(Q37880113)

24 August 2017

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title

Antioxidant and anti-proliferative properties of lycopene (English)

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24 August 2017

4

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24 August 2017

Mareike Kelkel

1

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24 August 2017

Marc Schumacher

series ordinal

2

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24 August 2017

Mario Dicato

series ordinal

3

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24 August 2017

publication date

26 May 2011

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24 August 2017

published in

Free Radical Research

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24 August 2017

volume

45

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24 August 2017

issue

8

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24 August 2017

page(s)

925-940

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A carotenogenic gene cluster from Brevibacterium linens with novel lycopene cyclase genes involved in the synthesis of aromatic carotenoids

24 August 2017

cites work

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Carotenoid content and in vitro bioaccessibility of lycopene from guava (Psidium guajava) and watermelon (Citrullus lanatus) by high-performance liquid chromatography diode array detection

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Carotenoids: actual knowledge on food sources, intakes, stability and bioavailability and their protective role in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Role of antioxidant lycopene in cancer and heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Absorption and transport of carotenoids

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Lycopene as the most efficient biological carotenoid singlet oxygen quencher

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Hypocholesterolemic effect of lycopene and beta-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Combinatorial antigenotoxic and anticarcinogenic effects of tomato and garlic through modulation of xenobiotic-metabolizing enzymes during hamster buccal pouch carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Lycopene: a review of its potential as an anticancer agent

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Chemopreventive efficacy of lycopene on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Intake of carotenoids and retinol in relation to risk of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Lycopene: a biologically important carotenoid for humans?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Long-term use of beta-carotene, retinol, lycopene, and lutein supplements and lung cancer risk: results from the VITamins And Lifestyle (VITAL) study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Comparative mechanisms and rates of free radical scavenging by carotenoid antioxidants.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Antioxidant and prooxidant properties of carotenoids

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Reactions of OOH radical with beta-carotene, lycopene, and torulene: hydrogen atom transfer and adduct formation mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Effect of lycopene and beta-carotene on peroxynitrite-mediated cellular modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Lycopene Content of Tomato Products: Its Stability, Bioavailability and In Vivo Antioxidant Properties

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Prolycopene, a Naturally Occuring Stereoisomer of Lycopene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Tomatoes versus lycopene in oxidative stress and carcinogenesis: conclusions from clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Antigenotoxicity and antimutagenicity of lycopene in HepG2 cell line evaluated by the comet assay and micronucleus test

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Lycopene activity against chemically induced DNA damage in Chinese hamster ovary cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Antimutagenic effects of lycopene and tomato purée

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

A dose-response study on the effects of purified lycopene supplementation on biomarkers of oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Absorption and subcellular localization of lycopene in human prostate cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Multitargeted therapy of cancer by lycopene

21 January 2018

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https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Chemoprotection against cancer by induction of phase 2 enzymes

21 January 2018

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https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Can dietary beta-carotene materially reduce human cancer rates?

21 January 2018

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https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Enzymatic metabolites of lycopene induce Nrf2-mediated expression of phase II detoxifying/antioxidant enzymes in human bronchial epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Nrf2/HO-1 signaling pathway may be the prime target for chemoprevention of cisplatin-induced nephrotoxicity by lycopene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Structure activity relationship of carotenoid derivatives in activation of the electrophile/antioxidant response element transcription system.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with promyelocytic leukemia nuclear bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Are the health attributes of lycopene related to its antioxidant function?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

beta-Carotene: an unusual type of lipid antioxidant

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Divergent optimum levels of lycopene, beta-carotene and lutein protecting against UVB irradiation in human fibroblastst

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Lycopene and beta-carotene protect against oxidative damage in HT29 cells at low concentrations but rapidly lose this capacity at higher doses.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Serum carotenoids and oxidative DNA damage in human lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Overview of mechanisms of action of lycopene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Effects of lycopene and tomato paste extracts on DNA and lipid oxidation in LNCaP human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Bisdemethylcurcumin and structurally related hispolon analogues of curcumin exhibit enhanced prooxidant, anti-proliferative and anti-inflammatory activities in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Prooxidant activity of curcumin: copper-dependent formation of 8-hydroxy-2'-deoxyguanosine in DNA and induction of apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Lycopene affects proliferation and apoptosis of four malignant cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Carotenoids induce apoptosis in the T-lymphoblast cell line Jurkat E6.1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27(Kip1) in the cyclin E-cdk2 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Lycopene inhibition of IGF-induced cancer cell growth depends on the level of cyclin D1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Lycopene inhibits matrix metalloproteinase-9 expression and down-regulates the binding activity of nuclear factor-kappa B and stimulatory protein-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Altered detoxification status and increased resistance to oxidative stress by K-ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Activation of antioxidant pathways in ras-mediated oncogenic transformation of human surface ovarian epithelial cells revealed by functional proteomics and mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Insulin-like growth factor-1 downregulates nuclear factor kappa B activation and upregulates interleukin-8 gene expression induced by tumor necrosis factor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Using DNA Microarray to Identify Sp1 as a Transcriptional Regulatory Element of Insulin-Like Growth Factor 1 in Cardiac Muscle Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Expression of nm23-H1 gene product in sarcomatous cancer cells of renal cell carcinoma: correlation with tumor stage and expression of matrix metalloproteinase-2, matrix metalloproteinase-9, sialyl Lewis X, and c-erbB-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Connexins, connexons, and intercellular communication

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Intercellular communication and carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Role of connexin genes in growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: relationship to their cancer chemopreventive action

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Stimulation of gap junctional communication: comparison of acyclo-retinoic acid and lycopene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Expression profiling by whole-genome microarray hybridization reveals differential gene expression in breast cancer cell lines after lycopene exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Gene signature of breast cancer cell lines treated with lycopene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

A prospective study of tomato products, lycopene, and prostate cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Chemoprevention of prostate cancer with lycopene in the TRAMP model

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Combinations of tomato and broccoli enhance antitumor activity in dunning r3327-h prostate adenocarcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Altered expression of anti and proapoptotic proteins during chemoprevention of hamster buccal pouch carcinogenesis by tomato and garlic combination

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Combination chemoprevention of experimental gastric carcinogenesis by s-allylcysteine and lycopene: modulatory effects on glutathione redox cycle antioxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Combination of S-allylcysteine and lycopene induces apoptosis by modulating Bcl-2, Bax, Bim and caspases during experimental gastric carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Lycopene and soy isoflavones in the treatment of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Melatonin antagonizes the intrinsic pathway of apoptosis via mitochondrial targeting of Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Melatonin: a pleiotropic molecule regulating inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: a review of the evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Melatonin is a scavenger of peroxynitrite

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Free Radical-Mediated Molecular Damage

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

The orphan receptor family RZR/ROR, melatonin and 5-lipoxygenase: an unexpected relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Chemopreventive effect of lycopene alone or with melatonin against the genesis of oxidative stress and mammary tumors induced by 7,12 dimethyl(a)benzanthracene in sprague dawely female rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Interaction of tomato lycopene and ketosamine against rat prostate tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Identification, expression, and substrate specificity of a mammalian beta-carotene 15,15'-dioxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Biochemical properties of purified recombinant human beta-carotene 15,15'-monooxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Lycopene biodistribution is altered in 15,15'-carotenoid monooxygenase knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Lycopenoids: are lycopene metabolites bioactive?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Loss of carotene-9',10'-monooxygenase expression increases serum and tissue lycopene concentrations in lycopene-fed mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

The biochemical characterization of ferret carotene-9',10'-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Acyclic carotenoids and their oxidation mixtures inhibit the growth of HL-60 human promyelocytic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

A novel cleavage product formed by autoxidation of lycopene induces apoptosis in HL-60 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Effects of acyclo-retinoic acid and lycopene on activation of the retinoic acid receptor and proliferation of mammary cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Lycopene oxidation product enhances gap junctional communication

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Apo-10'-lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Formation of cleavage products by autoxidation of lycopene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Identification and quantification of apo-lycopenals in fruits, vegetables, and human plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Lycopene epoxides and apo-lycopenals formed by chemical reactions and autoxidation in model systems and processed foods

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Enzymatic and oxidative metabolites of lycopene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Identification, quantification, and relative concentrations of carotenoids and their metabolites in human milk and serum.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Separation and identification of carotenoids and their oxidation products in the extracts of human plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

Carotenoid mixtures protect multilamellar liposomes against oxidative damage: synergistic effects of lycopene and lutein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2011.564168

10.3109/10715762.2011.564168

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference