(Q37859007)

24 August 2017

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title

From definition to implementation: a cross-industry perspective of past, current and future MIST strategies (English)

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24 August 2017

Angus N R Nedderman

1

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24 August 2017

Gordon J Dear

2

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24 August 2017

Stephanie North

3

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24 August 2017

R Scott Obach

4

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24 August 2017

David Higton

5

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24 August 2017

language of work or name

English

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publication date

29 March 2011

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24 August 2017

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24 August 2017

41

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24 August 2017

8

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24 August 2017

605-622

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Predicting circulating human metabolites: how good are we?

24 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Drug metabolites in safety testing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Hepatocyte-like cells derived from human embryonic stem cells specifically via definitive endoderm and a progenitor stage

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

HPLC-accelerator MS measurement of atrazine metabolites in human urine after dermal exposure.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

NMR spectroscopy as a tool to close the gap on metabolite characterization under MIST.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Increasing throughput and information content for in vitro drug metabolism experiments using ultra-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Thermospray liquid chromatography/mass spectrometry determination of drugs and their metabolites in biological fluids

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

MetaSite: understanding metabolism in human cytochromes from the perspective of the chemist

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Evaluation of preparative high performance liquid chromatography and cryoprobe-nuclear magnetic resonance spectroscopy for the early quantitative estimation of drug metabolites in human plasma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Metabolism of capecitabine, an oral fluorouracil prodrug: (19)F NMR studies in animal models and human urine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Nuclear magnetic resonance spectroscopy as a quantitative tool to determine the concentrations of biologically produced metabolites: implications in metabolites in safety testing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Development of an online p38α mitogen-activated protein kinase binding assay and integration of LC-HR-MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

A simple liquid chromatography-tandem mass spectrometry method to determine relative plasma exposures of drug metabolites across species for metabolite safety assessments

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Evaluation of accelerator mass spectrometry in a human mass balance and pharmacokinetic study-experience with 14C-labeled (R)-6-[amino(4- chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1- methyl-2(1H)-quinolinone (R115777), a far

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Update information on human P450s

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Metabolism and disposition of fluticasone furoate, an enhanced-affinity glucocorticoid, in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

N-O glucuronidation: a major human metabolic pathway in the elimination of two novel anti-convulsant drug candidates

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Human embryonic stem cell technologies and drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Investigating the human metabolism of acetaminophen using UPLC and exact mass oa-TOF MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Best practices in a tiered approach to metabolite quantification: views and recommendations of the European Bioanalysis Forum.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

The use of accelerator mass spectrometry to obtain early human ADME/PK data

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

The use of isotopes in the determination of absolute bioavailability of drugs in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Addressing metabolite safety during first-in-man studies using ¹⁴C-labeled drug and accelerator mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Biomedical accelerator mass spectrometry: recent applications in metabolism and pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

LC/MS applications in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

A comparison of quantitative NMR and radiolabelling studies of the metabolism and excretion of Statil (3-(4-bromo-2-fluorobenzyl)-4-oxo-3H-phthalazin-1-ylacetic acid) in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

An interface for direct analysis of (14)c in nonvolatile samples by accelerator mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Determination of exposure multiples of human metabolites for MIST assessment in preclinical safety species without using reference standards or radiolabeled compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Fluorine nuclear magnetic resonance spectroscopy of human biofluids in the field of metabolic studies of anticancer and antifungal fluoropyrimidine drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Validation of quantitative NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

On-line liquid chromatography-accurate radioisotope counting coupled with a radioactivity detector and mass spectrometer for metabolite identification in drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Safety assessment of drug metabolites: implications of regulatory guidance and potential application of genetically engineered mouse models that express human P450s.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Novel MS solutions inspired by MIST.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Metabolites in safety testing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

What is the objective of the mass balance study? A retrospective analysis of data in animal and human excretion studies employing radiolabeled drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Metabolites in safety testing (MIST): considerations of mechanisms of toxicity with dose, abundance, and duration of treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Quantifying the metabolic activation of nevirapine in patients by integrated applications of NMR and mass spectrometries

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Predicting drug metabolism--an evaluation of the expert system METEOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Obtaining exposures of metabolites in preclinical species through plasma pooling and quantitative NMR: addressing metabolites in safety testing (MIST) guidance without using radiolabeled compounds and chemically synthesized metabolite standards.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

A holistic strategy for characterizing the safety of metabolites through drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Assessment of a micropatterned hepatocyte coculture system to generate major human excretory and circulating drug metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Determination of boldenone sulfoconjugate and related steroid sulfates in equine urine by high-performance liquid chromatography/tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Metabolite quantitation: detector technology and MIST implications

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Identification of novel metabolites of colchicine in rat bile facilitated by enhanced online radiometric detection

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

In vivo modeling of human liver for pharmacological study using humanized mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Comparison of a 250 kV single-stage accelerator mass spectrometer with a 5 MV tandem accelerator mass spectrometer--fitness for purpose in bioanalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Challenges and solutions to metabolites in safety testing: impact of the International Conference on Harmonization M3(R2) guidance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

A software filter to remove interference ions from drug metabolites in accurate mass liquid chromatography/mass spectrometric analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Quantification and rapid metabolite identification in drug discovery using API time-of-flight LC/MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Integrated strategies for assessment of metabolite exposure in humans during drug development: analytical challenges and clinical development considerations.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

A retention-time-shift-tolerant background subtraction and noise reduction algorithm (BgS-NoRA) for extraction of drug metabolites in liquid chromatography/mass spectrometry data from biological matrices

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

An accurate-mass-based spectral-averaging isotope-pattern-filtering algorithm for extraction of drug metabolites possessing a distinct isotope pattern from LC-MS data

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

General implementation of the ERETIC method for pulsed field gradient probe heads.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Direct coupling of chromatographic separations to NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

NMR and HPLC-NMR spectroscopic studies of futile deacetylation in paracetamol metabolites in rat and man

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

Investigation of the human metabolism of antipyrine using coupled liquid chromatography and nuclear magnetic resonance spectroscopy of urine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.562330

10.3109/00498254.2011.562330

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference