(Q37778009)

23 August 2017

1 reference

title

DNA damage and polyploidization (English)

1 reference

23 August 2017

0 references

whole genome duplication

1 reference

based on heuristic

inferred from title

chromosome segregation

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20687469

17 June 2024

2

Randy Y. C. Poon

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20687469

17 June 2024

author name string

Jeremy Chow

1

1 reference

23 August 2017

Jeremy P.H. Chow

1

0 references

Randy Y.C. Poon

2

0 references

language of work or name

English

0 references

publication date

1 January 2010

1 reference

full work available at URL

23 August 2017

2010

0 references

http://link.springer.com/content/pdf/10.1007/978-1-4419-6199-0_4.pdf

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Advances in Experimental Medicine and Biology

17 June 2024

published in

1 reference

23 August 2017

volume

676

1 reference

23 August 2017

page(s)

57-71

1 reference

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

23 August 2017

cites work

1 reference

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14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

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Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris

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Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

17 June 2024

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Aneuploidy acts both oncogenically and as a tumor suppressor

17 June 2024

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The consequences of tetraploidy and aneuploidy

17 June 2024

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17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus

17 June 2024

8

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Multistage carcinogenesis in Barrett's esophagus

17 June 2024

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ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

17 June 2024

10

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Tetraploidy and chromosomal instability are early events during cervical carcinogenesis

17 June 2024

11

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High levels of chromosome instability in polyploids of Saccharomyces cerevisiae

17 June 2024

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Genome-wide genetic analysis of polyploidy in yeast

17 June 2024

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17 June 2024

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Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

17 June 2024

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Cell-to-cell fusion as a link between viruses and cancer.

17 June 2024

16

1 reference

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The clonal evolution of tumor cell populations

17 June 2024

17

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Were vertebrates octoploid?

17 June 2024

19

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

p53 represses the polyploidization of primary mammary epithelial cells by activating apoptosis.

17 June 2024

20

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines.

17 June 2024

21

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Centrosome aberrations: cause or consequence of cancer progression?

17 June 2024

22

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Multiple centrosomes: together they stand, divided they fall

17 June 2024

23

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Centrosome amplification can initiate tumorigenesis in flies.

17 June 2024

24

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells

17 June 2024

25

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

17 June 2024

26

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Spindle multipolarity is prevented by centrosomal clustering.

17 June 2024

27

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Extra centrosomes and/or chromosomes prolong mitosis in human cells

17 June 2024

28

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

A mechanism linking extra centrosomes to chromosomal instability

17 June 2024

29

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

In vivo hybridisation of human tumour and normal hamster cells.

17 June 2024

31

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Tumour-cell fusion as a source of myeloid traits in cancer

17 June 2024

32

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

The spindle-assembly checkpoint in space and time

17 June 2024

33

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint

17 June 2024

34

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death.

17 June 2024

35

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint

17 June 2024

36

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Characterization of the p53-dependent postmitotic checkpoint following spindle disruption

17 June 2024

37

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

The kinetics of p53 activation versus cyclin E accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint

17 June 2024

38

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

p53-independent abrogation of a postmitotic checkpoint contributes to human papillomavirus E6-induced polyploidy.

17 June 2024

39

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy

17 June 2024

40

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Aurora B-mediated abscission checkpoint protects against tetraploidization

17 June 2024

41

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defects

17 June 2024

42

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity

17 June 2024

43

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

17 June 2024

44

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Cell cycle progression and de novo centriole assembly after centrosomal removal in untransformed human cells

17 June 2024

45

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure

17 June 2024

46

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Human cancer cells commonly acquire DNA damage during mitotic arrest

17 June 2024

47

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Sustained mitotic block elicits DNA breaks: one-step alteration of ploidy and chromosome integrity in mammalian cells.

17 June 2024

48

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Prolonged mitosis versus tetraploid checkpoint: how p53 measures the duration of mitosis.

17 June 2024

49

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Endoreduplication in maize endosperm: involvement of m phase--promoting factor inhibition and induction of s phase--related kinases

17 June 2024

50

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles

17 June 2024

51

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Ubiquitin-dependent degradation of cyclin B is accelerated in polyploid megakaryocytes.

17 June 2024

52

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Construction by gene targeting in human cells of a "conditional' CDC2 mutant that rereplicates its DNA.

17 June 2024

53

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C

17 June 2024

54

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

The APC/C inhibitor, Emi1, is essential for prevention of rereplication

17 June 2024

55

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Cyclin-dependent kinases and S phase control in mammalian cells

17 June 2024

56

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Dial 9-1-1 for DNA damage: the Rad9-Hus1-Rad1 (9-1-1) clamp complex

17 June 2024

57

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

BRCA1 in cancer, cell cycle and genomic stability

17 June 2024

58

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Dual role for Drosophila epidermal growth factor receptor signaling in early wing disc development

17 June 2024

59

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

ATR: an essential regulator of genome integrity

17 June 2024

60

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Evidence that the ATR/Chk1 pathway maintains normal replication fork progression during unperturbed S phase.

17 June 2024

61

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Claspin: timing the cell cycle arrest when the genome is damaged

17 June 2024

62

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint

17 June 2024

63

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

The when and wheres of CDC25 phosphatases

17 June 2024

64

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

17 June 2024

Frontiers in bioscience

65

13

5016

Y. Chen

2008

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

CDC25 phosphatases in cancer cells: key players? Good targets?

17 June 2024

66

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Positive regulation of Wee1 by Chk1 and 14-3-3 proteins

17 June 2024

67

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Checkpoints: it takes more than time to heal some wounds

17 June 2024

71

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

17 June 2024

72

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

17 June 2024

73

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

17 June 2024

74

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Cohesins: chromosomal proteins that prevent premature separation of sister chromatids

17 June 2024

76

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

17 June 2024

77

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

The P53 pathway: what questions remain to be explored?

17 June 2024

78

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

17 June 2024

79

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

17 June 2024

80

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

17 June 2024

82

1 reference

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DNA damage triggers p21WAF1-dependent Emi1 down-regulation that maintains G2 arrest

17 June 2024

85

1 reference

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Computerized video time lapse study of cell cycle delay and arrest, mitotic catastrophe, apoptosis and clonogenic survival in irradiated 14-3-3sigma and CDKN1A (p21) knockout cell lines

17 June 2024

87

1 reference

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Endopolyploid cells produced after severe genotoxic damage have the potential to repair DNA double strand breaks

17 June 2024

88

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Current topics in pathology. Ergebnisse der Pathologie

17 June 2024

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60

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Drug-resistance enables selective killing of resistant leukemia cells: exploiting of drug resistance instead of reversal.

17 June 2024

90

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy

17 June 2024

91

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Spindle checkpoint function is required for mitotic catastrophe induced by DNA-damaging agents

17 June 2024

92

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https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

The in vitro micronucleus test: from past to future.

17 June 2024

93

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DNA repair pathways involved in anaphase bridge formation

17 June 2024

94

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p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells

17 June 2024

96

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Cell death by mitotic catastrophe: a molecular definition

17 June 2024

97

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Mechanisms of mitotic cell death induced by chemotherapy-mediated G2 checkpoint abrogation.

17 June 2024

98

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia

17 June 2024

99

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

17 June 2024

100

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Chk1 is haploinsufficient for multiple functions critical to tumor suppression

17 June 2024

101

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe

17 June 2024

102

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

The role of inhibitory phosphorylation of CDC2 following DNA replication block and radiation-induced damage in human cells

17 June 2024

103

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints.

17 June 2024

104

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Caffeine inhibits the checkpoint kinase ATM

17 June 2024

105

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

17 June 2024

106

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

17 June 2024

108

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

17 June 2024

109

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic cata

17 June 2024

110

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe

17 June 2024

112

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

17 June 2024

113

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

17 June 2024

114

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

17 June 2024

115

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

17 June 2024

116

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

A murine model of Nijmegen breakage syndrome

17 June 2024

117

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1.

17 June 2024

118

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

SV40 T antigen interacts with Nbs1 to disrupt DNA replication control.

17 June 2024

120

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Apoptosis regulation in tetraploid cancer cells

17 June 2024

121

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Polyploidization increases the sensitivity to DNA-damaging agents in mammalian cells

17 June 2024

122

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Masking and purging mutations following EMS treatment in haploid, diploid and tetraploid yeast (Saccharomyces cerevisiae)

17 June 2024

123

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Selective resistance of tetraploid cancer cells against DNA damage-induced apoptosis

17 June 2024

125

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Coincidence, coevolution, or causation? DNA content, cell size, and the C-value enigma

17 June 2024

126

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Tetraploidy in mice, embryonic cell number, and the grain of the developmental map

17 June 2024

128

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

The advantages and disadvantages of being polyploid

17 June 2024

129

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

You never know: Cdk inhibitors as anti-cancer drugs

17 June 2024

130

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

CDK1 inhibitors antagonize the immediate apoptosis triggered by spindle disruption but promote apoptosis following the subsequent rereplication and abnormal mitosis

17 June 2024

131

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Recent progress in the discovery and development of cyclin-dependent kinase inhibitors

17 June 2024

132

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

Mitotic death: a mechanism of survival? A review

17 June 2024

134

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_4

17 June 2024

Identifiers

0 references

1 reference