(Q38044430)

27 August 2017

title

Biochemical and functional characterization of the ROC domain of DAPK establishes a new paradigm of GTP regulation in ROCO proteins (English)

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27 August 2017

2

Adi Kimchi

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27 August 2017

Shani Bialik

1

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27 August 2017

publication date

1 October 2012

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Biochemical Society Transactions

27 August 2017

published in

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27 August 2017

volume

40

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27 August 2017

issue

5

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27 August 2017

page(s)

1052-1057

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The Roco protein family: a functional perspective

27 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

Lethal weapons: DAP-kinase, autophagy and cell death: DAP-kinase regulates autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

The tumor suppressor DAPK inhibits cell motility by blocking the integrin-mediated polarity pathway.

21 January 2018

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Uncoordinated regulation of stress fibers and focal adhesions by DAP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

DAPK activates MARK1/2 to regulate microtubule assembly, neuronal differentiation, and tau toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

The death-associated protein kinases: structure, function, and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

GTP binding to the ROC domain of DAP-kinase regulates its function through intramolecular signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

Death-associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

Homodimerization of the death-associated protein kinase catalytic domain: development of a new small molecule fluorescent reporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

Protein phosphatase 2A (PP2A) holoenzymes regulate death-associated protein kinase (DAPK) in ceramide-induced anoikis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

Molecular basis of the death-associated protein kinase-calcium/calmodulin regulator complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

Crystallization and preliminary X-ray analysis of two inhibitor complexes of the catalytic domain of death-associated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

Structure of the dimeric autoinhibited conformation of DAPK2, a pro-apoptotic protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

TSC2: filling the GAP in the mTOR signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

Leucine-rich repeat kinase 2 (LRRK2) cellular biology: a review of recent advances in identifying physiological substrates and cellular functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

Ca2+-dependent Phosphorylation of Syntaxin-1A by the Death-associated Protein (DAP) Kinase Regulates Its Interaction with Munc18

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

Developmental changes in distribution of death-associated protein kinase mRNAs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

DAPK1 variants are associated with Alzheimer's disease and allele-specific expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

Death-associated protein kinase expression in human temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

On the road to leucine-rich repeat kinase 2 signalling: evidence from cellular and in vivo studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

Mechanisms of LRRK2-mediated neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

DAP kinase mediates the phosphorylation of tropomyosin-1 downstream of the ERK pathway, which regulates the formation of stress fibers in response to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

DAPK-1 binding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120155

21 January 2018

Identifiers

DOI

10.1042/BST20120155

1 reference

27 August 2017

1 reference