(Q37788639)

23 August 2017

title

Genetics of childhood-onset inflammatory bowel disease (English)

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inflammatory bowel diseases

23 August 2017

main subject

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4

Jack Satsangi

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23 August 2017

Paul Henderson

1

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23 August 2017

Johan E van Limbergen

series ordinal

2

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23 August 2017

David C Wilson

series ordinal

3

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23 August 2017

Richard K Russell

series ordinal

5

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23 August 2017

publication date

1 January 2011

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Inflammatory Bowel Diseases

23 August 2017

published in

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23 August 2017

volume

17

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23 August 2017

issue

1

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23 August 2017

page(s)

346-361

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The genetics of Crohn's disease

23 August 2017

cites work

1 reference

Incidence of juvenile-onset Crohn's disease in Scotland: association with northern latitude and affluence

21 January 2018

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Regulatory lymphocytes and intestinal inflammation.

21 January 2018

1 reference

Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences

21 January 2018

1 reference

Specificities of inflammatory bowel disease in childhood

21 January 2018

1 reference

Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease

21 January 2018

1 reference

Incidence, clinical presentation and location at diagnosis of pediatric inflammatory bowel disease: a prospective population-based study in northern France (1988-1999).

21 January 2018

1 reference

Changing pattern of paediatric inflammatory bowel disease in northern Stockholm 1990-2001.

21 January 2018

1 reference

Inflammatory bowel disease in children and adolescents in Sweden, 1984-1995.

21 January 2018

1 reference

Paediatric inflammatory bowel disease during a 44-year period in Copenhagen County: occurrence, course and prognosis--a population-based study from the Danish Crohn Colitis Database

21 January 2018

1 reference

Epidemiology of pediatric chronic inflammatory bowel disease in central and western Slovenia, 1994-2005.

21 January 2018

1 reference

Natural history of pediatric Crohn's disease: a population-based cohort study

21 January 2018

1 reference

Increasing incidence of both juvenile-onset Crohn's disease and ulcerative colitis in Scotland

21 January 2018

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Incidence of inflammatory bowel disease in Scottish children between 1968 and 1983; marginal fall in ulcerative colitis, three-fold rise in Crohn's disease

21 January 2018

1 reference

Epidemiologic and clinical characteristics of children with newly diagnosed inflammatory bowel disease in wisconsin: a statewide population-based study

21 January 2018

1 reference

Increasing incidence of paediatric inflammatory bowel disease in Ontario, Canada: evidence from health administrative data.

21 January 2018

1 reference

Growth retardation in early-onset inflammatory bowel disease: should we monitor and treat these patients differently?

21 January 2018

1 reference

Perceived discrimination in education and employment by people with Crohn's disease: a case control study of educational achievement and employment

21 January 2018

1 reference

Morbidity of juvenile onset inflammatory bowel disease: effects on education and employment in early adult life.

21 January 2018

1 reference

Inflammatory bowel diseases in pediatric and adolescent patients: clinical, therapeutic, and psychosocial considerations

21 January 2018

1 reference

Children with early-onset inflammatory bowel disease (IBD): analysis of a pediatric IBD consortium registry.

21 January 2018

1 reference

Common variants at five new loci associated with early-onset inflammatory bowel disease

21 January 2018

1 reference

Environmental factors affecting inflammatory bowel disease: have we made progress?

21 January 2018

1 reference

A simple classification of Crohn's disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998.

21 January 2018

1 reference

Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease

21 January 2018

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Methotrexate following unsuccessful thiopurine therapy in pediatric Crohn's disease

21 January 2018

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Induction and maintenance infliximab therapy for the treatment of moderate-to-severe Crohn's disease in children.

21 January 2018

1 reference

Phenotypic and genotypic characteristics of inflammatory bowel disease in French Canadians: comparison with a large North American repository

21 January 2018

1 reference

Early-onset Crohn disease is associated with male sex and a polymorphism in the IL-6 promoter

21 January 2018

1 reference

Gender differences in presentation and course of disease in pediatric patients with Crohn disease

21 January 2018

1 reference

Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease

21 January 2018

1 reference

Variations in initial assessment and management of inflammatory bowel disease across Great Britain and Ireland

21 January 2018

1 reference

Long-term evolution of disease behavior of Crohn's disease

21 January 2018

1 reference

The incidence of inflammatory bowel disease in the pediatric population of Southwestern Ontario

21 January 2018

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Increased number and activation of colonic macrophages in pediatric patients with untreated Crohn's disease

21 January 2018

1 reference

Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking

21 January 2018

1 reference

21 January 2018

1 reference

Familial occurrence of inflammatory bowel disease

21 January 2018

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Familial aggregation in Crohn's disease: increased age-adjusted risk and concordance in clinical characteristics.

21 January 2018

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Familial empirical risks for inflammatory bowel disease: differences between Jews and non-Jews

21 January 2018

1 reference

A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci

21 January 2018

1 reference

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

21 January 2018

1 reference

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

21 January 2018

1 reference

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

21 January 2018

1 reference

Novel susceptibility genes in inflammatory bowel disease

21 January 2018

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New links to the pathogenesis of Crohn disease provided by genome-wide association scans

21 January 2018

1 reference

Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history.

21 January 2018

1 reference

Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease

21 January 2018

1 reference

Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci

21 January 2018

1 reference

Evidence for association of OCTN genes and IBD5 with ulcerative colitis

21 January 2018

1 reference

Analysis of the influence of OCTN1/2 variants within the IBD5 locus on disease susceptibility and growth indices in early onset inflammatory bowel disease

21 January 2018

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IBD5 is associated with an extensive complicated Crohn's disease feature: implications from genotype-phenotype analysis

21 January 2018

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CARD15 genotype and phenotype analysis in 55 pediatric patients with Crohn disease from Saxony, Germany

21 January 2018

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

21 January 2018

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Established genetic risk factors do not distinguish early and later onset Crohn's disease

21 January 2018

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Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease

21 January 2018

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Crohn's disease and the NOD2 gene: a role for paneth cells

21 January 2018

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Getting to the guts of NOD2.

21 January 2018

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MEKK4 sequesters RIP2 to dictate NOD2 signal specificity

21 January 2018

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Functional characterization of two novel 5' untranslated exons reveals a complex regulation of NOD2 protein expression

21 January 2018

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Nod2 is required for the regulation of commensal microbiota in the intestine

21 January 2018

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Activation of innate immune antiviral responses by Nod2

21 January 2018

1 reference

Genetics of the innate immune response in inflammatory bowel disease

21 January 2018

1 reference

Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses.

21 January 2018

1 reference

The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases

21 January 2018

1 reference

MAST3: a novel IBD risk factor that modulates TLR4 signaling

21 January 2018

1 reference

Clustering of (auto)immune diseases with early-onset and complicated inflammatory bowel disease

21 January 2018

1 reference

Regulation and function of proinflammatory TH17 cells

21 January 2018

1 reference

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

21 January 2018

1 reference

rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants

21 January 2018

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IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease

21 January 2018

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IL23R Arg381Gln is associated with childhood onset inflammatory bowel disease in Scotland

21 January 2018

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IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease

21 January 2018

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Genetic variants in IL-23R and ATG16L1 independently predispose to increased susceptibility to Crohn's disease in a Canadian population

21 January 2018

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IL23R haplotypes provide a large population attributable risk for Crohn's disease

21 January 2018

1 reference

Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci

21 January 2018

1 reference

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease

21 January 2018

1 reference

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

21 January 2018

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Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients

21 January 2018

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Increased expression of interleukin 17 in inflammatory bowel disease

21 January 2018

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IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease

21 January 2018

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RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F.

21 January 2018

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Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells

21 January 2018

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Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

21 January 2018

1 reference

Genetic association analysis of the functional c.714T>G polymorphism and mucosal expression of dectin-1 in inflammatory bowel disease

21 January 2018

1 reference

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

21 January 2018

1 reference

IL-27 abrogates receptor activator of NF-kappa B ligand-mediated osteoclastogenesis of human granulocyte-macrophage colony-forming unit cells through STAT1-dependent inhibition of c-Fos.

21 January 2018

1 reference

Interleukin 27: a double-edged sword for offense and defense

21 January 2018

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IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms

21 January 2018

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IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells

21 January 2018

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Regulation of immune responses by interleukin-27.

21 January 2018

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IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitis

21 January 2018

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Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

21 January 2018

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Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells

21 January 2018

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Regulation of the class II and class I MHC pathways in human THP-1 monocytic cells by interleukin-27.

21 January 2018

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Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis

21 January 2018

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Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

21 January 2018

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NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

21 January 2018

1 reference

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

21 January 2018

1 reference

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

21 January 2018

1 reference

ATG16L1andIL23RAre Associated With Inflammatory Bowel Diseases but Not With Celiac Disease in The Netherlands

21 January 2018

1 reference

Autophagy 16-like 1 rs2241880 G allele is associated with Crohn's disease in German children.

21 January 2018

1 reference

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

21 January 2018

1 reference

ATG16L1 T300A Shows Strong Associations With Disease Subgroups in a Large Australian IBD Population: Further Support for Significant Disease Heterogeneity

21 January 2018

1 reference

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

21 January 2018

1 reference

Parkinson disease, LRRK2 and the endocytic-autophagic pathway

21 January 2018

1 reference

Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach.

21 January 2018

1 reference

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

21 January 2018

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Germline variants of IRGM in childhood-onset Crohn's disease

21 January 2018

1 reference

Molecular reactions of protein phosphatases--insights from structure and chemistry

21 January 2018

1 reference

Myotubularin phosphatases: policing 3-phosphoinositides

21 January 2018

1 reference

FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphate

21 January 2018

1 reference

Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors

21 January 2018

1 reference

Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy

21 January 2018

1 reference

The relevance of the phosphatidylinositolphosphat-binding motif FRRGT of Atg18 and Atg21 for the Cvt pathway and autophagy

21 January 2018

1 reference

Unveiling the roles of autophagy in innate and adaptive immunity

21 January 2018

1 reference

Identification and characterization of a new gene from human chromosome 21 between markers D21S343 and D21S268 encoding a leucine-rich protein

21 January 2018

1 reference

Down syndrome critical region gene 2: expression during mouse development and in human cell lines indicates a function related to cell proliferation

21 January 2018

1 reference

A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes

21 January 2018

1 reference

The proteasome: a central regulator of inflammation and macrophage function

21 January 2018

1 reference

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

21 January 2018

1 reference

Comparative expression analysis and characterization of 20S proteasomes in human intestinal tissues: The proteasome pattern as diagnostic tool for IBD patients.

21 January 2018

1 reference

Bacteria-free solution derived from Lactobacillus plantarum inhibits multiple NF-kappaB pathways and inhibits proteasome function

21 January 2018

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Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs

21 January 2018

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Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk

21 January 2018

1 reference

Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis

21 January 2018

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Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-alpha production in mice

21 January 2018

1 reference

Association study of TNFSF15 polymorphisms in Japanese patients with inflammatory bowel disease

21 January 2018

1 reference

Role of TL1A and its receptor DR3 in two models of chronic murine ileitis

21 January 2018

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TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease

21 January 2018

1 reference

Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer

21 January 2018

1 reference

TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator

21 January 2018

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Modulation of T-cell responses to alloantigens by TR6/DcR3

21 January 2018

1 reference

Functional characterisation of decoy receptor 3 in Crohn's disease

21 January 2018

1 reference

DcR3 as a diagnostic parameter and risk factor for systemic lupus erythematosus

21 January 2018

1 reference

Drug insight: different mechanisms of action of tumor necrosis factor antagonists-passive-aggressive behavior?

21 January 2018

1 reference

Defective mucosal T cell death is sustainably reverted by infliximab in a caspase dependent pathway in Crohn's disease

21 January 2018

1 reference

Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease.

21 January 2018

1 reference

hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci

21 January 2018

1 reference

The Drosophila trithorax group gene tonalli (tna) interacts genetically with the Brahma remodeling complex and encodes an SP-RING finger protein

21 January 2018

1 reference

The novel PIAS-like protein hZimp10 is a transcriptional co-activator of the p53 tumor suppressor

21 January 2018

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The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development

21 January 2018

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The novel PIAS-like protein hZimp10 enhances Smad transcriptional activity.

21 January 2018

1 reference

TGF-β signalling from cell membrane to nucleus through SMAD proteins

21 January 2018

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Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

21 January 2018

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Smad3 knockout mice exhibit impaired intestinal mucosal healing

21 January 2018

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Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression.

21 January 2018

1 reference

Induction of peripheral CD4+ T-cell tolerance and CD8+ T-cell cross-tolerance by dendritic cells

21 January 2018

1 reference

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

21 January 2018

1 reference

Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome

21 January 2018

1 reference

The endoplasmic reticulum stress response in immunity and autoimmunity

21 January 2018

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From endoplasmic-reticulum stress to the inflammatory response

21 January 2018

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Endoplasmic reticulum stress and intestinal inflammation

21 January 2018

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An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

21 January 2018

1 reference

Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: impact on chronic inflammation

21 January 2018

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Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response

21 January 2018

1 reference

Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis

21 January 2018

1 reference

ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins

21 January 2018

1 reference

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

21 January 2018

1 reference

The calpain family and human disease

21 January 2018

1 reference

Genome-wide association studies provide new insights into type 2 diabetes aetiology

21 January 2018

1 reference

Calpain 10 gene polymorphisms are related, not to type 2 diabetes, but to increased serum cholesterol in Japanese

21 January 2018

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Calcium, protease action, and the regulation of the cell cycle

21 January 2018

1 reference

Calpain and caspase: can you tell the difference?

21 January 2018

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Targeting of the molecular chaperone oxygen-regulated protein 150 (ORP150) to mitochondria and its induction by cellular stress

21 January 2018

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Alteration of the unfolded protein response modifies neurodegeneration in a mouse model of Marinesco-Sjögren syndrome

21 January 2018

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Induction of apoptosis by cigarette smoke via ROS-dependent endoplasmic reticulum stress and CCAAT/enhancer-binding protein-homologous protein (CHOP).

21 January 2018

1 reference

What makes a good genetic association study?

21 January 2018

1 reference

Analysis of CARD15 Gene Variants in Italian Pediatric Patients with Inflammatory Bowel Diseases

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/IBD.21283

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23 August 2017

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