(Q37565298)

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Antitumor efficacy of the heparan sulfate mimic roneparstat (SST0001) against sarcoma models involves multi-target inhibition of receptor tyrosine kinases

scientific article published on 25 June 2016

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Europe PubMed Central

PMC publication ID

21 August 2017

Antitumor efficacy of the heparan sulfate mimic roneparstat (SST0001) against sarcoma models involves multi-target inhibition of receptor tyrosine kinases (English)

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Giuliana Cassinelli

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27374103%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Gian Paolo Dagrada

6

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10 June 2020

Nadia Zaffaroni

9

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10 June 2020

10

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10 June 2020

Silvana Pilotti

7

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Silvana Pilotti

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10 June 2020

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Enrica Favini

2

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10 June 2020

Laura Dal Bo

3

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10 June 2020

Monica Tortoreto

4

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10 June 2020

Marcella De Maglie

5

1 reference

Europe PubMed Central

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10 June 2020

Franco Zunino

8

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10 June 2020

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25 June 2016

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21 August 2017

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10 June 2020

7

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10 June 2020

30

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10 June 2020

47848-47863

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10 June 2020

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5216983/fullTextXML

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1 reference

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1 reference

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Heparanase stimulates chondrogenesis and is up-regulated in human ectopic cartilage: a mechanism possibly involved in hereditary multiple exostoses

1 reference

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23 August 2017

PG545 enhances anti-cancer activity of chemotherapy in ovarian models and increases surrogate biomarkers such as VEGF in preclinical and clinical plasma samples

1 reference

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23 August 2017

The heparan sulfate mimetic PG545 interferes with Wnt/β-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine

1 reference

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1 reference

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23 August 2017

Expression of heparanase in soft tissue sarcomas of adults

1 reference

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23 August 2017

Heparan sulfate signaling in cancer

1 reference

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23 August 2017

The potential of heparanase as a therapeutic target in cancer

1 reference

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1 reference

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23 August 2017

Impact of heparanase and the tumor microenvironment on cancer metastasis and angiogenesis: basic aspects and clinical applications

1 reference

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23 August 2017

ERBB4 confers metastatic capacity in Ewing sarcoma

1 reference

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23 August 2017

Systemic analysis of gene expression profiles identifies ErbB3 as a potential drug target in pediatric alveolar rhabdomyosarcoma

1 reference

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23 August 2017

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1 reference

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1 reference

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23 August 2017

Phosphoproteomics identifies driver tyrosine kinases in sarcoma cell lines and tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216983

23 August 2017

R1507, an anti-insulin-like growth factor-1 receptor (IGF-1R) antibody, and EWS/FLI-1 siRNA in Ewing's sarcoma: convergence at the IGF/IGFR/Akt axis

1 reference

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23 August 2017

Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotype

1 reference

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23 August 2017

Advances in sarcoma genomics and new therapeutic targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216983

23 August 2017

M402, a novel heparan sulfate mimetic, targets multiple pathways implicated in tumor progression and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216983

23 August 2017

Targeting the Insulin-Like Growth Factor 1 Receptor in Ewing's Sarcoma: Reality and Expectations

1 reference

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23 August 2017

Molecular diagnosis of dermatofibrosarcoma protuberans: a comparison between reverse transcriptase-polymerase chain reaction and fluorescence in situ hybridization methodologies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216983

23 August 2017

SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216983

23 August 2017

Pre-clinical and clinical significance of heparanase in Ewing's sarcoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5216983

23 August 2017

Cell death or survival promoted by alternative isoforms of ErbB4

1 reference

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23 August 2017

Synthetic heparan sulfate oligosaccharides inhibit endothelial cell functions essential for angiogenesis

1 reference

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23 August 2017

Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1-PI3K-Rac1 pathway

1 reference

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23 August 2017

Guidelines for the welfare and use of animals in cancer research

1 reference

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23 August 2017

Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models

1 reference

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23 August 2017

Heparan sulfate proteoglycans: structure, protein interactions and cell signaling

1 reference

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23 August 2017

Heparanase activity in alveolar and embryonal rhabdomyosarcoma: implications for tumor invasion

1 reference

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23 August 2017

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1 reference

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E-cadherin cell-cell adhesion in ewing tumor cells mediates suppression of anoikis through activation of the ErbB4 tyrosine kinase

1 reference

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23 August 2017

Heparanase: a target for drug discovery in cancer and inflammation

1 reference

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23 August 2017

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1 reference

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Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma.

1 reference

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New insights into signalling-pathway alterations in rhabdomyosarcoma

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6 September 2017

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6 September 2017

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6 September 2017

PG545, an angiogenesis and heparanase inhibitor, reduces primary tumor growth and metastasis in experimental pancreatic cancer.

1 reference

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6 September 2017

Antitumor efficacy of the heparanase inhibitor SST0001 alone and in combination with antiangiogenic agents in the treatment of human pediatric sarcoma models.

1 reference

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1 reference

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2 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/27374103

12 December 2020

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10.18632/ONCOTARGET.10292

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27374103%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

release_b6r5dk4oq5buvhhoick2k3fkie

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24 November 2022

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PMC publication ID

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PMC publication ID

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10 June 2020

PubMed publication ID

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27374103%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

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