(Q37365274)

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Mini-series: I. Basic science. Uncertainty and inaccuracy of predicting CYP-mediated in vivo drug interactions in the ICU from in vitro models: focus on CYP3A4.

scientific article published on 09 January 2009

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Europe PubMed Central

PubMed publication ID

19 August 2017

1 reference

Europe PubMed Central

Mini-series: I. Basic science. Uncertainty and inaccuracy of predicting CYP-mediated in vivo drug interactions in the ICU from in vitro models: focus on CYP3A4. (English)

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

Jean-francois Bergmann

3

object named as

Jean-François Bergmann

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

author name string

Stéphane Mouly

1

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

Christophe Meune

2

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

publication date

9 January 2009

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

Intensive Care Medicine

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

35

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

417-429

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

Metabolic basis of drug interactions in the intensive care unit

1 reference

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21 January 2018

Is age an independent risk factor of adverse drug reactions in hospitalized medical patients?

1 reference

https://api.crossref.org/works/10.1007%2FS00134-008-1384-1

21 January 2018

Monitoring drug therapy in the intensive care unit

1 reference

https://api.crossref.org/works/10.1007%2FS00134-008-1384-1

21 January 2018

Effect of multiple doses of rifampin on the [14C N-methyl] erythromycin breath test in healthy male volunteers

1 reference

https://api.crossref.org/works/10.1007%2FS00134-008-1384-1

21 January 2018

Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine [seecomments]

1 reference

https://api.crossref.org/works/10.1007%2FS00134-008-1384-1

21 January 2018

Drug-associated disease: cytochrome P450 interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

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A basic conceptual and practical overview of interactions with highly prescribed drugs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

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Effect of widely used combinations of antiretroviral therapy on liver CYP3A4 activity in HIV-infected patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

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Cytochrome P-450 2B6 is responsible for interindividual variability of propofol hydroxylation by human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

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Gastrointestinal absorption of drugs: methods and studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

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Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

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The human intestinal cytochrome P450 "pie".

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overview of enzymes of drug metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

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Multisite kinetic models for CYP3A4: simultaneous activation and inhibition of diazepam and testosterone metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

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Molecular and physical mechanisms of first-pass extraction

1 reference

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12 December 2020

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Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

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P-glycoprotein increases from proximal to distal regions of human small intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyp3A regulation: from pharmacology to nuclear receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug interactions in dentistry: the importance of knowing your CYPs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CO binding kinetics of human cytochrome P450 3A4. Specific interaction of substrates with kinetically distinguishable conformers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epinephrine, norepinephrine and dopamine infusions decrease propofol concentrations during continuous propofol infusion in an ovine model

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

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Contributions of CYP3A4, P-glycoprotein, and serum protein binding to the intestinal first-pass extraction of saquinavir

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative drug interactions prediction system (Q-DIPS): a computer-based prediction and management support system for drug metabolism interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanistic basis of adverse drug reactions: the perils of inappropriate dose schedules

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of enteral versus parenteral feeding on hepatic blood flow and steady state propofol pharmacokinetics in ICU patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate inhibition kinetics for cytochrome P450-catalyzed reactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate-dependent modulation of CYP3A4 catalytic activity: analysis of 27 test compounds with four fluorometric substrates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo and in vitro induction of human cytochrome P4503A4 by dexamethasone

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Codeine intoxication associated with ultrarapid CYP2D6 metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of significant contribution from CYP3A5 to hepatic drug metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human cytochrome P-450 3A4: in vitro drug-drug interaction patterns are substrate-dependent.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

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Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

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Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

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Midazolam metabolism by modified Caco-2 monolayers: effects of extracellular protein binding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

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Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

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The human hepatic cytochromes P450 involved in drug metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

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inferred from PubMed ID database lookup

Cytochrome P-450 3A4: regulation and role in drug metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

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A genetic test for immunosuppressant dose selection?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

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Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

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EUFEPS conference report. Optimising drug development: strategies to assess drug metabolism/transporter interaction potential - towards a consensus. European Federation of Pharmaceutical Sciences

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

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Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

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Inhibition and induction of cytochrome P450 and the clinical implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

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Premedication medicines do not cause drug metabolic interaction with propofol using human liver microsomes in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

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Assessment of drug-drug interactions: concepts and approaches

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

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Adverse drug reactions in the ICU: lessons learned

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunochemical identification of UGT isoforms in human small bowel and in caco-2 cell monolayers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

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Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

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based on heuristic

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Expression of a multidrug-resistance gene in human tumors and tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

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Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical importance of the cytochromes P450

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intensive Care of Patients with HIV Infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

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Potential for drug interactions in hospitalized cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of pharmacokinetics and drug-drug interactions from in vitro metabolism data

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

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Introduction to in vitro estimation of metabolic stability and drug interactions of new chemical entities in drug discovery and development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

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Drug-drug and drug-disease interactions in the ED: analysis of a high-risk population

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of drug metabolism and interactions on the basis of in vitro investigations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

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1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

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Role of a potent inhibitory monoclonal antibody to cytochrome P-450 3A4 in assessment of human drug metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triazolam substrate inhibition: evidence of competition for heme-bound reactive oxygen within the CYP3A4 active site

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal drug transporters: in vivo function and clinical importance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug interactions in the intensive care unit

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of losartan, an angiotensin II receptor antagonist, and its active metabolite EXP3174 in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

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Sufentanil potentiates the inhibitory effect of epinephrine on intestinal motility

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small Intestinal Cytochromes P450

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the intestinal digoxin absorption and exsorption by quinidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

1 reference

https://pubmed.ncbi.nlm.nih.gov/19132343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00134-008-1384-1

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

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