(Q37255178)

19 August 2017

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title

Therapy for osteosarcoma: where do we go from here? (English)

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19 August 2017

3

Richard Gorlick

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19 August 2017

Alexander J Chou

1

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19 August 2017

David S Geller

series ordinal

2

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19 August 2017

language of work or name

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1 January 2008

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19 August 2017

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19 August 2017

10

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19 August 2017

5

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19 August 2017

315-327

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https://scigraph.springernature.com/pub.10.2165/00148581-200810050-00005

19 August 2017

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12 December 2020

High-dose samarium-153 ethylene diamine tetramethylene phosphonate: low toxicity of skeletal irradiation in patients with osteosarcoma and bone metastases

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12 December 2020

The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity

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12 December 2020

The role of radiation treatment in the contemporary management of bone tumors

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12 December 2020

Human epidermal growth factor receptor 2 as a prognostic indicator in osteogenic sarcoma

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12 December 2020

Role of endothelin-1 in osteoblastic bone metastases

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12 December 2020

Advances that are changing the diagnosis and treatment of malignant bone tumors

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12 December 2020

Type-B-IIIa hip rotationplasty: an alternative operation for the treatment of malignant tumors of the femur in early childhood

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12 December 2020

Molecular Mechanisms of Bone Metastasis and Therapeutic Implications

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12 December 2020

Initial testing (stage 1) of sunitinib by the pediatric preclinical testing program

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12 December 2020

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: osteosarcoma and related tumors

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12 December 2020

Osteosarcoma: a randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high-dose methotrexate.

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12 December 2020

Efficacy and safety of liposomal anthracyclines in phase I/II clinical trials

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12 December 2020

Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis

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12 December 2020

RecQ helicases: caretakers of the genome

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12 December 2020

Expandable endoprosthesis reconstruction in skeletally immature patients with tumors

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12 December 2020

Preoperative evaluation and monitoring chemotherapy in patients with high-grade osteogenic and Ewing's sarcoma: review of current imaging modalities.

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12 December 2020

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12 December 2020

Essential role of RSK2 in c-Fos-dependent osteosarcoma development

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12 December 2020

Inhibition of platelet-derived growth factor-mediated proliferation of osteosarcoma cells by the novel tyrosine kinase inhibitor STI571.

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12 December 2020

Prognostic factors in osteosarcoma: a critical review.

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12 December 2020

Computed tomographic scan of the chest underestimates the number of metastatic lesions in osteosarcoma.

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12 December 2020

Post-translational modification of p53 in tumorigenesis

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12 December 2020

Small cell osteosarcoma of bone. Review of 72 cases

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12 December 2020

The FKBP12-rapamycin-binding domain is required for FKBP12-rapamycin-associated protein kinase activity and G1 progression

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12 December 2020

Evaluation of chemotherapy response in pediatric bone sarcomas by [F-18]-fluorodeoxy-D-glucose positron emission tomography

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12 December 2020

Long-term results of the co-operative German-Austrian-Swiss osteosarcoma study group's protocol COSS-86 of intensive multidrug chemotherapy and surgery for osteosarcoma of the limbs

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12 December 2020

Stem-like cells in bone sarcomas: implications for tumorigenesis

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12 December 2020

The effect of local recurrence on survival in resected osteosarcoma

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12 December 2020

Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma

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12 December 2020

Radiotherapy for local control of osteosarcoma.

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12 December 2020

New paradigms for therapy for osteosarcoma

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12 December 2020

A randomized controlled trial of octreotide pamoate long-acting release and carboplatin versus carboplatin alone in dogs with naturally occurring osteosarcoma: evaluation of insulin-like growth factor suppression and chemotherapy.

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12 December 2020

Pemetrexed, a novel antifolate therapeutic alternative for cancer chemotherapy

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12 December 2020

Investigation of the effect of pamidronate disodium on the in vitro viability of osteosarcoma cells from dogs

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12 December 2020

Treatment of metastatic osteosarcoma with the somatostatin analog OncoLar: significant reduction of insulin-like growth factor-1 serum levels

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12 December 2020

Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program

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12 December 2020

Her-2/neu expression in osteosarcoma increases risk of lung metastasis and can be associated with gene amplification

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12 December 2020

Sarcoma derived from cultured mesenchymal stem cells

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12 December 2020

[18F]Fluorodeoxyglucose positron emission tomography predicts outcome for Ewing sarcoma family of tumors

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12 December 2020

RANKL directly induces bone morphogenetic protein-2 expression in RANK-expressing POS-1 osteosarcoma cells.

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12 December 2020

Schedule-dependent synergism of methotrexate and vincristine against murine L1210 leukemia

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12 December 2020

Limb salvage compared with amputation for osteosarcoma of the distal end of the femur. A long-term oncological, functional, and quality-of-life study

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12 December 2020

The TOR pathway: a target for cancer therapy

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12 December 2020

Ifosfamide in Pediatric Solid Tumors

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12 December 2020

Pemetrexed: a multitargeted antifolate

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12 December 2020

A system for the surgical staging of musculoskeletal sarcoma

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12 December 2020

From methotrexate to pemetrexed and beyond. A review of the pharmacodynamic and clinical properties of antifolates

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12 December 2020

Outcome after local recurrence of osteosarcoma: the St. Jude Children's Research Hospital experience (1970-2000)

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12 December 2020

An expression signature classifies chemotherapy-resistant pediatric osteosarcoma

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12 December 2020

mTOR and cancer therapy

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12 December 2020

Primary osteogenic sarcoma. The rationale for preoperative chemotherapy and delayed surgery

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12 December 2020

PET imaging of osteosarcoma.

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12 December 2020

Alendronate regulates cell invasion and MMP-2 secretion in human osteosarcoma cell lines.

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12 December 2020

Prognostic and therapeutic relevance of HER2 expression in osteosarcoma and Ewing's sarcoma

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12 December 2020

Does the histological subtype of high-grade central osteosarcoma influence the response to treatment with chemotherapy and does it affect overall survival? A study on 570 patients of two consecutive trials of the European Osteosarcoma Intergroup

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12 December 2020

Novel antifolate drugs

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12 December 2020

Biologic therapy for osteosarcoma using liposome-encapsulated muramyl tripeptide

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12 December 2020

Liposomal encapsulated anthracyclines: new therapeutic horizons

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12 December 2020

Musculoskeletal tumor staging: 1988 update

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12 December 2020

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12 December 2020

Clinical activity of pemetrexed: a multitargeted antifolate anticancer agent

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12 December 2020

Palliative treatment for advanced or metastatic osteosarcoma

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12 December 2020

Osteosarcoma Necrosis Following Chemotherapy: Innate Biology Versus Treatment-Specific

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12 December 2020

Redundancy of autocrine loops in human osteosarcoma cells.

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12 December 2020

Common musculoskeletal tumors of childhood and adolescence

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12 December 2020

Rotationplasty in skeletally immature patients. Long-term followup results

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12 December 2020

Zoledronic acid suppresses lung metastases and prolongs overall survival of osteosarcoma-bearing mice

1 reference

12 December 2020

Chemotherapy resistance in osteosarcoma: current challenges and future directions.

1 reference

12 December 2020

Bulk disease as the major problem in the cure of paediatric sarcomas

1 reference

12 December 2020

Aerosol therapy for malignancy involving the lungs

1 reference

12 December 2020

Novel therapeutic approaches in pediatric and young adult sarcomas

1 reference

12 December 2020

Aerosol granulocyte macrophage-colony stimulating factor: a low toxicity, lung-specific biological therapy in patients with lung metastases

1 reference

12 December 2020

Postrelapse survival in osteosarcoma of the extremities: prognostic factors for long-term survival

1 reference

12 December 2020

Randomised phase II trial of pegylated liposomal doxorubicin (DOXIL/CAELYX) versus doxorubicin in the treatment of advanced or metastatic soft tissue sarcoma: a study by the EORTC Soft Tissue and Bone Sarcoma Group

1 reference

12 December 2020

Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications

1 reference

12 December 2020

Preoperative chemotherapy for osteogenic sarcoma:Selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy

1 reference

12 December 2020

Molecular mechanisms of resistance to antifolates, a review

1 reference

12 December 2020

ErbB2 expression is correlated with increased survival of patients with osteosarcoma

1 reference

12 December 2020

Neoadjuvant chemotherapy in the treatment of osteosarcoma of the extremities: preliminary results in 131 cases treated preoperatively with methotrexate and cisdiamminoplatinum

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12 December 2020

Insulinlike growth factor I: a potent mitogen for human osteogenic sarcoma

1 reference

12 December 2020

Treatment of osteosarcoma at first recurrence after contemporary therapy: the Memorial Sloan-Kettering Cancer Center experience.

1 reference

12 December 2020

The Istituto Rizzoli experience with small cell osteosarcoma.

1 reference

12 December 2020

Expression of HER2/erbB-2 correlates with survival in osteosarcoma

1 reference

12 December 2020

Involvement of multidrug resistance-associated protein 2 in in vivo cisplatin resistance of rat hepatoma AH66 cells.

1 reference

12 December 2020

The hazards of the biopsy, revisited. Members of the Musculoskeletal Tumor Society

1 reference

12 December 2020

A system of staging musculoskeletal neoplasms

1 reference

12 December 2020

CDKN2A gene deletions and loss of p16 expression occur in osteosarcomas that lack RB alterations

1 reference

12 December 2020

Phase II Trial Of Pegylated-liposomal Doxorubicin (Doxil™) In Sarcoma*

1 reference

12 December 2020

The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate

1 reference

12 December 2020

Cell-retained isoforms of vascular endothelial growth factor (VEGF) are correlated with poor prognosis in osteosarcoma

1 reference

12 December 2020

Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors.

1 reference

12 December 2020

CDK4 gene amplification in osteosarcoma: reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons

1 reference

12 December 2020

Inhalational interleukin-2 liposomes for pulmonary metastases: a phase I clinical trial

1 reference

12 December 2020

Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program.

1 reference

12 December 2020

Comparison of intra-arterial cis-diamminedichloroplatinum II with high-dose methotrexate and citrovorum factor rescue in the treatment of primary osteosarcoma

1 reference

12 December 2020

Advanced-technology radiation therapy in the management of bone and soft tissue sarcomas

1 reference

12 December 2020

Adjuvant chemotherapy for osteosarcoma

1 reference

12 December 2020

Predictive factors for local recurrence in osteosarcoma: 540 patients with extremity tumors followed for minimum 2.5 years after neoadjuvant chemotherapy.

1 reference

12 December 2020

The hazards of biopsy in patients with malignant primary bone and soft-tissue tumors

1 reference

12 December 2020

Long-term outcome for patients with nonmetastatic osteosarcoma of the extremity treated at the istituto ortopedico rizzoli according to the istituto ortopedico rizzoli/osteosarcoma-2 protocol: an updated report

1 reference

12 December 2020

Increased pre-therapeutic serum vascular endothelial growth factor in patients with early clinical relapse of osteosarcoma

1 reference

12 December 2020

Phase II study of ecteinascidin 743 in heavily pretreated patients with recurrent osteosarcoma

1 reference

12 December 2020

Phase II study of 5-fluorouracil/leucovorin for pediatric patients with malignant solid tumors.

1 reference

12 December 2020

Over-expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma.

1 reference

12 December 2020

Phase I pharmacokinetic and pharmacodynamic study of 17-N-allylamino-17-demethoxygeldanamycin in pediatric patients with recurrent or refractory solid tumors: a pediatric oncology experimental therapeutics investigators consortium study

1 reference

12 December 2020

Markers of angiogenesis and clinical features in patients with sarcoma

1 reference

12 December 2020

Phase II trial of liposomal doxorubicin (Doxil) in advanced soft tissue sarcomas

1 reference

12 December 2020

Pattern of disease recurrence and prognostic factors in patients with osteosarcoma treated with contemporary chemotherapy

1 reference

12 December 2020

Systemic relapse of patients with osteogenic sarcoma. Prognostic factors for long term survival

1 reference

12 December 2020

Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program.

1 reference

12 December 2020

Osteosarcoma of the pelvis: experience of the Cooperative Osteosarcoma Study Group

1 reference

12 December 2020

Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program

1 reference

12 December 2020

Human osteosarcoma-derived cell lines produce soluble factor(s) that induces differentiation of blood monocytes to osteoclast-like cells

1 reference

12 December 2020

Mechanisms of methotrexate resistance in osteosarcoma

1 reference

12 December 2020

Interleukin-2 liposome inhalation therapy is safe and effective for dogs with spontaneous pulmonary metastases

1 reference

12 December 2020

The retinoblastoma tumour suppressor in development and cancer

1 reference

12 December 2020

MRP subfamily transporters and resistance to anticancer agents

1 reference

12 December 2020

Biology and therapeutic advances for pediatric osteosarcoma

1 reference

12 December 2020

Essential erbB family phosphorylation in osteosarcoma as a target for CI-1033 inhibition

1 reference

12 December 2020

The role of methotrexate in osteosarcoma

1 reference

12 December 2020

Expression of insulin-like growth factor receptor, IGF-1, and IGF-2 in primary and metastatic osteosarcoma

1 reference

12 December 2020

HER2 amplification and overexpression is not present in pediatric osteosarcoma: a tissue microarray study

1 reference

12 December 2020

Anticancer Antifolates: Current Status and Future Directions

1 reference

12 December 2020

Sequence alterations in the reduced folate carrier are observed in osteosarcoma tumor samples.

1 reference

12 December 2020

Complications and surgical indications in 144 cases of nonmetastatic osteosarcoma of the extremities treated with neoadjuvant chemotherapy

1 reference

12 December 2020

Vascular endothelial growth factor expression in osteosarcoma

1 reference

12 December 2020

Surgical procedure and local recurrence in 223 patients treated 1982-1997 according to two osteosarcoma chemotherapy protocols. The Scandinavian Sarcoma Group experience

1 reference

12 December 2020

Rotationplasty as a reconstructive operation after tumor resection

1 reference

12 December 2020

Alteration of pRb/p16/cdk4 regulation in human osteosarcoma

1 reference

12 December 2020

Treatment algorithm for locally recurrent osteosarcoma based on local disease-free interval and the presence of lung metastasis.

1 reference

12 December 2020

Evaluation of the role of RANK and OPG genes in Paget's disease of bone

1 reference

12 December 2020

Osteosarcoma relapse after combined modality therapy: an analysis of unselected patients in the Cooperative Osteosarcoma Study Group (COSS)

1 reference

12 December 2020

10.2165/00148581-200810050-00005

Identifiers

DOI

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Dimensions Publication ID

19 August 2017

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