(Q37935680)

English

How ubiquitination regulates the TGF-β signalling pathway: new insights and new players: new isoforms of ubiquitin-activating enzymes in the E1-E3 families join the game

scientific article published on October 2011

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scholarly article

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Europe PubMed Central

PubMed publication ID

25 August 2017

1 reference

Europe PubMed Central

How ubiquitination regulates the TGF-β signalling pathway: new insights and new players: new isoforms of ubiquitin-activating enzymes in the E1-E3 families join the game (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

protein ubiquitination

1 reference

based on heuristic

inferred from title

author name string

Surinder M Soond

1

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

Andrew Chantry

2

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Europe PubMed Central

PubMed publication ID

25 August 2017

language of work or name

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publication date

1 October 2011

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Europe PubMed Central

PubMed publication ID

25 August 2017

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Europe PubMed Central

PubMed publication ID

25 August 2017

33

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

749-758

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Mechanisms of the epithelial-mesenchymal transition by TGF-beta

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

New regulatory mechanisms of TGF-beta receptor function

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Regulation of Smad activities

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Two major Smad pathways in TGF-beta superfamily signalling.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Transcriptional crosstalk between TGF-β and stem cell pathways in tumor cell invasion: role of EMT promoting Smad complexes

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

The amplified WWP1 gene is a potential molecular target in breast cancer

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Patented small molecule inhibitors in the ubiquitin proteasome system

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Alternative UPS drug targets upstream the 26S proteasome

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Modification of proteins by ubiquitin and ubiquitin-like proteins

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Activating the ubiquitin family: UBA6 challenges the field

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

UBE1L2, a novel E1 enzyme specific for ubiquitin

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

E1-L2 activates both ubiquitin and FAT10

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Basis for a ubiquitin-like protein thioester switch toggling E1–E2 affinity

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Mechanisms underlying ubiquitination

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

The unique N terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances checkpoint regulation of the APC.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Structure and function of ubiquitin conjugating enzyme E2-25K: the tail is a core-dependent activity element.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

The E2-E3 interaction in the N-end rule pathway: the RING-H2 finger of E3 is required for the synthesis of multiubiquitin chain

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

The CK2 phosphorylation of catalytic domain of Cdc34 modulates its activity at the G1 to S transition in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Cdc34 C-terminal tail phosphorylation regulates Skp1/cullin/F-box (SCF)-mediated ubiquitination and cell cycle progression.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Mechanism of lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Human Cdc34 employs distinct sites to coordinate attachment of ubiquitin to a substrate and assembly of polyubiquitin chains

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Recognition of the polyubiquitin proteolytic signal

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Proteasome-independent functions of ubiquitin in endocytosis and signaling

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Ubiquitination and proteasome-dependent degradation of human eukaryotic translation initiation factor 4E.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Regulation of TGF-beta family signaling by E3 ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

The utility F-box for protein destruction

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Tumor suppressor Fbxw7 regulates TGFβ signaling by targeting TGIF1 for degradation.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Calmodulin antagonizes a calcium-activated SCF ubiquitin E3 ligase subunit, FBXL2, to regulate surfactant homeostasis

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

ERK and the F-box protein betaTRCP target STAT1 for degradation

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

The HECT family of E3 ubiquitin ligases: multiple players in cancer development

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

SCF(beta-TrCP1) controls Smad4 protein stability in pancreatic cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Characterizing Class I WW domains defines key specificity determinants and generates mutant domains with novel specificities

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Arkadia-Smad7-mediated positive regulation of TGF-beta signaling in a rat model of tubulointerstitial fibrosis

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Identification of novel human WW domain-containing proteins by cloning of ligand targets

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Regulation of Immune Responses by E3 Ubiquitin-Protein Ligases

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

The Nedd4-like family of E3 ubiquitin ligases and cancer

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

The ubiquitin-activating enzyme E1 is phosphorylated and localized to the nucleus in a cell cycle-dependent manner

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Phosphorylation of ubiquitin-activating enzyme in cultured cells

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Nuclear localization of the ubiquitin-activating enzyme, E1, is cell-cycle-dependent

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Common variant of human NEDD4L activates a cryptic splice site to form a frameshifted transcript

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Wwp2-mediated ubiquitination of the RNA polymerase II large subunit in mouse embryonic pluripotent stem cells

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

WWP2 is an E3 ubiquitin ligase for PTEN.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Fbw7 isoform interaction contributes to cyclin E proteolysis.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Siah1 proteins enhance radiosensitivity of human breast cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Molecular characterisation of a recurrent, semi-cryptic RUNX1 translocation t(7;21) in myelodysplastic syndrome and acute myeloid leukaemia.

1 reference

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21 January 2018

Emerging roles of BRCA1 alternative splicing

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Identification of ubiquitin ligase activity of RBCK1 and its inhibition by splice variant RBCK2 and protein kinase Cbeta.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100057

21 January 2018

Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains

1 reference

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21 January 2018

Identifiers

10.1002/BIES.201100057

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

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