(Q37597886)

21 August 2017

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title

Structural and functional constraints in the evolution of protein families (English)

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21 August 2017

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2

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21 August 2017

3

Tom L Blundell

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PubMed ID

19756040

21 August 2017

Catherine Louise Worth

series ordinal

1

object named as

Catherine L Worth

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21 August 2017

16 September 2009

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Nature Reviews Molecular Cell Biology

21 August 2017

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21 August 2017

10

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21 August 2017

10

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21 August 2017

709-720

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https://scigraph.springernature.com/pub.10.1038/nrm2762

21 August 2017

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cites work

A survey of left-handed polyproline II helices

1 reference

Beta-bulges within loops as recurring features of protein structure

21 January 2018

1 reference

Evolution and the tertiary structure of proteins

21 January 2018

1 reference

The relation between the divergence of sequence and structure in proteins

31 March 2020

2 references

31 March 2020

12 December 2020

Evolutionary Rate at the Molecular Level

1 reference

Slightly Deleterious Mutant Substitutions in Evolution

31 March 2020

1 reference

Evolutionary processes and evolutionary noise at the molecular level. I. Functional density in proteins

31 March 2020

1 reference

Evolutionary processes and evolutionary noise at the molecular level. II. A selectionist model for random fixations in proteins

31 March 2020

1 reference

Evolutionary rate in the protein interaction network

31 March 2020

1 reference

Apparent dependence of protein evolutionary rate on number of interactions is linked to biases in protein-protein interactions data sets

31 March 2020

1 reference

No simple dependence between protein evolution rate and the number of protein-protein interactions: only the most prolific interactors tend to evolve slowly

31 March 2020

1 reference

PROTEIN FAMILIES AND THEIR EVOLUTION—A STRUCTURAL PERSPECTIVE

31 March 2020

1 reference

Thermodynamic stability of wild-type and mutant p53 core domain

31 March 2020

1 reference

Solution structure of p53 core domain: structural basis for its instability

31 March 2020

1 reference

Kinetic Instability of p53 Core Domain Mutants

31 March 2020

1 reference

Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations

31 March 2020

1 reference

Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

31 March 2020

1 reference

Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs

31 March 2020

1 reference

The 'evolvability' of promiscuous protein functions

31 March 2020

1 reference

Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization

31 March 2020

1 reference

Evolution of protein fold in the presence of functional constraints

31 March 2020

1 reference

The origin, evolution and structure of the protein world.

31 March 2020

1 reference

Genome and protein evolution in eukaryotes

31 March 2020

1 reference

Evolution of protein structures and functions

31 March 2020

1 reference

An integrated view of protein evolution

31 March 2020

1 reference

Orthologs, paralogs, and evolutionary genomics

31 March 2020

1 reference

Comparison of solvent-inaccessible cores of homologous proteins: definitions useful for protein modelling

31 March 2020

1 reference

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

31 March 2020

1 reference

Further developments of protein secondary structure prediction using information theory. New parameters and consideration of residue pairs

31 March 2020

1 reference

An algorithm for secondary structure determination in proteins based on sequence similarity

31 March 2020

1 reference

Configurations of Polypeptide Chains With Favored Orientations Around Single Bonds: Two New Pleated Sheets

31 March 2020

1 reference

The structure of proteins; two hydrogen-bonded helical configurations of the polypeptide chain

31 March 2020

1 reference

A revised set of potentials for beta-turn formation in proteins

31 March 2020

1 reference

Conformation of β-hairpins in protein structures

31 March 2020

1 reference

Analysis and prediction of the different types of beta-turn in proteins

31 March 2020

1 reference

Hydrogen bonding in globular proteins

31 March 2020

1 reference

Helix signals in proteins

31 March 2020

1 reference

Amino acid preferences for specific locations at the ends of alpha helices

31 March 2020

1 reference

A recurring two-hydrogen-bond motif incorporating a serine or threonine residue is found both at alpha-helical N termini and in other situations

31 March 2020

1 reference

A natural grouping of motifs with an aspartate or asparagine residue forming two hydrogen bonds to residues ahead in sequence: their occurrence at alpha-helical N termini and in other situations

31 March 2020

1 reference

Identification, classification, and analysis of beta-bulges in proteins

31 March 2020

1 reference

The beta bulge: a common small unit of nonrepetitive protein structure

31 March 2020

1 reference

Helix geometry in proteins

31 March 2020

1 reference

Secondary structures without backbone: an analysis of backbone mimicry by polar side chains in protein structures

31 March 2020

1 reference

Properties of polyproline II, a secondary structure element implicated in protein-protein interactions

31 March 2020

1 reference

One type of gamma-turn, rather than the other gives rise to chain-reversal in proteins

31 March 2020

1 reference

Is the evolution of insulin Darwinian or due to selectively neutral mutation?

31 March 2020

1 reference

Conservation and relative importance of residues across protein-protein interfaces

31 March 2020

1 reference

On the conservation of protein sequences in evolution

31 March 2020

1 reference

Evolutionarily conserved Galphabetagamma binding surfaces support a model of the G protein-receptor complex

31 March 2020

1 reference

Distinguishing structural and functional restraints in evolution in order to identify interaction sites.

31 March 2020

1 reference

Tertiary structural constraints on protein evolutionary diversity: templates, key residues and structure prediction

31 March 2020

1 reference

Environment-specific amino acid substitution tables: tertiary templates and prediction of protein folds

31 March 2020

1 reference

Protein stability promotes evolvability

31 March 2020

1 reference

Thermodynamic prediction of protein neutrality

31 March 2020

1 reference

Carbonyl-carbonyl interactions stabilize the partially allowed Ramachandran conformations of asparagine and aspartic acid.

31 March 2020

1 reference

Discarding functional residues from the substitution table improves predictions of active sites within three-dimensional structures

31 March 2020

1 reference

Hydrogen bonding increases packing density in the protein interior

31 March 2020

1 reference

Polar group burial contributes more to protein stability than nonpolar group burial

31 March 2020

1 reference

Do all backbone polar groups in proteins form hydrogen bonds?

31 March 2020

1 reference

Satisfying hydrogen bonding potential in proteins

31 March 2020

1 reference

Satisfaction of hydrogen-bonding potential influences the conservation of polar sidechains.

31 March 2020

1 reference

Deterministic features of side-chain main-chain hydrogen bonds in globular protein structures

31 March 2020

1 reference

Hydrogen bonds between short polar side chains and peptide backbone: prevalence in proteins and effects on helix-forming propensities

31 March 2020

1 reference

Conservation of folding and stability within a protein family: the tyrosine corner as an evolutionary cul-de-sac

31 March 2020

1 reference

The role of side-chain hydrogen bonds in the formation and stabilization of secondary structure in soluble proteins

31 March 2020

1 reference

Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme

31 March 2020

1 reference

HOMSTRAD: a database of protein structure alignments for homologous families

31 March 2020

1 reference

Helix stop signals in proteins and peptides: the capping box

31 March 2020

1 reference

Alpha-helix stability in proteins. I. Empirical correlations concerning substitution of side-chains at the N and C-caps and the replacement of alanine by glycine or serine at solvent-exposed surfaces

31 March 2020

1 reference

Aromatic-aromatic interaction: a mechanism of protein structure stabilization

31 March 2020

1 reference

Pi-pi interactions: the geometry and energetics of phenylalanine-phenylalanine interactions in proteins.

31 March 2020

1 reference

Amino-aromatic interactions in proteins

31 March 2020

1 reference

Amino/aromatic interactions in proteins: is the evidence stacked against hydrogen bonding?

31 March 2020

1 reference

Cation-pi interactions in structural biology

31 March 2020

1 reference

Crystal structure of an ancient protein: evolution by conformational epistasis

31 March 2020

1 reference

Conserved residues and the mechanism of protein folding

31 March 2020

1 reference

The Structure of the Transition State for Folding of Chymotrypsin Inhibitor 2 Analysed by Protein Engineering Methods: Evidence for a Nucleation-condensation Mechanism for Protein Folding

31 March 2020

1 reference

How evolution makes proteins fold quickly

31 March 2020

1 reference

Universally conserved positions in protein folds: reading evolutionary signals about stability, folding kinetics and function

31 March 2020

1 reference

Evolutionary conservation in protein folding kinetics.

31 March 2020

1 reference

Residues participating in the protein folding nucleus do not exhibit preferential evolutionary conservation.

31 March 2020

1 reference

Are residues in a protein folding nucleus evolutionarily conserved?

31 March 2020

1 reference

Kinetics, thermodynamics and evolution of non-native interactions in a protein folding nucleus

31 March 2020

1 reference

Large-scale co-evolution analysis of protein structural interlogues using the global protein structural interactome map (PSIMAP).

31 March 2020

1 reference

Protein co-evolution, co-adaptation and interactions

31 March 2020

1 reference

Evolutionary and physiological importance of hub proteins

31 March 2020

1 reference

Genomic function (communication arising): Rate of evolution and gene dispensability

31 March 2020

1 reference

Functional genomic analysis of the rates of protein evolution

31 March 2020

1 reference

Impact of transcriptional properties on essentiality and evolutionary rate

31 March 2020

1 reference

Why highly expressed proteins evolve slowly

31 March 2020

1 reference

A single determinant dominates the rate of yeast protein evolution

31 March 2020

1 reference

Understanding protein evolution: from protein physics to Darwinian selection

31 March 2020

1 reference

Gene expression and molecular evolution

31 March 2020

1 reference

Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution.

31 March 2020

1 reference

The folding of an immunoglobulin-like Greek key protein is defined by a common-core nucleus and regions constrained by topology

31 March 2020

1 reference

Protein misfolding, functional amyloid, and human disease

31 March 2020

1 reference

Competition between folding, native-state dimerisation and amyloid aggregation in beta-lactoglobulin.

31 March 2020

1 reference

Protein degradation and protection against misfolded or damaged proteins

31 March 2020

1 reference

Epigenetics: regulation through repression

31 March 2020

1 reference

CATH--a hierarchic classification of protein domain structures

31 March 2020

1 reference

PASS2: an automated database of protein alignments organised as structural superfamilies

31 March 2020

1 reference

A structural bioinformatics approach to the analysis of nonsynonymous single nucleotide polymorphisms (nsSNPs) and their relation to disease.

31 March 2020

1 reference

Searching protein structure databases with DaliLite v.3

31 March 2020

1 reference

Protein structure alignment by incremental combinatorial extension (CE) of the optimal path

31 March 2020

1 reference

MMDB: Entrez's 3D structure database

31 March 2020

1 reference

The Pfam protein families database

31 March 2020

1 reference

InterPro: the integrative protein signature database

31 March 2020

1 reference

31 March 2020

The PROSITE database.

1 reference

PRINTS and its automatic supplement, prePRINTS.

31 March 2020

1 reference

SMART, a simple modular architecture research tool: identification of signaling domains

31 March 2020

1 reference

The TIGRFAMs database of protein families

31 March 2020

1 reference

Gene3D: structural assignments for the biologist and bioinformaticist alike

31 March 2020

1 reference

SUPERFAMILY--sophisticated comparative genomics, data mining, visualization and phylogeny

31 March 2020

1 reference

PhyloFacts: an online structural phylogenomic encyclopedia for protein functional and structural classification

31 March 2020

1 reference

CDD: a conserved domain database for interactive domain family analysis

31 March 2020

1 reference

PairsDB atlas of protein sequence space

31 March 2020

1 reference

Review: what can structural classifications reveal about protein evolution?

31 March 2020

1 reference

JOY: protein sequence-structure representation and analysis.

31 March 2020

1 reference

Amino acid substitution matrices from protein blocks

31 March 2020

1 reference

Ulla: a program for calculating environment-specific amino acid substitution tables

31 March 2020

1 reference

Interactive Tree Of Life (iTOL): an online tool for phylogenetic tree display and annotation

31 March 2020

1 reference

ProDom: automated clustering of homologous domains

31 March 2020

1 reference

12 December 2020

Conservation of protein interaction network in evolution.

1 reference

12 December 2020

SCOP: a structural classification of proteins database for the investigation of sequences and structures

1 reference

12 December 2020

Conformation of beta-hairpins in protein structures. A systematic classification with applications to modelling by homology, electron density fitting and protein engineering

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRM2762

1 reference

21 August 2017

1 reference

PubMed ID

19756040