(Q37691709)

22 August 2017

Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1. (English)

1 reference

Amaury E Fernández-Montalván

22 August 2017

Susanne Müller

3

0 references

object named as

Amaury Fernández-Montalván

10

0 references

author name string

Marie Jung

1

1 reference

22 August 2017

Martin Philpott

2

1 reference

22 August 2017

Jessica Schulze

4

1 reference

22 August 2017

Volker Badock

5

1 reference

22 August 2017

Uwe Eberspächer

6

1 reference

22 August 2017

Dieter Moosmayer

7

1 reference

22 August 2017

Benjamin Bader

8

1 reference

22 August 2017

Norbert Schmees

9

1 reference

22 August 2017

Bernard Haendler

11

1 reference

22 August 2017

language of work or name

English

0 references

publication date

4 February 2014

1 reference

Journal of Biological Chemistry

22 August 2017

16

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

22 August 2017

289

1 reference

22 August 2017

13

1 reference

22 August 2017

9304-9319

1 reference

describes a project that uses

22 August 2017

PyMOL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pmc&rettype=xml&id=PMC3979416

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23 August 2017

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23 August 2017

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Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins

23 August 2017

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Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells

23 August 2017

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23 August 2017

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23 August 2017

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Bromodomain protein Brd4 associated with acetylated chromatin is important for maintenance of higher-order chromatin structure

23 August 2017

1 reference

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Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes.

23 August 2017

1 reference

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

23 August 2017

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Targeting MYC dependence in cancer by inhibiting BET bromodomains

23 August 2017

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

23 August 2017

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The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

23 August 2017

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Structural basis and specificity of acetylated transcription factor GATA1 recognition by BET family bromodomain protein Brd3

23 August 2017

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Real-time imaging of histone H4K12-specific acetylation determines the modes of action of histone deacetylase and bromodomain inhibitors

23 August 2017

1 reference

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Regulation of chromatin by histone modifications

23 August 2017

1 reference

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Suppression of inflammation by a synthetic histone mimic

23 August 2017

1 reference

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Selective inhibition of BET bromodomains

23 August 2017

1 reference

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Brd4 engagement from chromatin targeting to transcriptional regulation: selective contact with acetylated histone H3 and H4.

23 August 2017

1 reference

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Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy

23 August 2017

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Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain

23 August 2017

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23 August 2017

WHAT do viruses BET on?

1 reference

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Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution

23 August 2017

1 reference

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Cooperative binding of two acetylation marks on a histone tail by a single bromodomain

23 August 2017

1 reference

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23 August 2017

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Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA

23 August 2017

1 reference

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The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

23 August 2017

1 reference

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Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

The complex language of chromatin regulation during transcription

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

Solution structure of BRD7 bromodomain and its interaction with acetylated peptides from histone H3 and H4

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

Thermodynamic stability of carbonic anhydrase: measurements of binding affinity and stoichiometry using ThermoFluor.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

Selective recognition of acetylated histones by bromodomain proteins visualized in living cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

Bromodomain: an acetyl-lysine binding domain

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19)

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

You bet-cha: a novel family of transcriptional regulators

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

Structure and ligand of a histone acetyltransferase bromodomain

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

Denaturant m values and heat capacity changes: relation to changes in accessible surface areas of protein unfolding

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

Place your BETs: the therapeutic potential of bromodomains

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

Progress in the discovery of small-molecule inhibitors of bromodomain--histone interactions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

Bromodomains as therapeutic targets

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

Study of strong to ultratight protein interactions using differential scanning calorimetry

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

Disrupting the reader of histone language

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

Does bromodomain flexibility influence histone recognition?

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

Thermodynamic analysis of ligand-induced changes in protein thermal unfolding applied to high-throughput determination of ligand affinities with extrinsic fluorescent dyes.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

Measurement of dynamic protein binding to chromatin in vivo, using photobleaching microscopy

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979416

Site-directed mutagenesis by double polymerase chain reaction : megaprimer method

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24497639

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M113.523019

1 reference

22 August 2017

1 reference

22 August 2017

PubMed publication ID

24497639

1 reference