(Q37785995)

23 August 2017

title

Dynamics of telomeric chromatin at the crossroads of aging and cancer (English)

1 reference

23 August 2017

Jing Ye

1

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23 August 2017

Yunlin Wu

series ordinal

2

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23 August 2017

Eric Gilson

series ordinal

3

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23 August 2017

publication date

1 September 2010

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23 August 2017

published in

Essays in Biochemistry

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23 August 2017

volume

48

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23 August 2017

issue

1

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23 August 2017

page(s)

147-164

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The telomere story or the triumph of an open-minded research

23 August 2017

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Telomeres shorten during ageing of human fibroblasts

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Telomere length is paternally inherited and is associated with parental lifespan

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Telomere length predicts replicative capacity of human fibroblasts

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Telomeres and human disease: ageing, cancer and beyond

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Association between telomere length in blood and mortality in people aged 60 years or older

21 January 2018

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Telomere length and human telomerase reverse transcriptase expression as markers for progression and prognosis of colorectal carcinoma

21 January 2018

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The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

21 January 2018

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Telomeres and cardiovascular disease: does size matter?

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Rise in insulin resistance is associated with escalated telomere attrition

21 January 2018

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Leukocyte telomere dynamics: longitudinal findings among young adults in the Bogalusa Heart Study

21 January 2018

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A DNA damage checkpoint response in telomere-initiated senescence

21 January 2018

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DNA damage foci at dysfunctional telomeres

21 January 2018

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Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease

21 January 2018

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Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

21 January 2018

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Extension of life-span by introduction of telomerase into normal human cells

21 January 2018

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Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

21 January 2018

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Telomerase mutations in families with idiopathic pulmonary fibrosis

21 January 2018

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Short telomeres are a risk factor for idiopathic pulmonary fibrosis

21 January 2018

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Effects of telomerase and telomere length on epidermal stem cell behavior

21 January 2018

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Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres.

21 January 2018

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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

21 January 2018

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Inhibition of telomerase limits the growth of human cancer cells.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0480147

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0480147

Telomere reduction in human colorectal carcinoma and with ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Short telomeres in aggressive non-Hodgkin's lymphoma as a risk factor in lymphomagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Telomerase activity in human ovarian carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Clinical utility of telomerase in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Telomere position effect in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Mammalian telomeres end in a large duplex loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

G-quadruplex structures: in vivo evidence and function

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0480147

Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0480147

Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0480147

How shelterin protects mammalian telomeres

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0480147

A human telomeric protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Telomeric localization of TRF2, a novel human telobox protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Rap1 affects the length and heterogeneity of human telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

TIN2, a new regulator of telomere length in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

The telosome/shelterin complex and its functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

The CST complex and telomere maintenance: the exception becomes the rule

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

The shelterin protein TRF2 inhibits Chk2 activity at telomeres in the absence of DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

A topological mechanism for TRF2-enhanced strand invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

The Myb/SANT domain of the telomere-binding protein TRF2 alters chromatin structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

TRF2 promotes, remodels and protects telomeric Holliday junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

The effect of the TRF2 N-terminal and TRFH regions on telomeric G-quadruplex structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

TRF2 Protects Human Telomeres from End-to-End Fusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Distinct functions of POT1 at telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Pot1, the putative telomere end-binding protein in fission yeast and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Progressive cis-inhibition of telomerase upon telomere elongation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Control of human telomere length by TRF1 and TRF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

POT1 as a terminal transducer of TRF1 telomere length control

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Dynamics of protein binding to telomeres in living cells: implications for telomere structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

The POT1-TPP1 telomere complex is a telomerase processivity factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

A protein-counting mechanism for telomere length regulation in yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Homologous recombination generates T-loop-sized deletions at human telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Control of telomere length by a trimming mechanism that involves generation of t-circles

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Concordant expression of the telomerase-associated genes in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Increased expression of telomere length regulating factors TRF1, TRF2 and TIN2 in patients with adult T-cell leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Accumulation and altered localization of telomere-associated protein TRF2 in immortally transformed and tumor-derived human breast cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

TRF2 promotes multidrug resistance in gastric cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Expression of telomere-associated genes as prognostic markers for overall survival in patients with non-small cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Genetic dissection of the mechanisms underlying telomere-associated diseases: impact of the TRF2 telomeric protein on mouse epidermal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Caspase-dependent apoptosis induced by telomere cleavage and TRF2 loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

TRF2 dysfunction elicits DNA damage responses associated with senescence in proliferating neural cells and differentiation of neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Telomere protection mechanisms change during neurogenesis and neuronal maturation: newly generated neurons are hypersensitive to telomere and DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Role of TRF2 in the assembly of telomeric chromatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Nontelomeric TRF2-REST interaction modulates neuronal gene silencing and fate of tumor and stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Telomerase modulates Wnt signalling by association with target gene chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Regulation of telomerase activity in immortal cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Telomere dysfunction alters the chemotherapeutic profile of transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Tankyrase promotes telomere elongation in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Targeting telomeres and telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0480147

21 January 2018

Identifiers

DOI

10.1042/BSE0480147

1 reference

23 August 2017

1 reference