(Q38063484)

28 August 2017

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title

Potential of olive oil phenols as chemopreventive and therapeutic agents against cancer: a review of in vitro studies (English)

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28 August 2017

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Ivan Casaburi

1

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28 August 2017

Francesco Puoci

2

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28 August 2017

Adele Chimento

3

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28 August 2017

Rosa Sirianni

4

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28 August 2017

Carmen Ruggiero

5

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28 August 2017

Paola Avena

6

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28 August 2017

Vincenzo Pezzi

7

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28 August 2017

publication date

27 November 2012

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Molecular Nutrition and Food Research

28 August 2017

published in

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28 August 2017

volume

57

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28 August 2017

issue

1

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28 August 2017

page(s)

71-83

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Olive oil intake is inversely related to cancer prevalence: a systematic review and a meta-analysis of 13,800 patients and 23,340 controls in 19 observational studies

28 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Antioxidant and other biological activities of phenols from olives and olive oil.

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201200503

Toward a high yield recovery of antioxidants and purified hydroxytyrosol from olive mill wastewaters

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201200503

Phenolic compounds in olive oil: antioxidant, health and organoleptic activities according to their chemical structure

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201200503

Olive oil phenolics are dose-dependently absorbed in humans

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201200503

One-month administration of hydroxytyrosol, a phenolic antioxidant present in olive oil, to hyperlipemic rabbits improves blood lipid profile, antioxidant status and reduces atherosclerosis development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Effects of differing phenolic content in dietary olive oils on lipids and LDL oxidation--a randomized controlled trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Major phenolic compounds in olive oil modulate bone loss in an ovariectomy/inflammation experimental model

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Inhibition of hypoxia inducible factor-1alpha by dihydroxyphenylethanol, a product from olive oil, blocks microsomal prostaglandin-E synthase-1/vascular endothelial growth factor expression and reduces tumor angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Hydroxytyrosol rich extract from olive leaves modulates cell cycle progression in MCF-7 human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Oleuropein and hydroxytyrosol inhibit MCF-7 breast cancer cell proliferation interfering with ERK1/2 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on human breast cancer MCF-7 cells

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201200503

Cancer chemoprevention by hydroxytyrosol isolated from virgin olive oil through G1 cell cycle arrest and apoptosis.

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201200503

Multiple points of intervention in the prevention of cancer and other mutation-related diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201200503

Oxidative stress and cancer: have we moved forward?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Effect of the olive oil phenol hydroxytyrosol on human hepatoma HepG2 cells. Protection against oxidative stress induced by tert-butylhydroperoxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Tyrosol, the major extra virgin olive oil compound, restored intracellular antioxidant defences in spite of its weak antioxidative effectiveness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

An endogenous metabolite of dopamine, 3,4-dihydroxyphenylethanol, acts as a unique cytoprotective agent against oxidative stress-induced injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Effect of olive oils on biomarkers of oxidative DNA stress in Northern and Southern Europeans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Bioactivity and analysis of biophenols recovered from olive mill waste

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Hydroxytyrosol protects against oxidative DNA damage in human breast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Pyrrolidine dithiocarbamate induces apoptosis by a cytochrome c-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Overview of cell death signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Inhibition of p38/CREB phosphorylation and COX-2 expression by olive oil polyphenols underlies their anti-proliferative effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Antioxidants induce different phenotypes by a distinct modulation of signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Production of hydrogen peroxide is responsible for the induction of apoptosis by hydroxytyrosol on HL60 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Anti-proliferative and pro-apoptotic activities of hydroxytyrosol on different tumour cells: the role of extracellular production of hydrogen peroxide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Nutritional benefit of olive oil: the biological effects of hydroxytyrosol and its arylating quinone adducts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Common inheritance of susceptibility to colonic adenomatous polyps and associated colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

The effects of fish oil, olive oil, oleic acid and linoleic acid on colorectal neoplastic processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Effect of olive oil on early and late events of colon carcinogenesis in rats: modulation of arachidonic acid metabolism and local prostaglandin E(2) synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

The antioxidant/anticancer potential of phenolic compounds isolated from olive oil

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Potential anti-cancer effects of virgin olive oil phenols on colorectal carcinogenesis models in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Inhibitory effects of olive oil phenolics on invasion in human colon adenocarcinoma cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Cyclooxygenase, NSAIDs, and colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

p-HPEA-EDA, a phenolic compound of virgin olive oil, activates AMP-activated protein kinase to inhibit carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

No effects of olive oils with different phenolic content compared to corn oil on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Mediterranean diet and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Chemistry and health of olive oil phenolics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Phytochemicals in olive-leaf extracts and their antiproliferative activity against cancer and endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Hydroxytyrosol inhibits growth and cell proliferation and promotes high expression of sfrp4 in rat mammary tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Secreted antagonists of the Wnt signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

21 January 2018

Cancer statistics, 2009

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https://api.crossref.org/works/10.1002%2FMNFR.201200503

Integration of the extranuclear and nuclear actions of estrogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Rapid signaling by steroid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Plasma membrane estrogen receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Signal transduction. A new mediator for an old hormone?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Estrogen rapid action via protein complex formation involving ERalpha and Src.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Membrane initiated estrogen signaling in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Steering estrogen signals from the plasma membrane to the nucleus: two sides of the coin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Estrogen dendrimer conjugates that preferentially activate extranuclear, nongenomic versus genomic pathways of estrogen action

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Nature of functional estrogen receptors at the plasma membrane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

A transmembrane intracellular estrogen receptor mediates rapid cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Mechanisms of estrogen signaling and gene expression via GPR30

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

The novel estrogen receptor, G protein-coupled receptor 30, mediates the proliferative effects induced by 17beta-estradiol on mouse spermatogonial GC-1 cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

17 beta-estradiol activates rapid signaling pathways involved in rat pachytene spermatocytes apoptosis through GPR30 and ER alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Gper and ESRs are expressed in rat round spermatids and mediate oestrogen-dependent rapid pathways modulating expression of cyclin B1 and Bax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

The unfolding stories of GPR30, a new membrane-bound estrogen receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G(2) cell-cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Virtual and biomolecular screening converge on a selective agonist for GPR30.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

The HER-2 receptor and breast cancer: ten years of targeted anti-HER-2 therapy and personalized medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptin) in HER2-overexpressing breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erbB-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin) in breast cancer cells with Her-2/neu oncogene amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

A genomic explanation connecting "Mediterranean diet", olive oil and cancer: oleic acid, the main monounsaturated fatty acid of olive oil, induces formation of inhibitory "PEA3 transcription factor-PEA3 DNA binding site" complexes at the Her-2/neu (

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

CDK inhibitors: cell cycle regulators and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Peroxisome proliferator-activated receptor-gamma protects ERBB2-positive breast cancer cells from palmitate toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Fine-tuning the lipogenic/lipolytic balance to optimize the metabolic requirements of cancer cell growth: molecular mechanisms and therapeutic perspectives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Antiproliferative effects of dietary phenolic substances and hydrogen peroxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Different cytotoxic and clastogenic effects of epigallocatechin gallate in various cell-culture media due to variable rates of its oxidation in the culture medium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Factors affecting the ascorbate- and phenolic-dependent generation of hydrogen peroxide in Dulbecco's Modified Eagles Medium

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Molecular portraits of human breast tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Bioavailability of olive oil phenolic compounds in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Bioavailability and antioxidant effects of olive oil phenols in humans: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Hydroxytyrosol disposition in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

Daily consumption of a high-phenol extra-virgin olive oil reduces oxidative DNA damage in postmenopausal women

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201200503

21 January 2018

Identifiers

DOI

10.1002/MNFR.201200503

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28 August 2017

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