(Q37989394)

26 August 2017

title

Inflammatory bone loss: pathogenesis and therapeutic intervention (English)

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26 August 2017

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2

Josef S Smolen

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26 August 2017

Kurt Redlich

1

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26 August 2017

publication date

1 March 2012

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Nature Reviews Drug Discovery

26 August 2017

published in

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26 August 2017

volume

11

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26 August 2017

issue

3

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26 August 2017

page(s)

234-250

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https://scigraph.springernature.com/pub.10.1038/nrd3669

26 August 2017

exact match

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cites work

Bone remodeling: Multiple cellular interactions required for coupling of bone formation and resorption

1 reference

Wnt signaling and osteoblastogenesis

31 March 2020

1 reference

Cellular mechanisms of bone remodeling

31 March 2020

1 reference

Pathogenesis of osteoporosis

31 March 2020

1 reference

Regulation of adult bone turnover by sex steroids

31 March 2020

1 reference

Primary hyperparathyroidism and the skeleton

31 March 2020

1 reference

Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women.

31 March 2020

1 reference

Mortality after osteoporotic fractures

31 March 2020

1 reference

31 March 2020

1 reference

Immobility and bone loss in the aging adult

31 March 2020

1 reference

Exercise for preventing and treating osteoporosis in postmenopausal women

31 March 2020

1 reference

The role of exercise in the treatment of osteoporosis

31 March 2020

1 reference

Inflammation-induced bone loss: can it be prevented?

31 March 2020

1 reference

Radiographic changes in rheumatoid arthritis patients attaining different disease activity states with methotrexate monotherapy and infliximab plus methotrexate: the impacts of remission and tumour necrosis factor blockade

31 March 2020

1 reference

Canonical WNT Signaling Promotes Osteogenesis by Directly StimulatingRunx2Gene Expression

31 March 2020

1 reference

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

31 March 2020

1 reference

Gene expression profiles and transcription factors involved in parathyroid hormone signaling in osteoblasts revealed by microarray and bioinformatics

31 March 2020

1 reference

Bone anabolic effects of parathyroid hormone are blunted by deletion of the Wnt antagonist secreted frizzled-related protein-1.

31 March 2020

1 reference

Bone morphogenetic proteins and their antagonists

31 March 2020

1 reference

Regulation of the osteoblast-specific transcription factor, Runx2: responsiveness to multiple signal transduction pathways

31 March 2020

1 reference

Skeletal remodeling in health and disease

31 March 2020

1 reference

Networks and hubs for the transcriptional control of osteoblastogenesis.

31 March 2020

1 reference

Wnt signaling regulates hemopoiesis through stromal cells.

31 March 2020

1 reference

Towards an integrated view of Wnt signaling in development

31 March 2020

1 reference

Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling

31 March 2020

1 reference

Dihydrotestosterone-inducible dickkopf 1 from balding dermal papilla cells causes apoptosis in follicular keratinocytes

31 March 2020

1 reference

The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma

31 March 2020

1 reference

Dickkopf-1 is a master regulator of joint remodeling

31 March 2020

1 reference

Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

31 March 2020

1 reference

Characterization of the Structural Features and Interactions of Sclerostin: MOLECULAR INSIGHT INTO A KEY REGULATOR OF Wnt-MEDIATED BONE FORMATION

31 March 2020

1 reference

Parathyroid hormone receptor directly interacts with dishevelled to regulate beta-Catenin signaling and osteoclastogenesis

31 March 2020

1 reference

The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation

31 March 2020

1 reference

NFAT and Osterix cooperatively regulate bone formation

31 March 2020

1 reference

Inhibition of osteoblastic bone formation by nuclear factor-kappaB.

31 March 2020

1 reference

Novel functions for NFκB: inhibition of bone formation

31 March 2020

1 reference

Calcitonin impairs the anabolic effect of PTH in young rats and stimulates expression of sclerostin by osteocytes

31 March 2020

1 reference

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

31 March 2020

1 reference

Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone

31 March 2020

1 reference

Osteocytes as dynamic multifunctional cells

31 March 2020

1 reference

Osteocytes, mechanosensing and Wnt signaling

31 March 2020

1 reference

Towards quantitative 3D imaging of the osteocyte lacuno-canalicular network

31 March 2020

1 reference

SOST/sclerostin, an osteocyte-derived negative regulator of bone formation

31 March 2020

1 reference

IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase

31 March 2020

1 reference

Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer

31 March 2020

1 reference

Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice

31 March 2020

1 reference

GP130/OSMR is the only LIF/IL-6 family receptor complex to promote osteoblast differentiation of calvaria progenitors.

31 March 2020

1 reference

GP130 cytokines and bone remodelling in health and disease

31 March 2020

1 reference

Bone morphogenetic protein receptor IB signaling mediates apoptosis independently of differentiation in osteoblastic cells

31 March 2020

1 reference

Estrogen regulation of apoptosis in osteoblasts

31 March 2020

1 reference

Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis

31 March 2020

1 reference

Heritable sclerosing bone disorders: presentation and new molecular mechanisms

31 March 2020

1 reference

Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

31 March 2020

1 reference

Bone resorption by osteoclasts

31 March 2020

1 reference

Bone development and inflammatory disease is regulated by AP-1 (Fos/Jun).

31 March 2020

1 reference

Targeting inflammation by modulating the Jun/AP-1 pathway

31 March 2020

1 reference

AP-1 as a regulator of cell life and death

31 March 2020

1 reference

Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

31 March 2020

1 reference

Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts

31 March 2020

1 reference

Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities

31 March 2020

1 reference

Ion channels and transporters in osteoclasts

31 March 2020

1 reference

Human giant cell tumors of bone identification and characterization of cell types

31 March 2020

1 reference

RANK is essential for osteoclast and lymph node development

31 March 2020

1 reference

The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption.

31 March 2020

1 reference

Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse

31 March 2020

1 reference

c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling

31 March 2020

1 reference

Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis.

31 March 2020

1 reference

MCP-1 is induced by receptor activator of nuclear factor-{kappa}B ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony-stimulating factor suppression of osteoclast formation

31 March 2020

1 reference

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

31 March 2020

1 reference

Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo

31 March 2020

1 reference

MicroRNA biogenesis and regulation of bone remodeling

31 March 2020

1 reference

A microRNA expression signature of osteoclastogenesis

31 March 2020

1 reference

miR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop.

31 March 2020

1 reference

Impaired micro-RNA pathways diminish osteoclast differentiation and function

31 March 2020

1 reference

Generalised bone loss in patients with early rheumatoid arthritis

31 March 2020

1 reference

Bone loss in inflammatory arthritis: mechanisms and therapeutic approaches with bisphosphonates

31 March 2020

1 reference

Osteoporosis in inflammatory bowel disease

31 March 2020

1 reference

Inflammation Is The Main Determinant of Low Bone Mineral Density in Pediatric Inflammatory Bowel Disease

31 March 2020

1 reference

31 March 2020

Bone in celiac disease

1 reference

Altered bone metabolism in inflammatory disease: role for nutrition

31 March 2020

1 reference

Osteoclast function, bone turnover and inflammatory cytokines during infective exacerbations of cystic fibrosis

31 March 2020

1 reference

Bone mineral density and fractures in older men with chronic obstructive pulmonary disease or asthma

31 March 2020

1 reference

A longitudinal study of the relationship between periodontal disease and bone mineral density in community-dwelling older adults

31 March 2020

1 reference

Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-tumor necrosis factor in combination with osteoprotegerin or parathyroid hormone in tumor necrosis factor-mediated arthritis

31 March 2020

1 reference

Colitis causes bone loss in rats through suppression of bone formation

31 March 2020

1 reference

Dental infections and coronary atherosclerosis

31 March 2020

1 reference

B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease

31 March 2020

1 reference

Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection

31 March 2020

1 reference

31 March 2020

1 reference

Functional relevance of T helper 17 (Th17) cells and the IL-17 cytokine family in inflammatory bowel disease

31 March 2020

1 reference

Interleukin-6 modulates production of T lymphocyte–derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis

31 March 2020

1 reference

Tumor necrosis factor: a pleiotropic cytokine and therapeutic target

31 March 2020

1 reference

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1

31 March 2020

1 reference

The paradigm of IL-6: from basic science to medicine

31 March 2020

1 reference

IL-6: from its discovery to clinical applications

31 March 2020

1 reference

Tumor necrosis factor receptor and Fas signaling mechanisms.

31 March 2020

1 reference

Signal transduction by tumor necrosis factor: the Parker B. Francis Lectureship

31 March 2020

1 reference

TNF: a master switch for inflammation to cancer

31 March 2020

1 reference

Interleukin-1 induces tumor necrosis factor (TNF) in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits

31 March 2020

1 reference

Synergistic effects of glycoprotein 130 binding cytokines in combination with interleukin-1 on cartilage collagen breakdown

31 March 2020

1 reference

The effects of cytokines on metalloproteinase inhibitors (TIMP) and collagenase production by human chondrocytes and TIMP production by synovial cells and endothelial cells

31 March 2020

1 reference

Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts

31 March 2020

1 reference

Interleukin-1 and the Pathogenesis of the Acute-Phase Response

31 March 2020

1 reference

Regulation of the acute phase response by cytokines

31 March 2020

1 reference

Action of recombinant human interleukin 6, interleukin 1 beta and tumor necrosis factor alpha on the mRNA induction of acute-phase proteins

31 March 2020

1 reference

Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence

31 March 2020

1 reference

IL-6 mediates the effects of IL-1 or TNF, but not PTHrP or 1,25(OH)2D3, on osteoclast-like cell formation in normal human bone marrow cultures

31 March 2020

1 reference

Human interleukin-1-induced murine osteoclastogenesis is dependent on RANKL, but independent of TNF-alpha

31 March 2020

1 reference

IL-1alpha stimulation of osteoclast survival through the PI 3-kinase/Akt and ERK pathways

31 March 2020

1 reference

Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction

31 March 2020

1 reference

Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation

31 March 2020

1 reference

Impaired skeletal development in interleukin-6-transgenic mice: a model for the impact of chronic inflammation on the growing skeletal system

31 March 2020

1 reference

TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand

31 March 2020

1 reference

Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor.

31 March 2020

1 reference

Antiinflammatory effects of tumor necrosis factor on hematopoietic cells in a murine model of erosive arthritis

31 March 2020

1 reference

Tumor necrosis factor-alpha (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways

31 March 2020

1 reference

31 March 2020

1 reference

Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption

31 March 2020

1 reference

Macrophage fusion: the making of osteoclasts and giant cells

31 March 2020

1 reference

Rheumatoid synovitis. An extravascular immune complex disease

31 March 2020

1 reference

Fc receptor genes and the systemic lupus erythematosus diathesis

31 March 2020

1 reference

The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase

31 March 2020

1 reference

Long-term outcome of treating rheumatoid arthritis: results after 20 years

31 March 2020

1 reference

Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll-like receptor 4 and Fcγ receptor

31 March 2020

1 reference

The relation among stress, adrenalin, interleukin 6 and acute phase proteins in the rat

31 March 2020

1 reference

The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation

31 March 2020

1 reference

Effects of oestrogen deprivation on interleukin-6 production by peripheral blood mononuclear cells of postmenopausal women

31 March 2020

1 reference

Interleukin-11: a new cytokine critical for osteoclast development

31 March 2020

1 reference

Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient mice

31 March 2020

1 reference

Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha

31 March 2020

1 reference

The p55 TNF receptor mediates TNF inhibition of osteoblast differentiation independently of apoptosis

31 March 2020

1 reference

Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.

31 March 2020

1 reference

Tumor necrosis factor-alpha inhibits pre-osteoblast differentiation through its type-1 receptor

31 March 2020

1 reference

TNF-alpha inhibits BMP-induced osteoblast differentiation through activating SAPK/JNK signaling

31 March 2020

1 reference

TNF-alpha and IL-1beta inhibit RUNX2 and collagen expression but increase alkaline phosphatase activity and mineralization in human mesenchymal stem cells

31 March 2020

1 reference

Interleukin-6 inhibits bone formation in vitro

31 March 2020

1 reference

Interleukin-11 inhibits bone formation in vitro

31 March 2020

1 reference

Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

31 March 2020

1 reference

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

31 March 2020

1 reference

SOST and DKK: Antagonists of LRP Family Signaling as Targets for Treating Bone Disease

31 March 2020

1 reference

Chronic pediatric inflammatory diseases: effects on bone

31 March 2020

1 reference

Metabolic osteopathy in celiac disease: importance of a gluten-free diet

31 March 2020

1 reference

Using tetracyclines to treat osteoporotic/osteopenic bone loss: from the basic science laboratory to the clinic

31 March 2020

1 reference

How can we prevent multisystem complications of cystic fibrosis?

31 March 2020

1 reference

Bone loss in patients with active early rheumatoid arthritis: infliximab and methotrexate compared with methotrexate treatment alone. Explorative analysis from a 12-month randomised, double-blind, placebo-controlled study

31 March 2020

1 reference

Glucocorticoids suppress bone formation via the osteoclast

31 March 2020

1 reference

EULAR evidence-based recommendations on the management of systemic glucocorticoid therapy in rheumatic diseases.

31 March 2020

1 reference

Should bisphosphonates be used for long-term treatment of glucocorticoid-induced osteoporosis?

31 March 2020

1 reference

Increase in bone mineral density of patients with rheumatoid arthritis treated with anti-TNF-alpha antibody: a prospective open-label pilot study

31 March 2020

1 reference

Maintenance Infliximab Treatment Is Associated with Improved Bone Mineral Density in Crohn's Disease

31 March 2020

1 reference

Review article: the effects of antitumour necrosis factor-α on bone metabolism in inflammatory bowel disease.

31 March 2020

1 reference

Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of s

31 March 2020

1 reference

A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease

31 March 2020

1 reference

Current evidence for the management of rheumatoid arthritis with biological disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of RA.

31 March 2020

1 reference

Gene therapy for osteoporosis: evaluation in a murine ovariectomy model

31 March 2020

1 reference

Essential role of microRNA-155 in the pathogenesis of autoimmune arthritis in mice

31 March 2020

1 reference

Discovery, biology and therapeutic potential of RNA interference, microRNA and antagomirs

31 March 2020

1 reference

Therapeutic strategies for rheumatoid arthritis

31 March 2020

1 reference

Clinical efficacy and safety of abatacept in methotrexate-naive patients with early rheumatoid arthritis and poor prognostic factors

31 March 2020

1 reference

Inhibition of joint damage and improved clinical outcomes with rituximab plus methotrexate in early active rheumatoid arthritis: the IMAGE trial

31 March 2020

1 reference

Influence of Rituximab on markers of bone remodeling in patients with rheumatoid arthritis: a prospective open-label pilot study

31 March 2020

1 reference

An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis

31 March 2020

1 reference

Use of sirolimus (rapamycin) to treat refractory Crohn's disease

31 March 2020

1 reference

Mammalian target of rapamycin signaling is crucial for joint destruction in experimental arthritis and is activated in osteoclasts from patients with rheumatoid arthritis

31 March 2020

1 reference

Impact of sirolimus, tacrolimus and mycophenolate mofetil on osteoclastogenesis--implications for post-transplantation bone disease

31 March 2020

1 reference

regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis

31 March 2020

1 reference

PPARγ in bone homeostasis

31 March 2020

1 reference

M-CSF, TNFα and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase

31 March 2020

1 reference

Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro

31 March 2020

1 reference

Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives

31 March 2020

1 reference

Bortezomib inhibits human osteoclastogenesis.

31 March 2020

1 reference

Proteasome inhibitors abrogate osteoclast differentiation and osteoclast function

31 March 2020

1 reference

Bortezomib inhibits maturation and function of osteoclasts from PBMCs of patients with multiple myeloma by downregulating TRAF6.

31 March 2020

1 reference

Targeting the proteasome: partial inhibition of the proteasome by bortezomib or deletion of the immunosubunit LMP7 attenuates experimental colitis

31 March 2020

1 reference

Bortezomib attenuates murine collagen-induced arthritis

31 March 2020

1 reference

The proteasome inhibitor bortezomib drastically affects inflammation and bone disease in adjuvant-induced arthritis in rats

31 March 2020

1 reference

Bisphosphonates: the first 40 years

31 March 2020

1 reference

Treatment with fluoride or bisphosphonates prevents bone loss associated with colitis in the rat

31 March 2020

1 reference

Increased bone mass with pamidronate treatment in rheumatoid arthritis. Results of a three-year randomized, double-blind trial

31 March 2020

1 reference

Risedronate directly inhibits osteoclast differentiation and inflammatory bone loss

31 March 2020

1 reference

Long-term use of bisphosphonates in osteoporosis

31 March 2020

1 reference

Denosumab in postmenopausal women with low bone mineral density

31 March 2020

1 reference

Denosumab for prevention of fractures in postmenopausal women with osteoporosis

31 March 2020

1 reference

Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial

31 March 2020

1 reference

Effects of denosumab on bone mineral density and bone turnover in patients with rheumatoid arthritis receiving concurrent glucocorticoids or bisphosphonates

31 March 2020

1 reference

Clinical utility of denosumab for treatment of bone loss in men and women

31 March 2020

1 reference

Incidence, risk factors, and outcomes of osteonecrosis of the jaw: integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases.

31 March 2020

1 reference

Endogenous tissue engineering: PTH therapy for skeletal repair.

31 March 2020

1 reference

Pro-inflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNFalpha induce the mitogen-activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts

31 March 2020

1 reference

Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression

31 March 2020

1 reference

The application of target information and preclinical pharmacokinetic/pharmacodynamic modeling in predicting clinical doses of a Dickkopf-1 antibody for osteoporosis

31 March 2020

1 reference

Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones

31 March 2020

1 reference

Treatment with a sclerostin antibody increases cancellous bone formation and bone mass regardless of marrow composition in adult female rats.

31 March 2020

1 reference

Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis

31 March 2020

1 reference

Oropharyngeal skeletal disease accompanying high bone mass and novel LRP5 mutation

31 March 2020

1 reference

Heterotopic ossifications following implant surgery--epidemiology, therapeutical approaches and current concepts.

31 March 2020

1 reference

Complications of recombinant human BMP-2 for treating complex tibial plateau fractures: a preliminary report

31 March 2020

1 reference

A generalized skeletal hyperostosis in two siblings caused by a novel mutation in the SOST gene.

31 March 2020

1 reference

Adalimumab reduces hand bone loss in rheumatoid arthritis independent of clinical response: subanalysis of the PREMIER study

31 March 2020

1 reference

Risk factors for total tooth loss in the United States; longitudinal analysis of national data

31 March 2020

1 reference

How to report radiographic data in randomized clinical trials in rheumatoid arthritis: guidelines from a roundtable discussion

31 March 2020

1 reference

New therapies for treatment of rheumatoid arthritis

31 March 2020

1 reference

Evidence of radiographic benefit of treatment with infliximab plus methotrexate in rheumatoid arthritis patients who had no clinical improvement: a detailed subanalysis of data from the anti-tumor necrosis factor trial in rheumatoid arthritis with c

31 March 2020

1 reference

The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now?

31 March 2020

1 reference

Tocilizumab inhibits progression of joint damage in rheumatoid arthritis irrespective of its anti-inflammatory effects: disassociation of the link between inflammation and destruction

31 March 2020

1 reference

Regulation of microRNA by antagomirs: a new class of pharmacological antagonists for the specific regulation of gene function?

31 March 2020

1 reference

Targeting osteoclasts with zoledronic acid prevents bone destruction in collagen-induced arthritis.

31 March 2020

1 reference

Zoledronic acid protects against local and systemic bone loss in tumor necrosis factor-mediated arthritis

31 March 2020

1 reference

Preliminary evidence for a structural benefit of the new bisphosphonate zoledronic acid in early rheumatoid arthritis

31 March 2020

1 reference

Osteoprotegerin protects against generalized bone loss in tumor necrosis factor-transgenic mice

31 March 2020

1 reference

Additive bone-protective effects of anabolic treatment when used in conjunction with RANKL and tumor necrosis factor inhibition in two rat arthritis models

31 March 2020

1 reference

Physical disability in rheumatoid arthritis is associated with cartilage damage rather than bone destruction

31 March 2020

1 reference

Expert agreement confirms that negative changes in hand and foot radiographs are a surrogate for repair in patients with rheumatoid arthritis

31 March 2020

1 reference

Tumor necrosis factor alpha-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin

31 March 2020

1 reference

Lymphocytes and synovial fluid fibroblasts support osteoclastogenesis through RANKL, TNFα, and IL-7 in anin vitromodel derived from human psoriatic arthritis

31 March 2020

1 reference

Osteoclasts are essential for TNF-alpha-mediated joint destruction

31 March 2020

1 reference

Arthritis induces lymphocytic bone marrow inflammation and endosteal bone formation

31 March 2020

1 reference

Bone erosions and bone marrow edema as defined by magnetic resonance imaging reflect true bone marrow inflammation in rheumatoid arthritis

31 March 2020

1 reference

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

31 March 2020

1 reference

Quantitative histologic studies on the pathogenesis of periarticular osteoporosis in rheumatoid arthritis

31 March 2020

1 reference

Release of cartilage and bone macromolecules into synovial fluid: differences between psoriatic arthritis and rheumatoid arthritis

31 March 2020

1 reference

A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus

31 March 2020

1 reference

Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis

31 March 2020

1 reference

Ofatumumab, a fully human anti-CD20 monoclonal antibody, in biological-naive, rheumatoid arthritis patients with an inadequate response to methotrexate: a randomised, double-blind, placebo-controlled clinical trial

31 March 2020

1 reference

Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase II, randomized, placebo-controlled trial

31 March 2020

1 reference

Atacicept: targeting B cells in multiple sclerosis

31 March 2020

1 reference

Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma

31 March 2020

1 reference

Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey

31 March 2020

1 reference

Odanacatib in the treatment of postmenopausal women with low bone mineral density: Three-year continued therapy and resolution of effect

31 March 2020

1 reference

Synergistic roles of interleukin-6, interleukin-1, and tumor necrosis factor in the adrenocorticotropin response to bacterial lipopolysaccharide in vivo.

31 March 2020

1 reference

12 December 2020

Osteoporosis and inflammation

1 reference

12 December 2020

Patterns of radiological progression in early rheumatoid arthritis: results of an 8 year prospective study

1 reference

12 December 2020

The synovial expression and serum levels of interleukin-6, interleukin-11, leukemia inhibitory factor, and oncostatin M in rheumatoid arthritis

1 reference

12 December 2020

Mammalian target of rapamycin: a central node of complex signaling cascades

1 reference

12 December 2020

Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis 1

1 reference

12 December 2020

Rheumatoid arthritis and systemic lupus erythematosus as immune complex diseases.

1 reference

12 December 2020

Consensus on a core set of domains for psoriatic arthritis

1 reference

12 December 2020

Role of interleukin 6 (IL-6)/IL-6R-induced signal tranducers and activators of transcription and mitogen-activated protein kinase/extracellular.

1 reference

12 December 2020

Therapeutic blockade of TNF in patients with SLE-promising or crazy?

1 reference

12 December 2020

Joint erosions and patients with early rheumatoid arthritis

1 reference

12 December 2020

Role of members of the Wnt gene family in human hematopoiesis

1 reference

12 December 2020

Osteoclastogenesis--current knowledge and future perspectives.

1 reference

12 December 2020

Cytokine control of acute phase protein expression

1 reference

12 December 2020

Interleukin-1 and interleukin-1 antagonism

1 reference

12 December 2020

Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion

1 reference

12 December 2020

Pregnancy- and lactation-associated osteoporosis: a narrative mini-review.

1 reference

12 December 2020

Targeting the PI3K/Akt/mTOR pathway--beyond rapalogs

1 reference

12 December 2020

Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis

1 reference

12 December 2020

Very recent onset arthritis--clinical, laboratory, and radiological findings during the first year of disease

1 reference

12 December 2020

Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice

1 reference

12 December 2020

Loss of cortical bone from the metacarpal diaphysis in patients with rheumatoid arthritis: independent effects of systemic inflammation and glucocorticoids.

1 reference

12 December 2020

Recombinant IL-1 receptor antagonist protects against TNF-induced lethality in mice.

1 reference

12 December 2020

IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro

1 reference

12 December 2020

Ankylosing spondylitis, psoriatic arthritis, and reactive arthritis show increased bone resorption, but differ with regard to bone formation.

1 reference

12 December 2020

Low dose glucocorticoids in early rheumatoid arthritis.

1 reference

12 December 2020

Osteoporosis in patients with systemic lupus erythematosus.

1 reference

12 December 2020

Highly increased levels of tumor necrosis factor-alpha and other proinflammatory cytokines in psoriatic arthritis synovial fluid

1 reference

12 December 2020

Oral osteoporosis: is there an association between periodontitis and osteoporosis?

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD3669

1 reference

26 August 2017

1 reference