(Q34791985)

4 August 2017

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title

Mechanisms of clinically relevant drug interactions associated with tacrolimus (English)

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4 August 2017

4

Alfonso Lampen

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4 August 2017

Uwe Christians

1

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4 August 2017

Wolfgang Jacobsen

series ordinal

2

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4 August 2017

Leslie Z Benet

series ordinal

3

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4 August 2017

1 January 2002

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Clinical Pharmacokinetics

4 August 2017

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4 August 2017

41

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4 August 2017

813-851

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4 August 2017

11

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https://scigraph.springernature.com/pub.10.2165/00003088-200241110-00003

4 August 2017

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cites work

Metabolism of the macrolide immunosuppressant, tacrolimus, by the pig gut mucosa in the Ussing chamber

1 reference

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Pharmacokinetics of tacrolimus (FK506) in paediatric liver transplant recipients.

21 January 2018

1 reference

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https://api.crossref.org/works/10.2165%2F00003088-200241110-00003

Therapeutic monitoring of tacrolimus

21 January 2018

1 reference

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https://api.crossref.org/works/10.2165%2F00003088-200241110-00003

Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test

21 January 2018

1 reference

12 December 2020

Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir.

1 reference

12 December 2020

Isolation and mass spectrometric identification of five metabolites of FK-506, a novel macrolide immunosuppressive agent, from human plasma

1 reference

12 December 2020

Inferior outcome of two-haplotype matched renal transplants in blacks: role of early rejection

1 reference

12 December 2020

FK 506 inhibition of cyclosporine metabolism by human liver microsomes

1 reference

12 December 2020

Relationship of FK506 whole blood concentrations and efficacy and toxicity after liver and kidney transplantation

1 reference

12 December 2020

Correlation of rejection episodes with FK 506 dosage, FK 506 level, and steroids following primary orthotopic liver transplant

1 reference

12 December 2020

Interethnic difference in omeprazole's inhibition of diazepam metabolism.

1 reference

12 December 2020

Rosemary components inhibit benzo[a]pyrene-induced genotoxicity in human bronchial cells.

1 reference

12 December 2020

Interactions between FK506 and rifampicin or erythromycin in pediatric liver recipients

1 reference

12 December 2020

Are cytochrome P450 3A enzymes in the small intestine responsible for different cyclosporine metabolite patterns in stable male and female renal allograft recipients after co-administration of diltiazem?

1 reference

12 December 2020

Dexamethasone modulation of multidrug transporters in normal tissues.

1 reference

12 December 2020

Accumulation of lovastatin, but not pravastatin, in the blood of cyclosporine-treated kidney graft patients after multiple doses

1 reference

12 December 2020

Inhibition of dexamethasone-induced cytochrome P450-mediated mutagenicity and metabolism of aflatoxin B1 by Chinese medicinal herbs.

1 reference

12 December 2020

Diltiazem increases tacrolimus concentrations

1 reference

12 December 2020

Tacrolimus. A review of its pharmacology, and therapeutic potential in hepatic and renal transplantation

1 reference

12 December 2020

The efficacy of the combination of tacrolimus and mycophenolate mofetil for prevention of acute myocardial rejection is dependent on routine monitoring of mycophenolic acid trough acid levels

1 reference

12 December 2020

Gastrointestinal absorption of drugs: methods and studies

1 reference

12 December 2020

Effects of FK 506 on human hepatic microsomal cytochrome P-450-dependent drug metabolism in vitro

1 reference

12 December 2020

Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine.

1 reference

12 December 2020

Influence of race or ethnicity on pharmacokinetics of drugs

1 reference

12 December 2020

The effect of graft function on FK506 plasma levels, dosages, and renal function, with particular reference to the liver

1 reference

12 December 2020

Interaction between nelfinavir and tacrolimus after orthoptic liver transplantation in a patient coinfected with HIV and hepatitis C virus (HCV).

1 reference

12 December 2020

P-glycoprotein-dependent disposition kinetics of tacrolimus: studies in mdr1a knockout mice.

1 reference

12 December 2020

Clinical pharmacokinetics of mycophenolate mofetil

1 reference

12 December 2020

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

1 reference

12 December 2020

Tacrolimus in pediatric renal transplantation: a review

1 reference

12 December 2020

Human cytochrome P450 maximal activities in pediatric versus adult liver

1 reference

12 December 2020

Therapeutic relevance of pharmacogenetic factors in cardiovascular medicine

1 reference

12 December 2020

Comparison of the effects of tacrolimus and cyclosporine on the pharmacokinetics of mycophenolic acid

1 reference

12 December 2020

Serotonin selective reuptake inhibitor drug interactions and the cytochrome P450 system.

1 reference

12 December 2020

Suppression of constitutive and inducible cytochrome P450 gene expression by alpha-hederin in mice.

1 reference

12 December 2020

Concomitant human immunodeficiency virus protease inhibitor therapy markedly reduces tacrolimus metabolism and increases blood levels.

1 reference

12 December 2020

Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver

1 reference

12 December 2020

Novel immunosuppressive therapies for intestinal and hepatic diseases

1 reference

12 December 2020

Variable oral absorption of cyclosporine. A biopharmaceutical risk factor for chronic renal allograft rejection

1 reference

12 December 2020

POTENTIAL FOR IMPROVED THERAPEUTIC INDEX OF FK506 IN LIPOSOMAL FORMULATION DEMONSTRATED IN A MOUSE CARDIAC ALLOGRAFT MODEL1,2

1 reference

12 December 2020

Cyclosporine-ketoconazole interaction. Long-term follow-up and preliminary results of a randomized trial

1 reference

12 December 2020

Pharmacodynamics of immunosuppression by mycophenolic acid: inhibition of both lymphocyte proliferation and activation correlates with pharmacokinetics.

1 reference

12 December 2020

Tacrolimus oral bioavailability doubles with coadministration of ketoconazole

1 reference

12 December 2020

Structural basis of selective cytochrome P450 inhibition

1 reference

12 December 2020

Effects of intestinal CYP3A4 and P-glycoprotein on oral drug absorption--theoretical approach

1 reference

12 December 2020

The pharmacokinetics of water-in-oil-in-water-type multiple emulsion of a new tacrolimus formulation.

1 reference

12 December 2020

The effect of pantoprazole on tacrolimus and cyclosporin A blood concentration in transplant recipients

1 reference

12 December 2020

ATP-binding cassette transporters and calcineurin inhibitors: potential clinical implications

1 reference

12 December 2020

Interactions between tacrolimus and antimicrobial agents.

1 reference

12 December 2020

Dose linearity after oral administration of tacrolimus 1-mg capsules at doses of 3, 7, and 10 mg

1 reference

12 December 2020

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

1 reference

12 December 2020

Effects of itraconazole on tacrolimus blood concentrations in a renal transplant recipient

1 reference

12 December 2020

A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group

1 reference

12 December 2020

Pharmacokinetics and therapeutic drug monitoring of immunosuppressants

1 reference

12 December 2020

Effect of repeated oral doses of a novel immunosuppressive macrolide lactone on hepatic mixed-function oxidase system in the rat. Comparative study with ciclosporin

1 reference

12 December 2020

Tacrolimus-itraconazole interaction in a kidney transplant patient

1 reference

12 December 2020

Human P-glycoprotein as a multi-drug transporter analyzed by using transepithelial transport system.

1 reference

12 December 2020

Drug interactions in transplantation

1 reference

12 December 2020

Characterisation of CYP3A gene subfamily expression in human gastrointestinal tissues

1 reference

12 December 2020

A combined HPLC-ELISA evaluation of FK 506 in transplant patients

1 reference

12 December 2020

Interaction of citrus juices with felodipine and nifedipine

1 reference

12 December 2020

Comparison of the effects of the immunosuppressive agents FK 506 and cyclosporin A on rat kidney mitochondria.

1 reference

12 December 2020

The modulatory effect of diltiazem on human in vitro alloreactivity when used alone or in combination with cyclosporin A and/or methylprednisolone

1 reference

12 December 2020

Increased clearance of tacrolimus in children: need for higher doses and earlier initiation prior to bone marrow transplantation

1 reference

12 December 2020

Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of [...]

1 reference

12 December 2020

Lack of interaction between tacrolimus (FK506) and methotrexate in bone marrow transplant recipients

1 reference

12 December 2020

Evaluation of the drug interaction between intravenous high-dose fluconazole and cyclosporine or tacrolimus in bone marrow transplant patients.

1 reference

12 December 2020

The adverse impact of high cyclosporine. Clearance rates on the incidences of acute rejection and graft loss

1 reference

12 December 2020

Transplantation in the HIV+ patient

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12 December 2020

Concomitant use of cytochrome P450 3A4 inhibitors and simvastatin

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12 December 2020

Pharmacokinetics of mycophenolate mofetil are influenced by concomitant immunosuppression.

1 reference

12 December 2020

Therapeutic drug monitoring of immunosuppressant drugs.

1 reference

12 December 2020

Combination therapy with tacrolimus and mycophenolate mofetil following cardiac transplantation: importance of mycophenolic acid therapeutic drug monitoring

1 reference

12 December 2020

Clinical utility of monitoring tacrolimus blood concentrations in liver transplant patients

1 reference

12 December 2020

MDR1 Gene Expression in Lymphocytes of Patients with Renal Transplants

1 reference

12 December 2020

Drug metabolism: from experiments to regulatory aspects

1 reference

12 December 2020

Tacrolimus: a new immunosuppressive agent.

1 reference

12 December 2020

Multidrug resistance gene MDR1 expression: a gene transfection in vitro model and clinical analysis in cyclosporine-treated patients rejecting their renal grafts

1 reference

12 December 2020

Drug exsorption from blood into the gastrointestinal tract

1 reference

12 December 2020

Disposition of tacrolimus (FK 506) in rabbits. Role of red blood cell binding in hepatic clearance

1 reference

12 December 2020

Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery

1 reference

12 December 2020

Interactions of HIV protease inhibitors with ATP-dependent drug export proteins

1 reference

12 December 2020

Disposition of L-732,531, a potent immunosuppressant, in rats and baboons

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12 December 2020

Comparative tacrolimus pharmacokinetics: normal versus mildly hepatically impaired subjects

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12 December 2020

In-vitro metabolic studies of tacrolimus using precision-cut rat and human liver slices

1 reference

12 December 2020

Immunosuppressive activity of fosfomycin on human T-lymphocyte function in vitro

1 reference

12 December 2020

Pharmacological insights from P-glycoprotein knockout mice.

1 reference

12 December 2020

Post-transplant diabetes mellitus. The role of immunosuppression

1 reference

12 December 2020

Isolation and identification of a novel isomerized epoxide metabolite of FK-506 from erythromycin-induced rabbit liver microsomes

1 reference

12 December 2020

An FK506-sensitive transporter selectively decreases intracellular levels and potency of steroid hormones

1 reference

12 December 2020

Cyclosporine kinetics in healthy volunteers

1 reference

12 December 2020

Selective serotonin reuptake inhibitors and CNS drug interactions. A critical review of the evidence

1 reference

12 December 2020

Interaction of tacrolimus(FK506) and its metabolites with FKBP and calcineurin

1 reference

12 December 2020

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

1 reference

12 December 2020

Prednisone withdrawal 14 days after liver transplantation with mycophenolate: a prospective trial of cyclosporine and tacrolimus.

1 reference

12 December 2020

Effects of the immunosuppressant FK-506 and its analog FK-520 on hepatic and renal cytochrome P450 mixed-function oxidase

1 reference

12 December 2020

Interaction between FK 506 and cyclosporine in dogs

1 reference

12 December 2020

Effect of tacrolimus (FK506) and sirolimus (rapamycin) mono- and combination therapy in prolongation of renal allograft survival in the monkey

1 reference

12 December 2020

Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in transplant patients: are the statins mechanistically similar?

1 reference

12 December 2020

Bioassay of plasma specimens from liver transplant patients on FK 506 immunosuppression

1 reference

12 December 2020

Pharmacokinetics of cyclosporine and nephrotoxicity in orthotopic liver transplant patients rescued with FK 506

1 reference

12 December 2020

Effect of FK 506 on human hepatic cytochromes P-450: interaction with CyA

1 reference

12 December 2020

Interaction between FK506 and clotrimazole in a liver transplant recipient

1 reference

12 December 2020

Medicinal herbs in the United States: research needs

1 reference

12 December 2020

Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin

1 reference

12 December 2020

Physicochemical, pharmacokinetic and pharmacodynamic evaluation of liposomal tacrolimus (FK 506) in rats

1 reference

12 December 2020

Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers.

1 reference

12 December 2020

Isolation, identification, and biological activities of oxidative metabolites of FK506, a potent immunosuppressive macrolide lactone

1 reference

12 December 2020

Influence of P-glycoprotein on the transport and metabolism of indinavir in Caco-2 cells expressing cytochrome P-450 3A4

1 reference

12 December 2020

Atorvastatin transport in the Caco-2 cell model: contributions of P-glycoprotein and the proton-monocarboxylic acid co-transporter

1 reference

12 December 2020

The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells.

1 reference

12 December 2020

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

1 reference

12 December 2020

Early cellular rejection after orthotopic liver transplantation correlates with low concentrations of FK506 in hepatic tissue

1 reference

12 December 2020

Demographic factors influencing cyclosporine pharmacokinetic parameters in patients with uremia: racial differences in bioavailability

1 reference

12 December 2020

FK 506 metabolism in male and female rat liver microsomes.

1 reference

12 December 2020

Effect of cyclosporin A or tacrolimus on the function of blood-brain barrier cells.

1 reference

12 December 2020

Biochemistry of multidrug resistance mediated by the multidrug transporter

1 reference

12 December 2020

Interaction between FK 506 and clarithromycin in a renal transplant patient

1 reference

12 December 2020

Isolation of an immunosuppressive metabolite of FK506 generated by human microsome preparations

1 reference

12 December 2020

Area under the curve of Neoral and chronic use of mycophenolate mofetil

1 reference

12 December 2020

Bioequivalence of 1 and 5 mg tacrolimus capsules using a replicate study design

1 reference

12 December 2020

Interaction between tacrolimus and erythromycin

1 reference

12 December 2020

FK 506 interaction with danazol

1 reference

12 December 2020

Human P-glycoprotein transports cyclosporin A and FK506.

1 reference

12 December 2020

Therapeutic concentrations of cyclosporine A, but not FK506, increase P-glycoprotein expression in endothelial and renal tubule cells

1 reference

12 December 2020

Regulation of cytochromes P450 during inflammation and infection.

1 reference

12 December 2020

P-glycoprotein expression and regulation. Age-related changes and potential effects on drug therapy

1 reference

12 December 2020

Physicochemical properties of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis

1 reference

12 December 2020

Acute renal failure associated with the use of ibuprofen in two liver transplant recipients on FK506.

1 reference

12 December 2020

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine

1 reference

12 December 2020

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

1 reference

12 December 2020

The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates

1 reference

12 December 2020

Demographic considerations in tacrolimus pharmacokinetics.

1 reference

12 December 2020

Sex and ethnicity may chiefly influence the interaction of fluconazole with calcineurin inhibitors

1 reference

12 December 2020

Psychopharmacology and neuropsychiatric syndromes in organ transplantation

1 reference

12 December 2020

Renal histology with varying FK506 blood levels

1 reference

12 December 2020

Association of elevated FK 506 plasma levels with nephrotoxicity in liver-grafted patients

1 reference

12 December 2020

Newer immunosuppressive drugs: a review.

1 reference

12 December 2020

Towards a specific immunosuppression for pancreas and islet grafts

1 reference

12 December 2020

Newer antidepressants and the cytochrome P450 system

1 reference

12 December 2020

Factors affecting the pharmacokinetics of tacrolimus in the first year after renal transplantation. European Tacrolimus Multicentre Renal Study Group.

1 reference

12 December 2020

Interaction between tacrolimus and itraconazole in a heart-lung transplant recipient

1 reference

12 December 2020

Induction of hepatic bilirubin and drug metabolizing enzymes by individual herbs present in the traditional Chinese medicine, yin zhi huang.

1 reference

12 December 2020

P-glycoprotein expression is not a useful predictor of acute or chronic kidney graft rejection

1 reference

12 December 2020

Synthesis and pharmacokinetics of a novel macromolecular prodrug of Tacrolimus (FK506), FK506-dextran conjugate

1 reference

12 December 2020

Tacrolimus, a new immunosuppressant--a review of the literature

1 reference

12 December 2020

Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver

1 reference

12 December 2020

In vitro metabolism of simvastatin in humans [SBT]identification of metabolizing enzymes and effect of the drug on hepatic P450s

1 reference

12 December 2020

Inhibition of drug metabolism in rat and human liver microsomes by FK 506 and cyclosporine

1 reference

12 December 2020

Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin.

1 reference

12 December 2020

Further metabolism of FK506 (tacrolimus). Identification and biological activities of the metabolites oxidized at multiple sites of FK506

1 reference

12 December 2020

Randomised trial comparing tacrolimus (FK506) and cyclosporin in prevention of liver allograft rejection. European FK506 Multicentre Liver Study Group

1 reference

12 December 2020

Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat

1 reference

12 December 2020

Unexpected augmentation of mycophenolic acid pharmacokinetics in renal transplant patients receiving tacrolimus and mycophenolate mofetil in combination therapy, and analogous in vitro findings

1 reference

12 December 2020

Plasma vs whole blood for therapeutic drug monitoring of patients receiving FK 506 for immunosuppression

1 reference

12 December 2020

Use of midazolam as a human cytochrome P450 3A probe: II. Characterization of inter- and intraindividual hepatic CYP3A variability after liver transplantation.

1 reference

12 December 2020

The use of therapeutic drug monitoring to optimise immunosuppressive therapy

1 reference

12 December 2020

Increased drug delivery to the brain by P-glycoprotein inhibition

1 reference

12 December 2020

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

1 reference

12 December 2020

HMG-CoA reductase inhibitors in organ transplantation

1 reference

12 December 2020

Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome P-450p in rat hepatocytes in vivo and in primary monolayer culture

1 reference

12 December 2020

Tacrolimus: a further update of its pharmacology and therapeutic use in the management of organ transplantation

1 reference

12 December 2020

Phase III study comparing methotrexate and tacrolimus (prograf, FK506) with methotrexate and cyclosporine for graft-versus-host disease prophylaxis after HLA-identical sibling bone marrow transplantation

1 reference

12 December 2020

Drug interactions and interindividual variability of ciclosporin metabolism in the small intestine

1 reference

12 December 2020

FK 506 metabolism in human liver microsomes: investigation of the involvement of cytochrome P450 isozymes other than CYP3A4

1 reference

12 December 2020

Pharmacokinetics and bioavailability of mycophenolate mofetil in healthy subjects after single-dose oral and intravenous administration

1 reference

12 December 2020

Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver

1 reference

12 December 2020

Tacrolimus toxicity due to drug interaction with mibefradil in a patient after liver transplantation.

1 reference

12 December 2020

Clinical pharmacokinetics of tacrolimus

1 reference

12 December 2020

Interaction of cyclosporine and FK506 with diuretics in transplant patients

1 reference

12 December 2020

Therapeutic drug monitoring of cyclosporine and tacrolimus. Update on Lake Louise Consensus Conference on cyclosporin and tacrolimus

1 reference

12 December 2020

FK 506/fluconazole interaction enhances FK 506 nephrotoxicity

1 reference

12 December 2020

Toxic effects of immunosuppressive drugs: mechanisms and strategies for controlling them.

1 reference

12 December 2020

Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)

1 reference

12 December 2020

Reversal of multidrug resistance in Chinese hamster ovary cells by the immunosuppressive agent rapamycin.

1 reference

12 December 2020

Efficacy and safety of losartan in the treatment of hypertension in renal transplant recipients.

1 reference

12 December 2020

In-vitro interaction of a novel immunosuppressant, FK 506, and antacids

1 reference

12 December 2020

Drug interaction between mycophenolate mofetil and tacrolimus detectable within therapeutic mycophenolic acid monitoring in renal transplant patients

1 reference

12 December 2020

6',7'-Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein

1 reference

12 December 2020

Pitfalls in monitoring tacrolimus (FK 506)

1 reference

12 December 2020

Effects of an immunosuppressive agent, tacrolimus (FK-506), on the activities of cytochrome P-450-linked monooxygenase systems in rat liver microsomes

1 reference

12 December 2020

The use of other drugs to allow a lower dosage of cyclosporin to be used. Therapeutic and pharmacoeconomic considerations

1 reference

12 December 2020

Metabolic drug interactions with selective serotonin reuptake inhibitor (SSRI) antidepressants

1 reference

12 December 2020

A prospective, randomized trial to compare tacrolimus and prednisone with and without mycophenolate mofetil in patients undergoing renal transplantation: first report

1 reference

12 December 2020

Mycophenolate mofetil in combination with tacrolimus versus Neoral after liver transplantation.

1 reference

12 December 2020

Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir

1 reference

12 December 2020

St. John's wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy

1 reference

12 December 2020

Evidence that tacrolimus augments the bioavailability of mycophenolate mofetil through the inhibition of mycophenolic acid glucuronidation

1 reference

12 December 2020

Distribution and protein binding of FK506, a potent immunosuppressive macrolide lactone, in human blood and its uptake by erythrocytes

1 reference

12 December 2020

Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers

1 reference

12 December 2020

P-glycoprotein and drug therapy in organ transplantation

1 reference

12 December 2020

Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain

1 reference

12 December 2020

Tacrolimus. An update of its pharmacology and clinical efficacy in the management of organ transplantation

1 reference

12 December 2020

Variations in bioavailability of cyclosporine and relationship to clinical outcome in renal transplant subpopulations

1 reference

12 December 2020

1 reference

12 December 2020

A family of drug transporters: the multidrug resistance-associated proteins.

1 reference

12 December 2020

Evaluation of individual and combined neurotoxicity of the immunosuppressants cyclosporine and sirolimus by in vitro multinuclear NMR spectroscopy

1 reference

12 December 2020

Effects of intestinal and hepatic metabolism on the bioavailability of tacrolimus in rats

1 reference

12 December 2020

Current opinions on therapeutic drug monitoring of immunosuppressive drugs

1 reference

12 December 2020

Mycophenolate mofetil pharmacokinetics in transplant patients receiving cyclosporine or tacrolimus in combination therapy

1 reference

12 December 2020

Clinically significant drug interactions with new immunosuppressive agents

1 reference

12 December 2020

Modulation of microsomal cytochrome P450 by Scutellariae Radix and Gentianae scabrae Radix in rat liver.

1 reference

12 December 2020

Japanese study of FK 506 on kidney transplantation: the benefit of monitoring the whole blood FK 506 concentration. Japanese FK 506 Study Group

1 reference

12 December 2020

Sirolimus-tacrolimus combination immunosuppression

1 reference

12 December 2020

Interaction between tacrolimus and nefazodone in a stable renal transplant recipient

1 reference

12 December 2020

The effect of gut metabolism on tacrolimus bioavailability in renal transplant recipients

1 reference

12 December 2020

The pharmacological role of P-glycoprotein in the intestinal epithelium.

1 reference

12 December 2020

Interaction between tacrolimus and chloramphenicol in a renal transplant recipient.

1 reference

12 December 2020

Interactions of FK 506 and cyclosporine metabolism

1 reference

12 December 2020

The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups

1 reference

12 December 2020

Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine

1 reference

12 December 2020

Multidrug resistance activity in human lymphocytes

1 reference

12 December 2020

Contributions of hepatic and intestinal metabolism and P-glycoprotein to cyclosporine and tacrolimus oral drug delivery

1 reference

12 December 2020

P-glycoproteins and multidrug resistance

1 reference

12 December 2020

Clinically significant drug interactions with cyclosporin. An update

1 reference

12 December 2020

Bioequivalence of a new strength tacrolimus capsule under development

1 reference

12 December 2020

Effect of low- and high-fat meals on tacrolimus absorption following 5 mg single oral doses to healthy human subjects

1 reference

12 December 2020

Tacrolimus (FK506) ointment for atopic dermatitis: a phase I study in adults and children

1 reference

12 December 2020

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1 reference

12 December 2020

Inhibition and induction of cytochrome P450 and the clinical implications

1 reference

12 December 2020

Effects of some compounds isolated from Chinese medicinal herbs on hepatic microsomal cytochrome P-450 and their potential biological consequences

1 reference

12 December 2020

Pharmacokinetic advantages of a newly developed tacrolimus oil-in-water-type emulsion via the enteral route.

1 reference

12 December 2020

Reversal of multidrug resistance by tacrolimus hydrate

1 reference

12 December 2020

Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression.

1 reference

12 December 2020

A risk-benefit assessment of tacrolimus in transplantation

1 reference

12 December 2020

Theophylline metabolism in human liver microsomes: inhibition studies.

1 reference

12 December 2020

Possible interaction of ciprofloxacin with cyclosporin A

1 reference

12 December 2020

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

1 reference

12 December 2020

Clinical trials and transethnic pharmacology

1 reference

12 December 2020

Cyclosporine and tacrolimus (FK506): a comparison of efficacy and safety profiles

1 reference

12 December 2020

Mode of action of tacrolimus (FK506): molecular and cellular mechanisms.

1 reference

12 December 2020

Isolation and mass spectrometric identification of two metabolites of FK 506 from rat liver microsomal incubation media

1 reference

12 December 2020

Small intestinal metabolism of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor lovastatin and comparison with pravastatin

1 reference

12 December 2020

The interaction of diltiazem with lovastatin and pravastatin

1 reference

12 December 2020

Multidrug resistance-associated protein subfamily transporters and drug resistance

1 reference

12 December 2020

A prospective randomized trial of tacrolimus and prednisone versus tacrolimus, prednisone, and mycophenolate mofetil in primary adult liver transplant recipients: an interim report

1 reference

12 December 2020

Relevance of p-glycoprotein for the enteral absorption of cyclosporin A: in vitro-in vivo correlation

1 reference

12 December 2020

Effect of hepatic dysfunction and T tube clamping on FK 506 pharmacokinetics and trough concentrations

1 reference

12 December 2020

Inhibition of the multidrug efflux pump in isolated hepatocyte couplets by immunosuppressants FK506 and cyclosporine.

1 reference

12 December 2020

Effects of twenty-three drugs on the metabolism of FK506 by human liver microsomes

1 reference

12 December 2020

Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes

1 reference

12 December 2020

Nephrotoxicity by co-trimoxazole and cyclosporin in transplanted patients

1 reference

12 December 2020

Identification of a polymorphically expressed member of the human cytochrome P-450III family

1 reference

12 December 2020

Effects of rifampin on tacrolimus pharmacokinetics in healthy volunteers

1 reference

12 December 2020

Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability

1 reference

12 December 2020

Clinically significant pharmacokinetic drug interactions with psychoactive drugs: antidepressants and antipsychotics and the cytochrome P450 system

1 reference

12 December 2020

A general pattern for substrate recognition by P-glycoprotein.

1 reference

12 December 2020

Low systemic exposure to tacrolimus correlates with acute rejection

1 reference

12 December 2020

Gender differences in pharmacokinetics and pharmacodynamics

1 reference

12 December 2020

FK 506 in liver transplantation: correlation of whole blood levels with efficacy and toxicity. The US Multicenter FK 506 Dose Optimization

1 reference

12 December 2020

Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition

1 reference

12 December 2020

Molecular mechanisms of immunosuppressive chemical agents recently introduced in clinical transplantation protocols

1 reference

12 December 2020

Measurement of blood concentrations of FK506 (tacrolimus) and its metabolites in seven liver graft patients after the first dose by h.p.l.c.-MS and microparticle enzyme immunoassay (MEIA).

1 reference

12 December 2020

15-Desmethyl FK-506 and 15,31-desmethyl FK-506 from human liver microsomes: isolation, identification (by fast atom bombardment mass spectrometry and NMR), and evaluation of in vitro immunosuppressive activity

1 reference

12 December 2020

Rapamycin inhibits aldolase A expression during human lymphocyte activation

1 reference

12 December 2020

Active secretion and enterocytic drug metabolism barriers to drug absorption

1 reference

12 December 2020

Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms.

1 reference

12 December 2020

Human jejunal effective permeability and its correlation with preclinical drug absorption models

1 reference

12 December 2020

Clinical management of tacrolimus drug interactions in renal transplant patients

1 reference

12 December 2020

LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones

1 reference

12 December 2020

Effect of FK 506 chronic administration on bromosulphthalein hepatic excretion in rats

1 reference

12 December 2020

Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes

1 reference

12 December 2020

Coadministration of tacrolimus and mycophenolate mofetil in stable kidney transplant patients: pharmacokinetics and tolerability

1 reference

12 December 2020

In vitro immunosuppressive activity, isolation from pig liver microsomes and identification by electrospray ms-ms of a new FK-506 C19-C20 epoxide metabolite

1 reference

12 December 2020

Modulation of energy status and cytotoxicity induced by FK506 and cyclosporin A in a renal epithelial cell line

1 reference

12 December 2020

Chemosensitization and drug accumulation effects of VX-710, verapamil, cyclosporin A, MS-209 and GF120918 in multidrug resistant HL60/ADR cells expressing the multidrug resistance-associated protein MRP

1 reference

12 December 2020

Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study

1 reference

12 December 2020

Interactions of FK506 (tacrolimus) with clinically important drugs

1 reference

12 December 2020

The effects of relative timing of sirolimus and cyclosporine microemulsion formulation coadministration on the pharmacokinetics of each agent

1 reference

12 December 2020

The role of tacrolimus in adult kidney transplantation: a review

1 reference

12 December 2020

Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors

1 reference

12 December 2020

A comparison of tacrolimus (FK 506) and cyclosporine for immunosuppression in liver transplantation.

1 reference

12 December 2020

Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD.

1 reference

12 December 2020

In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism

1 reference

12 December 2020

Circadian variation of tacrolimus disposition in liver allograft recipients

1 reference

12 December 2020

High dose methylprednisolone increases plasma cyclosporin levels in renal transplant recipients

1 reference

12 December 2020

New insights into the pharmacodynamic and pharmacokinetic properties of statins.

1 reference

12 December 2020

Differences between white subjects and Chinese subjects in the in vivo inhibition of cytochrome P450s 2C19, 2D6, and 3A by omeprazole

1 reference

12 December 2020

Role of diltiazem on tacrolimus pharmacokinetics in tacrolimus-induced nephrotoxic rats

1 reference

12 December 2020

Toxicology and adverse effects of drugs used for immunosuppression in organ transplantation

1 reference

12 December 2020

Ciprofloxacin does not block the antiproliferative effect of tacrolimus

1 reference

12 December 2020

Direct demonstration of high affinity interactions of immunosuppressant drugs with the drug binding site of the human P-glycoprotein

1 reference

12 December 2020

Toxicity of FK 506 in the cynomolgus monkey: noncorrelation with FK 506 serum levels

1 reference

12 December 2020

Interaction between FK506 and erythromycin

1 reference

12 December 2020

Cytochrome P450-mediated drug interactions.

1 reference

12 December 2020

Measurement of tacrolimus (FK506) and its metabolites: a review of assay development and application in therapeutic drug monitoring and pharmacokinetic studies

1 reference

12 December 2020

Metabolism of FK506, a potent immunosuppressive agent, by cytochrome P450 3A enzymes in rat, dog and human liver microsomes

1 reference

12 December 2020

Update on immunosuppressive therapy

1 reference

12 December 2020

Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics

1 reference

12 December 2020

Modulation of drug metabolism in infectious and inflammatory diseases

1 reference

12 December 2020

Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3)

1 reference

12 December 2020

St John's Wort: effect on CYP3A4 activity

1 reference

12 December 2020

The use of plasma levels for FK 506 dosing in liver-grafted patients

1 reference

12 December 2020

The multidrug resistance protein family.

1 reference

12 December 2020

Tacrolimus pharmacokinetics in BMT patients

1 reference

12 December 2020

Renal allograft dysfunction associated with rifampin-tacrolimus interaction

1 reference

12 December 2020

Synergistic nephrotoxicity due to ciprofloxacin and cyclosporine

1 reference

12 December 2020

Diltiazem increases blood concentrations of cyclized cyclosporine metabolites resulting in different cyclosporine metabolite patterns in stable male and female renal allograft recipients

1 reference

12 December 2020

Pharmacokinetics of FK506 in liver transplant recipients after continuous intravenous infusion

1 reference

12 December 2020

Physiological changes during the menstrual cycle and their effects on the pharmacokinetics and pharmacodynamics of drugs

1 reference

12 December 2020

Analogs of 1,25-dihydroxyvitamin D3 as dose-reducing agents for classical immunosuppressants

1 reference

12 December 2020

Membrane transport of mycophenolate mofetil and its active metabolite, mycophenolic acid in MDCK and MDR1-MDCK cell monolayers

1 reference

12 December 2020

Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotype

1 reference

12 December 2020

Tacrolimus (FK506) and sirolimus (rapamycin) in combination are not antagonistic but produce extended graft survival in cardiac transplantation in the rat

1 reference

12 December 2020

Early versus late acute renal allograft rejection: impact on chronic rejection.

1 reference

12 December 2020

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1 reference

12 December 2020

Isolation and identification of a FK-506 C36-C37 dihydrodiol from erythromycin-induced rabbit liver microsomes

1 reference

12 December 2020

Multicenter randomized trial comparing tacrolimus (FK506) and cyclosporine in the prevention of renal allograft rejection: a report of the European Tacrolimus Multicenter Renal Study Group

1 reference

12 December 2020

Ketoconazole to reduce the need for cyclosporine after cardiac transplantation

1 reference

12 December 2020

Drug interactions of clinical significance with selective serotonin reuptake inhibitors

1 reference

12 December 2020

Experience of tacrolimus-based immunosuppression in living-related liver transplantation complicated with graft tuberculosis: interaction with rifampicin and side effects

1 reference

12 December 2020

Early fluctuation in cyclosporine A trough levels affects long-term outcome of kidney transplants.

1 reference

12 December 2020

Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat.

1 reference

12 December 2020

An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures

1 reference

12 December 2020

Pharmacokinetics of FK 506 in transplant patients

1 reference

12 December 2020

Acute renal failure secondary to oral ciprofloxacin therapy: a presentation of three cases and a review of the literature

1 reference

12 December 2020

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

1 reference

12 December 2020

CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells

1 reference

12 December 2020

Chemical modification of rapamycin: the discovery of SDZ RAD.

1 reference

12 December 2020

Specialized localization of P-glycoprotein recognized by MRK 16 monoclonal antibody in endothelial cells of the brain and the spinal cord.

1 reference

12 December 2020

P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs

1 reference

12 December 2020

Is the role of the small intestine in first-pass metabolism overemphasized?

1 reference

12 December 2020

In vitro and in situ absorption of SDZ-RAD using a human intestinal cell line (Caco-2) and a single pass perfusion model in rats: comparison with rapamycin

1 reference

12 December 2020

Expression of CYP3A4, CYP3A5 and CYP3A7 in human duodenal tissue

1 reference

12 December 2020

Cyclosporin metabolism in transplant patients

1 reference

12 December 2020

New developments in the immunosuppressive drug monitoring of cyclosporine, tacrolimus, and azathioprine

1 reference

12 December 2020

Grapefruit juice-drug interactions

1 reference

12 December 2020

Interaction between theophylline and tacrolimus in a renal transplant patient

1 reference

12 December 2020

Immunosuppression in pancreas transplantation: progress, problems and perspective

1 reference

12 December 2020

The disposition of 14C-labeled tacrolimus after intravenous and oral administration in healthy human subjects

1 reference

12 December 2020

The mechanism of action of cyclosporin A and FK506

1 reference

12 December 2020

Metabolism of FK 506 in differentially induced rat liver microsomes

1 reference

12 December 2020

The in vitro immunosuppressive activity of the C15-demethylated metabolite of FK-506 is governed by ring- and open-chain tautomerism effects.

1 reference

12 December 2020

Red wine decreases cyclosporine bioavailability

1 reference

12 December 2020

An overview of current cytochrome P450 technology for assessing the safety and efficacy of new materials.

1 reference

12 December 2020

Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide

1 reference

12 December 2020

Multidrug resistance in lung allograft recipients: possible correlation with the development of acute and chronic rejection.

1 reference

12 December 2020

Multidrug resistance in heart transplant patients: a preliminary communication on a possible mechanism of therapy-resistant rejection

1 reference

12 December 2020

The pharmacokinetic benefits of newly developed liposome-incorporated FK506

1 reference

12 December 2020

Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: interaction with cyclosporine

1 reference

12 December 2020

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1 reference

12 December 2020

Mycophenolic acid plasma concentrations in kidney allograft recipients with or without cyclosporin: a cross-sectional study

1 reference

12 December 2020

Chronopharmacokinetic study of a new immunosuppressive agent, FK 506, in mice

1 reference

12 December 2020

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

1 reference

12 December 2020

Consensus document: therapeutic monitoring of tacrolimus (FK-506).

1 reference

12 December 2020

Tacrolimus (FK506) metabolite patterns in blood from liver and kidney transplant patients

1 reference

12 December 2020

Tacrolimus rescue in liver transplant patients with refractory rejection or intolerance or malabsorption of cyclosporine. The US Multicenter FK506 Liver Study Group

1 reference

12 December 2020

Effect of time of meal consumption on bioavailability of a single oral 5 mg tacrolimus dose

1 reference

12 December 2020

Important interactions of drugs with immunosuppressive agents used in transplant recipients

1 reference

12 December 2020

FK506 (tacrolimus) and its immunoreactive metabolites in whole blood of liver transplant patients and subjects with mild hepatic dysfunction

1 reference

12 December 2020

Discovery of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis

1 reference

12 December 2020

Interaction between FK 506 and diltiazem in an animal model

1 reference

12 December 2020

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man

1 reference

12 December 2020

The effect of tacrolimus (FK506) on intestinal barrier function and cellular energy production in humans

1 reference

12 December 2020

FK 506 (Tacrolimus) metabolism by rat liver microsomes and its inhibition by other drugs

1 reference

12 December 2020

10.2165/00003088-200241110-00003

Identifiers

DOI

1 reference

Dimensions Publication ID

4 August 2017

0 references

1 reference