(Q37982890)

26 August 2017

The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases (English)

1 reference

26 August 2017

Peter W Stacpoole

1

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26 August 2017

4 April 2012

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26 August 2017

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26 August 2017

11

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26 August 2017

3

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26 August 2017

371-377

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Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

26 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Mitochondria, oxidants, and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Inherent abnormalities in energy metabolism in Alzheimer disease. Interaction with cerebrovascular compromise

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Mitochondrial abnormalities in Alzheimer brain: mechanistic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Approaches to the treatment of mitochondrial diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Why do cancers have high aerobic glycolysis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Increased superoxide accumulation in pyruvate dehydrogenase complex deficient fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

The Warburg effect and mitochondrial stability in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Mitochondria and the autophagy-inflammation-cell death axis in organismal aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

O2 uptake kinetics, pyruvate dehydrogenase activity, and muscle deoxygenation in young and older adults during the transition to moderate-intensity exercise

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Cell biology. Warburg effect and redox balance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Aging: a theory based on free radical and radiation chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

The Randle cycle revisited: a new head for an old hat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Pyruvate dehydrogenase kinase-4 deficiency lowers blood glucose and improves glucose tolerance in diet-induced obese mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Mitochondrial complex III regulates hypoxic activation of HIF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Alpha-keto acid dehydrogenase complexes. X. Regulation of the activity of the pyruvate dehydrogenase complex from beef kidney mitochondria by phosphorylation and dephosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Neuron-glia metabolic coupling and plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Heterogeneous distribution of pyruvate dehydrogenase in the matrix of mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Decreases in regional cerebral blood flow with normal aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Metabolic modulation of glioblastoma with dichloroacetate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Amyloid beta resistance in nerve cell lines is mediated by the Warburg effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Glucose-free fatty acid cycle operates in human heart and skeletal muscle in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

The spectrum of pyruvate dehydrogenase complex deficiency: clinical, biochemical and genetic features in 371 patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Cerebral glucose transport and metabolism in preterm human infants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Clinical spectrum, morbidity, and mortality in 113 pediatric patients with mitochondrial disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

The effect of dichloroacetate on health- and lifespan in C. elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Magnetic resonance spectroscopic investigation of mitochondrial fuel metabolism and energetics in cultured human fibroblasts: effects of pyruvate dehydrogenase complex deficiency and dichloroacetate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

A new level of architectural complexity in the human pyruvate dehydrogenase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

ß-Cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Lactic acidosis and other mitochondrial disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

The dichloroacetate dilemma: environmental hazard versus therapeutic goldmine--both or neither?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Metabolic Effects of Dichloroacetate in Patients with Diabetes Mellitus and Hyperlipoproteinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Treatment of congenital lactic acidosis with dichloroacetate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Chronic CSE treatment induces the growth of normal oral keratinocytes via PDK2 upregulation, increased glycolysis and HIF1α stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Regional aerobic glycolysis in the human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ ) deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2012.00805.X

10.1111/J.1474-9726.2012.00805.X

21 January 2018

Identifiers

DOI

1 reference

release_tzqhqbehq5c2rpyuunbgh55bv4

26 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/tzqhqbehq5c2rpyuunbgh55bv4

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

22321732

1 reference

PubMed ID

22321732