(Q38088318)

28 August 2017

title

Therapeutic strategies against protein misfolding in neurodegenerative diseases (English)

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28 August 2017

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Claudio Soto

1

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28 August 2017

Zane Martin

series ordinal

2

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28 August 2017

language of work or name

English

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publication date

10 December 2008

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Expert Opinion on Drug Discovery

28 August 2017

published in

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28 August 2017

volume

4

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28 August 2017

issue

1

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28 August 2017

page(s)

71-84

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Examining the structure of the mature amyloid fibril

28 August 2017

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

21 January 2018

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Observation of sequence specificity in the seeding of protein amyloid fibrils.

21 January 2018

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Seeding specificity in amyloid growth induced by heterologous fibrils

21 January 2018

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Common mechanisms of amyloid oligomer pathogenesis in degenerative disease

21 January 2018

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21 January 2018

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21 January 2018

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Alzheimer's and prion disease as disorders of protein conformation: implications for the design of novel therapeutic approaches

21 January 2018

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Conformational changes and disease--serpins, prions and Alzheimer's.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770802630455

Self-assembly of Abeta(1-42) into globular neurotoxins.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770802630455

In vitro and in vivo neurotoxicity of prion protein oligomers.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770802630455

Prefibrillar amyloid protein aggregates share common features of cytotoxicity.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770802630455

Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770802630455

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770802630455

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770802630455

Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770802630455

ABri peptide associated with familial British dementia forms annular and ring-like protofibrillar structures

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Prospects for gene therapy in inherited neurodegenerative diseases

21 January 2018

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RNAi therapy for neurodegenerative diseases.

21 January 2018

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Autotransplantation of bone marrow-derived stem cells as a therapy for neurodegenerative diseases

21 January 2018

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Therapeutic approaches to protein-misfolding diseases

21 January 2018

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Nicotine inhibits amyloid formation by the beta-peptide.

21 January 2018

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Nicotine breaks down preformed Alzheimer's beta-amyloid fibrils in vitro

21 January 2018

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Preventing misfolding of the prion protein by trimethylamine N-oxide

21 January 2018

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Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770802630455

Prevention of transthyretin amyloid disease by changing protein misfolding energetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Trans-suppression of misfolding in an amyloid disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Inhibiting transthyretin amyloid fibril formation via protein stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Protein engineering as a strategy to avoid formation of amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Disaggregation of Alzheimer beta-amyloid by site-directed mAb.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Immunotherapeutic relief from persistent infections and amyloid disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Abeta immunotherapy and other means to remove amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Immunization delays the onset of prion disease in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Immunotherapy for Alzheimer's disease and other dementias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Decrease in pathology and progression of scrapie after immunisation with synthetic prion protein peptides in hamsters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

DNA vaccination against mutant huntingtin ameliorates the HDR6/2 diabetic phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Immunological approaches as therapy for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

A safer vaccine for Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Immunotherapy for conformational diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Anti-aggregating antibodies, a new approach towards treatment of conformational diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Immunotherapy as a therapeutic treatment for neurodegenerative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human beta-amyloid precursor protein transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Metals and amyloid-beta in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Molecular pathways to neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Perturbed signal transduction in neurodegenerative disorders involving aberrant protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Neuroprotective and neurorestorative signal transduction mechanisms in brain aging: modification by genes, diet and behavior.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Excitotoxic and Excitoprotective Mechanisms: Abundant Targets for the Prevention and Treatment of Neurodegenerative Disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Apoptosis in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Inhibition of protein misfolding and aggregation by small rationally-designed peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Pharmaceutical strategies against amyloidosis: old and new drugs in targeting a "protein misfolding disease".

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Current trends in high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Screening for pharmacologic inhibitors of amyloid fibril formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Plaque busters: strategies to inhibit amyloid formation in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770802630455

The challenge of inhibiting Abeta polymerization

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770802630455

Design strategies for anti-amyloid agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic interactions as a common inhibition mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Apolipoprotein J and Alzheimer's amyloid beta solubility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Transthyretin sequesters amyloid beta protein and prevents amyloid formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Inhibition of Alzheimer β-Peptide Fibril Formation by Serum Amyloid P Component

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Alzheimer's peptide Abeta1-42 binds to two beta-sheets of alpha1-antichymotrypsin and transforms it from inhibitor to substrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Laminin inhibition of beta-amyloid protein (Abeta) fibrillogenesis and identification of an Abeta binding site localized to the globular domain repeats on the laminin a chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Laminin inhibits amyloid-beta-peptide fibrillation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Alzhemed: a potential treatment for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Copper, Zinc, and the Metallobiology of Alzheimer Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

21 January 2018

Metals and neuroscience.

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Metal complexing agents as therapies for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Roles of molecular chaperones in protein misfolding diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Adapting proteostasis for disease intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Stressing out the ER: a role of the unfolded protein response in prion-related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Protein-misfolding diseases and chaperone-based therapeutic approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Peptide inhibitors of beta amyloid aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

New strategy for the generation of specific D-peptide amyloid inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Inhibition of amyloid fibril formation by peptide analogues modified with alpha-aminoisobutyric acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Modified-peptide inhibitors of amyloid beta-peptide polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Inhibition of beta-amyloid(40) fibrillogenesis and disassembly of beta-amyloid(40) fibrils by short beta-amyloid congeners containing N-methyl amino acids at alternate residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Inhibition of toxicity in the beta-amyloid peptide fragment beta -(25-35) using N-methylated derivatives: a general strategy to prevent amyloid formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Recognition sequence design for peptidyl modulators of beta-amyloid aggregation and toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Characterization of cholyl-leu-val-phe-phe-ala-OH as an inhibitor of amyloid beta-peptide polymerization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

In vivo reversal of amyloid-beta lesions in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Beta-sheet breaker peptide prevents Abeta-induced spatial memory impairments with partial reduction of amyloid deposits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Converting a peptide into a drug: strategies to improve stability and bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Examination of the Structure of the Transthyretin Amyloid Fibril by Image Reconstruction from Electron Micrographs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770802630455

10.1517/13543770802630455

21 January 2018

Identifiers

DOI

1 reference

28 August 2017

1 reference