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Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease.
scientific article published on 03 September 2013
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Europe PubMed Central
PMC publication ID
3979087
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23998393%20AND%20SRC:MED&resulttype=core&format=json
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8 March 2020
title
Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3979087
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23998393%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 March 2020
main subject
Alzheimer's disease
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author
Jungsu Kim
series ordinal
4
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Europe PubMed Central
PMC publication ID
3979087
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23998393%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 March 2020
Mary J LaDu
series ordinal
5
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Europe PubMed Central
PMC publication ID
3979087
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23998393%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 March 2020
author name string
Andrew B Wolf
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1
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3979087
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23998393%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 March 2020
Jon Valla
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2
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3979087
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23998393%20AND%20SRC:MED&resulttype=core&format=json
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8 March 2020
Guojun Bu
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
3979087
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23998393%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 March 2020
Richard J Caselli
series ordinal
7
1 reference
stated in
Europe PubMed Central
PMC publication ID
3979087
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23998393%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 March 2020
Eric M Reiman
series ordinal
6
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Europe PubMed Central
PMC publication ID
3979087
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23998393%20AND%20SRC:MED&resulttype=core&format=json
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8 March 2020
language of work or name
English
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publication date
3 September 2013
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Europe PubMed Central
PMC publication ID
3979087
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23998393%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 March 2020
published in
Alzheimers Research & Therapy
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stated in
Europe PubMed Central
PMC publication ID
3979087
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23998393%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 March 2020
volume
5
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Europe PubMed Central
PMC publication ID
3979087
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23998393%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 March 2020
issue
5
1 reference
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Europe PubMed Central
PMC publication ID
3979087
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23998393%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 March 2020
page(s)
38
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Europe PubMed Central
PMC publication ID
3979087
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23998393%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 March 2020
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Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice
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Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
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Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease
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ApoE genotype accounts for the vast majority of AD risk and AD pathology
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23 August 2017
APOE genotype and cerebral blood flow in healthy young individuals
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23 August 2017
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23 August 2017
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Apolipoprotein E: far more than a lipid transport protein
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Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons
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Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease.
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Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease
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Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc
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Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer
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Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease
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APOE genotype alters glial activation and loss of synaptic markers in mice
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28 September 2017
Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
28 September 2017
The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
28 September 2017
Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
23 June 2018
Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
23 June 2018
Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
23 June 2018
Hippocampal volume differences between healthy young apolipoprotein E ε2 and ε4 carriers.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Identification of ApoE as an autocrine/paracrine factor that stimulates neural stem cell survival via MAPK/ERK signaling pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Influence of brain-derived neurotrophic-factor and apolipoprotein E genetic variants on hippocampal volume and memory performance in healthy young adults.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE ɛ4 allele.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Apolipoprotein-mediated lipid antigen presentation in B cells provides a pathway for innate help by NKT cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Cognitive domain decline in healthy apolipoprotein E epsilon4 homozygotes before the diagnosis of mild cognitive impairment.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational study
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Effect of carboxyl-terminal truncation on structure and lipid interaction of human apolipoprotein E4.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Isoform-specific effects of apolipoprotein E on secretion of inflammatory mediators in adult rat microglia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
A dual role for apolipoprotein e in neuroinflammation: anti- and pro-inflammatory activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Apolipoprotein E receptors mediate neurite outgrowth through activation of p44/42 mitogen-activated protein kinase in primary neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
APOE Genotype and an ApoE-mimetic Peptide Modify the Systemic and Central Nervous System Inflammatory Response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Apolipoprotein E epsilon 4 affects new learning in cognitively normal individuals at risk for Alzheimer's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Apolipoprotein E isoform mediated regulation of nitric oxide release
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
CNS synaptogenesis promoted by glia-derived cholesterol
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Oxidative damage is the earliest event in Alzheimer disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Energy hypometabolism in posterior cingulate cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Mitochondrial abnormalities in Alzheimer's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Preclinical memory decline in cognitively normal apolipoprotein E-epsilon4 homozygotes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087
retrieved
1 September 2018
Altered cholesterol metabolism in human apolipoprotein E4 knock-in mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23998393
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23998393
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1186/ALZRT204
1 reference
stated in
Europe PubMed Central
PMC publication ID
3979087
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23998393%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 March 2020
Dimensions Publication ID
1006087875
0 references
PMC publication ID
3979087
1 reference
stated in
Europe PubMed Central
PMC publication ID
3979087
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23998393%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 March 2020
PubMed publication ID
23998393
1 reference
stated in
Europe PubMed Central
PMC publication ID
3979087
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23998393%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 March 2020
ResearchGate publication ID
256376646
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