(Q37778010)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20687470%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

review article

1 reference

title

Role of the p53 family in stabilizing the genome and preventing polyploidization (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20687470%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Role of the p53 Family in Stabilizing the Genome and Preventing Polyploidization (English)

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

17 June 2024

main subject

whole genome duplication

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20687470

17 June 2024

author name string

Flaminia Talos

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20687470%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Ute M. Moll

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20687470

17 June 2024

language of work or name

English

0 references

publication date

1 January 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20687470%20AND%20SRC:MED&resulttype=core&format=json

full work available at URL

9 February 2020

number of pages

19

1 reference

based on heuristic

inferred from page(s)

http://link.springer.com/content/pdf/10.1007/978-1-4419-6199-0_5.pdf

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Advances in Experimental Medicine and Biology

17 June 2024

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20687470%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

volume

676

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20687470%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

page(s)

73-91

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20687470%20AND%20SRC:MED&resulttype=core&format=json

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

9 February 2020

cites work

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1073/PNAS.92.18.8493

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

1 reference

COCI

https://opencitations.net/index/coci/api/v1/citations/10.1038/21690

Cancer. p53, guardian of the genome

15 July 2023

1

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

p53, the cellular gatekeeper for growth and division

17 June 2024

2

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

17 June 2024

Surfing the p53 network

3

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Mutations of the Ki-ras, p53 and APC genes in adenocarcinomas of the human small intestine.

17 June 2024

4

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

17 June 2024

5

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas

17 June 2024

7

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

TP53 mutation and haplotype analysis of two large African American families

17 June 2024

9

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

17 June 2024

11

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

17 June 2024

12

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis

17 June 2024

13

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Effects of genetic background on tumorigenesis in p53-deficient mice

17 June 2024

14

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability

17 June 2024

20

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

17 June 2024

22

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

17 June 2024

23

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Regulation and mechanisms of gene amplification

17 June 2024

26

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Abnormal centrosome amplification in the absence of p53.

17 June 2024

29

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Genetic instability as a consequence of inappropriate entry into and progression through S-phase.

17 June 2024

30

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

17 June 2024

31

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Cell cycle checkpoint signaling through the ATM and ATR kinases

17 June 2024

32

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

DNA damage tumor suppressor genes and genomic instability

17 June 2024

33

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination

17 June 2024

34

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Tumor suppressor p53 represses transcription of RECQ4 helicase

17 June 2024

35

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

A role for ATR in the DNA damage-induced phosphorylation of p53

17 June 2024

36

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

17 June 2024

37

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

p53 prevents the accumulation of double-strand DNA breaks at stalled-replication forks induced by UV in human cells

17 June 2024

38

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

p53-dependent cell cycle control: response to genotoxic stress

17 June 2024

39

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Regulation of the G2/M transition by p53.

17 June 2024

40

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

p53: traffic cop at the crossroads of DNA repair and recombination

17 June 2024

42

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Characterization of the p53-dependent postmitotic checkpoint following spindle disruption

17 June 2024

44

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance

17 June 2024

45

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

17 June 2024

46

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

17 June 2024

47

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

17 June 2024

48

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

p53 Protein exhibits 3'-to-5' exonuclease activity

17 June 2024

49

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction

17 June 2024

51

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

p53's double life: transactivation-independent repression of homologous recombination.

17 June 2024

53

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

The DNA damage response: putting checkpoints in perspective

17 June 2024

55

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

On the road to cancer: aneuploidy and the mitotic checkpoint

17 June 2024

56

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

G1 tetraploidy checkpoint and the suppression of tumorigenesis

17 June 2024

57

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines.

17 June 2024

58

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Tetraploidy, aneuploidy and cancer

17 June 2024

59

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Cell biology: aneuploidy and cancer.

17 June 2024

60

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

17 June 2024

61

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

From polyploidy to aneuploidy, genome instability and cancer

17 June 2024

62

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

The advantages and disadvantages of being polyploid

17 June 2024

63

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

The role of hepatocytes and oval cells in liver regeneration and repopulation

17 June 2024

64

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Hepatic polyploidy and liver growth control.

17 June 2024

65

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

The American journal of cardiovascular pathology

17 June 2024

66

5

27

H.W. Vliegen

1995

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Centrosome multiplication accompanies a transient clustering of polyploid cells during tissue repair

17 June 2024

67

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Prevention of mammalian DNA reduplication, following the release from the mitotic spindle checkpoint, requires p53 protein, but not p53-mediated transcriptional activity

17 June 2024

68

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Radiobiological and genetic studies on a polyploid series (haploid to hexaploid) of Saccharomyces cerevisiae

17 June 2024

69

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Chromatin of endoreduplicated pavement cells has greater range of movement than that of diploid guard cells in Arabidopsis thaliana

17 June 2024

70

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

The nuclear envelope, a key structure in cellular integrity and gene expression

17 June 2024

71

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

High levels of chromosome instability in polyploids of Saccharomyces cerevisiae

17 June 2024

72

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Polyploidy in the haplontic yeast Schizosaccharomyces pombe: construction and analysis of strains

17 June 2024

73

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Polyploidization increases the sensitivity to DNA-damaging agents in mammalian cells

17 June 2024

74

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

17 June 2024

75

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Mitosis in a cell with multiple centrioles

17 June 2024

76

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

17 June 2024

77

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Tetraploidy and tumor development.

17 June 2024

78

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Guilt by association? p53 and the development of aneuploidy in cancer

17 June 2024

79

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Cell cycle progression after cleavage failure: mammalian somatic cells do not possess a "tetraploidy checkpoint".

17 June 2024

80

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure

17 June 2024

81

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells

17 June 2024

82

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Probing p53 biological functions through the use of genetically engineered mouse models

17 June 2024

83

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

17 June 2024

84

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm

17 June 2024

85

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination

17 June 2024

86

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Female embryonic lethality in mice nullizygous for both Msh2 and p53

17 June 2024

87

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

A role for mismatch repair in control of DNA ploidy following DNA damage

17 June 2024

88

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization

17 June 2024

89

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

17 June 2024

92

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

p63 is a p53 homologue required for limb and epidermal morphogenesis

17 June 2024

93

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family

17 June 2024

94

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

p63 and p73 do not contribute to p53-mediated lymphoma suppressor activity in vivo.

17 June 2024

95

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

p63 deficiency activates a program of cellular senescence and leads to accelerated aging

17 June 2024

96

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

p73 is not mutated in meningiomas as determined with a functional yeast assay but p73 expression increases with tumor grade.

17 June 2024

97

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Biochimica et Biophysica Acta

17 June 2024

98

1552

47

U.M. Moll

2001

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

p73: Friend or foe in tumorigenesis

17 June 2024

100

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Functional regulation of p73 and p63: development and cancer

17 June 2024

101

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Transdominant DeltaTAp73 isoforms are frequently up-regulated in ovarian cancer. Evidence for their role as epigenetic p53 inhibitors in vivo

17 June 2024

102

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

17 June 2024

104

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.

17 June 2024

105

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

P73 functionally replaces p53 in Adriamycin-treated, p53-deficient breast cancer cells

17 June 2024

106

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

A common E2F-1 and p73 pathway mediates cell death induced by TCR activation.

17 June 2024

109

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

17 June 2024

111

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

p73 suppresses polyploidy and aneuploidy in the absence of functional p53

17 June 2024

112

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Near-triploidy and near-tetraploidy in hematological malignancies and mutation of the p53 gene

17 June 2024

113

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

17 June 2024

114

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

p27 as a target for cancer therapeutics

17 June 2024

115

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

17 June 2024

116

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

17 June 2024

117

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1

17 June 2024

118

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

17 June 2024

119

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Skp2-dependent degradation of p27kip1 is essential for cell cycle progression

17 June 2024

120

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Ectopic expression of cyclin E allows non-endomitotic megakaryoblastic K562 cells to establish re-replication cycles

17 June 2024

121

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Increased D-type cyclin expression together with decreased cdc2 activity confers megakaryocytic differentiation of a human thrombopoietin-dependent hematopoietic cell line.

17 June 2024

122

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy

17 June 2024

123

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Chk1 and Chk2 kinases in checkpoint control and cancer

17 June 2024

124

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Induction of p57(KIP2) expression by p73beta.

17 June 2024

125

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

p21B, a variant of p21(Waf1/Cip1), is induced by the p53 family

17 June 2024

126

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Active Localization of the Retinoblastoma Protein in Chromatin and Its Response to S Phase DNA Damage

17 June 2024

127

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult

17 June 2024

128

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin

17 June 2024

129

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

17 June 2024

Identifiers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20687470%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference