(Q37851144)

24 August 2017

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title

Bioanalytical LC-MS of therapeutic oligonucleotides (English)

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24 August 2017

2

Wilfried M A Niessen

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24 August 2017

William D van Dongen

1

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24 August 2017

publication date

1 March 2011

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24 August 2017

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24 August 2017

volume

3

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24 August 2017

issue

5

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24 August 2017

page(s)

541-564

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Destroying RNA as a therapeutic approach

24 August 2017

cites work

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RNA interference and potential applications

21 January 2018

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Short interfering RNA (siRNA) as a novel therapeutic

21 January 2018

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RNA Interference with chemically modified siRNA.

21 January 2018

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Origins and Mechanisms of miRNAs and siRNAs

21 January 2018

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The promises and pitfalls of RNA-interference-based therapeutics

21 January 2018

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Unlocking the potential of the human genome with RNA interference

21 January 2018

1 reference

Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy.

21 January 2018

1 reference

Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo.

21 January 2018

1 reference

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

21 January 2018

1 reference

Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone

21 January 2018

1 reference

Inhibition of respiratory viruses by nasally administered siRNA.

21 January 2018

1 reference

Inhibition of HPV 16 E6 oncogene expression by RNA interference in vitro and in vivo

21 January 2018

1 reference

Antisense therapy in oncology: new hope for an old idea?

21 January 2018

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Bioanalysis of siRNA and oligonucleotide therapeutics in biological fluids and tissues

21 January 2018

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Tissue disposition of 2'-O-(2-methoxy) ethyl modified antisense oligonucleotides in monkeys

21 January 2018

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Phase I study of oblimersen sodium, an antisense to Bcl-2, in untreated older patients with acute myeloid leukemia: pharmacokinetics, pharmacodynamics, and clinical activity.

21 January 2018

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Bioavailability and efficacy of antisense morpholino oligomers targeted to c-myc and cytochrome P-450 3A2 following oral administration in rats

21 January 2018

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A competitive enzyme hybridization assay for plasma determination of phosphodiester and phosphorothioate antisense oligonucleotides

21 January 2018

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Critical topics in ensuring data quality in bioanalytical LC-MS method development

21 January 2018

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Analysis of native and chemically modified oligonucleotides by tandem ion-pair reversed-phase high-performance liquid chromatography/electrospray ionization mass spectrometry

21 January 2018

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Quantification of raf antisense oligonucleotide (rafAON) in biological matrices by LC-MS/MS to support pharmacokinetics of a liposome-entrapped rafAON formulation

21 January 2018

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Mass spectrometry of nucleic acids

21 January 2018

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Large-scale purification of synthetic oligonucleotides and carcinogen-modified oligodeoxynucleotides on a reverse-phase polystyrene (PRP-1) column

21 January 2018

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Analysis of Oligonucleotides by HPLC-Electrospray Ionization Mass Spectrometry

21 January 2018

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Analysis of polymerase chain reaction products by on-line liquid chromatography-mass spectrometry for genotyping of polymorphic short tandem repeat loci

21 January 2018

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Application of LC-MS for quantitative analysis and metabolite identification of therapeutic oligonucleotides

21 January 2018

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Characterization and quantification of Bcl-2 antisense G3139 and metabolites in plasma and urine by ion-pair reversed phase HPLC coupled with electrospray ion-trap mass spectrometry

21 January 2018

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Strategies for bioanalysis of an oligonucleotide class macromolecule from rat plasma using liquid chromatography-tandem mass spectrometry

21 January 2018

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Characterization of some physical and chromatographic properties of monolithic poly(styrene-co-divinylbenzene) columns

21 January 2018

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Analysis of biological and synthetic ribonucleic acids by liquid chromatography-mass spectrometry using monolithic capillary columns

21 January 2018

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Characterization of noncovalent complexes formed between minor groove binding molecules and duplex DNA by electrospray ionization-mass spectrometry

21 January 2018

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Studying noncovalent protein complexes by electrospray ionization mass spectrometry

21 January 2018

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Activation energies for dissociation of double strand oligonucleotide anions: evidence for watson-crick base pairing in vacuo

21 January 2018

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Comparison between solution-phase stability and gas-phase kinetic stability of oligodeoxynucleotide duplexes.

21 January 2018

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RNA-RNA noncovalent interactions investigated by microspray ionization mass spectrometry

21 January 2018

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Electrospray ionization mass spectrometry of oligonucleotide complexes with drugs, metals, and proteins.

21 January 2018

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Solution composition and thermal denaturation for the production of single-stranded PCR amplicons: piperidine-induced destabilization of the DNA duplex?

21 January 2018

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Ion-pair reversed-phase high-performance liquid chromatography analysis of oligonucleotides: retention prediction.

21 January 2018

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Analysis of nucleic acids by on-line liquid chromatography-mass spectrometry

21 January 2018

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Mass spectrometry and enzyme-linked immunosorbent assay methods for the quantitation of liposomal antisense oligonucleotide (LE-rafAON) in human plasma

21 January 2018

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Metabolite identification of small interfering RNA duplex by high-resolution accurate mass spectrometry

21 January 2018

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Utility of organic bases for improved electrospray mass spectrometry of oligonucleotides

21 January 2018

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Enhanced mass detection of oligonucleotides using reverse-phase high-performance liquid chromatography/electrospray ionization ion-trap mass spectrometry

21 January 2018

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Effect of instrument tuning on the detectabilityof biopolymers in electrospray ionization mass spectrometry

21 January 2018

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High-throughput biopolymer desalting by solid-phase extraction prior to mass spectrometric analysis

21 January 2018

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Verification of 50- to 100-mer DNA and RNA sequences with high-resolution mass spectrometry

21 January 2018

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Interpretation of oligonucleotide mass spectra for determination of sequence using electrospray ionization and tandem mass spectrometry.

21 January 2018

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Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS.

21 January 2018

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Development of an ion-pair reverse-phase liquid chromatographic/tandem mass spectrometry method for the determination of an 18-mer phosphorothioate oligonucleotide in mouse liver tissue

21 January 2018

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Chemistry at the 2' position of constituent nucleotides controls degradation pathways of highly modified oligonucleotide molecules.

21 January 2018

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Metabolism of GTI-2040, a phosphorothioate oligonucleotide antisense, using ion-pair reversed phase high performance liquid chromatography (HPLC) coupled with electrospray ion-trap mass spectrometry

21 January 2018

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On-line HPLC electrospray mass spectrometry of phosphorothioate oligonucleotide metabolites

21 January 2018

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Biodistribution and metabolism of immunostimulatory oligodeoxynucleotide CPG 7909 in mouse and rat tissues following subcutaneous administration

21 January 2018

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Observation of a small oligonucleotide duplex by electrospray ionization mass spectrometry

21 January 2018

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Charge-state reduction with improved signal intensity of oligonucleotides in electrospray ionization mass spectrometry

21 January 2018

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Charge State Reduction of Oligonucleotide Negative Ions from Electrospray Ionization

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/BIO.11.8

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24 August 2017

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