(Q38035144)

27 August 2017

MicroRNAs in the p53 network: micromanagement of tumour suppression (English)

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27 August 2017

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Heiko Hermeking

1

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PubMed ID

22898542

27 August 2017

language of work or name

English

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publication date

17 August 2012

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27 August 2017

Nature Reviews Cancer

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27 August 2017

12

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27 August 2017

613-626

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27 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrc3318

27 August 2017

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Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis

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MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth

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Genome-wide characterization of miR-34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysis

21 January 2018

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Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling

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p53 represses c-Myc through induction of the tumor suppressor miR-145

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The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia

21 January 2018

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Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

21 January 2018

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p53 activates the PANK1/miRNA-107 gene leading to downregulation of CDK6 and p130 cell cycle proteins

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miRNA regulation of Sdf1 chemokine signaling provides genetic robustness to germ cell migration

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Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells

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The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

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Role of DNA methylation in miR-200c/141 cluster silencing in invasive breast cancer cells

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miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells

21 January 2018

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miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions

21 January 2018

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A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition.

21 January 2018

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MiR-34 and SNAIL: another double-negative feedback loop controlling cellular plasticity/EMT governed by p53.

21 January 2018

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Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition

21 January 2018

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Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.

21 January 2018

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A microRNA DNA methylation signature for human cancer metastasis

21 January 2018

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The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

21 January 2018

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Wild-type p53 controls cell motility and invasion by dual regulation of MET expression

21 January 2018

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Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer

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21 January 2018

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p53 connects tumorigenesis and reprogramming to pluripotency

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p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells

21 January 2018

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Epithelial-mesenchymal transitions in development and disease

21 January 2018

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MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells

21 January 2018

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MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells

21 January 2018

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MicroRNA-145 is regulated by DNA methylation and p53 gene mutation in prostate cancer

21 January 2018

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FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis

21 January 2018

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The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells.

21 January 2018

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Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells

21 January 2018

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miR-34a repression of SIRT1 regulates apoptosis

21 January 2018

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miR-200c regulates induction of apoptosis through CD95 by targeting FAP-1

21 January 2018

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miR-15 and miR-16 induce apoptosis by targeting BCL2

21 January 2018

1 reference

Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development

21 January 2018

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Snail blocks the cell cycle and confers resistance to cell death

21 January 2018

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MicroRNAs in metabolism and metabolic disorders

21 January 2018

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Cellular metabolism and disease: what do metabolic outliers teach us?

21 January 2018

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Otto Warburg's contributions to current concepts of cancer metabolism

21 January 2018

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Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence

21 January 2018

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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

21 January 2018

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The interplay between MYC and HIF in cancer.

21 January 2018

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The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop

21 January 2018

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The Lin28/let-7 axis regulates glucose metabolism

21 January 2018

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P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis

21 January 2018

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miR-200 Inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1.

21 January 2018

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21 January 2018

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21 January 2018

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Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs

21 January 2018

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21 January 2018

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Eμ/miR-125b transgenic mice develop lethal B-cell malignancies.

21 January 2018

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miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto-oncogene in human invasive breast cancer.

21 January 2018

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Negative regulation of tumor suppressor p53 by microRNA miR-504

21 January 2018

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miR-33-mediated downregulation of p53 controls hematopoietic stem cell self-renewal

21 January 2018

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MicroRNA-1285 inhibits the expression of p53 by directly targeting its 3' untranslated region

21 January 2018

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miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma.

21 January 2018

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Negative regulation of the tumor suppressor p53 gene by microRNAs.

21 January 2018

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A combined array-based comparative genomic hybridization and functional library screening approach identifies mir-30d as an oncomir in cancer

21 January 2018

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Systematic proteome analysis identifies transcription factor YY1 as a direct target of miR-34a

21 January 2018

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MicroRNA-449 in cell fate determination

21 January 2018

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miR-449 inhibits cell proliferation and is down-regulated in gastric cancer

21 January 2018

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MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells

21 January 2018

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CPEB and two poly(A) polymerases control miR-122 stability and p53 mRNA translation

21 January 2018

1 reference

p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest

21 January 2018

1 reference

miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress

21 January 2018

1 reference

miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.

21 January 2018

1 reference

Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53.

21 January 2018

1 reference

Sequence variations of microRNAs in human cancer: alterations in predicted secondary structure do not affect processing.

21 January 2018

1 reference

In-depth characterization of the microRNA transcriptome in a leukemia progression model

21 January 2018

1 reference

Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells

21 January 2018

1 reference

Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation

21 January 2018

1 reference

Myc: Maestro of MicroRNAs

21 January 2018

1 reference

A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?

21 January 2018

1 reference

Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

21 January 2018

1 reference

A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells

21 January 2018

1 reference

RETRACTED: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function

21 January 2018

1 reference

Reduced expression of Dicer associated with poor prognosis in lung cancer patients.

21 January 2018

1 reference

Dicer, Drosha, and outcomes in patients with ovarian cancer

21 January 2018

1 reference

DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors

21 January 2018

1 reference

DICER1 mutations in familial pleuropulmonary blastoma

21 January 2018

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A resource of vectors and ES cells for targeted deletion of microRNAs in mice.

21 January 2018

1 reference

A pipeline for the generation of shRNA transgenic mice

21 January 2018

1 reference

A decade of exploring the cancer epigenome - biological and translational implications

21 January 2018

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Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer.

21 January 2018

1 reference

Epigenetic alteration of DNA in mucosal wash fluid predicts invasiveness of colorectal tumors.

21 January 2018

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The epigenetic progenitor origin of human cancer

21 January 2018

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A genetic model for colorectal tumorigenesis

21 January 2018

1 reference

Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy

21 January 2018

1 reference

Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice

21 January 2018

1 reference

Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles

21 January 2018

1 reference

Regulation of mRNA translation and stability by microRNAs

21 January 2018

1 reference

MicroRNAs: target recognition and regulatory functions

21 January 2018

1 reference

miR-34a and miR-15a/16 are co-regulated in non-small cell lung cancer and control cell cycle progression in a synergistic and Rb-dependent manner

21 January 2018

1 reference

Epigenetic inactivation of the miR-34a in hematological malignancies

21 January 2018

1 reference

Frequent downregulation of miR-34 family in human ovarian cancers

21 January 2018

1 reference

Epigenetic silencing of microRNA-34b/c plays an important role in the pathogenesis of malignant pleural mesothelioma.

21 January 2018

1 reference

CpG island methylation status of miRNAs in esophageal squamous cell carcinoma

21 January 2018

1 reference

MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells

21 January 2018

1 reference

miR-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer.

21 January 2018

1 reference

Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect

21 January 2018

1 reference

A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia

21 January 2018

1 reference

The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities

21 January 2018

1 reference

miR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer

21 January 2018

1 reference

MiR-15a and MiR-16 control Bmi-1 expression in ovarian cancer

21 January 2018

1 reference

miR-15a and miR-16-1 down-regulation in pituitary adenomas

21 January 2018

1 reference

Dysregulation of miR-15a and miR-214 in human pancreatic cancer

21 January 2018

1 reference

Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer

21 January 2018

1 reference

The miR-15a-miR-16-1 locus is homozygously deleted in a subset of prostate cancers

21 January 2018

1 reference

Association of microRNA expression with microsatellite instability status in colorectal adenocarcinoma

21 January 2018

1 reference

Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue

21 January 2018

1 reference

A restricted signature of miRNAs distinguishes APL blasts from normal promyelocytes

21 January 2018

1 reference

Epigenetic silencing of MicroRNA miR-107 regulates cyclin-dependent kinase 6 expression in pancreatic cancer

21 January 2018

1 reference

miRNA deregulation by epigenetic silencing disrupts suppression of the oncogene PLAG1 in chronic lymphocytic leukemia

21 January 2018

1 reference

Prognostic significance of miR-215 in colon cancer

21 January 2018

1 reference

Invasion front-specific expression and prognostic significance of microRNA in colorectal liver metastases

21 January 2018

1 reference

EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells

21 January 2018

1 reference

Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small cell lung cancer

21 January 2018

1 reference

Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer.

21 January 2018

1 reference

Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells

21 January 2018

1 reference

A miR-200 microRNA cluster as prognostic marker in advanced ovarian cancer

21 January 2018

1 reference

Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis

21 January 2018

1 reference

Somatic mutations and losses of expression of microRNA regulation-related genes AGO2 and TNRC6A in gastric and colorectal cancers

21 January 2018

1 reference

Myeloid cell differentiation arrest by miR-125b-1 in myelodysplastic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation

21 January 2018

1 reference

SnapShot: MicroRNAs in Cancer

21 January 2018

1 reference

microRNAs: a safeguard against turmoil?

31 March 2020

1 reference

DNA hypermethylation of microRNA-34b/c has prognostic value for stage Ⅰ non-small cell lung cancer

31 March 2020

1 reference

Hsa-miR-34c suppresses growth and invasion of human laryngeal carcinoma cells via targeting c-Met

31 March 2020

1 reference

MYCtranslocation-negative classical Burkitt lymphoma cases: an alternative pathogenetic mechanism involving miRNA deregulation

31 March 2020

1 reference

MicroRNAs differentially expressed in ACTH-secreting pituitary tumors

31 March 2020

1 reference

Down-regulation of miR-141 in gastric cancer and its involvement in cell growth

31 March 2020

1 reference

Genetic and epigenetic association studies suggest a role of microRNA biogenesis gene exportin-5 (XPO5) in breast tumorigenesis.

31 March 2020

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12 December 2020

MicroRNA-34b/c suppresses uveal melanoma cell proliferation and migration through multiple targets.

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12 December 2020

The rno-miR-34 family is upregulated and targets ACSL1 in dimethylnitrosamine-induced hepatic fibrosis in rats

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12 December 2020

Endometrial miR-200c is altered during transformation into cancerous states and targets the expression of ZEBs, VEGFA, FLT1, IKKβ, KLF9, and FBLN5.

1 reference

12 December 2020

Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas

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12 December 2020

MicroRNA miR-125b is a prognostic marker in human colorectal cancer

1 reference

12 December 2020

Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif

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12 December 2020

MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis

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12 December 2020

Altered miRNA and gene expression in acute myeloid leukemia with complex karyotype identify networks of prognostic relevance

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12 December 2020

p53 and microRNA-34 are suppressors of canonical Wnt signaling.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC3318

1 reference

PubMed ID

22898542

Dimensions Publication ID

27 August 2017

0 references

1 reference

PubMed ID

22898542