(Q37727112)

22 August 2017

1 reference

title

Depression gets old fast: do stress and depression accelerate cell aging? (English)

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22 August 2017

1

Owen M Wolkowitz

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22 August 2017

2

Elissa S Epel

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22 August 2017

Victor I Reus

3

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Synthia H Mellon

series ordinal

4

object named as

Synthia H Mellon

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22 August 2017

1 April 2010

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22 August 2017

Depression and Anxiety

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22 August 2017

27

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22 August 2017

327-338

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22 August 2017

4

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Psychosocial factors as a potential trigger of oxidative DNA damage in human leukocytes

22 August 2017

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The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men

21 January 2018

1 reference

Accelerated telomere erosion is associated with a declining immune function of caregivers of Alzheimer's disease patients

21 January 2018

1 reference

Anti-inflammatory effects of antidepressants: possibilities for preventives against Alzheimer's disease

21 January 2018

1 reference

Treatment of depression with antiglucocorticoid drugs

21 January 2018

1 reference

Insulin resistance, affective disorders, and Alzheimer's disease: review and hypothesis

21 January 2018

1 reference

Depression, endocrinologically a syndrome of premature aging?

21 January 2018

1 reference

7 January 2021

Should Depressive Syndromes Be Reclassified as "Metabolic Syndrome Type II"?

1 reference

7 January 2021

Chronic stress and immunosenescence: a review.

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7 January 2021

Mood disorders in the medically ill: scientific review and recommendations

1 reference

7 January 2021

Metabolic syndrome and major depressive disorder: co-occurrence and pathophysiologic overlap

1 reference

7 January 2021

Association of depression with medical illness: does cortisol play a role?

1 reference

7 January 2021

Hypercortisolemic depression is associated with the metabolic syndrome in late-life

1 reference

7 January 2021

Depressive symptoms as a predictor of cognitive decline: MacArthur Studies of Successful Aging.

1 reference

7 January 2021

Depressive symptoms and mortality in men: results from the Multiple Risk Factor Intervention Trial

1 reference

7 January 2021

Major depression in older medical inpatients predicts poor physical and mental health status over 12 months.

1 reference

7 January 2021

The relationship of depression to cardiovascular disease: epidemiology, biology, and treatment

1 reference

7 January 2021

Association between depression and mortality in older adults: the Cardiovascular Health Study

1 reference

7 January 2021

The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis.

1 reference

7 January 2021

Glucocorticoids, stress, and their adverse neurological effects: relevance to aging

1 reference

7 January 2021

Protective and damaging effects of stress mediators: the good and bad sides of the response to stress

1 reference

7 January 2021

A neural signaling triumvirate that influences ageing and age-related disease: insulin/IGF-1, BDNF and serotonin

1 reference

7 January 2021

Molecular pathology of aging and its implications for senescent coronary atherosclerosis

1 reference

7 January 2021

Clinical oxidation parameters of aging

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7 January 2021

Psychological and metabolic stress: a recipe for accelerated cellular aging?

1 reference

7 January 2021

Molecular mechanisms of aging-associated inflammation

1 reference

7 January 2021

Accelerated telomere shortening in response to life stress

1 reference

7 January 2021

Cell aging in relation to stress arousal and cardiovascular disease risk factors

1 reference

7 January 2021

Organismal stress and telomeric aging: an unexpected connection

1 reference

7 January 2021

THE EFFECTS OF STRESS ON DNA REPAIR CAPACITY

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7 January 2021

Increased serum levels of 8-hydroxy-2'-deoxyguanosine in clinical depression

1 reference

7 January 2021

Depression and possible cancer risk due to oxidative DNA damage

1 reference

7 January 2021

Chronic stress and age-related increases in the proinflammatory cytokine IL-6

1 reference

7 January 2021

Effects of aging and stress on hippocampal structure and function

1 reference

7 January 2021

A psychobiological perspective on genetic determinants of hypothalamus-pituitary-adrenal axis activity

1 reference

7 January 2021

Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children

1 reference

7 January 2021

Corticosteroid receptor genetic polymorphisms and stress responsivity

1 reference

7 January 2021

Glucocorticoids and neuro- and behavioural development.

1 reference

7 January 2021

Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women

1 reference

7 January 2021

Social support and resilience to stress across the life span: a neurobiologic framework

1 reference

7 January 2021

Neuroprotective and neurorestorative signal transduction mechanisms in brain aging: modification by genes, diet and behavior.

1 reference

7 January 2021

Glucocorticoids. Mood, memory, and mechanisms

1 reference

7 January 2021

When blue turns to grey: do stress and depression accelerate cell aging?

1 reference

7 January 2021

Stress hormone-related psychopathology: pathophysiological and treatment implications

1 reference

7 January 2021

Neurotransmitters, neurosteroids and neurotrophins: new models of the pathophysiology and treatment of depression

1 reference

7 January 2021

Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress

1 reference

7 January 2021

Neurobiological mechanisms in major depressive disorder

1 reference

7 January 2021

Discovering endophenotypes for major depression

1 reference

7 January 2021

The endophenotype concept in psychiatry: etymology and strategic intentions

1 reference

7 January 2021

When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders

1 reference

7 January 2021

Major depression in late life is associated with both hypo- and hypercortisolemia.

1 reference

7 January 2021

A new view on hypocortisolism

1 reference

7 January 2021

The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders

1 reference

7 January 2021

Tissue specificity of glucocorticoid sensitivity in healthy adults

1 reference

7 January 2021

Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders.

1 reference

7 January 2021

Glucocorticoid receptor isoforms generate transcription specificity.

1 reference

7 January 2021

The glucocorticoid receptor: coding a diversity of proteins and responses through a single gene

1 reference

7 January 2021

Two polymorphisms in the glucocorticoid receptor gene directly affect glucocorticoid-regulated gene expression.

1 reference

7 January 2021

The human glucocorticoid receptor: one gene, multiple proteins and diverse responses

1 reference

7 January 2021

Glucocorticoid action networks and complex psychiatric and/or somatic disorders

1 reference

7 January 2021

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

1 reference

7 January 2021

Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide

1 reference

7 January 2021

Glucocorticoids worsen excitotoxin-induced expression of pro-inflammatory cytokines in hippocampal cultures

1 reference

7 January 2021

An inflammatory review of glucocorticoid actions in the CNS.

1 reference

7 January 2021

Hypothalamo-pituitary-adrenal function in patients with depressive disorders is correlated with baseline cytokine levels, but not with cytokine responses to hydrocortisone

1 reference

7 January 2021

Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression

1 reference

7 January 2021

Cutaneous glucocorticoid receptor sensitivity and pro-inflammatory cytokine levels in antidepressant-resistant depression.

1 reference

7 January 2021

A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-kappaB signaling

1 reference

7 January 2021

A neurotrophic model for stress-related mood disorders

1 reference

7 January 2021

Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus.

1 reference

7 January 2021

Stress, depression and hippocampal apoptosis.

1 reference

7 January 2021

Lower hippocampal volume in patients suffering from depression: a meta-analysis

1 reference

7 January 2021

Hippocampal volume and depression: a meta-analysis of MRI studies

1 reference

7 January 2021

3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity

1 reference

7 January 2021

Does stress damage the brain?

1 reference

7 January 2021

Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders

1 reference

7 January 2021

Glucocorticoid-biogenic amine interactions in relation to mood and behavior

1 reference

7 January 2021

The effects of dexamethasone on plasma homovanillic acid and 3-methoxy-4-hydroxyphenylglycol. Evidence for abnormal corticosteroid-catecholamine interactions in major depression.

1 reference

7 January 2021

Prospective controlled studies of the behavioral and biological effects of exogenous corticosteroids

1 reference

7 January 2021

The 5-HT receptor ? G-protein ? effector system complex in depression I. Effect of glucocorticoids

1 reference

7 January 2021

Stress and depression: possible links to neuron death in the hippocampus

1 reference

7 January 2021

The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death

1 reference

7 January 2021

Peripheral markers of oxidative stress and excitotoxicity in neurodegenerative disorders: tools for diagnosis and therapy?

1 reference

7 January 2021

Glucocorticoid receptors modulate mitochondrial function: A novel mechanism for neuroprotection

1 reference

7 January 2021

Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine

1 reference

7 January 2021

Concentrations of 3 alpha-reduced neuroactive steroids and their precursors in plasma of patients with major depression and after clinical recovery.

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7 January 2021

Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes

1 reference

7 January 2021

Can the antidysphoric and anxiolytic profiles of selective serotonin reuptake inhibitors be related to their ability to increase brain 3 alpha, 5 alpha-tetrahydroprogesterone (allopregnanolone) availability?

1 reference

7 January 2021

Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS).

1 reference

7 January 2021

Developing an agenda for translational studies of resilience and vulnerability following trauma exposure

1 reference

7 January 2021

Neuroactive steroids modulate HPA axis activity and cerebral brain-derived neurotrophic factor (BDNF) protein levels in adult male rats

1 reference

7 January 2021

The neurosteroid tetrahydroprogesterone attenuates the endocrine response to stress and exerts glucocorticoid-like effects on vasopressin gene transcription in the rat hypothalamus.

1 reference

7 January 2021

Regeneration in a degenerating brain: potential of allopregnanolone as a neuroregenerative agent

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7 January 2021

Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury

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7 January 2021

The role of stress factors during aging of the immune system.

1 reference

7 January 2021

Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone.

1 reference

7 January 2021

Anti-stress effects of dehydroepiandrosterone: protection of rats against repeated immobilization stress-induced weight loss, glucocorticoid receptor production, and lipid peroxidation

1 reference

7 January 2021

Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties

1 reference

7 January 2021

The neuroimmunology of stress and depression.

1 reference

7 January 2021

Cytokines and major depression

1 reference

7 January 2021

Cytokines: abnormalities in major depression and implications for pharmacological treatment.

1 reference

7 January 2021

Chronic emotional stress exposure increases infarct size in rats: the role of oxidative and nitrosative damage in response to sympathetic hyperactivity

1 reference

7 January 2021

Depression and immune function: central pathways to morbidity and mortality

1 reference

7 January 2021

Low serum IL-10 concentrations and loss of regulatory association between IL-6 and IL-10 in adults with major depression

1 reference

7 January 2021

A meta-analysis of cytokines in major depression

1 reference

7 January 2021

A detailed examination of cytokine abnormalities in Major Depressive Disorder

1 reference

7 January 2021

Imbalance between pro- and anti-inflammatory cytokines, and between Th1 and Th2 cytokines in depressed patients: the effect of electroacupuncture or fluoxetine treatment

1 reference

7 January 2021

Interplay of TNF-alpha and IL-10 in regulating oxidative stress in isolated adult cardiac myocytes

1 reference

7 January 2021

Pro-inflammatory cytokines and their effects in the dentate gyrus

1 reference

7 January 2021

Inflammation is detrimental for neurogenesis in adult brain

1 reference

7 January 2021

The psychoneuroimmuno-pathophysiology of cytokine-induced depression in humans

1 reference

7 January 2021

IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors.

1 reference

7 January 2021

Interleukin-6 covaries inversely with hippocampal grey matter volume in middle-aged adults

1 reference

7 January 2021

Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression

1 reference

7 January 2021

Werner Syndrome as an example of inflamm-aging: possible therapeutic opportunities for a progeroid syndrome?

1 reference

7 January 2021

Oxidative stress and inflammation in brain aging: nutritional considerations

1 reference

7 January 2021

Telomere length assessment: biomarker of chronic oxidative stress?

1 reference

7 January 2021

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

1 reference

7 January 2021

Total antioxidant capacity and total oxidant status in patients with major depression: impact of antidepressant treatment

1 reference

7 January 2021

Relationships between perceived workload, stress and oxidative DNA damage

1 reference

7 January 2021

Major depressive disorder is accompanied with oxidative stress: short-term antidepressant treatment does not alter oxidative-antioxidative systems.

1 reference

7 January 2021

Accelerated apoptosis of blood leukocytes and oxidative stress in blood of patients with major depression

1 reference

7 January 2021

Invivo antioxidant status: a putative target of antidepressant action

1 reference

7 January 2021

TNF receptor superfamily-induced cell death: redox-dependent execution

1 reference

7 January 2021

Serum oxidized low-density lipoprotein is inversely correlated to telomerase activity in peripheral blood mononuclear cells of haemodialysis patients

1 reference

7 January 2021

Increased oxidative stress as a mechanism for decreased BDNF levels in acute manic episodes

1 reference

7 January 2021

The presence of ascorbate induces expression of brain derived neurotrophic factor in SH-SY5Y neuroblastoma cells after peroxide insult, which is associated with increased survival.

1 reference

7 January 2021

Is it time to reassess the BDNF hypothesis of depression?

1 reference

7 January 2021

TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment

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7 January 2021

Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication

1 reference

7 January 2021

Critical role of brain-derived neurotrophic factor in mood disorders

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7 January 2021

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

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7 January 2021

Local acute application of BDNF in the lesioned spinal cord anti-inflammatory and anti-oxidant effects

1 reference

7 January 2021

BDNF increases rat brain mitochondrial respiratory coupling at complex I, but not complex II

1 reference

7 January 2021

Telomerase mediates the cell survival-promoting actions of brain-derived neurotrophic factor and secreted amyloid precursor protein in developing hippocampal neurons.

1 reference

7 January 2021

Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging

1 reference

7 January 2021

Oxidative stress shortens telomeres

1 reference

7 January 2021

Telomeres and human aging: facts and fibs

1 reference

7 January 2021

Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging.

1 reference

7 January 2021

Reduced telomerase activity in human T lymphocytes exposed to cortisol

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7 January 2021

Telomere biology and cardiovascular disease.

1 reference

7 January 2021

Telomere shortening in atherosclerosis

1 reference

7 January 2021

Telomeres and cardiovascular disease: does size matter?

1 reference

7 January 2021

Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosis

1 reference

7 January 2021

Association between telomere length in blood and mortality in people aged 60 years or older

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7 January 2021

Telomerase modulates Wnt signalling by association with target gene chromatin

1 reference

7 January 2021

Telomerase: not just for the elongation of telomeres.

1 reference

7 January 2021

Leukocyte telomere length and cardiovascular disease in the cardiovascular health study

1 reference

7 January 2021

Childhood maltreatment and telomere shortening: preliminary support for an effect of early stress on cellular aging

1 reference

7 January 2021

The effects of social status on biological aging as measured by white-blood-cell telomere length.

1 reference

7 January 2021

Race/ethnicity and telomere length in the Multi-Ethnic Study of Atherosclerosis

1 reference

7 January 2021

Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart Study

1 reference

7 January 2021

The Association Between Physical Activity in Leisure Time and Leukocyte Telomere Length

1 reference

7 January 2021

Epigenetic control of cellular senescence in disease: opportunities for therapeutic intervention.

1 reference

7 January 2021

The epigenetic regulation of mammalian telomeres

1 reference

7 January 2021

Maternal care, the epigenome and phenotypic differences in behavior

1 reference

7 January 2021

The role of inflammatory mediators in the biology of major depression: central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neuroprotection

1 reference

7 January 2021

A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice

1 reference

7 January 2021

Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system?

1 reference

7 January 2021

Cytokine imbalance in the pathophysiology of major depressive disorder

1 reference

7 January 2021

The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

1 reference

7 January 2021

Role of neurotrophic factors in the etiology and treatment of mood disorders

1 reference

7 January 2021

Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications

1 reference

7 January 2021

Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors

1 reference

7 January 2021

Protective effects of lamotrigine, aripiprazole and escitalopram on depression-induced oxidative stress in rat brain.

1 reference

7 January 2021

Venlafaxine modulates depression-induced oxidative stress in brain and medulla of rat.

1 reference

7 January 2021

Central CRH system in depression and anxiety--evidence from clinical studies with CRH1 receptor antagonists

1 reference

7 January 2021

Increased telomerase activity and comprehensive lifestyle changes: a pilot study

1 reference

7 January 2021

Can meditation slow rate of cellular aging? Cognitive stress, mindfulness, and telomeres

1 reference

7 January 2021

Antiglucocorticoid treatments for mood disorders

1 reference

7 January 2021

Thiazolidinediones: novel treatments for cognitive deficits in mood disorders?

1 reference

7 January 2021

Insulin resistance in depressive disorders and Alzheimer's disease: revisiting the missing link hypothesis

1 reference

7 January 2021

Glutamate modulators as novel interventions for mood disorders

1 reference

7 January 2021

The role of glutamate in mood disorders: results from the ketamine in major depression study and the presumed cellular mechanism underlying its antidepressant effects

1 reference

7 January 2021

Glutamate-based antidepressants: 20 years on.

1 reference

7 January 2021

Riluzole in psychiatry: a systematic review of the literature

1 reference

7 January 2021

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

1 reference

7 January 2021

Antidepressant activity and calcium signaling cascades

1 reference

7 January 2021

Nicardipine improves the antidepressant action of ECT but does not improve cognition

1 reference

7 January 2021

Exercise treatment for depression

1 reference

7 January 2021

How effective are physical activity interventions for alleviating depressive symptoms in older people? A systematic review

1 reference

7 January 2021

Exercise for depression

1 reference

7 January 2021

Acute exercise ameliorates reduced brain-derived neurotrophic factor in patients with panic disorder.

1 reference

7 January 2021

Analysis of effects and pharmacokinetics of subcutaneously administered BDNF.

1 reference

7 January 2021

Conjugation of brain-derived neurotrophic factor to a blood-brain barrier drug targeting system enables neuroprotection in regional brain ischemia following intravenous injection of the neurotrophin.

1 reference

7 January 2021

Development of neuropeptide drugs that cross the blood-brain barrier

1 reference

7 January 2021

Telomerase induction in T cells: a cure for aging and disease?

1 reference

7 January 2021

Telomerase and the aging cell: implications for human health.

1 reference

7 January 2021

The effect of tumor necrosis factor antagonists on mood and mental health-associated quality of life: novel hypothesis-driven treatments for bipolar depression?

1 reference

7 January 2021

Shortened onset of action of antidepressants in major depression using acetylsalicylic acid augmentation: a pilot open-label study

1 reference

7 January 2021

New approaches to antidepressant drug design: cytokine-regulated pathways

1 reference

7 January 2021

Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase III trial.

1 reference

7 January 2021

Anti-inflammatory drugs in psychiatry

1 reference

7 January 2021

Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments

1 reference

7 January 2021

The link between childhood trauma and depression: insights from HPA axis studies in humans.

1 reference

7 January 2021

The enduring effects of abuse and related adverse experiences in childhood. A convergence of evidence from neurobiology and epidemiology

1 reference

7 January 2021

Stress-processes and depressive symptomatology.

1 reference

7 January 2021

Coping as a mediator of emotion

1 reference

7 January 2021

Does coping help? A reexamination of the relation between coping and mental health.

1 reference

7 January 2021

Identifiers

DOI

10.1002/DA.20686

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22 August 2017

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PubMed ID

20376837