(Q37953290)

25 August 2017

Ricin and Shiga toxins: effects on host cell signal transduction (English)

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25 August 2017

Dakshina M Jandhyala

1

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PubMed ID

22057792

25 August 2017

Cheleste M Thorpe

series ordinal

2

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PubMed ID

22057792

25 August 2017

Bruce Magun

series ordinal

3

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25 August 2017

1 January 2012

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Current Topics in Microbiology and Immunology

25 August 2017

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25 August 2017

357

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25 August 2017

41-65

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Hematopoietic cell kinase associates with the 40S ribosomal subunit and mediates the ribotoxic stress response to deoxynivalenol in mononuclear phagocytes

25 August 2017

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12 December 2020

Role of p38 MAP kinase pathway in a toxin-induced model of hemolytic uremic syndrome

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12 December 2020

NF-κB in immunobiology.

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12 December 2020

Endocytosis and intracellular transport of ricin: recent discoveries

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12 December 2020

Ribotoxic stress response: activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the alpha-sarcin/ricin loop in the 28S rRNA.

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12 December 2020

Shiga toxin 2 causes apoptosis in human brain microvascular endothelial cells via C/EBP homologous protein

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12 December 2020

Retrograde transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol

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12 December 2020

Furin-induced cleavage and activation of Shiga toxin.

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12 December 2020

The interaction of Ricinus communis agglutinin with normal and tumor cell surfaces.

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12 December 2020

TLR4 gene dosage contributes to endotoxin-induced acute respiratory inflammation

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12 December 2020

Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase and induces apoptosis

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12 December 2020

The Mitogen-activated protein kinase p38 links Shiga Toxin-dependent signaling and trafficking

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12 December 2020

From endoplasmic-reticulum stress to the inflammatory response

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12 December 2020

Macropinocytosis in Shiga toxin 1 uptake by human intestinal epithelial cells and transcellular transcytosis

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12 December 2020

Essential role for verotoxin in sustained stress-activated protein kinase and nuclear factor kappa B signaling, stimulated by Escherichia coli O157:H7 in Vero cells.

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12 December 2020

Something old, something new: indoor endotoxin, allergens and asthma

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12 December 2020

Shiga toxins activate translational regulation pathways in intestinal epithelial cells.

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12 December 2020

Rab6 coordinates a novel Golgi to ER retrograde transport pathway in live cells

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12 December 2020

Protein kinase Cdelta is activated by Shiga toxin and regulates its transport.

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12 December 2020

MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest

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12 December 2020

Nuclear factor-kappa B (NFkappaB) component p50 in blood mononuclear cells regulates endothelial tissue factor expression in sickle transgenic mice: implications for the coagulopathy of sickle cell disease

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12 December 2020

Shiga toxin 1-induced proinflammatory cytokine production is regulated by the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling pathway

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12 December 2020

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

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12 December 2020

Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA

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12 December 2020

Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif

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12 December 2020

Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response

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12 December 2020

Ribotoxic stress response to the trichothecene deoxynivalenol in the macrophage involves the SRC family kinase Hck.

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12 December 2020

Mining literature for a comprehensive pathway analysis: a case study for retrieval of homocysteine related genes for genetic and epigenetic studies

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12 December 2020

Site of action of a Vero toxin (VT2) from Escherichia coli O157:H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins.

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12 December 2020

Shiga toxin 2 and flagellin from shiga-toxigenic Escherichia coli superinduce interleukin-8 through synergistic effects on host stress-activated protein kinase activation

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12 December 2020

Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice

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12 December 2020

Plant ribosome-inactivating proteins type II induce the unfolded protein response in human cancer cells

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12 December 2020

IRE1 signaling affects cell fate during the unfolded protein response

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12 December 2020

Deoxynivalenol induces p38 interaction with the ribosome in monocytes and macrophages.

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12 December 2020

A murine model of HUS: Shiga toxin with lipopolysaccharide mimics the renal damage and physiologic response of human disease

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12 December 2020

Comparative induction of 28S ribosomal RNA cleavage by ricin and the trichothecenes deoxynivalenol and T-2 toxin in the macrophage

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12 December 2020

Shiga toxin 1 triggers a ribotoxic stress response leading to p38 and JNK activation and induction of apoptosis in intestinal epithelial cells

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12 December 2020

Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulum

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12 December 2020

Shiga toxin-induced tumor necrosis factor alpha expression: requirement for toxin enzymatic activity and monocyte protein kinase C and protein tyrosine kinases

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12 December 2020

Evidence for widespread epithelial damage and coincident production of monocyte chemotactic protein 1 in a murine model of intestinal ricin intoxication

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12 December 2020

Ultraviolet radiation triggers the ribotoxic stress response in mammalian cells.

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12 December 2020

Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation

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12 December 2020

Globotriaosyl ceramide (Gb3) expression in human tumour cells: intracellular trafficking defines a new retrograde transport pathway from the cell surface to the nucleus, which correlates with sensitivity to verotoxin.

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12 December 2020

Shiga toxin type 1 activates tumor necrosis factor-alpha gene transcription and nuclear translocation of the transcriptional activators nuclear factor-kappaB and activator protein-1.

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12 December 2020

Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation

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12 December 2020

Shiga toxin is transported from the endoplasmic reticulum following interaction with the luminal chaperone HEDJ/ERdj3.

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12 December 2020

NFkappaB promotes inflammation, coagulation, and fibrosis in the aging glomerulus

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12 December 2020

Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum

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12 December 2020

Shiga toxin produced by enterohemorrhagic Escherichia coli inhibits PI3K/NF-kappaB signaling pathway in globotriaosylceramide-3-negative human intestinal epithelial cells

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12 December 2020

von Willebrand factor and von Willebrand factor-cleaving metalloprotease activity in Escherichia coli O157:H7-associated hemolytic uremic syndrome

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12 December 2020

Depletion of sphingolipids facilitates endosome to Golgi transport of ricin

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12 December 2020

Ricin A chain utilises the endoplasmic reticulum-associated protein degradation pathway to enter the cytosol of yeast

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12 December 2020

Ceramide as a TLR4 agonist; a putative signalling intermediate between sphingolipid receptors for microbial ligands and TLR4.

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12 December 2020

Shiga toxin 1 induces apoptosis through the endoplasmic reticulum stress response in human monocytic cells

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12 December 2020

Apoptosis induction by the satratoxins and other trichothecene mycotoxins: relationship to ERK, p38 MAPK, and SAPK/JNK activation

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12 December 2020

Endocytosis, intracellular transport, and cytotoxic action of Shiga toxin and ricin

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12 December 2020

Endoplasmic reticulum stress in disease: mechanisms and therapeutic opportunities

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12 December 2020

Intracellular signaling events in CD77-mediated apoptosis of Burkitt's lymphoma cells

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12 December 2020

Ricin induces IL-8 secretion from human monocyte/macrophages by activating the p38 MAP kinase pathway.

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12 December 2020

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12 December 2020

A laboratory model of toxin-induced hemolytic uremic syndrome

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12 December 2020

Fractalkine and CX3CR1 mediate leukocyte capture by endothelium in response to Shiga toxin

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12 December 2020

Role of P38 MAPK, AP-1, and NF-kappaB in interleukin-1beta-induced IL-8 expression in human vascular smooth muscle cells

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12 December 2020

Globotriaosyl ceramide (CD77/Gb3) in the glycolipid-enriched membrane domain participates in B-cell receptor–mediated apoptosis by regulating Lyn kinase activity in human B cells

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12 December 2020

NALPs: a novel protein family involved in inflammation

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12 December 2020

Role of double-stranded RNA-activated protein kinase R (PKR) in deoxynivalenol-induced ribotoxic stress response

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12 December 2020

Rapid, sequential activation of mitogen-activated protein kinases and transcription factors precedes proinflammatory cytokine mRNA expression in spleens of mice exposed to the trichothecene vomitoxin

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12 December 2020

Efficient endosome-to-Golgi transport of Shiga toxin is dependent on dynamin and clathrin

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12 December 2020

Shiga toxin binding to globotriaosyl ceramide induces intracellular signals that mediate cytoskeleton remodeling in human renal carcinoma-derived cells

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12 December 2020

Shiga toxin increases formation of clathrin-coated pits through Syk kinase

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12 December 2020

Dependence of ricin toxicity on translocation of the toxin A-chain from the endoplasmic reticulum to the cytosol

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12 December 2020

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

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12 December 2020

Activation of Src family kinase yes induced by Shiga toxin binding to globotriaosyl ceramide (Gb3/CD77) in low density, detergent-insoluble microdomains

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12 December 2020

Vomitoxin-induced cyclooxygenase-2 gene expression in macrophages mediated by activation of ERK and p38 but not JNK mitogen-activated protein kinases

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12 December 2020

The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.

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12 December 2020

Globotriosyl ceramide is specifically recognized by the Escherichia coli verocytotoxin 2.

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12 December 2020

Pathogenesis of shigella diarrhea. XI. Isolation of a shigella toxin-binding glycolipid from rabbit jejunum and HeLa cells and its identification as globotriaosylceramide

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12 December 2020

Entry of ricin and Shiga toxin into cells: molecular mechanisms and medical perspectives

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12 December 2020

Molecular mechanism of interleukin-8 gene expression

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12 December 2020

Protein disulphide-isomerase reduces ricin to its A and B chains in the endoplasmic reticulum

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12 December 2020

Proinflammatory responses of human airway cells to ricin involve stress-activated protein kinases and NF-kappaB.

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12 December 2020

Cross-talk between the pathways leading to the induction of apoptosis and the secretion of tumor necrosis factor-alpha in ricin-treated RAW 264.7 cells

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12 December 2020

Immunohistochemical detection of the unfolded protein response in atherosclerotic plaques.

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12 December 2020

Role of the disulfide bond in Shiga toxin A-chain for toxin entry into cells

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12 December 2020

ZAK: a MAP3Kinase that transduces Shiga toxin- and ricin-induced proinflammatory cytokine expression.

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12 December 2020

The ribotoxic stress response as a potential mechanism for MAP kinase activation in xenobiotic toxicity

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12 December 2020

Activation of TNF-alpha transcription utilizes distinct MAP kinase pathways in different macrophage populations.

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12 December 2020

Shiga toxins stimulate secretion of interleukin-8 from intestinal epithelial cells

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12 December 2020

Globotetraosylceramide is recognized by the pig edema disease toxin

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12 December 2020

Structural determinants of Ricinus communis agglutinin and toxin specificity for oligosaccharides

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12 December 2020

Intrapulmonary delivery of ricin at high dosage triggers a systemic inflammatory response and glomerular damage

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12 December 2020

ZAK is required for doxorubicin, a novel ribotoxic stressor, to induce SAPK activation and apoptosis in HaCaT cells

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12 December 2020

Suppression of NF-kappa B activation and proinflammatory cytokine expression by Shiga toxin-producing Escherichia coli

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12 December 2020

Role of apoptotic signaling pathways in regulation of inflammatory responses to ricin in primary murine macrophages

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12 December 2020

Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced interleukin-6 upregulation in the macrophage.

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12 December 2020

Clathrin adaptor epsinR is required for retrograde sorting on early endosomal membranes

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12 December 2020

Shiga toxins induce, superinduce, and stabilize a variety of C-X-C chemokine mRNAs in intestinal epithelial cells, resulting in increased chemokine expression

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12 December 2020

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

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12 December 2020

NLRs join TLRs as innate sensors of pathogens

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12 December 2020

The inflammasome: first line of the immune response to cell stress

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12 December 2020

The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway

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12 December 2020

Identification of the carbohydrate receptor for Shiga toxin produced by Shigella dysenteriae type 1.

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12 December 2020

Administration of ricin induces a severe inflammatory response via nonredundant stimulation of ERK, JNK, and P38 MAPK and provides a mouse model of hemolytic uremic syndrome

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12 December 2020

Ricin inhibits activation of the unfolded protein response by preventing splicing of the HAC1 mRNA.

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12 December 2020

Identification and characterization of a novel MAP kinase kinase kinase, MLTK

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12 December 2020

Shiga toxin 1-induced activation of c-Jun NH(2)-terminal kinase and p38 in the human monocytic cell line THP-1: possible involvement in the production of TNF-alpha.

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12 December 2020

Stimulus-specific assembly of enhancer complexes on the tumor necrosis factor alpha gene promoter

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12 December 2020

New insights into the mechanism of IL-1beta maturation

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12 December 2020

RNA N-glycosidase activity of ricin A-chain. Mechanism of action of the toxic lectin ricin on eukaryotic ribosomes

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12 December 2020

Toll-like receptor priming sensitizes macrophages to proinflammatory cytokine gene induction by deoxynivalenol and other toxicants

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12 December 2020

Shiga toxin 1 induces apoptosis in the human myelogenous leukemia cell line THP-1 by a caspase-8-dependent, tumor necrosis factor receptor-independent mechanism

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12 December 2020

Specificity of Twelve Lectins Towards Oligosaccharides and Glycopeptides Related to N‐Glycosylproteins

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12 December 2020

The Unfolded Protein Response, Degradation from Endoplasmic Reticulum and Cancer

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12 December 2020

Shigatoxin-induced endothelin-1 expression in cultured podocytes autocrinally mediates actin remodeling

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12 December 2020

The caspase-1 inflammasome: a pilot of innate immune responses

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12 December 2020

Shiga toxin regulates its entry in a Syk-dependent manner

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12 December 2020

Endocytosis from coated pits of Shiga toxin: a glycolipid-binding protein from Shigella dysenteriae 1.

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12 December 2020

Inhibitors of protein kinase signaling pathways: emerging therapies for cardiovascular disease.

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12 December 2020

Apoptosis induced in Burkitt's lymphoma cells via Gb3/CD77, a glycolipid antigen.

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12 December 2020

Double-stranded RNA-activated protein kinase mediates induction of interleukin-8 expression by deoxynivalenol, Shiga toxin 1, and ricin in monocytes

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12 December 2020

Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways

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12 December 2020

Intracellular targeting of the endoplasmic reticulum/nuclear envelope by retrograde transport may determine cell hypersensitivity to verotoxin via globotriaosyl ceramide fatty acid isoform traffic.

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12 December 2020

Shiga toxin-2 triggers endothelial leukocyte adhesion and transmigration via NF-kappaB dependent up-regulation of IL-8 and MCP-1.

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12 December 2020

Pulmonary inflammation triggered by ricin toxin requires macrophages and IL-1 signaling

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12 December 2020

Emerging inflammasome effector mechanisms.

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12 December 2020

Ricin Toxin Activates the NALP3 Inflammasome

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12 December 2020

Shiga toxin 1-induced cytokine production is mediated by MAP kinase pathways and translation initiation factor eIF4E in the macrophage-like THP-1 cell line

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12 December 2020

Identifiers

DOI

10.1007/82_2011_181

1 reference

25 August 2017

1 reference

PubMed ID

22057792