(Q37591508)

21 August 2017

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title

Immunotherapy in elderly transplant recipients: a guide to clinically significant drug interactions (English)

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21 August 2017

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Dirk R J Kuypers

1

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21 August 2017

1 January 2009

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21 August 2017

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21 August 2017

26

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21 August 2017

9

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21 August 2017

715-737

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https://scigraph.springernature.com/pub.10.2165/11316480-000000000-00000

21 August 2017

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cites work

Gender-based effects on methylprednisolone pharmacokinetics and pharmacodynamics

1 reference

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https://api.crossref.org/works/10.2165%2F11316480-000000000-00000

A randomized, multicenter study of steroid avoidance, early steroid withdrawal or standard steroid therapy in kidney transplant recipients

21 January 2018

1 reference

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https://api.crossref.org/works/10.2165%2F11316480-000000000-00000

Pharmacokinetic evaluation of the possible interaction between selected concomitant medications and orlistat at steady state in healthy subjects

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.2165%2F11316480-000000000-00000

Mechanisms of clinically relevant drug interactions associated with tacrolimus

21 January 2018

1 reference

12 December 2020

Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring

1 reference

12 December 2020

The effect of sevelamer on the pharmacokinetics of cyclosporin A and mycophenolate mofetil after renal transplantation.

1 reference

12 December 2020

Clinical outcomes in elderly kidney transplant recipients are related to acute rejection episodes rather than pretransplant comorbidity

1 reference

12 December 2020

Predictors of chronic kidney disease in long-term survivors of lung and heart-lung transplantation

1 reference

12 December 2020

Nefazodone and cyp450 3a4 interactions with cyclosporine and tacrolimus1.

1 reference

12 December 2020

Cyclosporin pharmacokinetics in the elderly

1 reference

12 December 2020

Effects of Schisandra sphenanthera extract on the pharmacokinetics of tacrolimus in healthy volunteers

1 reference

12 December 2020

The effect of age, sex, and rifampin administration on intestinal and hepatic cytochrome P450 3A activity

1 reference

12 December 2020

Early mortality rates in older kidney recipients with comorbid risk factors

1 reference

12 December 2020

Quantitative prediction of macrolide drug-drug interaction potential from in vitro studies using testosterone as the human cytochrome P4503A substrate

1 reference

12 December 2020

The effect of sevelamer on tacrolimus target levels

1 reference

12 December 2020

Tacrolimus and cerivastatin pharmacokinetics and adverse effects after single and multiple dosing with cerivastatin in renal transplant recipients

1 reference

12 December 2020

1 reference

12 December 2020

Increase in tacrolimus trough levels after steroid withdrawal

1 reference

12 December 2020

Interaction between nelfinavir and tacrolimus after orthoptic liver transplantation in a patient coinfected with HIV and hepatitis C virus (HCV).

1 reference

12 December 2020

Clinical pharmacokinetics of mycophenolate mofetil

1 reference

12 December 2020

Everolimus exposure in cardiac transplant recipients is influenced by concomitant calcineurin inhibitor

1 reference

12 December 2020

Drug interaction between mycophenolate mofetil and rifampin: possible induction of uridine diphosphate-glucuronosyltransferase

1 reference

12 December 2020

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12 December 2020

The natural history of chronic allograft nephropathy

1 reference

12 December 2020

Comparison of the effects of tacrolimus and cyclosporine on the pharmacokinetics of mycophenolic acid

1 reference

12 December 2020

A matched cohort pharmacoepidemiological analysis of steroid free immunosuppression in renal transplantation

1 reference

12 December 2020

Everolimus in de novo cardiac transplantation: pharmacokinetics, therapeutic range, and influence on cyclosporine exposure

1 reference

12 December 2020

Population pharmacokinetics and Bayesian estimation of mycophenolic acid concentrations in stable renal transplant patients

1 reference

12 December 2020

Potent early immune response after kidney transplantation in patients of the European senior transplant program

1 reference

12 December 2020

A comparison of the effect of ciclosporin and sirolimus on the pharmokinetics of mycophenolate in renal transplant patients

1 reference

12 December 2020

Effect of orlistat on blood cyclosporin concentration in an obese heart transplant patient

1 reference

12 December 2020

Tacrolimus oral bioavailability doubles with coadministration of ketoconazole

1 reference

12 December 2020

Apparent clearance of sirolimus in heart transplant recipients: impact of primary diagnosis and serum lipids.

1 reference

12 December 2020

The effect of selective bowel decontamination on the pharmacokinetics of mycophenolate mofetil in liver transplant recipients.

1 reference

12 December 2020

Everolimus and reduced-exposure cyclosporine in de novo renal-transplant recipients: a three-year phase II, randomized, multicenter, open-label study

1 reference

12 December 2020

The effect of recipient's age on lung transplant outcome.

1 reference

12 December 2020

Safety and efficacy of statin therapy in patients switched from cyclosporine a to sirolimus after cardiac transplantation.

1 reference

12 December 2020

Does the evidence support the use of mycophenolate mofetil therapeutic drug monitoring in clinical practice? A systematic review.

1 reference

12 December 2020

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12 December 2020

Drug therapy in the elderly

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12 December 2020

Effect of cyclosporine withdrawal on mycophenolic acid pharmacokinetics in kidney transplant recipients with deteriorating renal function: preliminary report

1 reference

12 December 2020

Developmental pharmacokinetics of ciclosporin--a population pharmacokinetic study in paediatric renal transplant candidates.

1 reference

12 December 2020

Clinical pharmacokinetics and pharmacodynamics of tacrolimus in solid organ transplantation

1 reference

12 December 2020

Corticosteroid interactions with cyclosporine, tacrolimus, mycophenolate, and sirolimus: fact or fiction?

1 reference

12 December 2020

Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene

1 reference

12 December 2020

Kinetics of prednisolone and endogenous cortisol suppression in the elderly

1 reference

12 December 2020

Factors influencing the magnitude and clinical significance of drug interactions between azole antifungals and select immunosuppressants.

1 reference

12 December 2020

The effect of oral iron admiinistration on mycophenolate mofetil absorption in renal transplant recipients: a randomized, controlled trial

1 reference

12 December 2020

Glucuronide and glucoside conjugation of mycophenolic acid by human liver, kidney and intestinal microsomes

1 reference

12 December 2020

Voriconazole and sirolimus coadministration after allogeneic hematopoietic stem cell transplantation

1 reference

12 December 2020

Mycophenolic acid exposure after administration of mycophenolate mofetil in the presence and absence of cyclosporin in renal transplant recipients.

1 reference

12 December 2020

Longitudinal assessment of everolimus in de novo renal transplant recipients over the first post-transplant year: pharmacokinetics, exposure-response relationships, and influence on cyclosporine

1 reference

12 December 2020

Three-year efficacy and safety results from a study of everolimus versus mycophenolate mofetil in de novo renal transplant patients

1 reference

12 December 2020

Post-transplant diabetes mellitus in lung transplant recipients: incidence and risk factors

1 reference

12 December 2020

Probable interaction between efavirenz and cyclosporine

1 reference

12 December 2020

Lowered blood concentration of tacrolimus and its recovery with changes in expression of CYP3A and P-glycoprotein after high-dose steroid therapy

1 reference

12 December 2020

Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance

1 reference

12 December 2020

A randomized long-term trial of tacrolimus and sirolimus versus tacrolimus and mycophenolate mofetil versus cyclosporine (NEORAL) and sirolimus in renal transplantation. I. Drug interactions and rejection at one year

1 reference

12 December 2020

Prednisolone pharmacokinetics and pharmacodynamics in relation to sex and race

1 reference

12 December 2020

A clinical pharmacokinetic study of tacrolimus and sirolimus combination immunosuppression comparing simultaneous to separated administration

1 reference

12 December 2020

Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients.

1 reference

12 December 2020

Cyclosporine sparing with mycophenolate mofetil, daclizumab and corticosteroids in renal allograft recipients: the CAESAR Study

1 reference

12 December 2020

Relative tissue distributions of cyclosporine and sirolimus after concomitant peroral administration to the rat: evidence for pharmacokinetic interactions

1 reference

12 December 2020

Clinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipients

1 reference

12 December 2020

Sirolimus steady-state trough concentrations are not affected by bolus methylprednisolone therapy in renal allograft recipients

1 reference

12 December 2020

Acute rejection in the elderly recipient: influence of age in the outcome of kidney transplantation

1 reference

12 December 2020

Population pharmacokinetics of everolimus in de novo renal transplant patients: impact of ethnicity and comedications

1 reference

12 December 2020

The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes

1 reference

12 December 2020

Tacrolimus dose requirement in renal transplant recipients is significantly higher when used in combination with corticosteroids

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12 December 2020

Pharmacokinetic interaction between verapamil and everolimus in healthy subjects

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12 December 2020

Early clinical assessment of glucose metabolism in renal allograft recipients: diagnosis and prediction of post-transplant diabetes mellitus (PTDM).

1 reference

12 December 2020

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine

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12 December 2020

Pharmacokinetics and pharmacodynamic response of methylprednisolone in premenopausal renal transplant recipients

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12 December 2020

Do men and women differ in proximal small intestinal CYP3A or P-glycoprotein expression?

1 reference

12 December 2020

Cyclosporine-drug interactions and the influence of patient age

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12 December 2020

Reduced exposure to calcineurin inhibitors in renal transplantation

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12 December 2020

Exposure-response relationships and drug interactions of sirolimus

1 reference

12 December 2020

CYP3A5 and CYP3A4 but not MDR1 single-nucleotide polymorphisms determine long-term tacrolimus disposition and drug-related nephrotoxicity in renal recipients

1 reference

12 December 2020

Unexpected augmentation of mycophenolic acid pharmacokinetics in renal transplant patients receiving tacrolimus and mycophenolate mofetil in combination therapy, and analogous in vitro findings

1 reference

12 December 2020

An up-date review on individualized dosage adjustment of calcineurin inhibitors in organ transplant patients

1 reference

12 December 2020

Identification of the UDP-glucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism.

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12 December 2020

Multidrug resistance protein 2 genetic polymorphisms influence mycophenolic acid exposure in renal allograft recipients

1 reference

12 December 2020

Renal transplantation: older recipients and donors

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12 December 2020

The influence of CYP3A5 genotype on dexamethasone induction of CYP3A activity in African Americans

1 reference

12 December 2020

Impact of MDR1 and CYP3A5 on the oral clearance of tacrolimus and tacrolimus-related renal dysfunction in adult living-donor liver transplant patients

1 reference

12 December 2020

Role of Mrp2 in the hepatic disposition of mycophenolic acid and its glucuronide metabolites: effect of cyclosporine

1 reference

12 December 2020

Tacrolimus pharmacokinetics and pharmacogenetics: influence of adenosine triphosphate-binding cassette B1 (ABCB1) and cytochrome (CYP) 3A polymorphisms

1 reference

12 December 2020

Drug therapy in transplant recipients: special considerations in the elderly with comorbid conditions

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12 December 2020

Renal transplant recipients over aged 60 have diminished immune activity and a low risk of rejection

1 reference

12 December 2020

Effects of CYP3A5 and MDR1 single nucleotide polymorphisms on drug interactions between tacrolimus and fluconazole in renal allograft recipients

1 reference

12 December 2020

Cinacalcet's effect on the pharmacokinetics of tacrolimus, cyclosporine and mycophenolate in renal transplant recipients

1 reference

12 December 2020

The pharmacokinetics of mycophenolate mofetil in renal transplant recipients receiving standard-dose or low-dose cyclosporine, low-dose tacrolimus or low-dose sirolimus: the Symphony pharmacokinetic substudy

1 reference

12 December 2020

Role of p-glycoprotein inhibition for drug interactions: evidence from in vitro and pharmacoepidemiological studies

1 reference

12 December 2020

Long-term pharmacokinetic study of the novel combination of tacrolimus and sirolimus in de novo renal allograft recipients

1 reference

12 December 2020

Pharmacokinetic interactions augment toxicities of sirolimus/cyclosporine combinations.

1 reference

12 December 2020

Influence of interactions between immunosuppressive drugs on therapeutic drug monitoring

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12 December 2020

Active drug transport of immunosuppressants: new insights for pharmacokinetics and pharmacodynamics

1 reference

12 December 2020

Coadministration of tacrolimus with anti-acid drugs

1 reference

12 December 2020

Pharmacokinetic interaction between single oral doses of diltiazem and sirolimus in healthy volunteers

1 reference

12 December 2020

Glucocorticoids interfere with mycophenolate mofetil bioavailability in kidney transplantation

1 reference

12 December 2020

Pharmacokinetic interaction between saquinavir and cyclosporine

1 reference

12 December 2020

Influence of CYP3A5, ABCB1 and NR1I2 polymorphisms on prednisolone pharmacokinetics in renal transplant recipients

1 reference

12 December 2020

Cyclosporine withdrawal from a mycophenolate mofetil-containing immunosuppressive regimen: results of a five-year, prospective, randomized study

1 reference

12 December 2020

Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients

1 reference

12 December 2020

The impact of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T on early mycophenolic acid dose-interval exposure in de novo renal allograft recipients

1 reference

12 December 2020

Effect of intestinal CYP3A5 on postoperative tacrolimus trough levels in living-donor liver transplant recipients

1 reference

12 December 2020

Pharmacokinetic interactions with rifampicin : clinical relevance

1 reference

12 December 2020

A worldwide, phase III, randomized, controlled, safety and efficacy study of a sirolimus/cyclosporine regimen for prevention of acute rejection in recipients of primary mismatched renal allografts

1 reference

12 December 2020

Everolimus versus mycophenolate mofetil in the prevention of rejection in de novo renal transplant recipients: a 3-year randomized, multicenter, phase III study

1 reference

12 December 2020

Sirolimus allows early cyclosporine withdrawal in renal transplantation resulting in improved renal function and lower blood pressure

1 reference

12 December 2020

Effect of highly active antiretroviral therapy on tacrolimus pharmacokinetics in hepatitis C virus and HIV co-infected liver transplant recipients in the ANRS HC-08 study.

1 reference

12 December 2020

Erythromycin breath test results in elderly, very elderly, and frail elderly persons

1 reference

12 December 2020

Liver function and phase I drug metabolism in the elderly: a paradox

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12 December 2020

Tacrolimus-azithromycin interaction in a recipient of allogeneic bone marrow transplantation

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12 December 2020

Immunosuppression in older renal transplant patients

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12 December 2020

Toxicodynamic therapeutic drug monitoring of immunosuppressants: promises, reality, and challenges

1 reference

12 December 2020

Prevalence and risk factors of renal dysfunction after liver transplant: a single-center experience

1 reference

12 December 2020

Pharmacokinetic/pharmacodynamic drug interaction between rosiglitazone and mycophenolate mofetil in kidney transplantation: a case report

1 reference

12 December 2020

Cytochrome P450 3A4 and P-glycoprotein expression in human small intestinal enterocytes and hepatocytes: a comparative analysis in paired tissue specimens

1 reference

12 December 2020

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

1 reference

12 December 2020

Basiliximab-sirolimus-prednisone induction regimen followed by delayed low-dose cyclosporine in renal transplant recipients of living donors

1 reference

12 December 2020

Cyclosporine interacts with mycophenolic acid by inhibiting the multidrug resistance-associated protein 2.

1 reference

12 December 2020

A Bayesian approach for population pharmacokinetic modelling of sirolimus.

1 reference

12 December 2020

Effects of twenty-three drugs on the metabolism of FK506 by human liver microsomes

1 reference

12 December 2020

Methylprednisolone pharmacokinetics, cortisol response, and adverse effects in black and white renal transplant recipients

1 reference

12 December 2020

Sirolimus population pharmacokinetic/pharmacogenetic analysis and bayesian modelling in kidney transplant recipients

1 reference

12 December 2020

Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability

1 reference

12 December 2020

The clinical implications of ageing for rational drug therapy

1 reference

12 December 2020

Pharmacokinetics of tacrolimus-based combination therapies

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12 December 2020

Effects of carbamazepine on cyclosporine metabolism in pediatric renal transplant recipients

1 reference

12 December 2020

Explaining variability in mycophenolic acid exposure to optimize mycophenolate mofetil dosing: a population pharmacokinetic meta-analysis of mycophenolic acid in renal transplant recipients.

1 reference

12 December 2020

Fixed-dose sirolimus with reduced dose calcineurin inhibitor: the University of Colorado experience

1 reference

12 December 2020

The impact of age on rejection in kidney transplantation

1 reference

12 December 2020

Pharmacokinetics, safety, and efficacy of mycophenolate mofetil in combination with sirolimus or ciclosporin in renal transplant patients

1 reference

12 December 2020

Effect of cyclosporine on mycophenolic acid trough levels in kidney transplant recipients

1 reference

12 December 2020

Pharmacokinetics of prednisolone during administration of sirolimus in patients with renal transplants

1 reference

12 December 2020

Pharmacokinetic considerations relating to tacrolimus dosing in the elderly.

1 reference

12 December 2020

Impact of dialysis and older age on survival after liver transplantation.

1 reference

12 December 2020

Cyclosporin: an updated review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (neoral)1 in organ transplantation

1 reference

12 December 2020

Effects of the pharmacokinetic interaction between orally administered sirolimus and cyclosporine on the synergistic prolongation of heart allograft survival in rats

1 reference

12 December 2020

Cancers after renal transplantation

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12 December 2020

Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study

1 reference

12 December 2020

Risk factors for rhabdomyolysis with simvastatin and atorvastatin

1 reference

12 December 2020

Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression.

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of pravastatin in pediatric and adolescent cardiac transplant recipients on a regimen of triple immunosuppression

1 reference

12 December 2020

Nelfinavir, a protease inhibitor, increases sirolimus levels in a liver transplantation patient: a case report

1 reference

12 December 2020

Polyomavirus-associated nephropathy risk in kidney transplants: the influence of recipient age and donor gender.

1 reference

12 December 2020

Multicenter trial exploring calcineurin inhibitors avoidance in renal transplantation

1 reference

12 December 2020

The cost-effectiveness of induction immunosuppression in kidney transplantation.

1 reference

12 December 2020

Changes in lipid metabolism and effect of simvastatin in renal transplant recipients induced by cyclosporine or tacrolimus

1 reference

12 December 2020

Immunosuppressive therapy in older cardiac transplant patients

1 reference

12 December 2020

Outcomes in patients older than 60 years of age undergoing orthotopic heart transplantation: an analysis of the UNOS database

1 reference

12 December 2020

Interaction between cyclosporine A and verapamil, felodipine, and isradipine

1 reference

12 December 2020

The influence of age and sex on the clearance of cytochrome P450 3A substrates

1 reference

12 December 2020

Reduced elimination of cyclosporine A in elderly (>65 years) kidney transplant recipients

1 reference

12 December 2020

Effect of calcium-channel blockers on cyclosporine clearance and use in renal transplant patients

1 reference

12 December 2020

The influence of norfloxacin and metronidazole on the disposition of mycophenolate mofetil

1 reference

12 December 2020

Phenytoin decreases the blood concentrations of sirolimus in a liver transplant recipient: a case report

1 reference

12 December 2020

Randomized calcineurin inhibitor cross over study to measure the pharmacokinetics of co-administered enteric-coated mycophenolate sodium

1 reference

12 December 2020

Rifampin induces alterations in mycophenolic acid glucuronidation and elimination: implications for drug exposure in renal allograft recipients.

1 reference

12 December 2020

Pharmacokinetic interaction between levofloxacin and ciclosporin or tacrolimus in kidney transplant recipients: ciclosporin, tacrolimus and levofloxacin in renal transplantation

1 reference

12 December 2020

Independent predictors of renal dysfunction after heart transplantation in patients with normal pretransplant renal function.

1 reference

12 December 2020

Use of anti-CD25 monoclonal antibody in combination with rapamycin to eliminate cyclosporine treatment during the induction phase of immunosuppression

1 reference

12 December 2020

Tacrolimus dose requirement in relation to donor and recipient ABCB1 and CYP3A5 gene polymorphisms in Chinese liver transplant patients

1 reference

12 December 2020

The disposition of 14C-labeled tacrolimus after intravenous and oral administration in healthy human subjects

1 reference

12 December 2020

Effect of the treatment period with erythromycin on cytochrome P450 3A activity in humans.

1 reference

12 December 2020

Effects of calcineurin inhibitors on sirolimus pharmacokinetics during staggered administration in renal transplant recipients

1 reference

12 December 2020

Chronic renal failure after transplantation of a nonrenal organ

1 reference

12 December 2020

Clinical pharmacokinetics of everolimus

1 reference

12 December 2020

Cyclosporin A, but not tacrolimus, inhibits the biliary excretion of mycophenolic acid glucuronide possibly mediated by multidrug resistance-associated protein 2 in rats

1 reference

12 December 2020

Clinical predictors of renal allograft histopathology: a comparative study of single-lesion histology versus a composite, quantitative scoring system

1 reference

12 December 2020

Age, model for end-stage liver disease score, and organ functioning predict posttransplant tacrolimus neurotoxicity

1 reference

12 December 2020

Expression of CYP3A isoforms and P-glycoprotein in human stomach, jejunum and ileum.

1 reference

12 December 2020

Macrolide - induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin

1 reference

12 December 2020

ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation

1 reference

12 December 2020

The Effects of Polypharmacy in Older Adults

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12 December 2020

Superior outcomes in renal transplantation after early cyclosporine withdrawal and sirolimus maintenance therapy, regardless of baseline renal function

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12 December 2020

Cortisol pharmacodynamics after methylprednisolone administration in young and elderly males

1 reference

12 December 2020

10.2165/11316480-000000000-00000

Identifiers

DOI

1 reference

PubMed ID

19728747

Dimensions Publication ID

21 August 2017

0 references

1 reference

PubMed ID

19728747