(Q37600610)

21 August 2017

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title

Loss-of-function genetic screens as a tool to improve the diagnosis and treatment of cancer (English)

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21 August 2017

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2

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21 August 2017

J Mullenders

1

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PubMed ID

19767776

21 August 2017

language of work or name

English

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publication date

21 September 2009

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21 August 2017

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21 August 2017

28

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21 August 2017

50

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21 August 2017

4409-4420

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https://scigraph.springernature.com/pub.10.1038/onc.2009.295

21 August 2017

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Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

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Functional genomic analysis of the Wnt-wingless signaling pathway

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A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia

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Probing the human kinome for kinases involved in pancreatic cancer cell survival and gemcitabine resistance

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A genome-wide shRNA screen identifies GAS1 as a novel melanoma metastasis suppressor gene

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Knockdown screens to knockout HIV-1.

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Multidrug resistance in cancer: role of ATP-dependent transporters

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The art and design of genetic screens: mammalian culture cells

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Integrating genetic approaches into the discovery of anticancer drugs

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Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.

31 March 2020

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Arrayed adenoviral expression libraries for functional screening

31 March 2020

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A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen

31 March 2020

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31 March 2020

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Phase I dose escalation and pharmacokinetic study of BI 2536, a novel Polo-like kinase 1 inhibitor, in patients with advanced solid tumors.

31 March 2020

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Genome-wide functional analysis of human cell-cycle regulators.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.295

High-throughput RNAi screening by time-lapse imaging of live human cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

A loss-of-function RNA interference screen for molecular targets in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

An evaluation of the efficacy of topical application of salicylic acid for the treatment of familial cylindromatosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

A DNA integrity network in the yeast Saccharomyces cerevisiae

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

A Robust Toolkit for Functional Profiling of the Yeast Genome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

High-throughput fluorescence microscopy for systems biology

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

Whole genome functional analysis identifies novel components required for mitotic spindle integrity in human cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

High-content screening of functional genomic libraries

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

Cytochrome P450 pharmacogenetics and cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3beta/FBW7 loss of function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

Phase I study of YM155, a novel survivin suppressant, in patients with advanced solid tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

Why does cytotoxic chemotherapy cure only some cancers?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

31 March 2020

Targeted cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

Cancer proliferation gene discovery through functional genomics.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

IRF4 addiction in multiple myeloma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

Profiling essential genes in human mammary cells by multiplex RNAi screening

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

Systematic genetic analysis with ordered arrays of yeast deletion mutants

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

RNAi screen for rapid therapeutic target identification in leukemia patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

A genetic screen for candidate tumor suppressors identifies REST

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

Cell microarrays and RNA interference chip away at gene function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

Synthetic lethal screen identification of chemosensitizer loci in cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.295

31 March 2020

Identifiers

DOI

10.1038/ONC.2009.295

1 reference

21 August 2017

1 reference

PubMed ID

19767776