(Q37748108)

22 August 2017

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title

Metallo-aminopeptidase inhibitors (English)

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22 August 2017

4

Paweł Kafarski

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22 August 2017

1

Artur Mucha

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22 August 2017

2

Marcin Drag

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22 August 2017

John P Dalton

3

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22 August 2017

publication date

10 May 2010

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22 August 2017

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22 August 2017

volume

92

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22 August 2017

issue

11

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22 August 2017

page(s)

1509-1529

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Metalloaminopeptidases: common functional themes in disparate structural surroundings

22 August 2017

cites work

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12 December 2020

Expression of adipocyte-derived leucine aminopeptidase in endometrial cancer. Association with tumor grade and CA-125.

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12 December 2020

Discovery of Inhibitors of Escherichia coli Methionine Aminopeptidase with the Fe(II)-Form Selectivity and Antibacterial Activity †

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12 December 2020

Crystal structure of isoaspartyl aminopeptidase in complex with L-aspartate

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12 December 2020

Chemical target validation studies of aminopeptidase in malaria parasites using alpha-aminoalkylphosphonate and phosphonopeptide inhibitors

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12 December 2020

Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor

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12 December 2020

Purification and characterization of aminopeptidase N from Spodoptera litura expressed in Sf21 insect cells

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12 December 2020

Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase

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12 December 2020

Phebestin, a new inhibitor of aminopeptidase N, produced by Streptomyces sp. MJ716-m3

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12 December 2020

Stereoselective synthesis of 1-aminoalkanephosphonic acids with two chiral centers and their activity towards leucine aminopeptidase.

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12 December 2020

Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds.

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12 December 2020

Neuropeptidases and the metabolic inactivation of insect neuropeptides

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12 December 2020

Hydroxamates and aliphatic boronic acids: marker inhibitors for aminopeptidase

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12 December 2020

Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

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12 December 2020

Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors

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12 December 2020

Cerebrospinal fluid proteomic analysis reveals dysregulation of methionine aminopeptidase-2 expression in human and mouse neurofibromatosis 1-associated glioma

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12 December 2020

Metal ion substitution in the catalytic site greatly affects the binding of sulfhydryl-containing compounds to leucyl aminopeptidase.

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12 December 2020

Inhibition of aminopeptidases by aminophosphonates

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12 December 2020

Zinc Coordination Geometry and Ligand Binding Affinity: The Structural and Kinetic Analysis of the Second-Shell Serine 228 Residue and the Methionine 180 Residue of the Aminopeptidase from Vibrio proteolyticus †

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12 December 2020

Purification and characterization of hyperthermotolerant leucine aminopeptidase from Geobacillus thermoleovorans 47b.

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12 December 2020

Leucine aminopeptidase from red sea bream (Pagrus major) skeletal muscle: purification, characterization, cellular location, and tissue distribution

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12 December 2020

Novel 3-galloylamido-N'-substituted-2,6-piperidinedione-N-acetamide peptidomimetics as metalloproteinase inhibitors

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12 December 2020

Hydrolysis of thionopeptides by the aminopeptidase from Aeromonas proteolytica: insight into substrate binding

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12 December 2020

Design, synthesis and antimalarial activity of novel, quinoline-based, zinc metallo-aminopeptidase inhibitors.

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12 December 2020

Comparision of the cytotoxic effects of birch bark extract, betulin and betulinic acid towards human gastric carcinoma and pancreatic carcinoma drug-sensitive and drug-resistant cell lines.

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12 December 2020

Antitumor, anti-invasion, and antimetastatic effects of curcumin

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12 December 2020

Immunomodulatory activity of a methionine aminopeptidase-2 inhibitor on B cell differentiation

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12 December 2020

MAPs and POEP of the roads from prokaryotic to eukaryotic kingdoms

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12 December 2020

Kinetic, spectroscopic, and X-ray crystallographic characterization of the functional E151H aminopeptidase from Aeromonas proteolytica.

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12 December 2020

Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design

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12 December 2020

Structure of human methionine aminopeptidase-2 complexed with fumagillin

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12 December 2020

The type II secretion system of Legionella pneumophila elaborates two aminopeptidases, as well as a metalloprotease that contributes to differential infection among protozoan hosts.

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12 December 2020

Role of the invariant Asn345 and Asn435 residues in a leucine aminopeptidase from Bacillus kaustophilus as evaluated by site-directed mutagenesis

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12 December 2020

Potent and selective inhibition of zinc aminopeptidase A (EC 3.4.11.7, APA) by glutamyl aminophosphinic peptides: importance of glutamyl aminophosphinic residue in the P1 position

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12 December 2020

Identification of potent type I MetAP inhibitors by simple bioisosteric replacement. Part 1: Synthesis and preliminary SAR studies of thiazole-4-carboxylic acid thiazol-2-ylamide derivatives

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12 December 2020

Physiologically relevant metal cofactor for methionine aminopeptidase-2 is manganese

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12 December 2020

Leucine aminopeptidase: bestatin inhibition and a model for enzyme-catalyzed peptide hydrolysis

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12 December 2020

Crystal structure of aminopeptidase N from human pathogen Neisseria meningitidis

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12 December 2020

Crystal structure of the cold-active aminopeptidase from Colwellia psychrerythraea, a close structural homologue of the human bifunctional leukotriene A4 hydrolase

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12 December 2020

Correlation of tumor growth suppression and methionine aminopetidase-2 activity blockade using an orally active inhibitor

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12 December 2020

Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes

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12 December 2020

The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum.

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12 December 2020

Matrix metalloproteinase inhibitors for cancer therapy:the current situation and future prospects

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12 December 2020

The moonlighting enzyme CD13: old and new functions to target

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12 December 2020

Brain renin-angiotensin system blockade by systemically active aminopeptidase A inhibitors: a potential treatment of salt-dependent hypertension

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12 December 2020

Investigation of the active site of aminopeptidase A using a series of new thiol-containing inhibitors

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12 December 2020

Complexes of mutants of Escherichia coli aminopeptidase P and the tripeptide substrate ValProLeu

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12 December 2020

Purification and properties of major midgut leucyl aminopeptidase of Morimus funereus (Coleoptera, Cerambycidae) larvae.

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12 December 2020

Structure of aminopeptidase N from Escherichia coli complexed with the transition-state analogue aminophosphinic inhibitor PL250

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12 December 2020

Small molecule inhibitors of methionine aminopeptidase type 2 (MetAP-2).

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12 December 2020

Metal ions as cofactors for the binding of inhibitors to methionine aminopeptidase: a critical view of the relevance of in vitro metalloenzyme assays

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12 December 2020

MEROPS: the peptidase database

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12 December 2020

Methionine aminopeptidase 2 and cancer

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12 December 2020

A new one-Pot method for the synthesis of alpha-siloxyamides from aldehydes or ketones and its application to the synthesis of (-)-bestatin

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12 December 2020

Mutation of an aminopeptidase N gene is associated with Helicoverpa armigera resistance to Bacillus thuringiensis Cry1Ac toxin

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12 December 2020

Probestin, a new inhibitor of aminopeptidase M, produced by Streptomyces azureus MH663-2F6. I. Taxonomy, production, isolation, physico-chemical properties and biological activities.

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12 December 2020

Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase

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12 December 2020

Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations

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12 December 2020

Identification and quantification of leucine aminopeptidase in aged normal and cataractous human lenses and ability of bovine lens LAP to cleave bovine crystallins

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12 December 2020

The properties and functions of bacterial aminopeptidases.

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12 December 2020

Synthesis of p-hydroxyubenimex

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12 December 2020

Crystal structures of Staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate

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12 December 2020

Analyzing the binding of Co(II)-specific inhibitors to the methionyl aminopeptidases from Escherichia coli and Pyrococcus furiosus

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12 December 2020

Metalloform-selective inhibition: synthesis and structure-activity analysis of Mn(II)-form-selective inhibitors of Escherichia coli methionine aminopeptidase

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12 December 2020

Proteolysis and class I major histocompatibility complex antigen presentation

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12 December 2020

Leucine aminopeptidase of the human blood flukes, Schistosoma mansoni and Schistosoma japonicum.

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12 December 2020

The structure and main functions of aminopeptidase N.

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12 December 2020

Impaired angiogenesis in aminopeptidase N-null mice

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12 December 2020

"Mixed inhibitor-prodrug" as a new approach toward systemically active inhibitors of enkephalin-degrading enzymes

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12 December 2020

Characterization of a leucine aminopeptidase of Babesia gibsoni.

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12 December 2020

Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis †

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12 December 2020

The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: importance of active site metal ions in the binding of substrates and inhibitors.

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12 December 2020

Enkephalin metabolism by microglial aminopeptidase N (CD13)

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12 December 2020

The catalytic role of glutamate 151 in the leucine aminopeptidase from Aeromonas proteolytica

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12 December 2020

The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase

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12 December 2020

Individual stereoisomers of phosphinic dipeptide inhibitor of leucine aminopeptidase.

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12 December 2020

Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore

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12 December 2020

Investigations into microsporidian methionine aminopeptidase type 2: a therapeutic target for microsporidiosis

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12 December 2020

Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids

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12 December 2020

Computer-aided design and activity prediction of leucine aminopeptidase inhibitors

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12 December 2020

Acylnitrene Route to Vicinal Amino Alcohols. Application to the Synthesis of (-)-Bestatin and Analogues

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12 December 2020

Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme

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12 December 2020

A transition-state-analog inhibitor influences zinc-binding by Aeromonas aminopeptidase

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12 December 2020

Two continuous spectrophotometric assays for methionine aminopeptidase

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12 December 2020

Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases

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12 December 2020

L-lysinethiol: a subnanomolar inhibitor of aminopeptidase B.

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12 December 2020

Aminopeptidase N (APN/CD13) as a target for anti-cancer agent design

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12 December 2020

Expression and characterization of two functional methionine aminopeptidases from Mycobacterium tuberculosis H37Rv

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12 December 2020

alpha-Aminoalkylphosphonates as a tool in experimental optimisation of P1 side chain shape of potential inhibitors in S1 pocket of leucine- and neutral aminopeptidases

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12 December 2020

Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors

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12 December 2020

Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes

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12 December 2020

Bestatin as an experimental tool in mammals

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12 December 2020

Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases

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12 December 2020

Discovery and structural modification of inhibitors of methionine aminopeptidases from Escherichia coli and Saccharomyces cerevisiae

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12 December 2020

Kinetic and spectroscopic analysis of the catalytic role of H79 in the methionine aminopeptidase from Escherichia coli

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12 December 2020

Fasciola hepatica leucine aminopeptidase, a promising candidate for vaccination against ruminant fasciolosis

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12 December 2020

Synthesis and in vitro activities of new non-peptidic APA inhibitors.

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12 December 2020

Partial purification and characterization of an aminopeptidase from Eimeria tenella

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12 December 2020

Bestatin-mediated inhibition of leucine aminopeptidase may hinder HIV infection

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12 December 2020

Identification and characterization of Aedes aegypti aminopeptidase N as a putative receptor of Bacillus thuringiensis Cry11A toxin

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12 December 2020

Development of bestatin-based activity-based probes for metallo-aminopeptidases

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12 December 2020

Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties

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12 December 2020

Bestatin inhibits covalent coupling of [3H]LTA4 to human leukocyte LTA4hydrolase

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12 December 2020

Peptidyl hydroxamic acids as methionine aminopeptidase inhibitors

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12 December 2020

Design of novel inhibitors of aminopeptidases. Synthesis of peptide-derived diamino thiols and sulfur replacement analogues of bestatin

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12 December 2020

Characterization of a novel zinc-containing, lysine-specific aminopeptidase from the hyperthermophilic archaeon Pyrococcus furiosus

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12 December 2020

The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity

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12 December 2020

3-Amino-2-hydroxy-propionaldehyde and 3-amino-1-hydroxy-propan-2-one derivatives: new classes of aminopeptidase inhibitors

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12 December 2020

Human aminopeptidases: a review of the literature

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12 December 2020

Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes

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12 December 2020

3-Amino-2-tetralone derivatives: novel potent and selective inhibitors of aminopeptidase-M (EC 3.4.11.2)

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12 December 2020

Purification and properties of aminopeptidase H from chicken skeletal muscle

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12 December 2020

Identification of potent type I MetAPs inhibitors by simple bioisosteric replacement. Part 2: SAR studies of 5-heteroalkyl substituted TCAT derivatives

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12 December 2020

Phosphinic derivatives as new dual enkephalin-degrading enzyme inhibitors: synthesis, biological properties, and antinociceptive activities

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12 December 2020

Identification and characterization of Paragonimus westermani leucine aminopeptidase

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12 December 2020

Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470

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12 December 2020

alpha-aminoaldehydes: transition state analogue inhibitors of leucine aminopeptidase

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12 December 2020

Structural basis of catalysis by monometalated methionine aminopeptidase

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12 December 2020

Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism

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12 December 2020

Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects.

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12 December 2020

Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation.

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12 December 2020

The M18 aspartyl aminopeptidase of Plasmodium falciparum binds to human erythrocyte spectrin in vitro

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12 December 2020

CD13 is a novel mediator of monocytic/endothelial cell adhesion

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12 December 2020

Development of a transgenic mouse model susceptible to human coronavirus 229E.

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12 December 2020

Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials

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12 December 2020

Aminopeptidase A inhibitors as potential central antihypertensive agents

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12 December 2020

Metal mediated inhibition of methionine aminopeptidase by quinolinyl sulfonamides

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12 December 2020

4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo

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12 December 2020

Multiple molecular targets in cancer chemoprevention by curcumin

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12 December 2020

Orally active aminopeptidase A inhibitors reduce blood pressure: a new strategy for treating hypertension

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12 December 2020

Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents.

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12 December 2020

Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development

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12 December 2020

Roles of P67/MetAP2 as a tumor suppressor

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12 December 2020

Mutational analysis of the zinc metalloprotease EmpA of Vibrio anguillarum

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12 December 2020

Synthesis of sulfur-containing analogues of bestatin. Inhibition of aminopeptidases by alpha-thiolbestatin analogues

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12 December 2020

Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin.

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12 December 2020

Differential inhibition of aminopeptidase A and aminopeptidase N by new beta-amino thiols

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12 December 2020

The structure of bestatin

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12 December 2020

Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation

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12 December 2020

Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression

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12 December 2020

A synthetic method for diversification of the P1' substituent in phosphinic dipeptides as a tool for exploration of the specificity of the S1' binding pockets of leucine aminopeptidases

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12 December 2020

Metal-mediated inhibition of Escherichia coli methionine aminopeptidase: structure-activity relationships and development of a novel scoring function for metal-ligand interactions

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12 December 2020

First synthesis of alpha-aminoalkyl-(N-substituted)thiocarbamoyl-phosphinates: inhibitors of aminopeptidase N (APN/CD13) with the new zinc-binding group

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12 December 2020

Development of a working model of the active site in bovine lens leucine aminopeptidase: a density functional investigation

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12 December 2020

The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2

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12 December 2020

The Reaction Mechanism of Bovine Lens Leucine Aminopeptidase

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12 December 2020

MAP1D, a novel methionine aminopeptidase family member is overexpressed in colon cancer

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12 December 2020

Leucine aminopeptidase as a target for inhibitor design

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12 December 2020

Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: predominant role of angiotensin III in the control of vasopressin release

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12 December 2020

Metalloform-selective inhibitors of escherichia coli methionine aminopeptidase and X-ray structure of a Mn(II)-form enzyme complexed with an inhibitor

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12 December 2020

Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 2: SAR studies on the pyridine ring 3-substituent

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12 December 2020

CD13 (human aminopeptidase N) mediates human cytomegalovirus infection

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12 December 2020

RNA interference targeting leucine aminopeptidase blocks hatching of Schistosoma mansoni eggs.

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12 December 2020

CD13--not just a marker in leukemia typing

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12 December 2020

Inhibitors of Plasmodium falciparum methionine aminopeptidase 1b possess antimalarial activity

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12 December 2020

A first-in-man phase i and pharmacokinetic study on CHR-2797 (Tosedostat), an inhibitor of M1 aminopeptidases, in patients with advanced solid tumors

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12 December 2020

Phosphorus amino acid analogues as inhibitors of leucine aminopeptidase.

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12 December 2020

Aminopeptidase N in arterial hypertension

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12 December 2020

Betulinic acid inhibits aminopeptidase N activity

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12 December 2020

The 1.15A crystal structure of the Staphylococcus aureus methionyl-aminopeptidase and complexes with triazole based inhibitors

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12 December 2020

Inhibition of aminopeptidases by phosphonic acid and phosphinic acid analogues of aspartic and glutamic acids

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12 December 2020

alpha-Aminoboronic acid derivatives: effective inhibitors of aminopeptidases

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12 December 2020

The leucyl aminopeptidase from Helicobacter pylori is an allosteric enzyme

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12 December 2020

Leucine aminopeptidase is not essential for trimming peptides in the cytosol or generating epitopes for MHC class I antigen presentation

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12 December 2020

Inhibition of angiotensin III formation by thiol derivatives of acidic amino acids

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12 December 2020

Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin

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12 December 2020

Novel hydroxamic acid-related phosphinates: inhibition of neutral aminopeptidase N (APN)

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12 December 2020

Synthetic analogues of TNP-470 and ovalicin reveal a common molecular basis for inhibition of angiogenesis and immunosuppression

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12 December 2020

Histidines 345 and 378 of Bacillus stearothermophilus leucine aminopeptidase II are essential for the catalytic activity of the enzyme

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12 December 2020

The metabolism of neuropeptides. Phase separation of synaptic membrane preparations with Triton X-114 reveals the presence of aminopeptidase N.

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12 December 2020

Physiology of local renin-angiotensin systems.

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12 December 2020

Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding

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12 December 2020

Analyzing the catalytic role of Asp97 in the methionine aminopeptidase from Escherichia coli.

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12 December 2020

Peptide hydrolysis by the binuclear zinc enzyme aminopeptidase from Aeromonas proteolytica: a density functional theory study

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12 December 2020

N-hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide, a novel hydroxamic acid-based inhibitor of aminopeptidase N and its anti-angiogenic activity

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12 December 2020

Mechanistic role of each metal ion in Streptomyces dinuclear aminopeptidase: PEPTIDE hydrolysis and 7x10(10)-fold rate enhancement of phosphodiester hydrolysis

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12 December 2020

CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells

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12 December 2020

L-leucinthiol - a potent inhibitor of leucine aminopeptidase

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12 December 2020

PC18, a specific aminopeptidase N inhibitor, induces vasopressin release by increasing the half-life of brain angiotensin III.

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12 December 2020

Iron substitution for sodium in a carboxylate-bridged, heterodinuclear sodium-iron complex

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12 December 2020

Inhibition of leucine aminopeptidase by amino acid hydroxamates

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12 December 2020

Identification and properties of the cell membrane bound leucine aminopeptidase interacting with the potential immunostimulant and chemotherapeutic agent bestatin

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12 December 2020

An efficient stereoselective synthesis of [3S(1S,9S)]-3-[[[9-(benzoylamino) octahydro-6,10-dioxo-6H-pyridazino-(1,2-a)(1,2)-diazepin-1-yl]-carbonyl ]amino]-4-oxobutanoic acid, an interleukin converting enzyme (ICE) inhibitor

1 reference

12 December 2020

Probestin, a new inhibitor of aminopeptidase M, produced by Streptomyces azureus MH663-2F6. I. Taxonomy, production, isolation, physico-chemical properties and biological activities.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.43.143

Identifiers

DOI

10.1016/J.BIOCHI.2010.04.026

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22 August 2017

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