(Q37872786)

24 August 2017

1 reference

title

Profound changes in drug metabolism enzymes and possible effects on drug therapy in neonates and children (English)

1 reference

24 August 2017

Saskia N de Wildt

1

0 references

language of work or name

English

0 references

publication date

8 May 2011

1 reference

Expert Opinion on Drug Metabolism & Toxicology

24 August 2017

published in

1 reference

24 August 2017

volume

7

1 reference

24 August 2017

issue

8

1 reference

24 August 2017

page(s)

935-948

1 reference

Differences in absorption, distribution, metabolism and excretion of xenobiotics between the paediatric and adult populations

24 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Developmental pharmacology--drug disposition, action, and therapy in infants and children

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Identification of human UGT2B7 as the major isoform involved in the O-glucuronidation of chloramphenicol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

The ontogeny of drug metabolism enzymes and implications for adverse drug events

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Challenges for drug studies in children: CYP3A phenotyping as example

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Genetic polymorphism and toxicology--with emphasis on cytochrome p450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Determination of urinary metabolites of caffeine for the assessment of cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activity in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Metabolism of theophylline by cDNA-expressed human cytochromes P-450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Loss of response to melatonin treatment is associated with slow melatonin metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Delayed ontogenesis of CYP1A2 in the human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Biotransformation of caffeine in human liver microsomes from foetuses, neonates, infants and adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Caffeine citrate treatment for extremely premature infants with apnea: population pharmacokinetics, absolute bioavailability, and implications for therapeutic drug monitoring

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

The pharmacokinetics of caffeine in Nigerian children suffering from malaria and kwashiorkor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Reduced activities of cytochrome P450 1A2 and xanthine oxidase in children with growth hormone deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Six-month, prospective, longitudinal, open-label caffeine and dextromethorphan phenotyping study in children with growth hormone deficiency receiving recombinant human growth hormone replacement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Activities of cytochrome P450 1A2, N-acetyltransferase 2, xanthine oxidase, and cytochrome P450 2D6 are unaltered in children with cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Role of CYP2B6 in stereoselective human methadone metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Human hepatic CYP2B6 developmental expression: the impact of age and genotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

OPRM1 and CYP2B6 Gene Variants as Risk Factors in Methadone-Related Deaths

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Pharmacokinetics and pharmacodynamics of efavirenz and nelfinavir in HIV-infected children participating in an area-under-the-curve controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Comparison of enzyme kinetic parameters obtained in vitro for reactions mediated by human CYP2C enzymes including major CYP2C9 variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Effect of omeprazole treatment on diazepam plasma levels in slow versus normal rapid metabolizers of omeprazole.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Developmental expression of human hepatic CYP2C9 and CYP2C19.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Ontogenesis of CYP2C-dependent arachidonic acid metabolism in the human liver: relationship with sudden infant death syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Population pharmacokinetic analysis of Ibuprofen enantiomers in preterm newborn infants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Are cytochrome P450 CYP2C8 and CYP2C9 polymorphisms associated with ibuprofen response in very preterm infants?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Regioselective and stereoselective metabolism of ibuprofen by human cytochrome P450 2C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Developmental changes in pharmacokinetics and pharmacodynamics of warfarin enantiomers in Japanese children.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Oral anticoagulation with warfarin is significantly influenced by steroids and CYP2C9 polymorphisms in children with cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Pharmacokinetics of proton pump inhibitors in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Population pharmacokinetics of intravenous pantoprazole in paediatric intensive care patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Impact of the CYP2C19*17 allele on the pharmacokinetics of omeprazole and pantoprazole in children: evidence for a differential effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Single-dose, multiple-dose, and population pharmacokinetics of pantoprazole in neonates and preterm infants with a clinical diagnosis of gastroesophageal reflux disease (GERD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Understanding the relative roles of pharmacogenetics and ontogeny in pediatric drug development and regulatory science.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Identification of human cytochrome p450 isozymes involved in diphenhydramine N-demethylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Impact of environmental and genetic factors on codeine analgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Developmental changes in human liver CYP2D6 expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Ontogeny of dextromethorphan O- and N-demethylation in the first year of life

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Development of CYP2D6 and CYP3A4 in the first year of life

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Developmental pharmacology of tramadol during infancy: ontogeny, pharmacogenetics and elimination clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

The trial of infant response to diphenhydramine: the TIRED study--a randomized, controlled, patient-oriented trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Population pharmacokinetics and dose simulation of carvedilol in paediatric patients with congestive heart failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Codeine intoxication associated with ultrarapid CYP2D6 metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

The effect of CYP2D6 polymorphisms on the response to pain treatment for pediatric sickle cell pain crisis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Pharmacogenetics of codeine metabolism in an urban population of children and its implications for analgesic reliability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Codeine, ultrarapid-metabolism genotype, and postoperative death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Fatal hydrocodone overdose in a child: pharmacogenetics and drug interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Genetic variability in CYP3A5 and its possible consequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Expression of CYP3A in the human liver--evidence that the shift between CYP3A7 and CYP3A4 occurs immediately after birth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Variability of CYP3A7 expression in human fetal liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

CYP3A7 protein expression is high in a fraction of adult human livers and partially associated with the CYP3A7*1C allele

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Developmental expression of the major human hepatic CYP3A enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

CYP3A probes can quantitatively predict the in vivo kinetics of other CYP3A substrates and can accurately assess CYP3A induction and inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

13C-erythromycin breath test as a noninvasive measure of CYP3A activity in newborn infants: a pilot study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Pharmacokinetics and metabolism of intravenous midazolam in preterm infants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

The single-dose pharmacokinetics of midazolam and its primary metabolite in pediatric patients after oral and intravenous administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

The pharmacokinetics of midazolam in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

A maturation model for midazolam clearance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Placebo-controlled trial of midazolam sedation in mechanically ventilated newborn babies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Pharmacodynamics of midazolam in pediatric intensive care patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Clinical experience with continuous intravenous sedation using midazolam and fentanyl in the paediatric intensive care unit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Age is of influence on midazolam requirements in a paediatric intensive care unit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Population pharmacokinetics and metabolism of midazolam in pediatric intensive care patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Pharmacokinetics of midazolam in children: comparative study of intranasal and intravenous administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

The pharmacokinetics of midazolam in paediatric patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Incorporation of the genetic control of alcohol dehydrogenase into a physiologically based pharmacokinetic model for ethanol in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Developmental changes and polymorphism in human alcohol dehydrogenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Temporal expression of the human alcohol dehydrogenase gene family during liver development correlates with differential promoter activation by hepatocyte nuclear factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Genetic polymorphisms of human flavin-containing monooxygenase 3: implications for drug metabolism and clinical perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin-containing monooxygenase family of man, FMO1, FMO3 and FM04

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

In vitro hepatic metabolism explains higher clearance of voriconazole in children versus adults: role of CYP2C19 and flavin-containing monooxygenase 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Glucuronidation in humans. Pharmacogenetic and developmental aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

In vivo glucuronidation activity of drugs in neonates: extensive interindividual variability despite their young age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Epirubicin glucuronidation and UGT2B7 developmental expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Developmental aspects of human hepatic drug glucuronidation in young children and adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Pediatric development of glucuronidation: the ontogeny of hepatic UGT1A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Pharmacokinetics of irinotecan and its metabolites in pediatric cancer patients: a report from the children's oncology group

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Prolonged neutropenia after irinotecan-based chemotherapy in a child with polymorphisms of UGT1A1 and SLCO1B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Morphine glucuronidation in preterm neonates, infants and children younger than 3 years

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Morphine pharmacokinetics and pharmacodynamics in preterm and term neonates: secondary results from the NEOPAIN trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Postoperative pain in the neonate: age-related differences in morphine requirements and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Enterocytic CYP3A4 in a paediatric population: developmental changes and the effect of coeliac disease and cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Localization and mRNA expression of CYP3A and P-glycoprotein in human duodenum as a function of age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Pharmacokinetics and metabolism of oral midazolam in preterm infants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Renal-tubule metabolism of ifosfamide to the nephrotoxic chloroacetaldehyde: pharmacokinetic modeling for estimation of intracellular levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Renal ontogeny of ifosfamide nephrotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Cytochrome P450 3A and 2B6 in the developing kidney: implications for ifosfamide nephrotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Tailor-made drug treatment for children: creation of an infrastructure for data-sharing and population PK-PD modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Mechanistic basis of using body size and maturation to predict clearance in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Developmental aspects of theophylline metabolism in premature infants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Optimization of immunosuppressive drug monitoring in children.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

Evaluation of drug formularies for pediatric intensive care

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.577739

10.1517/17425255.2011.577739

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference