(Q37811888)

23 August 2017

The role of AIRE in human autoimmune disease (English)

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23 August 2017

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2

Nancy H Ruddle

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23 August 2017

3

Kevan C Herold

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23 August 2017

Eitan M Akirav

1

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23 August 2017

23 November 2010

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Nature Reviews Endocrinology

23 August 2017

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23 August 2017

7

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23 August 2017

1

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23 August 2017

25-33

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https://scigraph.springernature.com/pub.10.1038/nrendo.2010.200

23 August 2017

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cites work

Ltbetar signaling does not regulate Aire-dependent transcripts in medullary thymic epithelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Thymoma in patients with MG: characteristics and long-term outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Crossroads of extrathymic lymphocytes maturation pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Absence of Thymus in a Mouse Mutant

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Complete rescue of the nude mutant phenotype by a wild-type Foxn1 transgene.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Positive selection of thymocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Antigen presentation in the thymus for positive selection and central tolerance induction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Lymphotoxin pathway directs thymic Aire expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Projection of an immunological self shadow within the thymus by the aire protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Aire's partners in the molecular control of immunological tolerance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Transcriptional impact of Aire varies with cell type

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse

31 March 2020

2 references

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

31 March 2020

12 December 2020

Expression of AIRE gene in peripheral monocyte/dendritic cell lineage

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Deletional tolerance mediated by extrathymic Aire-expressing cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Human peripheral lymphoid tissues contain autoimmune regulator-expressing dendritic cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Animal models of autoimmune polyglandular syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Increased antigen presenting cell-mediated T cell activation in mice and patients without the autoimmune regulator

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Regulating self-tolerance by deregulating gene expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Chromosomal clustering of genes controlled by the aire transcription factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Modifier loci condition autoimmunity provoked by Aire deficiency

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Thymus-specific deletion of insulin induces autoimmune diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

A new model of insulin-deficient diabetes: male NOD mice with a single copy of Ins1 and no Ins2.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Mutations in the AIRE gene: effects on subcellular location and transactivation function of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Autoimmune polyendocrine syndrome type 1 in Norway: phenotypic variation, autoantibodies, and novel mutations in the autoimmune regulator gene.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Immunodeficiency mutation databases (IDbases).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Autoimmune polyendocrinopathy--candidosis--ectodermal dystrophy (APECED): autosomal recessive inheritance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Polyglandular autoimmune syndrome type I among Iranian Jews

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

An autosomal locus causing autoimmune disease: autoimmune polyglandular disease type I assigned to chromosome 21

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

High-resolution physical and transcriptional mapping of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy locus on chromosome 21q22.3 by FISH

31 March 2020

2 references

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

31 March 2020

12 December 2020

Localization of 16 exons to a 450-kb region involved in the autoimmune polyglandular disease type I (APECED) on human chromosome 21q22.3.

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Positional cloning of the APECED gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Autoimmune regulator AIRE: evidence for genetic differences between autoimmune hepatitis and hepatitis as part of the autoimmune polyglandular syndrome type 1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED): a model disease to study molecular aspects of endocrine autoimmunity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

A common and recurrent 13-bp deletion in the autoimmune regulator gene in British kindreds with autoimmune polyendocrinopathy type 1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Mutation analyses of North American APS-1 patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Evaluation of the autoimmune regulator (AIRE) gene mutations in a cohort of Italian patients with autoimmune-polyendocrinopathy-candidiasis-ectodermal-dystrophy (APECED) and in their relatives

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Novel AIRE mutations and P450 cytochrome autoantibodies in Central and Eastern European patients with APECED

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

APECED mutations in the autoimmune regulator (AIRE) gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Clinical manifestations and management of patients with autoimmune polyendocrine syndrome type I.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Detection of a complete autoimmune regulator gene deletion and two additional novel mutations in a cohort of patients with atypical phenotypic variants of autoimmune polyglandular syndrome type 1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome: time to review diagnostic criteria?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

STUDIES OF THE ADRENAL ANTIGENS AND ANTIBODIES IN ADDISON'S DISEASE.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

A POSSIBLE AUTOIMMUNE BASIS FOR ADDISON'S DISEASE IN THREE SIBLINGS, ONE WITH IDIOPATHIC HYPOPARATHYROIDISM, PERNICIOUS ANEMIA AND SUPERFICIAL MONILIASIS

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Addison's disease and diabetes mellitus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type 1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Interferon autoantibodies associated with AIRE deficiency decrease the expression of IFN-stimulated genes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Th17 and regulatory T cells in mediating and restraining inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Oral and oesophageal squamous cell carcinoma – A complication or component of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED, APS-I)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Severe malabsorption in autoimmune polyendocrinopathy-candidosis-ectodermal dystrophy syndrome successfully treated with immunosuppression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

T-cell large granular lymphocytic leukemia and pure red cell aplasia in a patient with type I autoimmune polyendocrinopathy: response to immunosuppressive therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome with renal failure: impact of posttransplant immunosuppression on disease activity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Deficiency of the autoimmune regulator AIRE in thymomas is insufficient to elicit autoimmune polyendocrinopathy syndrome type 1 (APS-1)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Gene defect behind APECED: a new clue to autoimmunity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

CD4+CD25+ T-regulatory cells are decreased in patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

A defect of regulatory T cells in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Aire regulates negative selection of organ-specific T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Differentiation of regulatory Foxp3+ T cells in the thymic cortex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Cytochrome P450IA2 and aromatic L-amino acid decarboxylase are hepatic autoantigens in autoimmune polyendocrine syndrome type I

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Prevalence and clinical associations of 10 defined autoantibodies in autoimmune polyendocrine syndrome type I.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Identification of tryptophan hydroxylase as an intestinal autoantigen

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17 alpha-hydroxylase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Aire-deficient C57BL/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2010.200

Antibodies to glutamic acid decarboxylase and insulin-dependent diabetes in patients with autoimmune polyendocrine syndrome type I.

31 March 2020

1 reference

12 December 2020

Genetic homogeneity of autoimmune polyglandular disease type I.

1 reference

12 December 2020

Severe autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy in an adolescent girl with a novel AIRE mutation: response to immunosuppressive therapy

1 reference

12 December 2020

A novel mutation of the autoimmune regulator gene in an Italian kindred with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, acting in a dominant fashion and strongly cosegregating with hypothyroid autoimmune thyroiditis.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRENDO.2010.200

1 reference

23 August 2017

1 reference

PubMed ID

21102544