(Q38072095)

28 August 2017

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title

Hedgehog pathway inhibitors: a patent review (2009--present). (English)

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28 August 2017

Matthew Kyle Hadden

1

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28 August 2017

language of work or name

English

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publication date

8 January 2013

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Expert Opinion on Therapeutic Patents

28 August 2017

published in

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28 August 2017

volume

23

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28 August 2017

issue

3

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28 August 2017

page(s)

345-361

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Activation of the hedgehog-signaling pathway in human cancer and the clinical implications

28 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Basal cell carcinomas: attack of the hedgehog

21 January 2018

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Medulloblastoma growth inhibition by hedgehog pathway blockade

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2013.757304

PATCHED and p53 gene alterations in sporadic and hereditary basal cell cancer.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Childhood medulloblastoma: current status of biology and treatment

21 January 2018

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Isochromosome 17q is a negative prognostic factor in poor-risk childhood medulloblastoma patients

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2013.757304

REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Chromosome 17p deletion in human medulloblastoma: a missing checkpoint in the Hedgehog pathway

21 January 2018

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Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development

21 January 2018

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Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

21 January 2018

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Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

21 January 2018

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Role of hedgehog signaling in ovarian cancer

21 January 2018

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Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation

21 January 2018

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Hedgehog signalling in prostate regeneration, neoplasia and metastasis

21 January 2018

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Targeting the Hedgehog signaling pathway for cancer therapy

21 January 2018

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Targeting Hedgehog--a cancer stem cell pathway

21 January 2018

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The Hedgehog's tale: developing strategies for targeting cancer

21 January 2018

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Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Hedgehog hopes lifted by approval... and stung by failure

21 January 2018

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Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

21 January 2018

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Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance

21 January 2018

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Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.

21 January 2018

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Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine

21 January 2018

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Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity

21 January 2018

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Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

21 January 2018

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A small molecule that binds Hedgehog and blocks its signaling in human cells

21 January 2018

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Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation

21 January 2018

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Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.

21 January 2018

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Negative regulation of Hedgehog signaling by liver X receptors

21 January 2018

1 reference

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Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2013.757304

1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

In vitro and in vivo characterization of a novel Hedgehog signaling antagonist in human glioblastoma cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Converse conformational control of smoothened activity by structurally related small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

A novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Design, synthesis, and biological evaluation of estrone-derived hedgehog signaling inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Spleen tyrosine kinase as a molecular target for treatment of leukemias and lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

The primary cilium as a Hedgehog signal transduction machine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Molecular pathways: the role of primary cilia in cancer progression and therapeutics with a focus on Hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Oxysterols are allosteric activators of the oncoprotein Smoothened

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

Evidence for allosteric interactions of antagonist binding to the smoothened receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.757304

10.1517/13543776.2013.757304

21 January 2018

Identifiers

DOI

1 reference

28 August 2017

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