(Q37829702)

24 August 2017

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title

Structure and function of histone H3 lysine 9 methyltransferases and demethylases (English)

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24 August 2017

Swathi Krishnan

1

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24 August 2017

Scott Horowitz

series ordinal

2

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24 August 2017

Raymond C Trievel

series ordinal

3

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24 August 2017

publication date

5 January 2011

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24 August 2017

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24 August 2017

volume

12

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24 August 2017

issue

2

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24 August 2017

page(s)

254-263

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Nucleosome and chromatin fiber dynamics

24 August 2017

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Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor

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Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression

21 January 2018

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Regulation of chromatin structure by site-specific histone H3 methyltransferases

21 January 2018

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JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor

21 January 2018

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The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

21 January 2018

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Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells

21 January 2018

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The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.

21 January 2018

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Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases

21 January 2018

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Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

21 January 2018

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PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase

21 January 2018

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Unsafe SETs: histone lysine methyltransferases and cancer

21 January 2018

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The Universal Protein Resource (UniProt) in 2010

21 January 2018

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Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

Role of histone methyltransferase G9a in CpG methylation of the Prader-Willi syndrome imprinting center

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas.

21 January 2018

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5-Aza-2'-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation

21 January 2018

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G9a and Glp methylate lysine 373 in the tumor suppressor p53

21 January 2018

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Histone-modifying enzymes: encrypting an enigmatic epigenetic code

21 January 2018

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A knot or not a knot? SETting the record 'straight' on proteins.

21 January 2018

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Mechanism of multiple lysine methylation by the SET domain enzyme Rubisco LSMT

21 January 2018

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Structure and catalytic mechanism of the human histone methyltransferase SET7/9

21 January 2018

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Structural basis for the product specificity of histone lysine methyltransferases

21 January 2018

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Regulation of p53 activity through lysine methylation

21 January 2018

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Structural basis for the methylation site specificity of SET7/9

21 January 2018

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Regulation of Estrogen Receptor α by the SET7 Lysine Methyltransferase

21 January 2018

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Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase

21 January 2018

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21 January 2018

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Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks

21 January 2018

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Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases

21 January 2018

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Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

21 January 2018

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Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a

21 January 2018

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Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines

21 January 2018

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Protein methyltransferases as a target class for drug discovery

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

Analysis of the substrate specificity of the Dim-5 histone lysine methyltransferase using peptide arrays

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

Protein lysine methyltransferase G9a acts on non-histone targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Sequence specificity and role of proximal amino acids of the histone H3 tail on catalysis of murine G9A lysine 9 histone H3 methyltransferase.

21 January 2018

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Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

Structural origins for the product specificity of SET domain protein methyltransferases

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

Catalytic roles for carbon-oxygen hydrogen bonding in SET domain lysine methyltransferases

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

SET7/9 Catalytic Mutants Reveal the Role of Active Site Water Molecules in Lysine Multiple Methylation

21 January 2018

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Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis.

21 January 2018

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Functional analysis of the N- and C-terminus of mammalian G9a histone H3 methyltransferase

21 January 2018

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Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9.

21 January 2018

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Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase

21 January 2018

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Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds

21 January 2018

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Roles of the EZH2 histone methyltransferase in cancer epigenetics

21 January 2018

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The polycomb group protein EZH2 is involved in progression of prostate cancer

21 January 2018

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SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells

21 January 2018

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Enhanced SMYD3 expression is essential for the growth of breast cancer cells

21 January 2018

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JmjC-domain-containing proteins and histone demethylation

21 January 2018

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A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation

21 January 2018

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KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development

21 January 2018

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PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression

21 January 2018

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Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development

21 January 2018

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A novel mutation in the PHF8 gene is associated with X-linked mental retardation with cleft lip/cleft palate

21 January 2018

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Screening of mutations in the PHF8 gene and identification of a novel mutation in a Finnish family with XLMR and cleft lip/cleft palate

21 January 2018

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Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

The X-linked mental retardation gene PHF8 is a histone demethylase involved in neuronal differentiation

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

PHF8 targets histone methylation and RNA polymerase II to activate transcription.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

Structural insights into a novel histone demethylase PHF8

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase

21 January 2018

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Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans

21 January 2018

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Structural insights into histone demethylation by JMJD2 family members.

21 January 2018

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Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

Structural basis of the recognition of a methylated histone tail by JMJD2A

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules

21 January 2018

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Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000545

Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201000545

Structural Insights of the Specificity and Catalysis of a Viral Histone H3 Lysine 27 Methyltransferase

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/CBIC.201000545

1 reference

24 August 2017

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