(Q37843987)

24 August 2017

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title

From conventional to unusual enzyme inhibitor scaffolds: the quest for target specificity (English)

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24 August 2017

1

Eric Meggers

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language of work or name

English

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publication date

15 February 2011

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Angewandte Chemie International Edition

24 August 2017

published in

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volume

50

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24 August 2017

issue

11

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24 August 2017

page(s)

2442-2448

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Chemical genetics resulting from a passion for synthetic organic chemistry.

24 August 2017

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The art of the chemical probe

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A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

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A quantitative analysis of kinase inhibitor selectivity

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On the potential of natural products in the discovery of pharma leads: a case for reassessment

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Natural products as chemical probes

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Targeting proteins with metal complexes

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Supramolecular interactions between functional metal complexes and proteins.

21 January 2018

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Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones

21 January 2018

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(Arene)Ru(II) complexes of epidermal growth factor receptor inhibiting tyrphostins with enhanced selectivity and cytotoxicity in cancer cells

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Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes

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From nonpeptide toward noncarbon protease inhibitors: metallacarboranes as specific and potent inhibitors of HIV protease

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Inorganic polyhedral metallacarborane inhibitors of HIV protease: a new approach to overcoming antiviral resistance

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Design of HIV protease inhibitors based on inorganic polyhedral metallacarboranes

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Functionalized Fullerenes in Water. The First 10 Years of Their Chemistry, Biology, and Nanoscience

21 January 2018

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Structural requirements for inhibitors of cytochromes P450 2B: assessment of the enzyme interaction with diamondoids

21 January 2018

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Optimizing the binding of fullerene inhibitors of the HIV-1 protease through predicted increases in hydrophobic desolvation

21 January 2018

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Molecular dynamics study of the connection between flap closing and binding of fullerene-based inhibitors of the HIV-1 protease

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Identification of polyoxometalates as nanomolar noncompetitive inhibitors of protein kinase CK2.

21 January 2018

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New protein kinase CK2 inhibitors: jumping out of the catalytic box.

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A mixed-valent ruthenium-oxo oxalato cluster Na7[Ru4(mu3-O)4(C2O4)6] with potent anti-HIV activities

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Enzyme-like catalysis by molecularly imprinted polymers

21 January 2018

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Molecularly imprinted microgels as enzyme inhibitors.

21 January 2018

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Mechanistic basis of enzyme-targeted drugs

21 January 2018

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Covalent modifiers: an orthogonal approach to drug design

21 January 2018

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Structural bioinformatics-based design of selective, irreversible kinase inhibitors

21 January 2018

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Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles

21 January 2018

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Targeted covalent drugs of the kinase family

21 January 2018

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Cysteine proteases as targets for metal-based drugs

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ANIE.201005673

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24 August 2017

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