(Q37785480)

23 August 2017

Therapeutic targeting of the prostate cancer microenvironment (English)

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23 August 2017

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Maria Karlou

1

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23 August 2017

Vassiliki Tzelepi

series ordinal

2

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23 August 2017

Eleni Efstathiou

series ordinal

3

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23 August 2017

language of work or name

English

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publication date

1 September 2010

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23 August 2017

Nature Reviews Urology

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23 August 2017

7

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23 August 2017

494-509

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23 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrurol.2010.134

23 August 2017

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Androgen-induced Wnt signaling in preosteoblasts promotes the growth of MDA-PCa-2b human prostate cancer cells

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EFFECT OF ORCHIECTOMY AND IRRADIATION ON CANCER OF THE PROSTATE

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Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer

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Phase III trial of androgen ablation with or without three cycles of systemic chemotherapy for advanced prostate cancer

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Autoradiographic studies of androgen-binding sites in the rat urogenital sinus and postnatal prostate

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Stromal-epithelial cell interactions and androgen receptor-coregulator recruitment is altered in the tissue microenvironment of prostate cancer.

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Androgen-independent prostate cancer DU145 cells suppress androgen-dependent growth of prostate stromal cells through production of inhibitory factors for androgen responsiveness

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Androgen responsiveness of stromal cells of the human prostate: regulation of cell proliferation and keratinocyte growth factor by androgen

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Targeting the stromal androgen receptor in primary prostate tumors at earlier stages

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Soluble factors derived from stroma activated androgen receptor phosphorylation in human prostate LNCaP cells: roles of ERK/MAP kinase

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Human prostate stromal cells stimulate increased PSA production in DHEA-treated prostate cancer epithelial cells

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31 March 2020

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Development of a second-generation antiandrogen for treatment of advanced prostate cancer

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Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study

31 March 2020

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Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation

31 March 2020

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The Sonic Hedgehog pathway stimulates prostate tumor growth by paracrine signaling and recapitulates embryonic gene expression in tumor myofibroblasts

31 March 2020

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CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer

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Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling

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Hedgehog signaling promotes prostate xenograft tumor growth

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Sonic hedgehog gene-enhanced tissue engineering for bone regeneration

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Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis

31 March 2020

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An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.

31 March 2020

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Initial modulation of the tumor microenvironment accounts for thalidomide activity in prostate cancer.

31 March 2020

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Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

31 March 2020

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A paracrine requirement for hedgehog signalling in cancer

31 March 2020

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Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

31 March 2020

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Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

31 March 2020

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The role of fibroblast growth factors and their receptors in prostate cancer.

31 March 2020

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Fibroblast growth factors and their receptors in urological cancers: basic research and clinical implications

31 March 2020

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Fibroblast growth factor-2 mediates transforming growth factor-beta action in prostate cancer reactive stroma

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Effect of keratinocyte growth factor on cell viability in primary cultured human prostate cancer stromal cells

31 March 2020

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FGF8 over-expression in prostate cancer is associated with decreased patient survival and persists in androgen independent disease

31 March 2020

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Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells

31 March 2020

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Identification of the fibroblast growth factor receptor of Swiss 3T3 cells and mouse skeletal muscle myoblasts

31 March 2020

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Pharmacological inhibition of FGF receptor signaling inhibits LNCaP prostate tumor growth, promatrilysin, and PSA expression

31 March 2020

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A neutralizing anti-fibroblast growth factor (FGF) 8 monoclonal antibody shows anti-tumor activity against FGF8b-expressing LNCaP xenografts in androgen-dependent and -independent conditions

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Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence

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Regulation of angiogenesis and vascular permeability by Src family kinases: opportunities for therapeutic treatment of solid tumors.

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Tumor necrosis factor-alpha supports the survival of osteoclasts through the activation of Akt and ERK.

31 March 2020

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Neuropeptide-induced androgen independence in prostate cancer cells: roles of nonreceptor tyrosine kinases Etk/Bmx, Src, and focal adhesion kinase

31 March 2020

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Bone-targeted Src SH2 inhibitors block Src cellular activity and osteoclast-mediated resorption

31 March 2020

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Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity

31 March 2020

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31 March 2020

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Interleukin-8 confers androgen-independent growth and migration of LNCaP: differential effects of tyrosine kinases Src and FAK.

31 March 2020

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Src inhibitor dasatinib inhibits growth of breast cancer cells by modulating EGFR signaling.

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Identification and validation of phospho-SRC, a novel and potential pharmacodynamic biomarker for dasatinib (SPRYCEL), a multi-targeted kinase inhibitor

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Src as a therapeutic target in men with prostate cancer and bone metastases

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Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530.

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Hand-foot syndrome after dose-dense adjuvant chemotherapy for breast cancer: a case series

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Prostate tumor progression is mediated by a paracrine TGF-beta/Wnt3a signaling axis

31 March 2020

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Stromal transforming growth factor-beta signaling mediates prostatic response to androgen ablation by paracrine Wnt activity

31 March 2020

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Expression of transforming growth factor-beta 1 and growth in soft agar differentiate prostate carcinoma-associated fibroblasts from normal prostate fibroblasts.

31 March 2020

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Insensitivity to transforming growth factor-beta results from promoter methylation of cognate receptors in human prostate cancer cells (LNCaP).

31 March 2020

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Transforming growth factor-beta promotes invasion in tumorigenic but not in nontumorigenic human prostatic epithelial cells.

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Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression.

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Transforming growth factor-beta signaling in prostate stromal cells supports prostate carcinoma growth by up-regulating stromal genes related to tissue remodeling

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The role of transforming growth factor-beta-mediated tumor-stroma interactions in prostate cancer progression: an integrative approach

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TGFbeta signaling in growth control, cancer, and heritable disorders

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Targeting TGF-beta in prostate cancer: therapeutic possibilities during tumor progression

31 March 2020

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Stromal expression of connective tissue growth factor promotes angiogenesis and prostate cancer tumorigenesis

31 March 2020

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Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells

31 March 2020

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Tolerization of tumor-specific T cells despite efficient initial priming in a primary murine model of prostate cancer

31 March 2020

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Cutting Edge: Tumor-specific CD8+ T cells infiltrating prostatic tumors are induced to become suppressor cells

31 March 2020

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TGF-beta signaling and androgen receptor status determine apoptotic cross-talk in human prostate cancer cells

31 March 2020

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Androgen receptor: a key molecule in the progression of prostate cancer to hormone independence

31 March 2020

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Preoperative plasma levels of transforming growth factor beta(1) (TGF-beta(1)) strongly predict progression in patients undergoing radical prostatectomy

31 March 2020

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Expression and distribution of transforming growth factor-beta isoforms and their signaling receptors in growing human bone.

31 March 2020

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Osteoblast-derived TGF-β1 modulates matrix degrading protease expression and activity in prostate cancer cells

31 March 2020

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Matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis

31 March 2020

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In vitro human osteoblast and extracellular matrix changes after transforming growth factor beta 1 treatment

31 March 2020

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Osteoblast conditioned media contain TGF-beta1 and modulate the migration of prostate tumor cells and their interactions with extracellular matrix components

31 March 2020

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Receptor activator of NF-kappaB Ligand (RANKL) expression is associated with epithelial to mesenchymal transition in human prostate cancer cells.

31 March 2020

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Tranilast inhibits hormone refractory prostate cancer cell proliferation and suppresses transforming growth factor beta1-associated osteoblastic changes

31 March 2020

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Inhibition of transforming growth factor-beta signaling in human cancer: targeting a tumor suppressor network as a therapeutic strategy

31 March 2020

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A phase III study of subconjunctival human anti-transforming growth factor beta(2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy.

31 March 2020

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Systemic administration of a soluble betaglycan suppresses tumor growth, angiogenesis, and matrix metalloproteinase-9 expression in a human xenograft model of prostate cancer

31 March 2020

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New experimental markers for early detection of high-risk prostate cancer: role of cell-cell adhesion and cell migration

31 March 2020

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Integrins in prostate cancer progression

31 March 2020

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Unique expression pattern of the alpha6beta4 integrin and laminin-5 in human prostate carcinoma

31 March 2020

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Specific alterations in the expression of alpha 3 beta 1 and alpha 6 beta 4 integrins in highly invasive and metastatic variants of human prostate carcinoma cells selected by in vitro invasion through reconstituted basement membrane

31 March 2020

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Integrin-regulated FAK-Src signaling in normal and cancer cells

31 March 2020

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MEK kinase activity is not necessary for Raf-1 function

31 March 2020

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Targeting ECM-integrin interaction with liposome-encapsulated small interfering RNAs inhibits the growth of human prostate cancer in a bone xenograft imaging model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

Prostate cancer specific integrin alphavbeta3 modulates bone metastatic growth and tissue remodeling

31 March 2020

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Cell-matrix adhesion in vascular development

31 March 2020

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Imaging of integrins as biomarkers for tumor angiogenesis

31 March 2020

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Requirement of vascular integrin alpha v beta 3 for angiogenesis

31 March 2020

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Inhibition of alpha(v)beta3 integrin reduces angiogenesis, bone turnover, and tumor cell proliferation in experimental prostate cancer bone metastases

31 March 2020

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Insulin-Like Growth Factor (IGF) family and prostate cancer

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

In vivo effects of the human type I insulin-like growth factor receptor antibody A12 on androgen-dependent and androgen-independent xenograft human prostate tumors

31 March 2020

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Combined in vivo effect of A12, a type 1 insulin-like growth factor receptor antibody, and docetaxel against prostate cancer tumors.

31 March 2020

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Notch signaling: a potential therapeutic target in prostate cancer.

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A role for notch signaling in stromal survival and differentiation during prostate development

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Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator

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Intracellular signaling pathways regulating radioresistance of human prostate carcinoma cells.

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Differential expression of steroid receptors in prostate tissues before and after radiation therapy for prostatic adenocarcinoma

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Androgen induces adaptation to oxidative stress in prostate cancer: implications for treatment with radiation therapy

31 March 2020

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Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial

31 March 2020

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6-month androgen suppression plus radiation therapy vs radiation therapy alone for patients with clinically localized prostate cancer: a randomized controlled trial

31 March 2020

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Radiation-induced HIF-1alpha cell survival pathway is inhibited by soy isoflavones in prostate cancer cells

31 March 2020

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c-Src-p38 mitogen-activated protein kinase signaling is required for Akt activation in response to ionizing radiation

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

The Src inhibitor AZD0530 blocks invasion and may act as a radiosensitizer in lung cancer cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

Docetaxel down-regulates the expression of androgen receptor and prostate-specific antigen but not prostate-specific membrane antigen in prostate cancer cell lines: implications for PSA surrogacy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

Inhibition of the androgen receptor as a novel mechanism of taxol chemotherapy in prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

Cytotoxic effects induced by docetaxel, gefitinib, and cyclopamine on side population and nonside population cell fractions from human invasive prostate cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

Phase II trial of bevacizumab, thalidomide, docetaxel, and prednisone in patients with metastatic castration-resistant prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

Combination of bevacizumab and docetaxel in docetaxel-pretreated hormone-refractory prostate cancer: a phase 2 study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

Drug penetration in solid tumours

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

The hypoxic tumour microenvironment and metastatic progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

Hypoxia--a key regulatory factor in tumour growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

Dynamics of hypoxia, proliferation and apoptosis after irradiation in a murine tumor model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

Hypoxic radiosensitization: adored and ignored

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

Androgen Withdrawal in Patients Reduces Prostate Cancer Hypoxia: Implications for Disease Progression and Radiation Response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

Expression of BNIP3 correlates with hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha and the androgen receptor in prostate cancer and is regulated directly by hypoxia but not androgens in cell lines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

Oxygen dependence of the metabolic activation and cytotoxicity of tirapazamine: implications for extravascular transport and activity in tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

Involvement of human cytochromes P450 (CYP) in the reductive metabolism of AQ4N, a hypoxia activated anthraquinone di-N-oxide prodrug

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

The relevance of a hypoxic tumour microenvironment in prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

Tumor hypoxia, DNA repair and prostate cancer progression: new targets and new therapies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

Angiogenesis in life, disease and medicine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

Angiogenesis and metastasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

How the extracellular matrix and macrophages contribute to angiogenesis-dependent diseases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

Microvessel density in prostate carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

Tumor angiogenesis correlates with progression after radical prostatectomy but not with pathologic stage in Gleason sum 5 to 7 adenocarcinoma of the prostate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

Angiogenesis as a therapeutic target

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2010.134

Conversion from a paracrine to an autocrine mechanism of androgen-stimulated growth during malignant transformation of prostatic epithelial cells

31 March 2020

1 reference

12 December 2020

Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways

1 reference

12 December 2020

Inhibition of transforming growth factor-beta activity decreases angiogenesis in a human prostate cancer-reactive stroma xenograft model

1 reference

12 December 2020

Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium

1 reference

12 December 2020

Prostate cancer cells-osteoblast interaction shifts expression of growth/survival-related genes in prostate cancer and reduces expression of osteoprotegerin in osteoblasts.

1 reference

12 December 2020

Transforming growth factor-beta 1 overproduction in prostate cancer: effects on growth in vivo and in vitro

1 reference

12 December 2020

Androgen receptor-negative human prostate cancer cells induce osteogenesis in mice through FGF9-mediated mechanisms

1 reference

12 December 2020

Elevated levels of circulating interleukin-6 and transforming growth factor-beta1 in patients with metastatic prostatic carcinoma

1 reference

12 December 2020

Fibroblast growth factor receptor 2 limits and receptor 1 accelerates tumorigenicity of prostate epithelial cells

1 reference

12 December 2020

Osteoblast-derived TGF-beta1 modulates matrix degrading protease expression and activity in prostate cancer cells

1 reference

12 December 2020

Osteoblasts modulate secretion of urokinase-type plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9) in human prostate cancer cells promoting migration and matrigel invasion.

1 reference

12 December 2020

The characterization of the receptor for endothelial cell growth factor by covalent ligand attachment.

1 reference

12 December 2020

SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro

1 reference

12 December 2020

Stromal cell heterogeneity in fibroblast growth factor-mediated stromal-epithelial cell cross-talk in premalignant prostate tumors

1 reference

12 December 2020

Localization of type 5 17beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase, and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry

1 reference

12 December 2020

Loss of responsiveness to transforming growth factor beta induces malignant transformation of nontumorigenic rat prostate epithelial cells.

1 reference

12 December 2020

Prolonged survival of rats with intracranial C6 gliomas by treatment with TGF-beta antisense gene

1 reference

12 December 2020

SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice

1 reference

12 December 2020

Mitogenic conversion of transforming growth factor-beta1 effect by oncogenic Ha-Ras-induced activation of the mitogen-activated protein kinase signaling pathway in human prostate cancer.

1 reference

12 December 2020

The distribution of secondary growths in cancer of the breast. 1889

1 reference

12 December 2020

Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling.

1 reference

12 December 2020

Activation of the hedgehog pathway in advanced prostate cancer

1 reference

12 December 2020

Androgens induce the expression of vascular endothelial growth factor in human fetal prostatic fibroblasts

1 reference

12 December 2020

Altered expression of androgen receptor in the malignant epithelium and adjacent stroma is associated with early relapse in prostate cancer

1 reference

12 December 2020

Increased expression of fibroblast growth factor 6 in human prostatic intraepithelial neoplasia and prostate cancer

1 reference

12 December 2020

Loss of expression of transforming growth factor-beta receptors is associated with poor prognosis in prostate cancer patients

1 reference

12 December 2020

Modulation of transforming growth factor beta 1 effects on prostate cancer cell proliferation by growth factors and extracellular matrix.

1 reference

12 December 2020

Reactive stroma as a predictor of biochemical-free recurrence in prostate cancer

1 reference

12 December 2020

Acceleration of human prostate cancer growth in vivo by factors produced by prostate and bone fibroblasts

1 reference

12 December 2020

Fibronectin confers survival against chemotherapeutic agents but not against radiotherapy in DU145 prostate cancer cells: involvement of the insulin like growth factor-1 receptor

1 reference

12 December 2020

Malignant transformation of human prostatic epithelium is associated with the loss of androgen receptor immunoreactivity in the surrounding stroma.

1 reference

12 December 2020

Comparative gene expression profile analysis of GLI and c-MYC in an epithelial model of malignant transformation.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRUROL.2010.134

1 reference

23 August 2017

1 reference