(Q37357014)

19 August 2017

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title

Scaffold proteins and immune-cell signalling (English)

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signaling adaptor activity

19 August 2017

main subject

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Gene Ontology release 2020-05-02

1

Andrey S Shaw

1 reference

19 August 2017

Erin L Filbert

2

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19 August 2017

publication date

1 January 2009

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Nature Reviews Immunology

19 August 2017

published in

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19 August 2017

volume

9

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19 August 2017

issue

1

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19 August 2017

page(s)

47-56

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https://scigraph.springernature.com/pub.10.1038/nri2473

19 August 2017

exact match

0 references

1 reference

Platelet-derived growth factor receptor-mediated signal transduction from endosomes

31 March 2020

1 reference

Signal transduction by the TCR for antigen

31 March 2020

1 reference

31 March 2020

1 reference

Signalling pathways of the TNF superfamily: a double-edged sword

31 March 2020

1 reference

Activation of T lymphocytes and the role of the adapter LAT.

31 March 2020

1 reference

The SLP-76 family of adapter proteins

31 March 2020

1 reference

Scaffolds, adaptors and linkers of TCR signaling: theory and practice

31 March 2020

1 reference

Neurabin: a novel neural tissue-specific actin filament-binding protein involved in neurite formation

31 March 2020

1 reference

Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties

31 March 2020

1 reference

Environmental-dependent acceleration of a developmental switch: the floral transition

31 March 2020

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Signal transduction: hanging on a scaffold.

31 March 2020

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AKAP signalling complexes: focal points in space and time

31 March 2020

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Cutting edge: A-kinase anchor proteins are involved in maintaining resting T cells in an inactive state.

31 March 2020

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Scaffold proteins confer diverse regulatory properties to protein kinase cascades.

31 March 2020

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Membrane recruitment of scaffold proteins drives specific signaling

31 March 2020

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Wiring diagrams of MAPK regulation by MEKK1, 2, and 3.

31 March 2020

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Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics

31 March 2020

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Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms

31 March 2020

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Engineering synthetic signaling proteins with ultrasensitive input/output control

31 March 2020

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Calcium signaling mechanisms in T lymphocytes

31 March 2020

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Coordinating ERK/MAPK signalling through scaffolds and inhibitors

31 March 2020

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KSR and CNK: two scaffolds regulating RAS-mediated RAF activation

31 March 2020

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KSR, a novel protein kinase required for RAS signal transduction

31 March 2020

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The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

31 March 2020

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The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction

31 March 2020

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Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression

31 March 2020

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C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1

31 March 2020

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A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila

31 March 2020

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CNK, a RAF-binding multidomain protein required for RAS signaling

31 March 2020

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Emerging roles of pseudokinases

31 March 2020

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WNKs: protein kinases with a unique kinase domain

31 March 2020

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CASK Functions as a Mg2+-independent neurexin kinase

31 March 2020

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C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation

31 March 2020

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Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling

31 March 2020

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Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo

31 March 2020

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The role of erk1 and erk2 in multiple stages of T cell development.

31 March 2020

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The MAPK scaffold kinase suppressor of Ras is involved in ERK activation by stress and proinflammatory cytokines and induction of arthritis

31 March 2020

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JNK and p38 MAP kinases in CD4+ and CD8+ T cells

31 March 2020

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MAP kinases in the immune response

31 March 2020

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The JIP group of mitogen-activated protein kinase scaffold proteins

31 March 2020

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The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK.

31 March 2020

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Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules

31 March 2020

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Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production

31 March 2020

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NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain

31 March 2020

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Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex

31 March 2020

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The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway

31 March 2020

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The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling

31 March 2020

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Calcium signalling in lymphocyte activation and disease

31 March 2020

1 reference

Ahnak is critical for cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation

31 March 2020

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Ahnak protein activates protein kinase C (PKC) through dissociation of the PKC-protein phosphatase 2A complex

31 March 2020

1 reference

AHNAK-mediated activation of phospholipase C-gamma1 through protein kinase C.

31 March 2020

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A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation

31 March 2020

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AHNAK, a protein that binds and activates phospholipase C-gamma1 in the presence of arachidonic acid

31 March 2020

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The Homer family proteins

31 March 2020

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Modulation of synaptic signalling complexes by Homer proteins

31 March 2020

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Homer: a link between neural activity and glutamate receptor function

31 March 2020

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Homer modulates NFAT-dependent signaling during muscle differentiation

31 March 2020

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NFAT Binding and Regulation of T Cell Activation by the Cytoplasmic Scaffolding Homer Proteins

31 March 2020

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The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

31 March 2020

1 reference

Pellino proteins: novel players in TLR and IL-1R signalling

31 March 2020

1 reference

Oligomerisation of Tube and Pelle leads to nuclear localisation of dorsal

31 March 2020

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Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex

31 March 2020

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Cutting edge: mouse pellino-2 modulates IL-1 and lipopolysaccharide signaling

31 March 2020

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Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein

31 March 2020

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BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2

31 March 2020

1 reference

NLRs at the intersection of cell death and immunity

31 March 2020

1 reference

NALP inflammasomes: a central role in innate immunity.

31 March 2020

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The inflammasome: a danger sensing complex triggering innate immunity

31 March 2020

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Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis

31 March 2020

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NALP1 in vitiligo-associated multiple autoimmune disease

31 March 2020

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Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

31 March 2020

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Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1

31 March 2020

1 reference

A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses

31 March 2020

1 reference

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

31 March 2020

1 reference

Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation

31 March 2020

1 reference

Synaptic structure and development: the neuromuscular junction

31 March 2020

1 reference

Immune synapses in T-cell activation

31 March 2020

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Signal-processing machines at the postsynaptic density

31 March 2020

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MAGUK proteins: structure and role in the tight junction

31 March 2020

1 reference

PDZ domain proteins of synapses

31 March 2020

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MAGUKs in synapse assembly and function: an emerging view

31 March 2020

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DLGH1 is a negative regulator of T-lymphocyte proliferation

31 March 2020

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Discs large (Dlg1) complexes in lymphocyte activation

31 March 2020

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Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes

31 March 2020

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Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells

31 March 2020

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Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors

31 March 2020

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The many paths to p38 mitogen-activated protein kinase activation in the immune system

31 March 2020

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Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases

31 March 2020

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A role for the p38 MAP kinase pathway in the nuclear shuttling of NFATp

31 March 2020

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Nuclear factor of activated T cells c is a target of p38 mitogen-activated protein kinase in T cells

31 March 2020

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The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse

31 March 2020

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Maintenance and modulation of T cell polarity

31 March 2020

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A Network of PDZ-Containing Proteins Regulates T Cell Polarity and Morphology during Migration and Immunological Synapse Formation

31 March 2020

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Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines

31 March 2020

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Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton

31 March 2020

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Spinophilin: from partners to functions

31 March 2020

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Spinophilin participates in information transfer at immunological synapses

31 March 2020

1 reference

Internalization of inactive EGF receptor into endosomes and the subsequent activation of endosome-associated EGF receptors. Epidermal growth factor

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19104498

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

1 reference

https://pubmed.ncbi.nlm.nih.gov/19104498

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

What do scaffold proteins really do?

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19104498

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRI2473

1 reference

Dimensions Publication ID

19 August 2017

1045559155

0 references

1 reference