(Q37577903)

21 August 2017

1 reference

title

Nrf2 and antioxidant defense against CYP2E1 toxicity (English)

1 reference

21 August 2017

1

Arthur Cederbaum

1 reference

PubMed ID

19671018

21 August 2017

language of work or name

English

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publication date

1 October 2009

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Expert Opinion on Drug Metabolism & Toxicology

21 August 2017

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21 August 2017

5

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21 August 2017

10

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21 August 2017

1223-1244

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Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1.

21 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

The alcohol-inducible form of cytochrome P450 (CYP 2E1): role in toxicology and regulation of expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Alcohol and oxidative liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Implication of free radical mechanisms in ethanol-induced cellular injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Pathogenesis of alcoholic liver disease with particular emphasis on oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Introduction-serial review: alcohol, oxidative stress and cell injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Oxidants and antioxidants in alcohol-induced liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Reactive oxygen species-induced molecular damage and its application in pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Distribution of ethanol-induced protein adducts in vivo: relationship to tissue injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Alcohol and mitochondria: a dysfunctional relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

A review of the role of reactive oxygen and nitrogen species in alcohol-induced mitochondrial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Tumor necrosis factor in alcohol enhanced endotoxin liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Spin trapping of free radical species produced during the microsomal metabolism of ethanol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

The involvement of free radicals in the mechanisms of monooxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Antioxidant defence mechanisms: from the beginning to the end (of the beginning).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Effect of ethanol on cytochrome P450 2E1 (CYP2E1), lipid peroxidation, and serum protein adduct formation in relation to liver pathology pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Ebselen prevents early alcohol-induced liver injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Delivery of the Cu/Zn-superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride- and iron-dependent microsomal lipid peroxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Oxidative stress, toxicology, and pharmacology of CYP2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanisms of regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Cytochrome P450 2E1: its clinical and toxicological role

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Assessment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

CYP2E1 and oxidative liver injury by alcohol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Insulin signaling in the transcriptional and posttranscriptional regulation of CYP2E1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Multiple mechanisms in the regulation of ethanol-inducible cytochrome P450IIE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Characterization of cytochrome P4502E1 turnover in transfected HepG2 cells expressing human CYP2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

21 January 2018

From fat to inflammation

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Markedly enhanced cytochrome P450 2E1 induction and lipid peroxidation is associated with severe liver injury in fish oil-ethanol-fed rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

The effect of ethanol-induced cytochrome p4502E1 on the inhibition of proteasome activity by alcohol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Stable expression of human cytochrome P4502E1 in HepG2 cells: characterization of catalytic activities and production of reactive oxygen intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Cytotoxicity and apoptosis produced by arachidonic acid in Hep G2 cells overexpressing human cytochrome P4502E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Ethanol cytotoxicity to a transfected HepG2 cell line expressing human cytochrome P4502E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Ethanol-induced apoptosis to stable HepG2 cell lines expressing human cytochrome P-4502E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Removal of glutathione produces apoptosis and necrosis in HepG2 cells overexpressing CYP2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against toxicity caused by glutathione depletion in HepG2 cells expressing CYP2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Spin trapping agents (Tempol and POBN) protect HepG2 cells overexpressing CYP2E1 against arachidonic acid toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against cytochrome P450 2E1-dependent toxicity in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Role of calcium and calcium-activated proteases in CYP2E1-dependent toxicity in HEPG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Cyclosporine A protects against arachidonic acid toxicity in rat hepatocytes: role of CYP2E1 and mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

CYP2E1 overexpression in HepG2 cells induces glutathione synthesis by transcriptional activation of gamma-glutamylcysteine synthetase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Induction of catalase, alpha, and microsomal glutathione S-transferase in CYP2E1 overexpressing HepG2 cells and protection against short-term oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Cytochrome P450 2E1 responsiveness in the promoter of glutamate-cysteine ligase catalytic subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

The heme oxygenase system: a regulator of second messenger gases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Increased expression of cytochrome P450 2E1 induces heme oxygenase-1 through ERK MAPK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Heme oxygenase-1 protects HepG2 cells against cytochrome P450 2E1-dependent toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Nrf2 as a target for cancer chemoprevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Nrf2-Keap1 defines a physiologically important stress response mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Transcription factor Nrf2 protects HepG2 cells against CYP2E1 plus arachidonic acid-dependent toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Selective induction of coumarin 7-hydroxylase by pyrazole in D2 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Pyrazole induced oxidative liver injury independent of CYP2E1/2A5 induction due to Nrf2 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Nuclear factor-eythroid 2-related factor 2 prevents alcohol-induced fulminant liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Ethanol-induced expression of glutamate-cysteine ligase catalytic subunit gene is mediated by NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Nrf2-mediated transcriptional induction of antioxidant response in mouse embryos exposed to ethanol in vivo: implications for the prevention of fetal alcohol spectrum disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Acute cadmium chloride administration induces hepatic and renal CYP2A5 mRNA, protein and activity in the mouse: involvement of transcription factor NRF2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Antioxidants Enhance Mammalian Proteasome Expression through the Keap1-Nrf2 Signaling Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

Alcohol Mediates Increases in Hepatic and Serum Nonheme Iron Stores in a Rat Model for Alcohol-Induced Liver Injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903143769

10.1517/17425250903143769

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference

PubMed ID

19671018