(Q38032459)

27 August 2017

title

Metabolome 2.0: quantitative genetics and network biology of metabolic phenotypes (English)

1 reference

27 August 2017

Marc-Emmanuel Dumas

1

0 references

publication date

1 October 2012

1 reference

27 August 2017

1 reference

27 August 2017

volume

8

1 reference

27 August 2017

issue

10

1 reference

27 August 2017

page(s)

2494-2502

1 reference

'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

27 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Metabonomics: a platform for studying drug toxicity and gene function

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Systematic functional analysis of the yeast genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Homeostatic signature of anabolic steroids in cattle using 1H-13C HMBC NMR metabonomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Selection of biomarkers by a multivariate statistical processing of composite metabonomic data sets using multiple factor analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

The challenges of modeling mammalian biocomplexity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Gut microorganisms, mammalian metabolism and personalized health care

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Metabolic phenotyping in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Human metabolic phenotype diversity and its association with diet and blood pressure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Metabotyping of Caenorhabditis elegans reveals latent phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

A metabolomic and systems biology perspective on the brain of the fragile X syndrome mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Probing molecular dynamics in chromatographic systems using high-resolution 1H magic-angle-spinning NMR spectroscopy: interaction between p-Xylene and C18-bonded silica

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Metabonomic assessment of physiological disruptions using 1H-13C HMBC-NMR spectroscopy combined with pattern recognition procedures performed on filtered variables.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Gas chromatography of volatiles from breath and urine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Closed-loop, multiobjective optimization of two-dimensional gas chromatography/mass spectrometry for serum metabolomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Data analysis tool for comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Metabolic profiling of glucuronides in human urine by LC-MS/MS and partial least-squares discriminant analysis for classification and prediction of gender

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

High-throughput and multiplexed LC/MS/MRM method for targeted metabolomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Precision mapping of the metabolome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Human metabolic profiles are stably controlled by genetic and environmental variation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Analyzing the physiological signature of anabolic steroids in cattle urine using pyrolysis/metastable atom bombardment mass spectrometry and pattern recognition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic 1H NMR data sets

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Analytic properties of statistical total correlation spectroscopy based information recovery in 1H NMR metabolic data sets

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Statistical heterospectroscopy, an approach to the integrated analysis of NMR and UPLC-MS data sets: application in metabonomic toxicology studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Targeted profiling: quantitative analysis of 1H NMR metabolomics data

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Between-person comparison of metabolite fitting for NMR-based quantitative metabolomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Application of a Bayesian deconvolution approach for high-resolution (1)H NMR spectra to assessing the metabolic effects of acute phenobarbital exposure in liver tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Identification and quantification of metabolites in (1)H NMR spectra by Bayesian model selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

BATMAN--an R package for the automated quantification of metabolites from nuclear magnetic resonance spectra using a Bayesian model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Statistical recoupling prior to significance testing in nuclear magnetic resonance based metabonomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Pharmaco-metabonomic phenotyping and personalized drug treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Evaluation of the orthogonal projection on latent structure model limitations caused by chemical shift variability and improved visualization of biomarker changes in 1H NMR spectroscopic metabonomic studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Statistical significance for genomewide studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Metabolic profiling and the metabolome-wide association study: significance level for biomarker identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Two-dimensional statistical recoupling for the identification of perturbed metabolic networks from NMR spectroscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Evidence of different metabolic phenotypes in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Metabolomics-on-a-chip and predictive systems toxicology in microfluidic bioartificial organs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

The dynamic range of the human metabolome revealed by challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Genetical genomics: the added value from segregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Genetics of gene expression surveyed in maize, mouse and man

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Genetic analysis of the mouse brain proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Comprehensive metabolic profiling and phenotyping of interspecific introgression lines for tomato improvement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

A genome-wide perspective of genetic variation in human metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

A genome-wide association study of metabolic traits in human urine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Human metabolic individuality in biomedical and pharmaceutical research

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

R/qtl: QTL mapping in experimental crosses

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Mapping quantitative trait loci by an extension of the Haley-Knott regression method using estimating equations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

PLINK: a tool set for whole-genome association and population-based linkage analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Genetic determinants of metabolism in health and disease: from biochemical genetics to genome-wide associations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Genome-wide association study identifies multiple loci influencing human serum metabolite levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Stitching together multiple data dimensions reveals interacting metabolomic and transcriptomic networks that modulate cell regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

A human gut microbial gene catalogue established by metagenomic sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Enterotypes of the human gut microbiome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Metabolic pathways in the post-genome era.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

KEGG: Kyoto Encyclopedia of Genes and Genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

KEGG: kyoto encyclopedia of genes and genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

MSEA: a web-based tool to identify biologically meaningful patterns in quantitative metabolomic data

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Consensus-phenotype integration of transcriptomic and metabolomic data implies a role for metabolism in the chemosensitivity of tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

A global test for groups of genes: testing association with a clinical outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

The protein kinase complement of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Grasping at molecular interactions and genetic networks in Drosophila melanogaster using FlyNets, an Internet database

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Correlation between transcriptome and interactome mapping data from Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Toward a protein-protein interaction map of the budding yeast: A comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Integrating physical and genetic maps: from genomes to interaction networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

A network view of disease and compound screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Molecular networks as sensors and drivers of common human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

NEW: network-enabled wisdom in biology, medicine, and health care

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

ConsensusPathDB--a database for integrating human functional interaction networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Graph-based methods for analysing networks in cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Metabolomics-on-a-chip and metabolic flux analysis for label-free modeling of the internal metabolism of HepG2/C3A cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Gas chromatography mass spectrometry–based metabolite profiling in plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Metabolic profiling strategy of Caenorhabditis elegans by whole-organism nuclear magnetic resonance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Characterization of Isotopic Abundance Measurements in High Resolution FT-ICR and Orbitrap Mass Spectra for Improved Confidence of Metabolite Identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Assessment of Analytical Reproducibility of1H NMR Spectroscopy Based Metabonomics for Large-Scale Epidemiological Research: the INTERMAP Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Cryogenic Probe13C NMR Spectroscopy of Urine for Metabonomic Studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Global metabolic profiling procedures for urine using UPLC–MS

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

The evolution of partial least squares models and related chemometric approaches in metabonomics and metabolic phenotyping

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Untargeted Metabolome Quantitative Trait Locus Mapping Associates Variation in Urine Glycerate to Mutant Glycerate Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

Broad-Ranging Natural Metabotype Variation Drives Physiological Plasticity in Healthy Control Inbred Rat Strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

The genetics of plant metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB25167A

21 January 2018

Identifiers

DOI

10.1039/C2MB25167A

1 reference

27 August 2017

1 reference