(Q37638143)

21 August 2017

1 reference

title

Activation of the hedgehog-signaling pathway in human cancer and the clinical implications (English)

1 reference

21 August 2017

L Yang

1

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21 August 2017

G Xie

series ordinal

2

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21 August 2017

Q Fan

series ordinal

3

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21 August 2017

J Xie

series ordinal

4

1 reference

21 August 2017

language of work or name

English

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publication date

23 November 2009

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21 August 2017

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21 August 2017

29

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21 August 2017

469-481

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21 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/onc.2009.392

21 August 2017

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cites work

Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

MSX2 stimulates chondrocyte maturation by controlling Ihh expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Ultraviolet radiation mutagenesis of hedgehog pathway genes in basal cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating dally and dally-like.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog signaling and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Glypican-mediated endocytosis of Hedgehog has opposite effects in flies and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Medulloblastoma growth inhibition by hedgehog pathway blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Role of hedgehog signaling in ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Sertoli cell signaling by Desert hedgehog regulates the male germline

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

The Hedgehog signaling pathway as a target for anticancer drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Heterozygous mutations in the tumor suppressor gene PATCHED provoke basal cell carcinoma-like features in human organotypic skin cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Protein kinase Cdelta negatively regulates hedgehog signaling by inhibition of Gli1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Small molecule modulation of Smoothened activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Teratogen-mediated inhibition of target tissue response to Shh signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Vertebrate Smoothened functions at the primary cilium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Insulin-like growth factor 2 is required for progression to advanced medulloblastoma in patched1 heterozygous mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Heparan sulfate-modulated, metalloprotease-mediated sonic hedgehog release from producing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Essential role of stromally induced hedgehog signaling in B-cell malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Ligand-dependent activation of the hedgehog pathway in glioma progenitor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Genetic determinants of basal cell carcinoma risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Basal cell carcinomas: attack of the hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog signaling promotes prostate xenograft tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Development of mammary tumors by conditional expression of GLI1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog signaling is dispensable for adult hematopoietic stem cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Altered neural cell fates and medulloblastoma in mouse patched mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Dual and opposing roles of primary cilia in medulloblastoma development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Suppressing Wnt signaling by the hedgehog pathway through sFRP-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

C2cd3 is required for cilia formation and Hedgehog signaling in mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Naturally occurring small-molecule inhibitors of hedgehog/GLI-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Activation of the hedgehog pathway in human hepatocellular carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Cilia and Hedgehog responsiveness in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog signalling in the mouse requires intraflagellar transport proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Dual degradation signals control Gli protein stability and tumor formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Orchestrating ontogenesis: variations on a theme by sonic hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Regulation of Hh/Gli signaling by dual ubiquitin pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog signaling in development and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog signalling in prostate regeneration, neoplasia and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

SCL/TAL1 interrupting locus derepresses GLI1 from the negative control of suppressor-of-fused in pancreatic cancer cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog signalling in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Characterization of sonic hedgehog as a novel NF-kappaB target gene that promotes NF-kappaB-mediated apoptosis resistance and tumor growth in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

The GLI gene is a member of the Kruppel family of zinc finger proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

The GLI gene encodes a nuclear protein which binds specific sequences in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Sufu recruits GSK3beta for efficient processing of Gli3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Beta-arrestin-mediated localization of smoothened to the primary cilium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

A frequent activated smoothened mutation in sporadic basal cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Cooperation between GLI and JUN enhances transcription of JUN and selected GLI target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Autoproteolysis in hedgehog protein biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Loss of suppressor-of-fused function promotes tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Stroma-initiated hedgehog signaling takes center stage in B-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog signaling is activated in subsets of esophageal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Gas1 extends the range of Hedgehog action by facilitating its signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Cyclopamine and jervine in embryonic rat tongue cultures demonstrate a role for Shh signaling in taste papilla development and patterning: fungiform papillae double in number and form in novel locations in dorsal lingual epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

First-in-class, first-in-human phase I results of targeted agents: highlights of the 2008 American society of clinical oncology meeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Mutations affecting segment number and polarity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Boc is a receptor for sonic hedgehog in the guidance of commissural axons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog signalling in cancer formation and maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog/Ras interactions regulate early stages of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Progenitor cell maintenance requires numb and numblike during mouse neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

The product of hedgehog autoproteolytic cleavage active in local and long-range signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Cholesterol modification of hedgehog signaling proteins in animal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Impaired hippocampal plasticity in mice lacking the Cbeta1 catalytic subunit of cAMP-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Stem cells, cancer, and cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Sonic hedgehog mediates the polarizing activity of the ZPA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Activation of heterotrimeric G proteins by Smoothened

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

The GLI-Kruppel family of human genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Intraflagellar transport and cilium-based signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Inhibition of androgen-independent prostate cancer cell growth is enhanced by combination therapy targeting Hedgehog and ErbB signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Activation of the hedgehog pathway in advanced prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog: an attribute to tumor regrowth after chemoradiotherapy and a target to improve radiation response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Pharmacologic retinoid signaling and physiologic retinoic acid receptor signaling inhibit basal cell carcinoma tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

A small molecule that binds Hedgehog and blocks its signaling in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Structural analysis of glycosaminoglycans in animals bearing mutations in sugarless, sulfateless, and tout-velu. Drosophila homologues of vertebrate genes encoding glycosaminoglycan biosynthetic enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Divergence of hedgehog signal transduction mechanism between Drosophila and mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog signaling in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog signaling pathway: development of antagonists for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Implications of hedgehog signaling antagonists for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

A role of PDGFRalpha in basal cell carcinoma proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Activating Smoothened mutations in sporadic basal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Crosstalk of hedgehog and Wnt pathways in gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

The ihog cell-surface proteins bind Hedgehog and mediate pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

A paracrine requirement for hedgehog signalling in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog signal activation in oesophageal cancer patients undergoing neoadjuvant chemoradiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog signaling promotes the degradation of tumor suppressor Sufu through the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Extensive phosphorylation of Smoothened in Hedgehog pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Disruption of IFT results in both exocrine and endocrine abnormalities in the pancreas of Tg737(orpk) mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog pathway inhibitor HhAntag691 is a potent inhibitor of ABCG2/BCRP and ABCB1/Pgp

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Hedgehog regulates smoothened activity by inducing a conformational switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

The EWS/FLI1 oncogenic transcription factor deregulates GLI1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Targeting the Hedgehog pathway in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Molecular biology of basal and squamous cell carcinomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.392

31 March 2020

Identifiers

DOI

10.1038/ONC.2009.392

1 reference

21 August 2017

1 reference