(Q37975555)

26 August 2017

Targeting the Hedgehog signaling pathway for cancer therapy (English)

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26 August 2017

3

1 reference

26 August 2017

6

Fazlul H Sarkar

1 reference

26 August 2017

Yiwei Li

1

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26 August 2017

Ma'in Y Maitah

series ordinal

2

1 reference

26 August 2017

Dejuan Kong

series ordinal

4

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26 August 2017

Bin Bao

series ordinal

5

1 reference

26 August 2017

language of work or name

English

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publication date

1 January 2012

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Expert Opinion on Therapeutic Targets

26 August 2017

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26 August 2017

16

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26 August 2017

1

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26 August 2017

49-66

1 reference

Hallmarks of Cancer: The Next Generation

26 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

21 January 2018

Cancer statistics, 2010

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Targeting Wnt signaling: can we safely eradicate cancer stem cells?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

CUX1/Wnt signaling regulates epithelial mesenchymal transition in EBV infected epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Cancer chemoprevention with dietary phytochemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Apoptosis by dietary factors: the suicide solution for delaying cancer growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Molecular pathway for (-)-epigallocatechin-3-gallate-induced cell cycle arrest and apoptosis of human prostate carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Activation of the hedgehog-signaling pathway in human cancer and the clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Hedgehog signalling: how to get from Smo to Ci and Gli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Hedgehog signaling: a biophysical or biomechanical modulator in embryonic development?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Cilia and developmental signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Hedgehog signaling and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Patched acts catalytically to suppress the activity of Smoothened

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

New aspects of Wnt signaling pathways in higher vertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Hedgehog signaling in animal development: paradigms and principles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

The hedgehog signaling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Dual Phosphorylation of suppressor of fused (Sufu) by PKA and GSK3beta regulates its stability and localization in the primary cilium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Notch signalling regulates stem cell numbers in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Telomerase-immortalized human mammary stem/progenitor cells with ability to self-renew and differentiate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Transcriptional crosstalk between TGF-β and stem cell pathways in tumor cell invasion: role of EMT promoting Smad complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Hedgehog: functions and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Hedgehog signalling as a target in cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

The role of the hedgehog signaling pathway in the development of basal cell carcinoma and opportunities for treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

A novel mutation of the PTCH1 gene activates the Shh/Gli signaling pathway in a Chinese family with nevoid basal cell carcinoma syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Novel PTCH1 mutations in Japanese Nevoid basal cell carcinoma syndrome patients: two familial and three sporadic cases including the first Japanese patient with medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Gene silencing of transcription factor Gli2 inhibits basal cell carcinomalike tumor growth in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

GLI1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Sonic hedgehog expression correlates with distant metastasis in pancreatic adenocarcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

The expression pattern of PDX-1, SHH, Patched and Gli-1 is associated with pathological and clinical features in human pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Hedgehog signaling and therapeutics in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Activation of the Hedgehog pathway in chronic myelogeneous leukemia patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Hedgehog pathway activation in chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Hedgehog signaling pathway is activated in diffuse large B-cell lymphoma and contributes to tumor cell survival and proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Hedgehog signaling in prostate growth and benign prostate hyperplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Prostate cancer and Hedgehog signalling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Lack of demonstrable autocrine hedgehog signaling in human prostate cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Hedgehog signaling pathway mediates the progression of non-invasive breast cancer to invasive breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Hedgehog signaling induced by breast cancer cells promotes osteoclastogenesis and osteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Hedgehog and epithelial-mesenchymal transition signaling in normal and malignant epithelial cells of the esophagus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Cross talk between hedgehog and epithelial-mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Retracted: Up-Regulation of Sonic Hedgehog Contributes to TGF-β1-Induced Epithelial to Mesenchymal Transition in NSCLC Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

The hedgehog pathway inhibitor GDC-0449 shows potential in skin and other cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Hedgehog antagonist GDC-0449 is effective in the treatment of advanced basal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Topical treatment of Basal cell carcinomas in nevoid Basal cell carcinoma syndrome with a smoothened inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Hedgehog signaling drives cellular survival in human colon carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

HH/GLI signalling as a new therapeutic target for patients with oral squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Gli2 expression and human bladder transitional carcinoma cell invasiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Sonic hedgehog alleviates the inhibitory effects of high glucose on the osteoblastic differentiation of bone marrow stromal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Reduction of human embryonal rhabdomyosarcoma tumor growth by inhibition of the hedgehog signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Nutritional and socioeconomic factors in relation to prostate cancer mortality: a cross-national study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Does high soy milk intake reduce prostate cancer incidence? The Adventist Health Study (United States)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

The curcuma antioxidants: pharmacological effects and prospects for future clinical use. A review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Modulation of inflammatory mediators by ibuprofen and curcumin treatment during chronic inflammation in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Review: green tea polyphenols in chemoprevention of prostate cancer: preclinical and clinical studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

(-)-Epigallocatechin-3-gallate induces apoptosis and suppresses proliferation by inhibiting the human Indian Hedgehog pathway in human chondrosarcoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Effect of resveratrol on growth of 4T1 breast cancer cells in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

The role of vitamin D in cancer prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Emerging regulatory paradigms for control of gene expression by 1,25-dihydroxyvitamin D3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Vitamin D3 inhibits hedgehog signaling and proliferation in murine Basal cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Novel Hedgehog pathway targets against basal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Assessing the efficacy of the hedgehog pathway inhibitor vitamin D3 in a murine xenograft model for pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.617367

10.1517/14728222.2011.617367

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference