(Q37912165)

30 June 2019

review article

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title

Xenobiotic metabolomics: major impact on the metabolome (English)

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30 June 2019

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3

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30 June 2019

author name string

Frank J Gonzalez

series ordinal

4

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30 June 2019

language of work or name

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3 August 2011

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30 June 2019

Annual Review of Pharmacology and Toxicology

published in

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30 June 2019

volume

52

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30 June 2019

page(s)

37-56

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30 June 2019

Fenofibrate-induced rhabdomyolysis in two dialysis patients with hypothyroidism

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The human colonic microflora influences the alterations of xenobiotic-metabolizing enzymes by catechins in male F344 rats

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Use of liquid chromatography/time-of-flight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids

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Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis

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Urinary metabolite profiling reveals CYP1A2-mediated metabolism of NSC686288 (aminoflavone).

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A metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine in the mouse

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The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A.

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The metabolomics of (+/-)-arecoline 1-oxide in the mouse and its formation by human flavin-containing monooxygenases

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12 December 2020

Effect of fenofibrate on oxidative DNA damage and on gene expression related to cell proliferation and apoptosis in rats

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12 December 2020

A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach

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12 December 2020

Safety considerations with fibrate therapy

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A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model

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12 December 2020

Role of pregnane X receptor in control of all-trans retinoic acid (ATRA) metabolism and its potential contribution to ATRA resistance.

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12 December 2020

Medicinal importance of grapefruit juice and its interaction with various drugs

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12 December 2020

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12 December 2020

Acute renal failure secondary to fenofibrate monotherapy-induced rhabdomyolysis

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12 December 2020

PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators

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12 December 2020

Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice

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12 December 2020

Metabolomics: a global biochemical approach to drug response and disease

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12 December 2020

A metabolomic perspective of melatonin metabolism in the mouse

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Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model

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N-Acetylcysteine prevents ifosfamide-induced nephrotoxicity in rats

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Antibiotic-induced perturbations of the intestinal microbiota alter host susceptibility to enteric infection

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Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment

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A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4

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Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS).

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Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation

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12 December 2020

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

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12 December 2020

Fenofibrate metabolism in the cynomolgus monkey using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry-based metabolomics.

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12 December 2020

Top-down systems biology modeling of host metabotype-microbiome associations in obese rodents

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12 December 2020

Multivariate modeling strategy for intercompartmental analysis of tissue and plasma 1H NMR spectrotypes

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12 December 2020

New metabolites of fenofibrate in Sprague-Dawley rats by UPLC-ESI-QTOF-MS-based metabolomics coupled with LC-MS/MS

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12 December 2020

Differential hepatic effects of perfluorobutyrate mediated by mouse and human PPAR-alpha.

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12 December 2020

The role of gut microbiota in drug response.

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12 December 2020

Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity

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12 December 2020

Human urinary metabolomic profile of PPARalpha induced fatty acid beta-oxidation.

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12 December 2020

Radiation metabolomics. 2. Dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice

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12 December 2020

Radiation metabolomics. 3. Biomarker discovery in the urine of gamma-irradiated rats using a simplified metabolomics protocol of gas chromatography-mass spectrometry combined with random forests machine learning algorithm.

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12 December 2020

Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism

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12 December 2020

The metabolism and disposition of 14C-fenofibrate in human volunteers

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12 December 2020

Intestinal microbiota regulate xenobiotic metabolism in the liver

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12 December 2020

NMR-based metabonomics analysis of mouse urine and fecal extracts following oral treatment with the broad-spectrum antibiotic enrofloxacin (Baytril).

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12 December 2020

The role of mass spectrometry-based metabolomics in medical countermeasures against radiation

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12 December 2020

Obesity and the human microbiome

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12 December 2020

A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation

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12 December 2020

Use of pharmaco-metabonomics for early prediction of acetaminophen-induced hepatotoxicity in humans

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12 December 2020

The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice

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12 December 2020

The influence of pomegranate by-product and punicalagins on selected groups of human intestinal microbiota

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12 December 2020

Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics.

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12 December 2020

The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models

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12 December 2020

Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation

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12 December 2020

Spectroscopic and statistical techniques for information recovery in metabonomics and metabolomics

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12 December 2020

Induction of epigenetic alterations by dietary and other environmental factors

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12 December 2020

Metabolomics identifies novel Hnf1alpha-dependent physiological pathways in vivo

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12 December 2020

Pregnane X receptor-mediated induction of Cyp3a by black cohosh

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12 December 2020

Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics

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12 December 2020

Pharmacometabonomics as an effector for personalized medicine.

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12 December 2020

Interactions between gut microbiota and host metabolism predisposing to obesity and diabetes

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12 December 2020

The effect of grapefruit juice on drug disposition

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12 December 2020

Effect of antibiotic treatment on the intestinal metabolome

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12 December 2020

A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics

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12 December 2020

Radiation metabolomics. 4. UPLC-ESI-QTOFMS-Based metabolomics for urinary biomarker discovery in gamma-irradiated rats

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12 December 2020

Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1).

1 reference

12 December 2020

Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus

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12 December 2020

The metabolism and disposition of fenofibrate in rat, guinea pig, and dog

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12 December 2020

Comparative toxicity and safety profile of fenofibrate and other fibric acid derivatives

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12 December 2020

Evidence that isoniazid and ethanol induce the same microsomal cytochrome P-450 in rat liver, an isozyme homologous to rabbit liver cytochrome P-450 isozyme 3a

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12 December 2020

Decreased Concentration of Phenacetin in Plasma of Cigarette Smokers

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12 December 2020

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

1 reference

12 December 2020

Inactivation of Digoxin by the Gut Flora: Reversal by Antibiotic Therapy

1 reference

12 December 2020

Fenofibrate: Metabolism and Species Differences for Peroxisome Proliferation in Cultured Hepatocytes

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12 December 2020

Systematic functional analysis of the yeast genome

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12 December 2020

10.1146/ANNUREV-PHARMTOX-010611-134748

Identifiers

DOI

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30 June 2019

PMC publication ID

6300990

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30 June 2019

PubMed publication ID

21819238

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30 June 2019