(Q38058564)

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17 February 2020

title

Controversies in granzyme biology (English)

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17 February 2020

1

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17 February 2020

Joseph A. Trapani

series ordinal

2

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17 February 2020

author name string

D Brasacchio

series ordinal

3

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17 February 2020

publication date

1 December 2012

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17 February 2020

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17 February 2020

volume

80

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17 February 2020

issue

6

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17 February 2020

page(s)

477-487

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A quarter century of granzymes

17 February 2020

cites work

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A natural killer cell granule protein that induces DNA fragmentation and apoptosis

21 January 2018

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Human and murine granzyme B exhibit divergent substrate preferences

21 January 2018

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The major human and mouse granzymes are structurally and functionally divergent

21 January 2018

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Human and mouse granzyme A induce a proinflammatory cytokine response.

21 January 2018

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Human granzyme B is essential for DNA fragmentation of susceptible target cells

21 January 2018

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Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

21 January 2018

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Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

21 January 2018

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Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity

21 January 2018

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Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

21 January 2018

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Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis

21 January 2018

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Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.

21 January 2018

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Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics.

21 January 2018

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Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner.

21 January 2018

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A role for granzyme M in TLR4-driven inflammation and endotoxicosis.

21 January 2018

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Extracellular activities of human granzymes. I. Granzyme A induces IL6 and IL8 production in fibroblast and epithelial cell lines

21 January 2018

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Mouse granzyme K has pro-inflammatory potential.

21 January 2018

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Granzyme A causes detachment of alveolar epithelial A549 cells accompanied by promotion of interleukin-8 release

21 January 2018

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Extracellular granzymes: current perspectives

21 January 2018

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Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin.

21 January 2018

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Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis

21 January 2018

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Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma

21 January 2018

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Granzyme B induces smooth muscle cell apoptosis in the absence of perforin: involvement of extracellular matrix degradation

21 January 2018

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Perforin-independent extracellular granzyme B activity contributes to abdominal aortic aneurysm

21 January 2018

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Granzyme B contributes to extracellular matrix remodeling and skin aging in apolipoprotein E knockout mice

21 January 2018

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Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

21 January 2018

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The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes

21 January 2018

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The structural basis for membrane binding and pore formation by lymphocyte perforin

21 January 2018

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Granzyme B delivery via perforin is restricted by size, but not by heparan sulfate-dependent endocytosis

21 January 2018

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Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin

21 January 2018

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A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death

21 January 2018

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Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death

21 January 2018

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Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis

21 January 2018

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Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes

21 January 2018

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In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells

21 January 2018

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Nephritogenic T cells use granzyme C as a cytotoxic mediator

21 January 2018

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Cell death induced by granzyme C.

21 January 2018

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Structure of granzyme C reveals an unusual mechanism of protease autoinhibition

21 January 2018

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Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo

21 January 2018

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Granzyme C supports efficient CTL-mediated killing late in primary alloimmune responses

21 January 2018

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Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis

21 January 2018

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Long-range disruption of gene expression by a selectable marker cassette

21 January 2018

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Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions.

21 January 2018

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Granzyme F induces a novel death pathway characterized by Bid-independent cytochrome c release without caspase activation

21 January 2018

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Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition

21 January 2018

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Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program

21 January 2018

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Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death.

21 January 2018

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Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells

21 January 2018

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Valosin-containing protein cleavage by granzyme K accelerates an endoplasmic reticulum stress leading to caspase-independent cytotoxicity of target tumor cells.

21 January 2018

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Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity

21 January 2018

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Ignition of p53 bomb sensitizes tumor cells to granzyme K-mediated cytolysis.

21 January 2018

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Unexpected role for granzyme K in CD56bright NK cell-mediated immunoregulation of multiple sclerosis

21 January 2018

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Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis

21 January 2018

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Biology of granzyme M: a serine protease with unique features

21 January 2018

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Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells

21 January 2018

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Heat shock protein 75 (TRAP1) antagonizes reactive oxygen species generation and protects cells from granzyme M-mediated apoptosis.

21 January 2018

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Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation

21 January 2018

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FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade

21 January 2018

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NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network

21 January 2018

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Nucleophosmin is cleaved and inactivated by the cytotoxic granule protease granzyme M during natural killer cell-mediated killing

21 January 2018

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Granzyme M mediates a novel form of perforin-dependent cell death

21 January 2018

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Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway.

21 January 2018

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The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity

21 January 2018

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Human and mouse granzyme M display divergent and species-specific substrate specificities

21 January 2018

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A triple-mutated allele of granzyme B incapable of inducing apoptosis

21 January 2018

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Granzyme B encoded by the commonly occurring human RAH allele retains pro-apoptotic activity.

21 January 2018

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Genotypic variation and phenotypic characterization of granzyme B gene polymorphisms.

21 January 2018

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Defective gammadelta T-cell function and granzyme B gene polymorphism in a cohort of newly diagnosed breast cancer patients

21 January 2018

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High frequency of QPY allele and linkage disequilibrium of granzyme-B in Epstein-Barr-virus-associated hemophagocytic lymphohistiocytosis

21 January 2018

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Sequence analysis of the granulysin and granzyme B genes in familial hemophagocytic lymphohistiocytosis

21 January 2018

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Genetic variants of human granzyme B predict transplant outcomes after HLA matched unrelated bone marrow transplantation for myeloid malignancies.

21 January 2018

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The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains.

21 January 2018

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Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin.

21 January 2018

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Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction

21 January 2018

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UVA induces granzyme B in human keratinocytes through MIF: implication in extracellular matrix remodeling.

21 January 2018

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Granzyme B and perforin: constitutive expression in human polymorphonuclear neutrophils

21 January 2018

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Human neutrophils lack granzyme A, granzyme B, and perforin

21 January 2018

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Expression of granzyme A in human polymorphonuclear neutrophils

21 January 2018

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Granzymes A and B are not expressed in human neutrophils

21 January 2018

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Granzyme G is expressed in the two-cell stage mouse embryo and is required for the maternal-zygotic transition

21 January 2018

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Granzyme N, a novel granzyme, is expressed in spermatocytes and spermatids of the mouse testis

21 January 2018

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Filamin (280-kDa Actin-binding Protein) Is a Caspase Substrate and Is Also Cleaved Directly by the Cytotoxic T Lymphocyte Protease Granzyme B during Apoptosis

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/TAN.12014

1 reference

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17 February 2020

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