(Q37537084)

20 August 2017

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title

3-D structure and dynamics of protein kinase B-new mechanism for the allosteric regulation of an AGC kinase (English)

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20 August 2017

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Banafshé Larijani

3

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author name string

Véronique Calleja

series ordinal

1

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PMC publication ID

2682354

20 August 2017

Michel Laguerre

series ordinal

2

1 reference

20 August 2017

20 February 2009

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Journal of Chemical Biology

20 August 2017

15

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based on heuristic

inferred from page(s)

published in

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20 August 2017

2

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20 August 2017

1

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20 August 2017

11-25

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https://scigraph.springernature.com/pub.10.1007/s12154-009-0016-8

20 August 2017

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cites work

Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition

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Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

23 August 2017

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The potential role of Akt phosphorylation in human cancers

23 August 2017

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Deregulation of the Akt pathway in human cancer

23 August 2017

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23 August 2017

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FRET-based biosensors for protein kinases: illuminating the kinome

23 August 2017

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A new mutational AKTivation in the PI3K pathway

23 August 2017

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AKT/PKB signaling: navigating downstream

23 August 2017

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Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation

23 August 2017

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Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo

23 August 2017

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The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module

23 August 2017

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Networks for the allosteric control of protein kinases

23 August 2017

1 reference

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Lining the pockets of kinases and phosphatases.

23 August 2017

1 reference

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Protein-protein interactions in the allosteric regulation of protein kinases

23 August 2017

1 reference

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Signal propagation from membrane messengers to nuclear effectors revealed by reporters of phosphoinositide dynamics and Akt activity

23 August 2017

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The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation

23 August 2017

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PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

23 August 2017

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

23 August 2017

1 reference

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Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA

23 August 2017

1 reference

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Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

23 August 2017

1 reference

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Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter

23 August 2017

1 reference

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Regulation of protein kinases; controlling activity through activation segment conformation

23 August 2017

1 reference

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PDK1, the master regulator of AGC kinase signal transduction

23 August 2017

1 reference

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Electrostatic sequestration of PIP2 on phospholipid membranes by basic/aromatic regions of proteins

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Solution structure and backbone dynamics of the pleckstrin homology domain of the human protein kinase B (PKB/Akt). Interaction with inositol phosphates

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Crystal structure of an inactive Akt2 kinase domain

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Ten years of protein kinase B signalling: a hard Akt to follow

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

PKB/AKT: functional insights from genetic models

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Regulation of Akt/PKB activation by tyrosine phosphorylation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Role of translocation in the activation and function of protein kinase B

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Mechanism of activation of protein kinase B by insulin and IGF-1

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Revealing signaling in single cells by single- and two-photon fluorescence lifetime imaging microscopy

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Molecular imaging of Akt kinase activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

In vivo role of the phosphate groove of PDK1 defined by knockin mutation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Live-cell molecular analysis of Akt activation reveals roles for activation loop phosphorylation

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Akt activation by growth factors is a multiple-step process: the role of the PH domain

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Interdomain conformational changes in Akt activation revealed by chemical cross-linking and tandem mass spectrometry

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

AKT signaling in normal and malignant cells

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Colorectal cancer: mutations in a signalling pathway

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Fluorescent indicators for Akt/protein kinase B and dynamics of Akt activity visualized in living cells

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

Monitoring conformational changes of proteins in cells by fluorescence lifetime imaging microscopy

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682354

10.1007/S12154-009-0016-8

1 September 2018

Identifiers

DOI

1 reference

20 August 2017

1 reference

PMC publication ID

2682354

20 August 2017

PubMed publication ID

19568789

1 reference

PMC publication ID

2682354