(Q38150711)

29 August 2017

title

Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer (English)

1 reference

29 August 2017

Anders M Lindroth

3

0 references

Stefan M. Pfister

object named as

Stefan M Pfister

2

0 references

Peter Lichter

6

object named as

Peter Lichter

1 reference

29 August 2017

Christoph Plass

1

1 reference

29 August 2017

Olga Bogatyrova

4

1 reference

29 August 2017

Rainer Claus

5

1 reference

29 August 2017

language of work or name

1 reference

9 October 2013

1 reference

29 August 2017

published in

Nature Reviews Genetics

1 reference

29 August 2017

volume

14

1 reference

29 August 2017

issue

11

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29 August 2017

page(s)

765-780

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29 August 2017

1 reference

A decade of exploring the cancer epigenome - biological and translational implications

21 January 2018

1 reference

CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future

21 January 2018

1 reference

Cancer genetics and epigenetics: two sides of the same coin?

21 January 2018

1 reference

Cancer epigenetics: from mechanism to therapy

21 January 2018

1 reference

Interplay between the cancer genome and epigenome

21 January 2018

1 reference

Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma

21 January 2018

1 reference

Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA

21 January 2018

1 reference

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

21 January 2018

1 reference

Increased methylation variation in epigenetic domains across cancer types

21 January 2018

1 reference

Induction of Tumors in Mice by Genomic Hypomethylation

21 January 2018

1 reference

EUKARYOTIC CYTOSINE METHYLTRANSFERASES

21 January 2018

1 reference

Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

21 January 2018

1 reference

Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer

21 January 2018

1 reference

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma

21 January 2018

1 reference

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

21 January 2018

1 reference

CpG island methylator phenotype in colorectal cancer

21 January 2018

1 reference

A DNA hypermethylation module for the stem/progenitor cell signature of cancer.

21 January 2018

1 reference

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

21 January 2018

1 reference

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

21 January 2018

1 reference

Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

21 January 2018

1 reference

Epigenomic analysis of multilineage differentiation of human embryonic stem cells

21 January 2018

1 reference

Human DNA methylomes at base resolution show widespread epigenomic differences

21 January 2018

1 reference

Large-scale methylation domains mark a functional subset of neuronally expressed genes.

21 January 2018

1 reference

Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer

21 January 2018

1 reference

Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains

21 January 2018

1 reference

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

21 January 2018

1 reference

Paired-end mapping reveals extensive structural variation in the human genome

21 January 2018

1 reference

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

21 January 2018

1 reference

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

21 January 2018

1 reference

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

21 January 2018

1 reference

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

21 January 2018

1 reference

Recurring mutations found by sequencing an acute myeloid leukemia genome

21 January 2018

1 reference

DNMT3A Mutations in Acute Myeloid Leukemia

21 January 2018

1 reference

SDH mutations establish a hypermethylator phenotype in paraganglioma.

21 January 2018

1 reference

Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor

21 January 2018

1 reference

Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing

21 January 2018

1 reference

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

21 January 2018

1 reference

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

21 January 2018

1 reference

The genetic landscape of the childhood cancer medulloblastoma

21 January 2018

1 reference

Dissecting the genomic complexity underlying medulloblastoma

21 January 2018

1 reference

Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

21 January 2018

1 reference

21 January 2018

Cancer genome landscapes

1 reference

Computational approaches to identify functional genetic variants in cancer genomes

21 January 2018

1 reference

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

21 January 2018

1 reference

Somatic mutations in the neurofibromatosis 1 gene in human tumors

21 January 2018

1 reference

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

21 January 2018

1 reference

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

21 January 2018

1 reference

DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45.

21 January 2018

1 reference

Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.

21 January 2018

1 reference

Epigenetic reprogramming in mammalian development

21 January 2018

1 reference

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

21 January 2018

1 reference

Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia

21 January 2018

1 reference

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

21 January 2018

1 reference

TET2 mutations in acute myeloid leukemia (AML): results from a comprehensive genetic and clinical analysis of the AML study group

21 January 2018

1 reference

IDH mutation impairs histone demethylation and results in a block to cell differentiation

21 January 2018

1 reference

Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy

21 January 2018

1 reference

Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomas

21 January 2018

1 reference

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

21 January 2018

1 reference

New functions for an old variant: no substitute for histone H3.3.

21 January 2018

1 reference

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

21 January 2018

1 reference

The partial tandem duplication of ALL1 in acute myeloid leukemia with normal cytogenetics or trisomy 11 is restricted to one chromosome

21 January 2018

1 reference

Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: a study of the Acute Myeloid Leukemia Study Group Ulm.

21 January 2018

1 reference

MLL translocations, histone modifications and leukaemia stem-cell development

21 January 2018

1 reference

H3K79 methylation profiles define murine and human MLL-AF4 leukemias

21 January 2018

1 reference

hDOT1L links histone methylation to leukemogenesis

21 January 2018

1 reference

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

21 January 2018

1 reference

The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma

21 January 2018

1 reference

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

21 January 2018

1 reference

Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer

21 January 2018

1 reference

Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer

21 January 2018

1 reference

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

21 January 2018

1 reference

Medulloblastomics: the end of the beginning

21 January 2018

1 reference

Collections of simultaneously altered genes as biomarkers of cancer cell drug response

21 January 2018

1 reference

ATP-dependent chromatin remodeling: genetics, genomics and mechanisms

21 January 2018

1 reference

The biology of chromatin remodeling complexes

21 January 2018

1 reference

The spectrum of SWI/SNF mutations, ubiquitous in human cancers

21 January 2018

1 reference

SWI/SNF nucleosome remodellers and cancer.

21 January 2018

1 reference

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

21 January 2018

1 reference

Mutations and deletions of ARID1A in breast tumors.

21 January 2018

1 reference

The genetic landscape of mutations in Burkitt lymphoma

21 January 2018

1 reference

Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma

21 January 2018

1 reference

ARID1A mutations in cancer: another epigenetic tumor suppressor?

21 January 2018

1 reference

Rhabdoid tumors: an initial clue to the role of chromatin remodeling in cancer

21 January 2018

1 reference

Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer

21 January 2018

1 reference

Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas

21 January 2018

1 reference

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

21 January 2018

1 reference

Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas

21 January 2018

1 reference

Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma

21 January 2018

1 reference

The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression

21 January 2018

1 reference

DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors

21 January 2018

1 reference

Association of age at diagnosis and genetic mutations in patients with neuroblastoma.

21 January 2018

1 reference

ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells

21 January 2018

1 reference

Distinct factors control histone variant H3.3 localization at specific genomic regions

21 January 2018

1 reference

The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9

21 January 2018

1 reference

Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin

21 January 2018

1 reference

ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome

21 January 2018

1 reference

Altered telomeres in tumors with ATRX and DAXX mutations

21 January 2018

1 reference

Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

21 January 2018

1 reference

Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia.

21 January 2018

1 reference

Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth

21 January 2018

1 reference

Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors

21 January 2018

1 reference

Epigenetic regulation of the tumor suppressor gene TCF21 on 6q23-q24 in lung and head and neck cancer.

21 January 2018

1 reference

Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia

21 January 2018

1 reference

An integrated encyclopedia of DNA elements in the human genome

21 January 2018

1 reference

Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer

21 January 2018

1 reference

In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma

21 January 2018

1 reference

Low-dose decitabine versus best supportive care in elderly patients with intermediate- or high-risk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy: final results of the randomized phase III study of the European Organisation fo

21 January 2018

1 reference

Inhibitors of DNA methylation: beyond myelodysplastic syndromes

21 January 2018

1 reference

Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia

21 January 2018

1 reference

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

21 January 2018

1 reference

Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma

21 January 2018

1 reference

Preliminary evidence of disease response to the pan deacetylase inhibitor panobinostat (LBH589) in refractory Hodgkin Lymphoma.

21 January 2018

1 reference

A phase I study of oral panobinostat alone and in combination with docetaxel in patients with castration-resistant prostate cancer.

21 January 2018

1 reference

Histone acetyl transferases as emerging drug targets.

21 January 2018

1 reference

The MYST family of histone acetyltransferases and their intimate links to cancer.

21 January 2018

1 reference

Small molecule inhibitors of histone acetyltransferases as epigenetic tools and drug candidates

21 January 2018

1 reference

The structural basis of protein acetylation by the p300/CBP transcriptional coactivator

21 January 2018

1 reference

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

21 January 2018

1 reference

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

21 January 2018

1 reference

Progress in the discovery of small-molecule inhibitors of bromodomain--histone interactions

21 January 2018

1 reference

Selective inhibition of BET bromodomains

21 January 2018

1 reference

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

21 January 2018

1 reference

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

21 January 2018

1 reference

Targeting MYC dependence in cancer by inhibiting BET bromodomains

21 January 2018

1 reference

Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming

21 January 2018

1 reference

FLASH assembly of TALENs for high-throughput genome editing

21 January 2018

1 reference

SnapShot: glioblastoma multiforme

21 January 2018

1 reference

Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN.

21 January 2018

1 reference

Histone methylation by PRC2 is inhibited by active chromatin marks

21 January 2018

1 reference

H3K36 methylation antagonizes PRC2-mediated H3K27 methylation

21 January 2018

1 reference

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

21 January 2018

1 reference

Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome

21 January 2018

1 reference

Genome-wide profiling of CpG methylation identifies novel targets of aberrant hypermethylation in myeloid leukemia

21 January 2018

1 reference

Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells

21 January 2018

1 reference

Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis

21 January 2018

1 reference

High-throughput DNA methylation profiling using universal bead arrays

21 January 2018

1 reference

Ultra-low-input, tagmentation-based whole-genome bisulfite sequencing

21 January 2018

1 reference

The GLIB technique for genome-wide mapping of 5-hydroxymethylcytosine

21 January 2018

1 reference

Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.

21 January 2018

1 reference

Mapping accessible chromatin regions using Sono-Seq

21 January 2018

1 reference

Methods for identifying higher-order chromatin structure

21 January 2018

1 reference

High-resolution genome-wide mapping of histone modifications

21 January 2018

1 reference

High-resolution profiling of histone methylations in the human genome

21 January 2018

1 reference

A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis

21 January 2018

1 reference

Principles and challenges of genomewide DNA methylation analysis

21 January 2018

1 reference

Linking DNA methyltransferases to epigenetic marks and nucleosome structure genome-wide in human tumor cells

21 January 2018

1 reference

Whole-genome chromatin profiling from limited numbers of cells using nano-ChIP-seq

21 January 2018

1 reference

Restriction landmark genome scanning for aberrant methylation in primary refractory and relapsed acute myeloid leukemia; involvement of the WIT-1 gene

21 January 2018

1 reference

Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies

31 March 2020

1 reference

IntOGen-mutations identifies cancer drivers across tumor types.

31 March 2020

1 reference

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

31 March 2020

1 reference

Role of TET2 mutations in myeloproliferative neoplasms

31 March 2020

1 reference

Molecular biology. Genetic events that shape the cancer epigenome

31 March 2020

1 reference

Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance

31 March 2020

1 reference

Decitabine induces very early in vivo DNA methylation changes in blasts from patients with acute myeloid leukemia

31 March 2020

1 reference

Methylation profiling of CpG islands in human breast cancer cells

31 March 2020

1 reference

DNA methylation patterns of the calcitonin gene in human lung cancers and lymphomas.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24105274

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

New approach for detection of amplification in cancer DNA using restriction landmark genomic scanning

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24105274

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRG3554

1 reference

Dimensions Publication ID

29 August 2017

1006119577

0 references

1 reference