(Q37724050)

English

Efficient affinity maturation of antibody variable domains requires co-selection of compensatory mutations to maintain thermodynamic stability

scientific article published on 28 March 2017

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scholarly article

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Europe PubMed Central

22 August 2017

Efficient affinity maturation of antibody variable domains requires co-selection of compensatory mutations to maintain thermodynamic stability (English)

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Europe PubMed Central

22 August 2017

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based on heuristic

inferred from title

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28349921%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Peter M. Tessier

5

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3 June 2020

author name string

Mark C Julian

1

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3 June 2020

Lijuan Li

2

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3 June 2020

Shekhar Garde

3

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3 June 2020

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28 March 2017

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22 August 2017

Scientific Reports

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3 June 2020

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3 June 2020

45259

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3 June 2020

copyright license

Creative Commons Attribution 4.0 International

28 March 2017

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April 2022 Public Data File from Crossref

copyright status

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https://scigraph.springernature.com/pub.10.1038/srep45259

0 references

Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires

1 reference

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23 August 2017

Optimizing antibody expression by using the naturally occurring framework diversity in a live bacterial antibody display system

1 reference

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23 August 2017

GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

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23 August 2017

Design and Optimization of Anti-amyloid Domain Antibodies Specific for β-Amyloid and Islet Amyloid Polypeptide

1 reference

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23 August 2017

Co-evolution of affinity and stability of grafted amyloid-motif domain antibodies

1 reference

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23 August 2017

A switchable yeast display/secretion system

1 reference

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23 August 2017

Increased Fab thermoresistance via VH-targeted directed evolution

1 reference

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23 August 2017

Advances in Antibody Design

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23 August 2017

An antibody with a variable-region coiled-coil "knob" domain

1 reference

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23 August 2017

What makes a protein fold amenable to functional innovation? Fold polarity and stability trade-offs

1 reference

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23 August 2017

Design of synthetic autonomous VH domain libraries and structural analysis of a VH domain bound to vascular endothelial growth factor

1 reference

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23 August 2017

Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation

1 reference

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23 August 2017

Rational design of potent domain antibody inhibitors of amyloid fibril assembly

1 reference

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23 August 2017

Engineering antibody fitness and function using membrane-anchored display of correctly folded proteins.

1 reference

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23 August 2017

Structure-based design of conformation- and sequence-specific antibodies against amyloid β.

1 reference

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23 August 2017

Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies

1 reference

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23 August 2017

High-resolution description of antibody heavy-chain repertoires in humans

1 reference

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23 August 2017

Synthetic antibodies designed on natural sequence landscapes

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23 August 2017

A De Novo Protein Binding Pair By Computational Design and Directed Evolution

1 reference

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23 August 2017

Beyond natural antibodies: the power of in vitro display technologies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

Mutational effects and the evolution of new protein functions.

1 reference

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23 August 2017

Stability and CDR composition biases enrich binder functionality landscapes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

Protocol for the selection of single-domain antibody fragments by third generation intracellular antibody capture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

Structural Bases for Stability–Function Tradeoffs in Antibiotic Resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

Stability effects of mutations and protein evolvability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

Genetic and Structural Characterization of an L201P Global Suppressor Substitution in TEM-1 β-Lactamase

1 reference

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23 August 2017

Picomolar affinity fibronectin domains engineered utilizing loop length diversity, recursive mutagenesis, and loop shuffling

1 reference

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23 August 2017

Intense neutral drifts yield robust and evolvable consensus proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

How protein stability and new functions trade off

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

A decade of yeast surface display technology: where are we now?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

Comprehensive analysis of the factors contributing to the stability and solubility of autonomous human VH domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

Isolating and engineering human antibodies using yeast surface display

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

Canonical sampling through velocity rescaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

Comparison of multiple Amber force fields and development of improved protein backbone parameters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

Protein stability promotes evolvability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

Protein production by auto-induction in high density shaking cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

A structure-based database of antibody variable domain diversity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

Thermodynamic prediction of protein neutrality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

A biomolecular force field based on the free enthalpy of hydration and solvation: the GROMOS force-field parameter sets 53A5 and 53A6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

Motif-grafted antibodies containing the replicative interface of cellular PrP are specific for PrPSc

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

Contributions of CDR3 to V H H domain stability and the design of monobody scaffolds for naive antibody libraries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

Structural bases of stability-function tradeoffs in enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

Electrostatics of nanosystems: application to microtubules and the ribosome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

Selection for improved protein stability by phage display.

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23 August 2017

Canonical dynamics: Equilibrium phase-space distributions

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23 August 2017

Yeast surface display for screening combinatorial polypeptide libraries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

A relationship between protein stability and protein function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 August 2017

High-affinity self-reactive human antibodies by design and selection: targeting the integrin ligand binding site

1 reference

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23 August 2017

Single-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotides

1 reference

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23 August 2017

Directed evolution of anti-HER2 DARPins by SNAP display reveals stability/function trade-offs in the selection process

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

6 September 2017

Engineering aggregation-resistant antibodies

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

6 September 2017

Computer simulation of liquid crystals

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6 September 2017

The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

14 September 2017

The targeting of somatic hypermutation

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28 September 2017

Rational design of antibody protease inhibitors

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

28 September 2017

A general approach to antibody thermostabilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 June 2018

Mutational analysis of 48G7 reveals that somatic hypermutation affects both antibody stability and binding affinity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 June 2018

Optimizing protein stability in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

23 June 2018

Using circular dichroism collected as a function of temperature to determine the thermodynamics of protein unfolding and binding interactions

1 reference

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23 June 2018

The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin

1 reference

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1 September 2018

Mutational analysis of domain antibodies reveals aggregation hotspots within and near the complementarity determining regions

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5368667

1 September 2018

Improving the stability of an antibody variable fragment by a combination of knowledge-based approaches: validation and mechanisms.

1 reference

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1 September 2018

Atomic resolution structures of CTX-M beta-lactamases: extended spectrum activities from increased mobility and decreased stability.

1 reference

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1 September 2018

Codon bias and plasticity in immunoglobulins

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1 September 2018

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

1 reference

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21 January 2018

An integrated approach to extreme thermostabilization and affinity maturation of an antibody

1 reference

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1 October 2018

Sequence statistics reliably predict stabilizing mutations in a protein domain

2 references

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1 October 2018

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21 January 2018

Stability and function: two constraints in the evolution of barstar and other proteins

1 reference

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1 October 2018

Mutual Stabilization of VLand VHin Single-Chain Antibody Fragments, Investigated with Mutants Engineered for Stability†

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21 January 2018

Codon bias targets mutation.

1 reference

https://api.crossref.org/works/10.1038%2FSREP45259

21 January 2018

Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping hydrophobicity at the nanoscale: applications to heterogeneous surfaces and proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/28349921

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SREP45259

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28349921%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28349921%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28349921%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

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