(Q48424611)

English

Telomerase mediates the cell survival-promoting actions of brain-derived neurotrophic factor and secreted amyloid precursor protein in developing hippocampal neurons.

scientific article published in December 2002

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12486164%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

Telomerase mediates the cell survival-promoting actions of brain-derived neurotrophic factor and secreted amyloid precursor protein in developing hippocampal neurons (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12486164%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

3

object named as

Mark P Mattson

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12486164%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

author name string

Weiming Fu

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12486164%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

Chengbiao Lu

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12486164%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

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publication date

1 December 2002

1 reference

Europe PubMed Central

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15 December 2019

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12486164%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

22

1 reference

Europe PubMed Central

PMC publication ID

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15 December 2019

24

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12486164%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

10710-10719

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12486164%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-apoptotic role of telomerase in pheochromocytoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of insulin-like growth factor 1 on PHA-stimulated cord blood mononuclear cell telomerase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-derived neurotrophic factor mediates the anti-apoptotic effect of NMDA in cerebellar granule neurons: signal transduction cascades and site of ethanol action.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia up-regulates telomerase activity via mitogen-activated protein kinase signaling in human solid tumor cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of phosphatidylinositol 3-kinase, but not extracellular-regulated kinases, is necessary to mediate brain-derived neurotrophic factor-induced motoneuron survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted form of amyloid precursor protein enhances basal glucose and glutamate transport and protects against oxidative impairment of glucose and glutamate transport in synaptosomes by a cyclic GMP-mediated mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of NR2B-containing NMDA receptors prevents BDNF enhancement of glutamatergic transmission in hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of the p50 subunit of nuclear factor-kappaB increases the vulnerability of hippocampal neurons to excitotoxic injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling events regulating the neurodevelopmental triad. Glutamate and secreted forms of beta-amyloid precursor protein as examples

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of Akt kinase inhibits apoptosis and changes in Bcl-2 and Bax expression induced by nitric oxide in primary hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain derived neurotrophic factor protects human neuroblastoma cells from DNA damaging agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Basic FGF-induced activation of telomerase in rheumatoid synoviocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-kappa B regulates transcription of the mouse telomerase catalytic subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progesterone regulates human telomerase reverse transcriptase gene expression via activation of mitogen-activated protein kinase signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon alpha down-regulates telomerase reverse transcriptase and telomerase activity in human malignant and nonmalignant hematopoietic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autocrine transforming growth factor beta suppresses telomerase activity and transcription of human telomerase reverse transcriptase in human cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of telomerase activity and TERT expression during brain development in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced activity of cloned hamster TERT gene promoter in transformed cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trk receptors: mediators of neurotrophin action

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pre- and postnatal expression of brain-derived neurotrophic factor mRNA/protein and tyrosine protein kinase receptor B mRNA in the mouse hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Telomerase protects developing neurons against DNA damage-induced cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol-3-kinase-Akt kinase and p42/p44 mitogen-activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cells Expressing mRNA for Neurotrophins and their Receptors During Embryonic Rat Development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles for mitotic history in the generation and degeneration of hippocampal neuroarchitecture.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional characterization and developmental regulation of mouse telomerase RNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of intracellular Ca2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophins and neuronal plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Bcl-2 in the brain-derived neurotrophic factor survival response

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptide growth factors protect against ischemia in culture by preventing nitric oxide toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of brain-derived neurotrophic factor and p145TrkB affects survival, differentiation, and invasiveness of human neuroblastoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of cyclic GMP in the regulation of neuronal calcium and survival by secreted forms of beta-amyloid precursor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted form of amyloid beta/A4 protein precursor (APP) binds to two distinct APP binding sites on rat B103 neuron-like cells through two different domains, but only one site is involved in neuritotropic activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted forms of beta-amyloid precursor protein modulate dendrite outgrowth and calcium responses to glutamate in cultured embryonic hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA strand breaks induced by sustained glutamate excitotoxicity in primary neuronal cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comprehensive study of the spatiotemporal pattern of beta-amyloid precursor protein mRNA and protein in the rat brain: lack of modulation by exogenously applied nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of neuroprotective kappa B-dependent transcription by secreted forms of the Alzheimer's beta-amyloid precursor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in beta amyloid precursor protein secretion associated with the proliferative status of CNS derived progenitor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular basis of artifacts in the detection of telomerase activity and a modified primer for a more robust 'TRAP' assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Telomerase activity is induced in human peripheral B lymphocytes by the stimulation to antigen receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reverse transcriptase motifs in the catalytic subunit of telomerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunocytochemical localization of TrkB in the central nervous system of the adult rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophins protect cultured cerebellar granule neurons against the early phase of cell death by a two-component mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophin regulation of the developing nervous system: analyses of knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extension of life-span by introduction of telomerase into normal human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted form of beta-amyloid precursor protein activates protein kinase C and phospholipase Cgamma1 in cultured embryonic rat neocortical cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential role of mouse telomerase in highly proliferative organs

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophins rescue cerebellar granule neurons from oxidative stress-mediated apoptotic death: selective involvement of phosphatidylinositol 3-kinase and the mitogen-activated protein kinase pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of phosphatidylinositol 3-kinase by brain-derived neurotrophic factor gene transfection in septo-hippocampal cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antisense telomerase treatment: induction of two distinct pathways, apoptosis and differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Telomerase is controlled by protein kinase Calpha in human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct activation of TERT transcription by c-MYC.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12486164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.22-24-10710.2002

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12486164%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12486164%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12486164%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

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