(Q37228986)

English

A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells

scientific article published on 28 July 2016

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells (English)

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

1 reference

based on heuristic

inferred from title

object named as

Luca Sala

1

0 references

Alessandra Moretti

object named as

Alessandra Moretti

5

0 references

object named as

Milena Bellin

9

0 references

Christine Mummery

object named as

Christine L Mummery

7

0 references

Adriaan P IJzerman

object named as

Adriaan P IJzerman

8

0 references

Karl-Ludwig Laugwitz

6

object named as

Karl-Ludwig Laugwitz

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

author name string

Zhiyi Yu

2

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Dorien Ward-van Oostwaard

3

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Jacobus Pd van Veldhoven

4

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

publication date

28 July 2016

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

EMBO Molecular Medicine

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

8

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

9

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

1065-1081

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity

1 reference

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Experimentally-Based Computational Investigation into Beat-To-Beat Variability in Ventricular Repolarization and Its Response to Ionic Current Inhibition

1 reference

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The genetics underlying acquired long QT syndrome: impact for genetic screening

1 reference

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A 2015 focus on preventing drug-induced arrhythmias.

1 reference

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Synthesis and biological evaluation of negative allosteric modulators of the Kv11.1(hERG) channel

1 reference

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A perspective on stem cell modeling of amyotrophic lateral sclerosis

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1 reference

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A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm.

1 reference

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1 reference

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Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

1 reference

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Pharmacological and electrophysiological characterization of AZSMO-23, an activator of the hERG K(+) channel

1 reference

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Immaturity of human stem-cell-derived cardiomyocytes in culture: fatal flaw or soluble problem?

1 reference

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6 September 2017

Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue

1 reference

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Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia

1 reference

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6 September 2017

Genome editing of isogenic human induced pluripotent stem cells recapitulates long QT phenotype for drug testing

1 reference

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International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.

1 reference

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1 reference

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HERG1 channel agonists and cardiac arrhythmia

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Induced pluripotent stem cell-derived cardiomyocytes for drug development and toxicity testing.

1 reference

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6 September 2017

Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome

1 reference

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6 September 2017

Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays

1 reference

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MICE models: superior to the HERG model in predicting Torsade de Pointes

1 reference

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Impact of genetics on the clinical management of channelopathies

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6 September 2017

Genetics of congenital and drug-induced long QT syndromes: current evidence and future research perspectives

1 reference

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6 September 2017

Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes

1 reference

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Induced pluripotent stem cells: the new patient?

1 reference

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6 September 2017

Long-QT syndrome: from genetics to management

1 reference

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Maximum diastolic potential of human induced pluripotent stem cell-derived cardiomyocytes depends critically on I(Kr).

1 reference

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Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel

1 reference

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6 September 2017

Rescue of aberrant gating by a genetically encoded PAS (Per-Arnt-Sim) domain in several long QT syndrome mutant human ether-á-go-go-related gene potassium channels

1 reference

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6 September 2017

Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation

1 reference

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6 September 2017

Drug-induced long QT syndrome

1 reference

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6 September 2017

Patient-specific induced pluripotent stem-cell models for long-QT syndrome

1 reference

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6 September 2017

Revealing the structural basis of action of hERG potassium channel activators and blockers

1 reference

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6 September 2017

Low incidence of sudden cardiac death in a Swedish Y111C type 1 long-QT syndrome population

1 reference

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6 September 2017

PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance

1 reference

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6 September 2017

Therapeutic strategies for long-QT syndrome: does the molecular substrate matter?

1 reference

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hERG1 channel activators: a new anti-arrhythmic principle

1 reference

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Self-augmentation of the lengthening of repolarization is related to the shape of the cardiac action potential: implications for reverse rate dependency

1 reference

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The effect of changes in core body temperature on the QT interval in beagle dogs: a previously ignored phenomenon, with a method for correction

1 reference

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6 September 2017

Molecular aspects of the congenital and acquired Long QT Syndrome: clinical implications

1 reference

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6 September 2017

Mouse models of long QT syndrome

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Drug-induced torsades de pointes: the evolving role of pharmacogenetics

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hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines

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Specific therapy based on the genotype and cellular mechanism in inherited cardiac arrhythmias. Long QT syndrome and Brugada syndrome

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Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel

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14 September 2017

Multiple mechanisms in the long-QT syndrome. Current knowledge, gaps, and future directions. The SADS Foundation Task Force on LQTS.

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3 September 2018

MY APPROACH to the long QT syndrome (LQTS).

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3 September 2018

Mechanism of action of a novel human ether-a-go-go-related gene channel activator

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3 September 2018

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3 September 2018

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12 December 2020

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https://pubmed.ncbi.nlm.nih.gov/27470144

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An underrecognized challenge in evaluating postmarketing drug safety

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The long QT syndrome

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12 December 2020

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Gene specific therapy for cardiac disease: the case of long QT syndrome

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12 December 2020

based on heuristic

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Beat-to-Beat variability of repolarization determines proarrhythmic outcome in dogs susceptible to drug-induced torsades de pointes

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12 December 2020

based on heuristic

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Pharmacological activation of Kv11.1 in transgenic long QT-1 rabbits

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https://pubmed.ncbi.nlm.nih.gov/27470144

12 December 2020

based on heuristic

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Low penetrance in the long-QT syndrome: clinical impact

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https://pubmed.ncbi.nlm.nih.gov/27470144

12 December 2020

based on heuristic

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Identifiers

10.15252/EMMM.201606260

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

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