(Q38002888)

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Metabotropic glutamate receptor 4 (mGlu4)-positive allosteric modulators for the treatment of Parkinson's disease: historical perspective and review of the patent literature

scientific article published on 16 April 2012

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scholarly article

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Europe PubMed Central

PubMed publication ID

26 August 2017

Metabotropic glutamate receptor 4 (mGlu4)-positive allosteric modulators for the treatment of Parkinson's disease: historical perspective and review of the patent literature (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

Parkinson's disease

1 reference

based on heuristic

inferred from title

Craig W. Lindsley

1

object named as

Craig W Lindsley

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

author name string

Corey R Hopkins

2

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

language of work or name

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publication date

16 April 2012

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

Expert Opinion on Therapeutic Patents

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Europe PubMed Central

PubMed publication ID

26 August 2017

22

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

461-481

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

Parkinson's disease: mechanisms and models

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Neurobiology and treatment of Parkinson's disease

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Non-motor symptoms of Parkinson's disease: diagnosis and management

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Parkinson's disease therapeutics: new developments and challenges since the introduction of levodopa

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Genetic and environmental factors in the cause of Parkinson's disease

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3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists

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On the presence of 3-hydroxytyramine in brain.

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The etiology of Parkinson's disease with emphasis on the MPTP story

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The levodopa wearing-off phenomenon in Parkinson's disease: pharmacokinetic considerations

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Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia

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Do dopamine agonists or levodopa modify Parkinson's disease progression?

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Neuroprotective effects of a selective N-methyl-D-aspartate NR2B receptor antagonist in the 6-hydroxydopamine rat model of Parkinson's disease

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Adenosine A(2A) Receptor Antagonists and Parkinson's Disease

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The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease.

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Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels

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Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist

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Small Molecule c-jun-N-terminal Kinase (JNK) Inhibitors Protect Dopaminergic Neurons in a Model of Parkinson's Disease

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JNK Inhibition Protects Dopamine Neurons and Provides Behavioral Improvement in a Rat 6-hydroxydopamine Model of Parkinson's Disease

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Recent advances in the design and development of novel negative allosteric modulators of mGlu(5)

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mGluR4-positive allosteric modulation as potential treatment for Parkinson's disease.

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Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics

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The functional anatomy of basal ganglia disorders

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Neural mechanisms in disorders of movement.

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Primate models of movement disorders of basal ganglia origin

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Reversal of experimental parkinsonism by lesions of the subthalamic nucleus

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D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons

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Cortico-basal ganglia-cortical circuitry in Parkinson's disease reconsidered

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Functional neurosurgery for movement disorders: a historical perspective

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Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia

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Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

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Pharmacology and functions of metabotropic glutamate receptors

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Pharmacological agents acting at subtypes of metabotropic glutamate receptors

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Regulation of neurotransmitter release by metabotropic glutamate receptors

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Positive and negative allosteric modulation of metabotropic glutamate receptors: emerging therapeutic potential

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Distribution of group III mGluRs in rat basal ganglia with subtype-specific antibodies.

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Intrapallidal metabotropic glutamate receptor activation in a rat model of Parkinson's disease: behavioral and histological analyses

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The influence of group III metabotropic glutamate receptor stimulation by (1S,3R,4S)-1-aminocyclo-pentane-1,3,4-tricarboxylic acid on the parkinsonian-like akinesia and striatal proenkephalin and prodynorphin mRNA expression in rats.

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Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes

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Synthesis and biological evaluation of (2S)- and (2R)-2-(3'-phosphonobicyclo[1.1.1]pentyl)glycines as novel group III selective metabotropic glutamate receptor ligands

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A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists

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Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABAergic systems

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Metabotropic glutamate receptor subtype 4 selectively modulates both glutamate and GABA transmission in the striatum: implications for Parkinson's disease treatment

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A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential

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A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain

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Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.

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(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

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"Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology

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Chemical switch of a metabotropic glutamate receptor 2 silent allosteric modulator into dual metabotropic glutamate receptor 2/3 negative/positive allosteric modulators

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Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.

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Integrated synthetic, pharmacological, and computational investigation of cis-2-(3,5-dichlorophenylcarbamoyl)cyclohexanecarboxylic acid enantiomers as positive allosteric modulators of metabotropic glutamate receptor subtype 4.

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Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs)

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Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators

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The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.

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Identifiers

10.1517/13543776.2012.679437

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

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