores, microtubules, and chromosomes in rat oocytes during meiosis

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7 January 2021

Localization of mitotic arrest deficient 1 (MAD1) in mouse oocytes during the first meiosis and its functions as a spindle checkpoint protein

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7 January 2021

Aurora B phosphorylates multiple sites on mitotic centromere-associated kinesin to spatially and temporally regulate its function

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7 January 2021

Identifiers

DOI

10.1002/EM.20412

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19 August 2017

1 reference

PubMed ID

18626998