(Q37900938)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21755605%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

review article

1 reference

title

Lipid-sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21755605%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21755605%20AND%20SRC:MED&resulttype=core&format=json

Renato Mariani-Costantini

7 February 2020

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21755605%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Giuseppe Palasciano

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21755605%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Antonio Moschetta

5

1 reference

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7 February 2020

author name string

Chiara Degirolamo

2

1 reference

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7 February 2020

publication date

16 February 2011

1 reference

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Wiley interdisciplinary reviews. Systems biology and medicine

7 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21755605%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

volume

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21755605%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

issue

5

1 reference

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7 February 2020

page(s)

562-587

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21755605%20AND%20SRC:MED&resulttype=core&format=json

Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)

7 February 2020

cites work

1 reference

21 January 2018

The metabolic syndrome

1 reference

Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation

21 January 2018

1 reference

Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement

21 January 2018

1 reference

The metabolic syndrome--a new worldwide definition

21 January 2018

1 reference

Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation

21 January 2018

1 reference

The nuclear receptor superfamily: the second decade

21 January 2018

1 reference

Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network

21 January 2018

1 reference

Nuclear receptors and lipid physiology: opening the X-files

21 January 2018

1 reference

The RXR heterodimers and orphan receptors

21 January 2018

1 reference

Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation

21 January 2018

1 reference

Minireview: nuclear receptor coactivators--an update

21 January 2018

1 reference

A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex

21 January 2018

1 reference

The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors.

21 January 2018

1 reference

Fat and beyond: the diverse biology of PPARgamma

21 January 2018

1 reference

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

21 January 2018

1 reference

PPAR-gamma: adipogenic regulator and thiazolidinedione receptor

21 January 2018

1 reference

15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma

21 January 2018

1 reference

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

21 January 2018

1 reference

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

21 January 2018

1 reference

Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor

21 January 2018

1 reference

PPARs: diverse regulators in energy metabolism and metabolic diseases

21 January 2018

1 reference

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

21 January 2018

1 reference

Novel peroxisome proliferator activated receptor-alpha agonists

21 January 2018

1 reference

Nuclear receptors as drug targets in metabolic diseases: new approaches to therapy

21 January 2018

1 reference

Peroxisome proliferator-activated receptor-alpha (PPARalpha): at the crossroads of obesity, diabetes and cardiovascular disease

21 January 2018

1 reference

Mechanism of action of fibrates on lipid and lipoprotein metabolism

21 January 2018

1 reference

The effect of PPAR-alpha agonism on apolipoprotein metabolism in humans

21 January 2018

1 reference

Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells

21 January 2018

1 reference

Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus

21 January 2018

1 reference

Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner

21 January 2018

1 reference

Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators

21 January 2018

1 reference

Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis

21 January 2018

1 reference

A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders

21 January 2018

1 reference

Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice

21 January 2018

1 reference

Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9.

21 January 2018

1 reference

Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor.

21 January 2018

1 reference

Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators

21 January 2018

1 reference

Regulation of triglyceride metabolism by PPARs: fibrates and thiazolidinediones have distinct effects

21 January 2018

1 reference

Fibrates in 2003: therapeutic action in atherogenic dyslipidaemia and future perspectives

21 January 2018

1 reference

Alterations of lipids and apolipoprotein CIII in very low density lipoprotein subspecies in type 2 diabetes

21 January 2018

1 reference

Fenofibrate for cardiovascular disease prevention in metabolic syndrome and type 2 diabetes mellitus

21 January 2018

1 reference

Regulation of human apoA-I by gemfibrozil and fenofibrate through selective peroxisome proliferator-activated receptor alpha modulation

21 January 2018

1 reference

Effects of atorvastatin versus fenofibrate on apoB-100 and apoA-I kinetics in mixed hyperlipidemia.

21 January 2018

1 reference

Bezafibrate for the secondary prevention of myocardial infarction in patients with metabolic syndrome

21 January 2018

1 reference

Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease

21 January 2018

1 reference

Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial

21 January 2018

1 reference

Relation of gemfibrozil treatment and lipid levels with major coronary events: VA-HIT: a randomized controlled trial

21 January 2018

1 reference

Effects of a potent and selective PPAR-alpha agonist in patients with atherogenic dyslipidemia or hypercholesterolemia: two randomized controlled trials

21 January 2018

1 reference

Potent and selective PPAR-alpha agonist LY518674 upregulates both ApoA-I production and catabolism in human subjects with the metabolic syndrome

21 January 2018

1 reference

Identification of a physiologically relevant endogenous ligand for PPARalpha in liver

21 January 2018

1 reference

After the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study: implications for fenofibrate

21 January 2018

1 reference

PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators

21 January 2018

1 reference

Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting

21 January 2018

1 reference

PPARalpha governs glycerol metabolism

21 January 2018

1 reference

Mechanism of action of the nongenotoxic peroxisome proliferators: role of the peroxisome proliferator-activator receptor alpha.

21 January 2018

1 reference

Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids

21 January 2018

1 reference

Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

21 January 2018

1 reference

Peroxisome proliferator-activated receptor beta/delta as a therapeutic target for metabolic diseases

21 January 2018

1 reference

PPAR delta: a dagger in the heart of the metabolic syndrome

21 January 2018

1 reference

Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation

21 January 2018

1 reference

Molecular recognition of fatty acids by peroxisome proliferator-activated receptors

21 January 2018

1 reference

Regulatory functions of PPARbeta in metabolism: implications for the treatment of metabolic syndrome

21 January 2018

1 reference

Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects

21 January 2018

1 reference

Evidence that peroxisome proliferator-activated receptor delta influences cholesterol metabolism in men.

21 January 2018

1 reference

Features of the metabolic syndrome are modulated by an interaction between the peroxisome proliferator-activated receptor-delta -87T>C polymorphism and dietary fat in French-Canadians.

21 January 2018

1 reference

Genetic polymorphisms in peroxisome proliferator-activated receptor delta associated with obesity

21 January 2018

1 reference

Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

21 January 2018

1 reference

PPAR delta agonists and metabolic diseases

21 January 2018

1 reference

A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport

21 January 2018

1 reference

Regulation of muscle fiber type and running endurance by PPARdelta

21 January 2018

1 reference

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

21 January 2018

1 reference

AMPK and PPARdelta agonists are exercise mimetics

21 January 2018

1 reference

PPARdelta-mediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis

21 January 2018

1 reference

Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome

21 January 2018

1 reference

Activation of PPARdelta alters lipid metabolism in db/db mice.

21 January 2018

1 reference

Effects of peroxisome proliferator-activated receptor alpha/delta agonists on HDL-cholesterol in vervet monkeys

21 January 2018

1 reference

The nuclear receptors peroxisome proliferator-activated receptor alpha and Rev-erbalpha mediate the species-specific regulation of apolipoprotein A-I expression by fibrates

21 January 2018

1 reference

Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men.

21 January 2018

1 reference

Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist.

21 January 2018

1 reference

PPAR-β/δ agonists for Type 2 diabetes and dyslipidemia: an adopted orphan still looking for a home

21 January 2018

1 reference

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer

21 January 2018

1 reference

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

21 January 2018

1 reference

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation

21 January 2018

1 reference

Transcriptional control of adipocyte formation

21 January 2018

1 reference

Adipocyte differentiation from the inside out

21 January 2018

1 reference

PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance

21 January 2018

1 reference

PPAR gamma is required for placental, cardiac, and adipose tissue development

21 January 2018

1 reference

Non-DNA binding, dominant-negative, human PPARgamma mutations cause lipodystrophic insulin resistance

21 January 2018

1 reference

PPAR gamma and human metabolic disease

21 January 2018

1 reference

Functional implications of genetic variation in human PPARgamma

21 January 2018

1 reference

New PPARG mutation leads to lipodystrophy and loss of protein function that is partially restored by a synthetic ligand

21 January 2018

1 reference

A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy

21 January 2018

1 reference

The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes

21 January 2018

1 reference

Retinoid x receptor heterodimers in the metabolic syndrome

21 January 2018

1 reference

Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones

21 January 2018

1 reference

Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle

21 January 2018

1 reference

Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance

21 January 2018

1 reference

PPAR-gamma agonists and their role in type 2 diabetes mellitus management

21 January 2018

1 reference

Cidea is associated with lipid droplets and insulin sensitivity in humans

21 January 2018

1 reference

Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27.

21 January 2018

1 reference

The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation

21 January 2018

1 reference

PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene

21 January 2018

1 reference

Fat poetry: a kingdom for PPAR gamma

21 January 2018

1 reference

Oral antihyperglycemic therapy for type 2 diabetes mellitus.

21 January 2018

1 reference

PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein

21 January 2018

1 reference

Insulin sensitivity: modulation by nutrients and inflammation

21 January 2018

1 reference

Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation

21 January 2018

1 reference

Role of peroxisome proliferator-activated receptor gamma in glucose-induced insulin secretion

21 January 2018

1 reference

Identification and characterization of peroxisome proliferator response element in the mouse GLUT2 promoter

21 January 2018

1 reference

Identification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter

21 January 2018

1 reference

Inflammation and metabolic disorders

21 January 2018

1 reference

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

21 January 2018

1 reference

Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation

21 January 2018

1 reference

Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase

21 January 2018

1 reference

Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance

21 January 2018

1 reference

Peroxisome proliferator-activated receptor gamma activation promotes infiltration of alternatively activated macrophages into adipose tissue.

21 January 2018

1 reference

Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

21 January 2018

1 reference

Macrophage peroxisome proliferator activated receptor gamma as a therapeutic target to combat Type 2 diabetes

21 January 2018

1 reference

Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone

21 January 2018

1 reference

Muscle-specific Pparg deletion causes insulin resistance

21 January 2018

1 reference

Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

21 January 2018

1 reference

Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice

21 January 2018

1 reference

Cell-specific determinants of peroxisome proliferator-activated receptor gamma function in adipocytes and macrophages

21 January 2018

1 reference

PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization

21 January 2018

1 reference

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.

21 January 2018

1 reference

Peroxisome proliferator-activated receptor-gamma calls for activation in moderation: lessons from genetics and pharmacology

21 January 2018

1 reference

Molecular characterization of new selective peroxisome proliferator-activated receptor gamma modulators with angiotensin receptor blocking activity

21 January 2018

1 reference

PPAR modulators and PPAR pan agonists for metabolic diseases: the next generation of drugs targeting peroxisome proliferator-activated receptors?

21 January 2018

1 reference

The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression.

21 January 2018

1 reference

A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily

21 January 2018

1 reference

LXR, a nuclear receptor that defines a distinct retinoid response pathway

21 January 2018

1 reference

An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

21 January 2018

1 reference

Liver X Receptor Signaling Pathways in Cardiovascular Disease

21 January 2018

1 reference

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

21 January 2018

1 reference

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

21 January 2018

1 reference

Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta.

21 January 2018

1 reference

Separate and overlapping metabolic functions of LXRalpha and LXRbeta in C57Bl/6 female mice

21 January 2018

1 reference

Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR.

21 January 2018

1 reference

A transcriptional co-repressor that interacts with nuclear hormone receptors

21 January 2018

1 reference

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

21 January 2018

1 reference

Liver X receptors as integrators of metabolic and inflammatory signaling

21 January 2018

1 reference

Assessing the effects of LXR agonists on cellular cholesterol handling: a stable isotope tracer study

21 January 2018

1 reference

Autoregulation of the human liver X receptor alpha promoter

21 January 2018

1 reference

Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages

21 January 2018

1 reference

Identification of macrophage liver X receptors as inhibitors of atherosclerosis

21 January 2018

1 reference

Accumulation of foam cells in liver X receptor-deficient mice

21 January 2018

1 reference

Atherosclerosis. the road ahead

21 January 2018

1 reference

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

21 January 2018

1 reference

ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR.

21 January 2018

1 reference

The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver

21 January 2018

1 reference

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

21 January 2018

1 reference

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

21 January 2018

1 reference

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

21 January 2018

1 reference

Efflux and atherosclerosis: the clinical and biochemical impact of variations in the ABCA1 gene

21 January 2018

1 reference

The liver X receptor ligand T0901317 down-regulates APOA5 gene expression through activation of SREBP-1c

21 January 2018

1 reference

Apolipoprotein E and atherosclerosis

21 January 2018

1 reference

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

21 January 2018

1 reference

Liver X receptor agonists inhibit tissue factor expression in macrophages

21 January 2018

1 reference

Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages

21 January 2018

1 reference

Liver x receptor agonists inhibit cytokine-induced osteopontin expression in macrophages through interference with activator protein-1 signaling pathways

21 January 2018

1 reference

Niemann-Pick C1 like 1 gene expression is down-regulated by LXR activators in the intestine

21 January 2018

1 reference

Antiatherosclerotic effects of a novel synthetic tissue-selective steroidal liver X receptor agonist in low-density lipoprotein receptor-deficient mice

21 January 2018

1 reference

Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo

21 January 2018

1 reference

Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters

21 January 2018

1 reference

Genetic basis of sitosterolemia

21 January 2018

1 reference

Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption

21 January 2018

1 reference

Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.

21 January 2018

1 reference

Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface

21 January 2018

1 reference

Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion

21 January 2018

1 reference

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

21 January 2018

1 reference

LXRs regulate the balance between fat storage and oxidation.

21 January 2018

1 reference

The enzymes, regulation, and genetics of bile acid synthesis

21 January 2018

1 reference

Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).

21 January 2018

1 reference

The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.

21 January 2018

1 reference

LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor

21 January 2018

1 reference

Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.

21 January 2018

1 reference

Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue

21 January 2018

1 reference

Research resource: nuclear hormone receptor expression in the endocrine pancreas

21 January 2018

1 reference

LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function

21 January 2018

1 reference

SREBPs: transcriptional mediators of lipid homeostasis

21 January 2018

1 reference

An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing

21 January 2018

1 reference

Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors

21 January 2018

1 reference

The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR

21 January 2018

1 reference

The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse

21 January 2018

1 reference

Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element

21 January 2018

1 reference

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

21 January 2018

1 reference

Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia

21 January 2018

1 reference

Identification of a nuclear receptor that is activated by farnesol metabolites

21 January 2018

1 reference

Identification of a nuclear receptor for bile acids

21 January 2018

1 reference

Bile acids: natural ligands for an orphan nuclear receptor

21 January 2018

1 reference

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

21 January 2018

1 reference

Cholesterol gallstone disease.

21 January 2018

1 reference

Prevention of cholesterol gallstone disease by FXR agonists in a mouse model.

21 January 2018

1 reference

Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol

21 January 2018

1 reference

Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters

21 January 2018

1 reference

Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation

21 January 2018

1 reference

Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element

21 January 2018

1 reference

Ligand-dependent coactivation of the human bile acid receptor FXR by the peroxisome proliferator-activated receptor gamma coactivator-1alpha.

21 January 2018

1 reference

The methyl transferase PRMT1 functions as co-activator of farnesoid X receptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes

21 January 2018

1 reference

Identification of DRIP205 as a coactivator for the Farnesoid X receptor.

21 January 2018

1 reference

Methylation at arginine 17 of histone H3 is linked to gene activation

21 January 2018

1 reference

Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1

21 January 2018

1 reference

Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR

21 January 2018

1 reference

Identification of a chemical tool for the orphan nuclear receptor FXR.

21 January 2018

1 reference

The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors

21 January 2018

1 reference

A natural product that lowers cholesterol as an antagonist ligand for FXR.

21 January 2018

1 reference

A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR

21 January 2018

1 reference

6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.

21 January 2018

1 reference

Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid

21 January 2018

1 reference

Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity

21 January 2018

1 reference

Identification of gene-selective modulators of the bile acid receptor FXR.

21 January 2018

1 reference

Farnesoid X Receptor Activates Transcription of the Phospholipid Pump MDR3

21 January 2018

1 reference

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

21 January 2018

1 reference

Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis

21 January 2018

1 reference

FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine

21 January 2018

1 reference

The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp

21 January 2018

1 reference

FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption

21 January 2018

1 reference

Farnesoid X Receptor Regulates Bile Acid-Amino Acid Conjugation

21 January 2018

1 reference

Regulation of the mouse organic solute transporter alpha-beta, Ostalpha-Ostbeta, by bile acids

21 January 2018

1 reference

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

21 January 2018

1 reference

Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4

21 January 2018

1 reference

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

21 January 2018

1 reference

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

21 January 2018

1 reference

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

21 January 2018

1 reference

The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity

21 January 2018

1 reference

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

21 January 2018

1 reference

The farnesoid X-receptor is an essential regulator of cholesterol homeostasis

21 January 2018

1 reference

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

21 January 2018

1 reference

The effects of cholestyramine on high density lipoprotein metabolism

21 January 2018

1 reference

Chenodeoxycholic acid therapy for hypertriglyceridaemia in men.

21 January 2018

1 reference

Bile acids enhance low density lipoprotein receptor gene expression via a MAPK cascade-mediated stabilization of mRNA.

21 January 2018

1 reference

The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice

21 January 2018

1 reference

Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

21 January 2018

1 reference

Chenodiol (chenodeoxycholic acid) for dissolution of gallstones: the National Cooperative Gallstone Study. A controlled trial of efficacy and safety

21 January 2018

1 reference

Serum Lipids in Cholelithiasis: Effect of Chenodeoxycholic Acid Therapy

21 January 2018

1 reference

Bile acids decrease hepatic paraoxonase 1 expression and plasma high-density lipoprotein levels via FXR-mediated signaling of FGFR4.

21 January 2018

1 reference

A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids

21 January 2018

1 reference

Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters

21 January 2018

1 reference

Bile acid reduces the secretion of very low density lipoprotein by repressing microsomal triglyceride transfer protein gene expression mediated by hepatocyte nuclear factor-4.

21 January 2018

1 reference

Farnesoid X receptor is essential for normal glucose homeostasis

21 January 2018

1 reference

FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice

21 January 2018

1 reference

Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor

21 January 2018

1 reference

Regulation of pyruvate dehydrogenase kinase expression by the farnesoid X receptor

21 January 2018

1 reference

Bile acid sequestrants and the treatment of type 2 diabetes mellitus

21 January 2018

1 reference

The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition.

21 January 2018

1 reference

Glucose regulates the expression of the farnesoid X receptor in liver

21 January 2018

1 reference

Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1.

21 January 2018

1 reference

Regulation of carbohydrate metabolism by the farnesoid X receptor

21 January 2018

1 reference

Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle

21 January 2018

1 reference

Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP

21 January 2018

1 reference

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

21 January 2018

1 reference

Transgenic Mice Expressing Human Fibroblast Growth Factor-19 Display Increased Metabolic Rate and Decreased Adiposity

21 January 2018

1 reference

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

21 January 2018

1 reference

Intestinal ecology in the metabolic syndrome.

21 January 2018

1 reference

Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5

21 January 2018

1 reference

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

21 January 2018

1 reference

FXR-mediated regulation of eNOS expression in vascular endothelial cells

21 January 2018

1 reference

Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration

21 January 2018

1 reference

Downregulation of endothelin-1 by farnesoid X receptor in vascular endothelial cells

21 January 2018

1 reference

Expression and activation of the farnesoid X receptor in the vasculature

21 January 2018

1 reference

Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice

21 January 2018

1 reference

Effects of FXR in foam-cell formation and atherosclerosis development

21 January 2018

1 reference

PGC1α expression is controlled in skeletal muscles by PPARβ, whose ablation results in fiber-type switching, obesity, and type 2 diabetes

21 January 2018

1 reference